Results 31 to 40 of about 24,360 (295)

Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort [PDF]

, 2019
Telomere length has been accepted widely as a biomarker of aging. Recently, a novel candidate biomarker has been suggested to predict an individual’s chronological age with high accuracy: The epigenetic clock is based on the weighted DNA methylation ...
Banszerus, Verena L., Demuth, Ilja, König, Maximilian, Salewsky, Bastian, Vetter, Valentin M.   +4 more
core   +1 more source

Predicting cell types and genetic variations contributing to disease by combining GWAS and epigenetic data [PDF]

, 2013
Genome-wide association studies (GWASs) identify single nucleotide polymorphisms (SNPs) that are enriched in individuals suffering from a given disease. Most disease-associated SNPs fall into non-coding regions, so that it is not straightforward to infer
A Milosavljevic, A Pekowska, A Visel, AJ Saldanha, AM Mondul, Anjana Rao, Anna Gerasimova, AR Quinlan, BE Bernstein, BE Himes, BE Stranger, Bin Li, Bjoern Peters, C Ober, C Zang, Consortium The International HapMap, D Karolchik, DB Hancock, DG Torgerson, E Birney, E Noguchi, EK Miller, F Castro-Giner, G Hon, GE Zentner, Gregory Seumois, J Ernst, J Ernst, J Harrow, Jason Greenbaum, JH Kim, JJ Farrell, KM Ansel, LD Ward, Lukas Chavez, MA Schaub, MF Moffatt, MF Moffatt, MJ de Hoon, MP Creyghton, MT Maurano, ND Heintzman, NU Rashid, Pandurangan Vijayanand, PB Talbert, PM Sleiman, PM Visscher, R Bhandare, R Jaenisch, S Chanock, S Michel, S Weidinger, T Hirota, TH Pham, W Yu, Y Li, Y Zhang, Yi-Hsiang Hsu   +57 more
core   +13 more sources

Cumulative stress, PTSD, and emotion dysregulation during pregnancy and epigenetic age acceleration in Hispanic mothers and their newborn infants

Epigenetics, 2023
Pregnancy can exacerbate or prompt the onset of stress-related disorders, such as post-traumatic stress disorder (PTSD). PTSD is associated with heightened stress responsivity and emotional dysregulation, as well as increased risk of chronic disorders ...
Seyma Katrinli, Alicia K Smith, Stacy S. Drury, Jonathan Covault, Julian D. Ford, Vijender Singh, Bo Reese, Amy Johnson, Victoria Scranton, Pamela Fall, Margaret Briggs-Gowan, Damion J Grasso   +11 more
doaj   +1 more source

Menopause accelerates biological aging [PDF]

, 2016
Although epigenetic processes have been linked to aging and disease in other systems, it is not yet known whether they relate to reproductive aging. Recently, we developed a highly accurate epigenetic biomarker of age (known as the “epigenetic clock ...
Absher, D, Assimes, TL, Bandinelli, S, Chen, BH, Ferrucci, L, Hernandez, DG, Horvath, S, Kuh, D, Kusters, CDJ, Levine, ME, Lu, AT, Manson, JE, Quach, A, Ritz, BR, Salfati, E, Singleton, AB, Teschendorff, AE, Widschwendter, M, Wong, A   +18 more
core   +1 more source

Epigenetic Age Acceleration Was Delayed in Schizophrenia

Schizophrenia Bulletin, 2020
Abstract Schizophrenia is a serious neuropsychiatric disorder with abnormal age-related neurodevelopmental (or neurodegenerative) trajectories. Although an accelerated aging hypothesis of schizophrenia has been proposed, the quantitative study of the disruption of the physiological trajectory caused by schizophrenia is inconclusive.
Xiaohui, Wu, Junping, Ye, Zhongju, Wang, Cunyou, Zhao   +3 more
openaire   +3 more sources

Epigenetic clock analysis of blood samples in drug-naive first-episode schizophrenia patients

BMC Psychiatry, 2023
Background Schizophrenia (SCZ) is a severe and chronic psychiatric disorder with premature age-related physiological changes. However, numerous previous studies examined the epigenetic age acceleration in SCZ patients and yielded inconclusive results. In
Zongchang Li, Xiaofen Zong, David Li, Ying He, Jinsong Tang, Maolin Hu, Xiaogang Chen   +6 more
doaj   +1 more source

Epigenetic mutation load is weakly correlated with epigenetic age acceleration

Aging, 2020
DNA methylation (DNAm) age estimators are widely used to study aging-related conditions. It is not yet known whether DNAm age is associated with the accumulation of stochastic epigenetic mutations (SEMs), which reflect dysfunctions of the epigenetic maintenance system.
Yan, Qi, Paul, Kimberly C, Lu, Ake T, Kusters, Cynthia, Binder, Alexandra M, Horvath, Steve, Ritz, Beate   +6 more
openaire   +4 more sources

Epigenetic Age Acceleration [PDF]

Circulation: Genomic and Precision Medicine, 2018
See Article by Roetker et al Epigenetic age seems like a concept pulled from a futuristic science-fiction movie where a drop of blood is fed into a machine, in which an algorithm churns through an accumulation of chemical groups coating a strand of DNA and spits out an individual’s true age reflecting a lifetime of experiences and exposures ...
openaire   +2 more sources

Epigenetic clocks derived from western samples differentially reflect Taiwanese health outcomes

Frontiers in Genetics, 2023
Introduction: Several epigenetic clocks have been developed, with five measures of epigenetic age acceleration (EAA) especially receiving extensive investigations: HannumEAA, IEAA, PhenoEAA, GrimEAA, and DunedinPACE.
Wan-Yu Lin, Wan-Yu Lin, Wan-Yu Lin
doaj   +1 more source

DNA methylation age is accelerated in alcohol dependence. [PDF]

, 2018
Alcohol dependence (ALC) is a chronic, relapsing disorder that increases the burden of chronic disease and significantly contributes to numerous premature deaths each year.
Hlady, Ryan A, Horvath, Steve, Kaminsky, Zachary A, Lee, Jisoo, Lohoff, Falk W, Muench, Christine, Philibert, Robert, Robertson, Keith D, Rosen, Allison D   +8 more
core   +2 more sources