Results 11 to 20 of about 24,360 (295)

Associations between medium- and long-term exposure to air temperature and epigenetic age acceleration

Environment International, 2023
Climate change poses a serious threat to human health worldwide, while aging populations increase. However, no study has ever investigated the effects of air temperature on epigenetic age acceleration.
Wenli Ni, Nikolaos Nikolaou, Cavin K. Ward-Caviness, Susanne Breitner, Kathrin Wolf, Siqi Zhang, Rory Wilson, Melanie Waldenberger, Annette Peters, Alexandra Schneider   +9 more
doaj   +3 more sources

Epigenetic Age Acceleration and Hearing: Observations From the Baltimore Longitudinal Study of Aging

Frontiers in Aging Neuroscience, 2021
Objectives: Age-related hearing loss (ARHL) is highly prevalent among older adults, but the potential mechanisms and predictive markers for ARHL are lacking.
Pei-Lun Kuo, Ann Zenobia Moore, Frank R. Lin, Frank R. Lin, Luigi Ferrucci   +4 more
doaj   +3 more sources

Association between sleep disordered breathing and epigenetic age acceleration: Evidence from the Multi-Ethnic Study of Atherosclerosis

EBioMedicine, 2019
Background: Sleep disordered breathing (SDB) is a common disorder that results in oxidative stress and inflammation and is associated with multiple age-related health outcomes.
Xiaoyu Li, Roby Joehanes, Ina Hoeschele, Stephen S. Rich, Jerome I. Rotter, Daniel Levy, Yongmei Liu, Susan Redline, Tamar Sofer   +8 more
doaj   +3 more sources

Prenatal and birth associations of epigenetic gestational age acceleration in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort

Epigenetics, 2022
Gestational age (GA) is an important determinant of child health and disease risk. Two epigenetic GA clocks have been developed using DNA methylation (DNAm) patterns in cord blood.
Saher Daredia, Karen Huen, Lars Van Der Laan, Philip A. Collender, Jamaji C. Nwanaji-Enwerem, Kim Harley, Julianna Deardorff, Brenda Eskenazi, Nina Holland, Andres Cardenas   +9 more
doaj   +2 more sources

Systematic underestimation of the epigenetic clock and age acceleration in older subjects

Genome Biology, 2019
Background The Horvath epigenetic clock is widely used. It predicts age quite well from 353 CpG sites in the DNA methylation profile in unknown samples and has been used to calculate “age acceleration” in various tissues and environments.
Louis Y. El Khoury, Tyler Gorrie-Stone, Melissa Smart, Amanda Hughes, Yanchun Bao, Alexandria Andrayas, Joe Burrage, Eilis Hannon, Meena Kumari, Jonathan Mill, Leonard C. Schalkwyk   +10 more
doaj   +2 more sources

Association of cardiovascular health and epigenetic age acceleration [PDF]

Clinical Epigenetics, 2021
Abstract Background Cardiovascular health (CVH) has been defined by the American Heart Association (AHA) as the presence of the “Life’s Simple 7” ideal lifestyle and clinical factors. CVH is known to predict longevity and freedom from cardiovascular disease, the leading cause of death for women in the United States.
Tess D. Pottinger, Sadiya S. Khan, Yinan Zheng, Wei Zhang, Hilary A. Tindle, Matthew Allison, Gretchen Wells, Aladdin H. Shadyab, Rami Nassir, Lisa Warsinger Martin, JoAnn E. Manson, Donald M. Lloyd-Jones, Philip Greenland, Andrea A. Baccarelli, Eric A. Whitsel, Lifang Hou   +15 more
openaire   +5 more sources

Evaluation of Epigenetic Age Acceleration Scores and Their Associations with CVD-Related Phenotypes in a Population Cohort

Biology, 2022
We evaluated associations between nine epigenetic age acceleration (EAA) scores and 18 cardiometabolic phenotypes using an Eastern European ageing population cohort richly annotated for a diverse set of phenotypes (subsample, n = 306; aged 45–69 years ...
Olga Chervova, Elizabeth Chernysheva , Kseniia Panteleeva , Tyas Arum Widayati , Natalie Hrbkova, Jadesada Schneider , Vladimir Maximov , Andrew Ryabikov , Taavi Tillmann , Hynek Pikhart, Martin Bobak , Vitaly Voloshin , Sofia Malyutina , Stephan Beck    +13 more
doaj   +1 more source

Metal mixtures and DNA methylation measures of biological aging in American Indian populations

Environment International, 2023
Introduction: Native American communities suffer disproportionately from elevated metal exposures and increased risk for cardiovascular diseases and diabetes. DNA methylation is a sensitive biomarker of aging-related processes and novel epigenetic-based “
Kaila Boyer, Arce Domingo-Relloso, Enoch Jiang, Karin Haack, Walter Goessler, Ying Zhang, Jason G. Umans, Daniel W. Belsky, Shelley A. Cole, Ana Navas-Acien, Allison Kupsco   +10 more
doaj   +1 more source

DNA methylation age at birth and childhood: performance of epigenetic clocks and characteristics associated with epigenetic age acceleration in the Project Viva cohort

Clinical Epigenetics, 2023
Background Epigenetic age acceleration (EAA) and epigenetic gestational age acceleration (EGAA) are biomarkers of physiological development and may be affected by the perinatal environment.
Anne K. Bozack, Sheryl L. Rifas-Shiman, Diane R. Gold, Zachary M. Laubach, Wei Perng, Marie-France Hivert, Andres Cardenas   +6 more
doaj   +1 more source

Accelerated epigenetic aging in Down syndrome [PDF]

Aging Cell, 2015
SummaryDown Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging
Horvath S, GARAGNANI, PAOLO, BACALINI, MARIA GIULIA, PIRAZZINI, CHIARA, SALVIOLI, STEFANO, Gentilini D, Di Blasio AM, GIULIANI, CRISTINA, Tung S, Vinters HV, FRANCESCHI, CLAUDIO   +10 more
openaire   +5 more sources