Results 21 to 30 of about 24,360 (295)

Accelerated epigenetic aging in newborns with Down syndrome [PDF]

Aging Cell, 2022
AbstractAccelerated aging is a hallmark of Down syndrome (DS), with adults experiencing early‐onset Alzheimer's disease and premature aging of the skin, hair, and immune and endocrine systems. Accelerated epigenetic aging has been found in the blood and brain tissue of adults with DS but when premature aging in DS begins remains unknown.
Xu, K, Li, S, Muskens, IS, Elliott, N, Myint, SS, Pandey, P, Hansen, HM, Morimoto, LM, Kang, AY, Ma, X, Metayer, C, Mueller, BA, Roberts, I, Walsh, KM, Horvath, S, Wiemels, JL, Smith, AJ   +16 more
openaire   +4 more sources

Associations between epigenetic age acceleration and infertility

Human Reproduction, 2022
AbstractSTUDY QUESTIONIs the use of ART, a proxy for infertility, associated with epigenetic age acceleration?SUMMARY ANSWERThe epigenetic age acceleration measured by Dunedin Pace of Aging methylation (DunedinPoAm) differed significantly between non-ART and ART mothers.WHAT IS KNOWN ALREADYAmong mothers who used ART, epigenetic age acceleration may be
Lee, Yunsung, Bohlin, Jon, Page, Christian Magnus, Nustad, Haakon E., Harris, Jennifer Ruth, Magnus, Per Minor, Magnus, Per, Jugessur, Astanand, Magnus, Maria Christine, Håberg, Siri Eldevik, Hanevik, Hans Ivar   +10 more
openaire   +6 more sources

Epigenetic Age Acceleration Reflects Long-Term Cardiovascular Health [PDF]

Circulation Research, 2021
Rationale: Epigenetic aging is a novel measure of biological age, reflecting exposures and disease risks independent of chronological age. It may serve as a useful biomarker of cardiovascular health (CVH) or cardiovascular disease risk for early detection or prevention.
Brian T. Joyce, Tao Gao, Yinan Zheng, Jiantao Ma, Shih-Jen Hwang, Lei Liu, Drew Nannini, Steve Horvath, Ake T. Lu, Norrina Bai Allen, David R. Jacobs, Myron Gross, Amy Krefman, Hongyan Ning, Kiang Liu, Cora E. Lewis, Pamela J. Schreiner, Stephen Sidney, James M. Shikany, Daniel Levy, Philip Greenland, Lifang Hou, Donald Lloyd-Jones   +22 more
openaire   +2 more sources

Time to relapse in chronic lymphocytic leukemia and DNA-methylation-based biological age

Clinical Epigenetics, 2023
Chronic lymphocytic leukemia (CLL) is a mature B cell neoplasm with a predilection for older individuals. While previous studies have identified epigenetic signatures associated with CLL, whether age-related DNA methylation changes modulate CLL relapse ...
Drew R. Nannini, Rene Cortese, Peter Egwom, Senthilnathan Palaniyandi, Gerhard C. Hildebrandt   +4 more
doaj   +1 more source

Multi-omic underpinnings of epigenetic aging and human longevity

Nature Communications, 2023
Biological aging is accompanied by increasing morbidity, mortality, and healthcare costs; however, its molecular mechanisms are poorly understood. Here, we use multi-omic methods to integrate genomic, transcriptomic, and metabolomic data and identify ...
Lucas A. Mavromatis, Daniel B. Rosoff, Andrew S. Bell, Jeesun Jung, Josephin Wagner, Falk W. Lohoff   +5 more
doaj   +1 more source

Epigenetic Age Acceleration Is Not Associated with Age-Related Macular Degeneration [PDF]

International Journal of Molecular Sciences, 2021
DNA methylation age (DNAm age) estimation is a powerful biomarker of human ageing. To date, epigenetic clocks have not been evaluated in age-related macular degeneration (AMD). Here, we perform genome-wide DNA methylation analyses in blood of AMD patients with a documented smoking history (14 AMD, 16 Normal), identifying loci of differential ...
Neil Saptarshi, Daniel Green, Angela Cree, Andrew Lotery, Luminita Paraoan, Louise F. Porter   +5 more
openaire   +4 more sources

Obesity accelerates epigenetic aging of human liver [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Because obese people are at an increased risk of many age-related diseases, it is a plausible hypothesis that obesity increases the biological age of some tissues and cell types. However, it has been difficult to detect such an accelerated aging effect because it is unclear how to measure tissue age.
Horvath, Steve, Erhart, Wiebke, Brosch, Mario, Ammerpohl, Ole, von Schönfels, Witigo, Ahrens, Markus, Heits, Nils, Bell, Jordana T, Tsai, Pei-Chien, Spector, Tim D, Deloukas, Panos, Siebert, Reiner, Sipos, Bence, Becker, Thomas, Röcken, Christoph, Schafmayer, Clemens, Hampe, Jochen   +16 more
openaire   +3 more sources

Alcohol consumption and epigenetic age acceleration in young adults [PDF]

Aging, 2023
Alcohol is a widely consumed substance in the United States, however its effect on aging remains understudied. In this study of young adults, we examined whether cumulative alcohol consumption, i.e., alcohol years of beer, liquor, wine, and total alcohol, and recent binge drinking, were associated with four measures of age-related epigenetic changes ...
Nannini, Drew R, Joyce, Brian T, Zheng, Yinan, Gao, Tao, Wang, Jun, Liu, Lei, Jacobs, David R, Schreiner, Pamela J, Liu, Chunyu, Dai, Qi, Horvath, Steve, Lu, Ake T, Yaffe, Kristine, Greenland, Philip, Lloyd-Jones, Donald M, Hou, Lifang   +15 more
openaire   +3 more sources

The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936 [PDF]

, 2015
Background: The DNA methylation-based 'epigenetic clock' correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and
Corley, Janie, Cox, Simon R, Deary, Ian J, Gibson, Jude, Harris, Sarah E, Horvath, Steve, Marioni, Riccardo E, McRae, Allan F, Muniz-Terrera, Graciela, Murphy, Lee, Pattie, Alison, Redmond, Paul, Ritchie, Stuart J, Shah, Sonia, Starr, John M, Taylor, Adele, Visscher, Peter M, Wray, Naomi R   +17 more
core   +1 more source

Cytomegalovirus infection accelerates epigenetic aging

Experimental Gerontology, 2015
Epigenetic mechanisms such as DNA methylation (DNAm) have a central role in the regulation of gene expression and thereby in cellular differentiation and tissue homeostasis. It has recently been shown that aging is associated with profound changes in DNAm. Several of these methylation changes take place in a clock-like fashion, i.e.
Jylhava Juulia, Kananen Laura, Jylha Marja, Marttila Saara, Nevalainen Tapio, Hervonen Antti, Hurme Mikko, Hurme Mikko   +7 more
openaire   +2 more sources