Results 171 to 180 of about 14,860 (271)

KoMethylNet: a novel epigenetic clock based on neural network analysis of DNA methylation data and epigenetic age acceleration in a Korean population. [PDF]

BMC Med
Yun D, Oh K, Kim Y, Ahn YM, Parikh HM, Meng X, Wang Z, Song N.   +7 more
europepmc   +1 more source

Novel Epigenetic Clock Biomarkers of Age-Related Macular Degeneration. [PDF]

Front Med (Lausanne), 2022
Mallik S, Grodstein F, Bennett DA, Vavvas DG, Lemos B.   +4 more
europepmc   +1 more source

EXPRESSION OF CONCERN : A Novel Technique for Estimating Age and Demography of Long‐Lived Seabirds (Genus Pterodroma ) Using an Epigenetic Clock for Gould's Petrel ( Pterodroma leucoptera ) [PDF]

openalex   +1 more source

METTL1‐Mediated M7G tRNA Modification Promotes Residual Liver Regeneration After Hepatectomy via Translational Control

Advanced Science, EarlyView.
METTL1 and its mediated m7G tRNA modification are significantly up‐regulated after partial hepatectomy (PHx). Overexpression of METTL1 improves the efficiency of liver regeneration after PHx, increases the proliferation of hepatocytes, and accelerates the recovery of liver function.
Manling Huang, Shuirong Lin, Yutong Zhao, Jiale Chen, Linyuan Huang, Yuyao Liu, Zixin Huang, Dongxin An, Yifan Zhang, Zimin Song, Xi Yu, Yunpeng Hua, Jing Wang, Weiwei Wang, Yu Guo, Ming Kuang, Fang Wang, Shuibin Lin, Shunli Shen   +18 more
wiley   +1 more source

Epigenetic age and fertility timeline: testing an epigenetic clock to forecast in vitro fertilization success rate. [PDF]

Reprod Biol Endocrinol
Marinello D, Reschini M, Di Stefano G, Carullo G, Casalechi M, Tarantini L, Albetti B, Bollati V, Viganò P, Somigliana E, Li Piani L.   +10 more
europepmc   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Decoding disease-specific ageing mechanisms through pathway-level epigenetic clock: insights from multi-cohort validation. [PDF]

EBioMedicine
Li P, Zhu J, Wang S, Zhuang H, Zhang S, Huang Z, Cai F, Song Z, Liu Y, Liu W, Freidel S, Wang S, Schwarz E, Chen J.   +13 more
europepmc   +1 more source

Epigenetic Clock Explains White Matter Hyperintensity Burden Irrespective of Chronological Age. [PDF]

Biology (Basel), 2022
Jiménez-Balado J, Giralt-Steinhauer E, Fernández-Pérez I, Rey L, Cuadrado-Godia E, Ois Á, Rodríguez-Campello A, Soriano-Tárraga C, Lazcano U, Macias-Gómez A, Suárez-Pérez A, Revert A, Estragués I, Beltrán-Mármol B, Medrano-Martorell S, Capellades J, Roquer J, Jiménez-Conde J.   +17 more
europepmc   +1 more source

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

Epigenetic age acceleration in idiopathic pulmonary fibrosis revealed by DNA methylation clocks

Daniel Kurbanov, Farida Ahangari, Taylor Adams, Ruben De Man, Jessica Tang, Marianne Carlon, Nebal Abu Hussein, Emmanuela Cortesi, Marta Zapata, Laurens De Sadeleer, Wim Wuyts, Bart Vanaudenaerde, Naftali Kaminski, John E. McDonough   +13 more
openalex   +1 more source