Results 61 to 70 of about 24,360 (295)

Dietary intervention modifies DNA methylation age assessed by the epigenetic clock [PDF]

, 2018
Scope: Alterations in DNA methylation patterns are correlated with aging, environmental exposures and disease pathophysiology; the possibility of reverting or preventing these processes through dietary intervention is gaining momentum.
Aryee, Barres, Baylin, Breton, Byun, Byun, Castro, Celis-Morales, Chen, Fang, Fodinger, Friso, Hannum, Hobbs, Horvath, Horvath, Horvath, Issa, Jung, Kok, Liew, Luczak, Maegawa, Magalhães, Mandaviya, Marioni, Marioni, Mathers, Mathers, Milenkovic, Milenkovic, Perna, Pirouzpanah, Piyathilake, Quach, Robertson, Russo, Teschendorff, Winkels, Zannas, Zhong   +40 more
core   +2 more sources

Infant’s DNA Methylation Age at Birth and Epigenetic Aging Accelerators

BioMed Research International, 2016
Knowing the biological age of the neonates enables us to evaluate and better understand the health and maturity comprehensively. However, because of dearth of biomarkers, it is difficult to quantify the neonatal biological age. Here we sought to quantify and assess the variability in biological age at birth and to better understand how the aging rates ...
Ruheena Javed, Weidan Chen, Fangqin Lin, Huiying Liang   +3 more
openaire   +2 more sources

Epigenetic aging in cows is accelerated by milk production

Epigenetics, 2023
DNA methylation has proven to be the most promising age-predictive biomarker in mammals resulting in the emergence of 'epigenetic clocks' that describe the relationship between methylation levels and age. Using Targeted bisulfite Sequencing, we evaluated blood DNA-methylation data from 96 domesticated cows (Bos Taurus) of which 88 were adults and 8 ...
Prashansa Ratan, Liudmilla Rubbi, Michael Thompson, Kaushik Naresh, Jolena Waddell, Barbara Jones, Matteo Pellegrini   +6 more
openaire   +3 more sources

DNA Methylation Analysis Validates Organoids as a Viable Model for Studying Human Intestinal Aging. [PDF]

, 2020
Background & aimsThe epithelia of the intestine and colon turn over rapidly and are maintained by adult stem cells at the base of crypts. Although the small intestine and colon have distinct, well-characterized physiological functions, it remains ...
Coppola, Giovanni, Horvath, Steve, Jones, D Leanne, Lewis, Sophia K, Martin, Martin G, Nachun, Daniel   +5 more
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Socioeconomic Position and DNA Methylation Age Acceleration across the Lifecourse. [PDF]

, 2018
Accelerated DNA methylation age is linked to all-cause mortality and environmental factors, but studies of associations with socioeconomic position are limited.
Amanda Hughes, Aryee, Benzeval, Bird, Christiansen, Dugué, Eilis Hannon, Fiorito, Galobardes, Gassen, Goldberg, Gorrie-Stone, Hannum, HM Revenue and Customs, Horvath, Houseman, Huang, Joe Burrage, Jonathan Mill, Kananen, Karlsson Linnér, Knies, Leo Schalkwyk, Marioni, Marioni, Meena Kumari, Melissa Smart, Moran, Nevalainen, Nwanaji-Enwerem, Quach, Seeman, Simons, Suderman, Tyler Gorrie-Stone, Wolf, World Health Organization, Yanchun Bao, Zannas, Zhang   +39 more
core   +2 more sources

Open access-enabled evaluation of epigenetic age acceleration in colorectal cancer and development of a classifier with diagnostic potential

Frontiers in Genetics, 2023
Aberrant DNA methylation (DNAm) is known to be associated with the aetiology of cancer, including colorectal cancer (CRC). In the past, the availability of open access data has been the main driver of innovative method development and research training ...
Tyas Arum Widayati, Jadesada Schneider, Jadesada Schneider, Kseniia Panteleeva, Elizabeth Chernysheva, Natalie Hrbkova, Stephan Beck, Vitaly Voloshin, Olga Chervova   +8 more
doaj   +1 more source

Growth disrupting mutations in epigenetic regulatory molecules are associated with abnormalities of epigenetic aging. [PDF]

, 2019
Germline mutations in fundamental epigenetic regulatory molecules including DNA methyltransferase 3 alpha (DNMT3A) are commonly associated with growth disorders, whereas somatic mutations are often associated with malignancy.
Aksglaede, L, Baple, EL, Baralle, D, Chioza, BA, Crosby, AH, Cross, HE, Dabir, T, Dempster, E, Hunter, MF, Jeffries, AR, Kamath, A, Kumar, A, Mackay, DJG, Maroofian, R, Mill, J, Newbury-Ecob, R, Patton, MA, Rezwan, FI, Salter, CG, Selicorni, A, Springer, A, Tatton-Brown, K, Temple, IK, Van Maldergem, L, Varghese, V, Yachelevich, N   +25 more
core   +7 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Histone deacetylase adaptation in single ventricle heart disease and a young animal model of right ventricular hypertrophy. [PDF]

, 2017
BackgroundHistone deacetylase (HDAC) inhibitors are promising therapeutics for various forms of cardiac diseases. The purpose of this study was to assess cardiac HDAC catalytic activity and expression in children with single ventricle (SV) heart disease ...
A Cevik, A Correa-Villasenor, A deAlmeida, A Granger, A Kulkarni, AP Vlahos, C Scholz, Carlin S Long, CL Antos, D Sedmera, DD Lemon, DJ Cao, Douglas D Lemon, J Lu, JP Cardinale, JW Newburger, JW Rossano, JW Rossano, Karin Nunley, Katharina M Lutter, KB Schuetze, Kimberly M Demos-Davies, KM Demos-Davies, M Tanno, MA Cavasin, MA Cavasin, Maria A Cavasin, MP Gupta, OA O'Connor, PA Marks, PC Frommelt, Q Yang, R Kirk, RG Ohye, S Chen, Sam Payne, SD Miyamoto, SD Miyamoto, SD Miyamoto, Shelley D Miyamoto, SJ Nakano, SK Mani, SM Williams, TA McKinsey, TG Gillette, Timothy A McKinsey, VM Klimek, Weston W Blakeslee, WJ Kowalski, WW Blakeslee   +49 more
core   +1 more source