Results 31 to 40 of about 5,571,062 (272)

Epigenetic Age Acceleration Was Delayed in Schizophrenia

Schizophrenia Bulletin, 2020
Abstract Schizophrenia is a serious neuropsychiatric disorder with abnormal age-related neurodevelopmental (or neurodegenerative) trajectories. Although an accelerated aging hypothesis of schizophrenia has been proposed, the quantitative study of the disruption of the physiological trajectory caused by schizophrenia is inconclusive.
Xiaohui, Wu, Junping, Ye, Zhongju, Wang, Cunyou, Zhao   +3 more
openaire   +3 more sources

Time to relapse in chronic lymphocytic leukemia and DNA-methylation-based biological age

Clinical Epigenetics, 2023
Chronic lymphocytic leukemia (CLL) is a mature B cell neoplasm with a predilection for older individuals. While previous studies have identified epigenetic signatures associated with CLL, whether age-related DNA methylation changes modulate CLL relapse ...
Drew R. Nannini, Rene Cortese, Peter Egwom, Senthilnathan Palaniyandi, Gerhard C. Hildebrandt   +4 more
doaj   +1 more source

Multi-omic underpinnings of epigenetic aging and human longevity

Nature Communications, 2023
Biological aging is accompanied by increasing morbidity, mortality, and healthcare costs; however, its molecular mechanisms are poorly understood. Here, we use multi-omic methods to integrate genomic, transcriptomic, and metabolomic data and identify ...
Lucas A. Mavromatis, Daniel B. Rosoff, Andrew S. Bell, Jeesun Jung, Josephin Wagner, Falk W. Lohoff   +5 more
doaj   +1 more source

Epigenetic Age Acceleration Assessed with Human White-Matter Images [PDF]

, 2017
Item does not contain fulltextThe accurate estimation of age using methylation data has proved a useful and heritable biomarker, with acceleration in epigenetic age predicting a number of age-related phenotypes.
Blangero, J., Almasy, L., Hodgson, K., Goring, H.H., Knowles, E.E., Olvera, R.L., Curran, J.E., Carless, M.A., Mathias, S., Duggirala, R., Yao, N., Fox, P.T., Sprooten, E., Glahn, D.C., Kulkarni, H.   +14 more
core   +2 more sources

Epigenetic aging in cows is accelerated by milk production

Epigenetics, 2023
DNA methylation has proven to be the most promising age-predictive biomarker in mammals resulting in the emergence of 'epigenetic clocks' that describe the relationship between methylation levels and age. Using Targeted bisulfite Sequencing, we evaluated blood DNA-methylation data from 96 domesticated cows (Bos Taurus) of which 88 were adults and 8 ...
Prashansa Ratan, Liudmilla Rubbi, Michael Thompson, Kaushik Naresh, Jolena Waddell, Barbara Jones, Matteo Pellegrini   +6 more
openaire   +3 more sources

HIV, pathology and epigenetic age acceleration in different human tissues [PDF]

, 2022
Epigenetic clocks based on patterns of DNA methylation have great importance in understanding aging and disease; however, there are basic questions to be resolved in their application.
Morgello, Susan, Lin, David TS, Kobor, Michael S, Jamieson, Beth D, Zoller, Joseph A., Levine, Andrew J, Kobor, Michael S., Horvath, Steve, Zoller, Joseph A, Singer, Elyse, Levine, Andrew J., Said, Jonathan W., Jamieson, Beth D., Said, Jonathan W, Yong, William H, Lin, David T. S., Yong, William H.   +16 more
core   +1 more source

Epigenetic age acceleration among survivors of pediatric medulloblastoma and primitive neuroectodermal tumor [PDF]

, 2022
Survivors of childhood central nervous system (CNS) tumors experience early-onset aging-related phenotypes. DNA methylation (DNAm) age is an emerging epigenetic biomarker of physiologic age and may be predictive of chronic health conditions in long-term ...
Melissa A. Richard, Michael E. Scheurer, Rachel D. Harris, Kevin Wilhelm, Scheurer, Michael E, Gramatges, Maria Monica J, Philip J. Lupo, Brown, Austin L, Maria Monica J. Gramatges, Harris, Rachel D, Lupo, Philip J, Richard, Melissa A, Wilhelm, Kevin, Austin L. Brown   +13 more
core   +1 more source

Refining the Role of Epigenetic Age Acceleration in Cardiotoxicity Research. [PDF]

JACC CardioOncol
Cao J, Han W, Liu Y.
europepmc   +4 more sources

The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936 [PDF]

, 2015
BACKGROUND: The DNA methylation-based 'epigenetic clock' correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and
Deary, Ian J., Pattie, Alison, Horvath, Steve, Wray, Naomi R., Harris, Sarah E., Starr, John M., Marioni, Riccardo E, McRae, Allan F, Starr, John M, Murphy, Lee, Ritchie, Stuart J., Muniz-Terrera, Graciela, McRae, Allan F., Ritchie, Stuart J, Marioni, Riccardo E., Taylor, Adele, Deary, Ian J, Visscher, Peter M, Corley, Janie, Murphy, Lee; id_orcid, Redmond, Paul, Wray, Naomi R, Visscher, Peter M., Gibson, Jude, Cox, Simon R, Shah, Sonia, Cox, Simon R., Harris, Sarah E   +27 more
core   +1 more source

Accelerated epigenetic aging in Werner syndrome

Aging, 2017
Individuals suffering from Werner syndrome (WS) exhibit many clinical signs of accelerated aging. While the underlying constitutional mutation leads to accelerated rates of DNA damage, it is not yet known whether WS is also associated with an increased epigenetic age according to a DNA methylation based biomarker of aging (the "Epigenetic Clock ...
Maierhofer, Anna, Flunkert, Julia, Oshima, Junko, Martin, George M, Haaf, Thomas, Horvath, Steve   +5 more
openaire   +4 more sources