Results 21 to 30 of about 5,571,062 (272)

Association of cardiovascular health and epigenetic age acceleration [PDF]

Clinical Epigenetics, 2021
Abstract Background Cardiovascular health (CVH) has been defined by the American Heart Association (AHA) as the presence of the “Life’s Simple 7” ideal lifestyle and clinical factors. CVH is known to predict longevity and freedom from cardiovascular disease, the leading cause of death for women in the United States.
Tess D. Pottinger, Sadiya S. Khan, Yinan Zheng, Wei Zhang, Hilary A. Tindle, Matthew Allison, Gretchen Wells, Aladdin H. Shadyab, Rami Nassir, Lisa Warsinger Martin, JoAnn E. Manson, Donald M. Lloyd-Jones, Philip Greenland, Andrea A. Baccarelli, Eric A. Whitsel, Lifang Hou   +15 more
openaire   +5 more sources

Ethnicity-specific patterns of epigenetic age acceleration in rheumatoid arthritis [PDF]

\ua9 The Author(s) 2025.Rheumatoid arthritis (RA) is an age-related chronic inflammatory disease which may include accelerated biological ageing processes in its pathogenesis.
Dunne N, van der Helm-van Mil A, Duggal NA, Pratt AG, Padyukov L, Sharma-Oates A, Lord JM, Raza K, Rivera N, Jones SW   +9 more
core   +7 more sources

Accelerated epigenetic aging in newborns with Down syndrome [PDF]

Aging Cell, 2022
AbstractAccelerated aging is a hallmark of Down syndrome (DS), with adults experiencing early‐onset Alzheimer's disease and premature aging of the skin, hair, and immune and endocrine systems. Accelerated epigenetic aging has been found in the blood and brain tissue of adults with DS but when premature aging in DS begins remains unknown.
Xu, K, Li, S, Muskens, IS, Elliott, N, Myint, SS, Pandey, P, Hansen, HM, Morimoto, LM, Kang, AY, Ma, X, Metayer, C, Mueller, BA, Roberts, I, Walsh, KM, Horvath, S, Wiemels, JL, Smith, AJ   +16 more
openaire   +4 more sources

Metal mixtures and DNA methylation measures of biological aging in American Indian populations

Environment International, 2023
Introduction: Native American communities suffer disproportionately from elevated metal exposures and increased risk for cardiovascular diseases and diabetes. DNA methylation is a sensitive biomarker of aging-related processes and novel epigenetic-based “
Kaila Boyer, Arce Domingo-Relloso, Enoch Jiang, Karin Haack, Walter Goessler, Ying Zhang, Jason G. Umans, Daniel W. Belsky, Shelley A. Cole, Ana Navas-Acien, Allison Kupsco   +10 more
doaj   +1 more source

Association between work characteristics and epigenetic age acceleration: cross-sectional results from UK – Understanding Society study [PDF]

, 2022
Occupation-related stress and work characteristics are possible determinants of social inequalities in epigenetic aging but have been little investigated.
Vineis, Paolo, Ala-Mursula, Leena, Järvelin, M.-R. (Marjo-Riitta), Virtanen, Marianna, Virtanen, M. (Marianna), Fiorito, G. (Giovanni), Robinson, O. (Oliver), Freni-Sterrantino, A, Fiorito, Giovanni, Freni-Sterrantino, Anna, Vineis, P. (Paolo), Freni Sterrantino, Anna, Ala-Mursula, L, Fiorito, G, Jarvelin, M-R, Robinson, Oliver, d'Errico, A, Freni-Sterrantino, A. (Anna), D'errico, Angelo, Virtanen, M,, Robinson, O, d’Errico, A. (Angelo), Ala-Mursula, L. (Leena), Vineis, P, d’Errico, Angelo, Jarvelin, Marjo-Riitta   +25 more
core   +1 more source

DNA methylation age at birth and childhood: performance of epigenetic clocks and characteristics associated with epigenetic age acceleration in the Project Viva cohort

Clinical Epigenetics, 2023
Background Epigenetic age acceleration (EAA) and epigenetic gestational age acceleration (EGAA) are biomarkers of physiological development and may be affected by the perinatal environment.
Anne K. Bozack, Sheryl L. Rifas-Shiman, Diane R. Gold, Zachary M. Laubach, Wei Perng, Marie-France Hivert, Andres Cardenas   +6 more
doaj   +1 more source

Epigenetic Age Acceleration and Hearing: Observations From the Baltimore Longitudinal Study of Aging

Frontiers in Aging Neuroscience, 2021
Objectives: Age-related hearing loss (ARHL) is highly prevalent among older adults, but the potential mechanisms and predictive markers for ARHL are lacking.
Pei-Lun Kuo, Ann Zenobia Moore, Frank R. Lin, Frank R. Lin, Luigi Ferrucci   +4 more
doaj   +1 more source

Childhood sleep health and epigenetic age acceleration in late adolescence: cross-sectional and longitudinal analyses [PDF]

, 2023
Aim: Investigate if childhood measures of sleep health are associated with epigenetic age acceleration in late adolescence. Methods: Parent-reported sleep trajectories from age 5 to 17, self-reported sleep problems at age 17, and six measures of ...
Huang, R-C (15628547), Balfour, D (15761624), Reynolds, AC (15761633), Phillip Melton (14744191), McVeigh, JE (15761627), Wanstall, S (15761630), Cohen-Woods, S (15761636), Eastwood, PR (15696653)   +7 more
core   +2 more sources

Epigenetic Age Acceleration Is Not Associated with Age-Related Macular Degeneration [PDF]

International Journal of Molecular Sciences, 2021
DNA methylation age (DNAm age) estimation is a powerful biomarker of human ageing. To date, epigenetic clocks have not been evaluated in age-related macular degeneration (AMD). Here, we perform genome-wide DNA methylation analyses in blood of AMD patients with a documented smoking history (14 AMD, 16 Normal), identifying loci of differential ...
Neil Saptarshi, Daniel Green, Angela Cree, Andrew Lotery, Luminita Paraoan, Louise F. Porter   +5 more
openaire   +5 more sources

Accelerated epigenetic aging in Down syndrome [PDF]

Aging Cell, 2015
SummaryDown Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging
Horvath S, GARAGNANI, PAOLO, BACALINI, MARIA GIULIA, PIRAZZINI, CHIARA, SALVIOLI, STEFANO, Gentilini D, Di Blasio AM, GIULIANI, CRISTINA, Tung S, Vinters HV, FRANCESCHI, CLAUDIO   +10 more
openaire   +5 more sources