Results 11 to 20 of about 5,571,062 (272)

Epigenetic age acceleration and clinical outcomes in gliomas.

PLoS ONE, 2020
Epigenetic age acceleration-the difference between an individual's DNA methylation age and chronological age-is associated with many diseases including cancer. This study aims to evaluate epigenetic age acceleration as a prognostic biomarker for gliomas.
Chunlei Zheng, Nathan A Berger, Li Li, Rong Xu   +3 more
doaj   +5 more sources

Epigenetic mutation load is weakly correlated with epigenetic age acceleration [PDF]

Aging, 2020
DNA methylation (DNAm) age estimators are widely used to study aging-related conditions. It is not yet known whether DNAm age is associated with the accumulation of stochastic epigenetic mutations (SEMs), which reflect dysfunctions of the epigenetic ...
Yan, Qi, Horvath, Steve, Paul, Kimberly C, Binder, Alexandra M, Kusters, Cynthia, Lu, Ake T, Ritz, Beate   +6 more
core   +5 more sources

Associations between epigenetic age acceleration and infertility [PDF]

Human Reproduction, 2022
STUDY QUESTION: Is the use of ART, a proxy for infertility, associated with epigenetic age acceleration? SUMMARY ANSWER: The epigenetic age acceleration measured by Dunedin Pace of Aging methylation (DunedinPoAm) differed significantly between non-ART ...
Lee, Yunsung, Magnus, Per Minor, Håberg, Siri Eldevik, Page, Christian Magnus, Bohlin, Jon, Magnus, Per, Harris, Jennifer R, Hanevik, Hans I, Harris, Jennifer Ruth, Magnus, Maria C, Håberg, Siri E, Page, Christian M, Jugessur, Astanand, Magnus, Maria Christine, Nustad, Haakon E, Nustad, Haakon E., Hanevik, Hans Ivar   +16 more
core   +7 more sources

Exposure to Violence Accelerates Epigenetic Aging in Children [PDF]

Scientific Reports, 2017
Epigenetic processes, including DNA methylation, change reliably with age across the lifespan, such that DNA methylation can be used as an “epigenetic clock”.
Tanja Jovanovic, L. Alexander Vance, Dorthie Cross, Anna K. Knight, Varun Kilaru, Vasiliki Michopoulos, Torsten Klengel, Alicia K. Smith   +7 more
doaj   +3 more sources

Subjective sleep problems is associated with epigenetic age acceleration: a Mendelian randomization study

陆军军医大学学报
Objective To investigate the potential causal associations between 3 common subjective sleep problems, daytime sleepiness, insomnia, and sleep apnea, and epigenetic age acceleration.
LI Xiaomei, REN Hao, ZHANG Zheng
doaj   +2 more sources

Parental epigenetic age acceleration and risk of adverse birth outcomes: the Norwegian mother, father and child cohort study [PDF]

BMC Medicine
Background Few studies have examined associations between maternal epigenetic age acceleration and adverse birth outcomes, and none have investigated paternal epigenetic age acceleration.
Maria C. Magnus, Yunsung Lee, Ellen Ø. Carlsen, Lise A. Arge, Astanand Jugessur, Liv G. Kvalvik, Nils-Halvdan Morken, Cecilia H. Ramlau-Hansen, Mikko Myrskylä, Per Magnus, Siri E. Håberg   +10 more
doaj   +2 more sources

Epigenetic age acceleration, neonatal morbidities, and neurobehavioral profiles in infants born very preterm

Epigenetics, 2023
Epigenetic age acceleration is a risk factor for chronic diseases of ageing and may reflect aspects of biological ageing. However, few studies have examined epigenetic ageing during the early neonatal period in preterm infants, who are at heightened risk
Uriel Paniagua, Barry M. Lester, Carmen J. Marsit, Marie Camerota, Brian S. Carter, Jennifer F. Check, Jennifer Helderman, Julie A. Hofheimer, Elisabeth C. McGowan, Charles R. Neal, Steven L. Pastyrnak, Lynne M. Smith, Sheri A. DellaGrotta, Lynne M. Dansereau, T. Michael O’Shea, Todd M. Everson   +15 more
doaj   +3 more sources

Epigenetic age acceleration in peripheral blood correlates with brain-MRI age acceleration. [PDF]

Brain
As the world's population ages, more and more people are expected to suffer from age-related diseases. Biological aging markers derived from DNA methylation and brain structure show promise in predicting health outcomes.
Sant'Anna Barbosa Ferreira P, van Dongen J, den Braber A, Boomsma DI, de Geus EJC, van 't Ent D.   +5 more
europepmc   +5 more sources

Dissecting epigenetic age acceleration in amyotrophic lateral sclerosis. [PDF]

Epigenomics
Aim: We compared signatures of epigenetic aging in amyotrophic lateral sclerosis (ALS) patients and healthy controls to investigate the role of potential confounders and genetic subgroups.
Merbaum P, Zwamborn R, Hop P, Sequencing Consortium PMA, van Rheenen W, Veldink J.   +5 more
europepmc   +5 more sources

Systematic underestimation of the epigenetic clock and age acceleration in older subjects [PDF]

Genome Biology, 2019
Background The Horvath epigenetic clock is widely used. It predicts age quite well from 353 CpG sites in the DNA methylation profile in unknown samples and has been used to calculate “age acceleration” in various tissues and environments.
Louis Y. El Khoury, Tyler Gorrie-Stone, Melissa Smart, Amanda Hughes, Yanchun Bao, Alexandria Andrayas, Joe Burrage, Eilis Hannon, Meena Kumari, Jonathan Mill, Leonard C. Schalkwyk   +10 more
doaj   +2 more sources