Results 61 to 70 of about 5,571,062 (272)

Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization

Clinical Epigenetics, 2023
Background Aging has been reported as a major risk factor for severe symptoms and higher mortality rates in COVID-19 patients. Molecular hallmarks such as epigenetic alterations and telomere attenuation reflect the biological process of aging. Epigenetic
Yosra Bejaoui, Fathima Humaira Amanullah, Mohamad Saad, Sara Taleb, Martina Bradic, Andre Megarbane, Ali Ait Hssain, Charbel Abi Khalil, Nady El Hajj   +8 more
doaj   +1 more source

Epigenetic Age Acceleration and Chronological Age: Associations With Cognitive Performance in Daily Life [PDF]

Innov Aging
DNA methylation-derived epigenetic clocks offer the opportunity to examine aspects of age acceleration (ie, the difference between an individual's biological age and chronological age), which vary among individuals and may better account for age-related ...
Reid, Kerry, Sliwinski, Martin, Harrington, Karra D., Pasquini, Giancarlo, Zavala, Daisy V., Bernard, Kristin, Gopalan, Shyamalika, Scott, Stacey B., Dzikowski, Natalie, Mogle, Jacqueline, Graham-Engeland, Jennifer E., Veeramah, Krishna, Engeland, Christopher G.   +12 more
europepmc   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Epigenetic age acceleration and psychosocial stressors in early childhood. [PDF]

Epigenomics
The impact of psychosocial stress on mental and physical health is well-documented. Adverse experiences that occur early in life are particularly impactful on later life health. Epigenetic modifications, such as DNA methylation, have been proposed as a possible mechanism to mediate the impact of childhood events on adult health outcomes.
Mulligan CJ.
europepmc   +3 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Epigenetic age acceleration correlates with BMI in young adults

Aging, 2023
Obesity increases the risk of Type 2 diabetes, cardiovascular disease, several types of cancer, and other age-related disorders. Among older adults, obesity is also related to epigenetic age, typically measured with DNA methylation (DNAm). Because less is known about obesity and epigenetic aging earlier in the lifespan, this study examined the ...
Foster, Christy Anne, Barker-Kamps, Malcolm, Goering, Marlon, Patki, Amit, Tiwari, Hemant K., Mrug, Sylvie   +5 more
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Infant’s DNA Methylation Age at Birth and Epigenetic Aging Accelerators

BioMed Research International, 2016
Knowing the biological age of the neonates enables us to evaluate and better understand the health and maturity comprehensively. However, because of dearth of biomarkers, it is difficult to quantify the neonatal biological age. Here we sought to quantify and assess the variability in biological age at birth and to better understand how the aging rates ...
Ruheena Javed, Weidan Chen, Fangqin Lin, Huiying Liang   +3 more
openaire   +2 more sources

Oxidative stress and epigenetic regulation in ageing and age-related diseases [PDF]

, 2013
Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available ...
Francesco Spallotta, Spallotta, Francesco, Gaetano, Carlo, Sergio Valente, Chiara Cencioni, Antonello Mai, Cencioni, Chiara, Valente, Sergio, Carlo Gaetano, Mai, Antonello, Martelli, Fabio, Zeiher, Andreas M., Fabio Martelli, Andreas Zeiher   +13 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source