Results 171 to 180 of about 431,319 (321)

A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration

Ageing Research Reviews, 2021
Lara Oblak, Jeroen van der Zaag, A. Higgins-Chen, M. Levine, M. Boks   +4 more
semanticscholar   +1 more source

Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

Genome Medicine, 2019
DNA methylation changes with age. Chronological age predictors built from DNA methylation are termed ‘epigenetic clocks’. The deviation of predicted age from the actual age (‘age acceleration residual’, AAR) has been reported to be associated with death.
Qian Zhang, C. Vallerga, R. Walker, Tian Lin, A. Henders, G. Montgomery, Ji He, Dongsheng Fan, Javed Fowdar, M. Kennedy, T. Pitcher, J. Pearson, G. Halliday, J. Kwok, I. Hickie, S. Lewis, T. Anderson, P. Silburn, G. Mellick, S. Harris, P. Redmond, A. Murray, D. Porteous, C. Haley, K. Evans, A. McIntosh, Jian Yang, J. Gratten, R. Marioni, N. Wray, I. Deary, A. McRae, P. Visscher   +32 more
semanticscholar   +1 more source

A PANoptosis‐Based Signature for Survival and Immune Predication in Glioblastoma Multiforme

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PANoptosis is a concept of total cell death characterized by pyroptosis, apoptosis, and necroptosis. We aimed to explore the clinical significance of PANoptosis‐related genes (PARGs) in glioblastoma multiforme (GBM). Methods Expression profiles of GBM were downloaded from the XENA database as a training dataset to construct a ...
Jun Yang, Da Lin, Dongyuan Liu, Dongxu Zhang, Hao Wang   +4 more
wiley   +1 more source

Epigenetic clock and methylation studies in the rhesus macaque [PDF]

, 2020
Steve Horvath, Joseph A. Zoller, Amin Haghani, Anna J. Jasinska, Ken Raj, Charles E. Breeze, Jason Ernst, Julie A. Mattison   +7 more
openalex   +1 more source

Associations of Age, Sex, Race/Ethnicity, and Education With 13 Epigenetic Clocks in a Nationally Representative U.S. Sample: The Health and Retirement Study [PDF]

, 2021
Eileen M. Crimmins, Bharat Thyagarajan, Morgan E. Levine, David R. Weir, Jessica D. Faul   +4 more
openalex   +1 more source

Systematic underestimation of the epigenetic clock and age acceleration in older subjects

Genome Biology, 2019
The Horvath epigenetic clock is widely used. It predicts age quite well from 353 CpG sites in the DNA methylation profile in unknown samples and has been used to calculate “age acceleration” in various tissues and environments.
L. E. El Khoury, T. Gorrie-Stone, M. Smart, A. Hughes, Y. Bao, Alexandria Andrayas, Joe Burrage, E. Hannon, M. Kumari, J. Mill, L. Schalkwyk   +10 more
semanticscholar   +1 more source

Screening for Social Determinants of Health in Patients with Systemic Lupus Erythematosus: A Point‐of‐Care Feasibility Study

Arthritis Care &Research, Accepted Article.
Objectives Social determinants of health (SDoH) can impact outcomes but are not routinely screened for in US outpatient rheumatology clinics. This study determined the feasibility of routine point‐of‐care SDoH screening among patients with systemic lupus erythematosus (SLE), and associated barriers and facilitators at the physician, care team, and ...
S. Sam Lim, Vijay R. Nadipelli, Michelle Bruno, Daphne Lew, Bernard Rubin, Charmayne M. Dunlop‐Thomas, Kelsey Hulcher, Kristi R. Mitchell, Lydia Demetriou, Jeff Berko, Jason Bao, Alfred H.J. Kim   +11 more
wiley   +1 more source

Epigenetic age acceleration and risk of aortic valve stenosis: a bidirectional Mendelian randomization study

Clinical Epigenetics
Background Aortic valve stenosis (AVS) is the most prevalent cardiac valve lesion in developed countries, and pathogenesis is closely related to aging.
Wanqian Pan, Qi Huang, Le Zhou, Jia Lin, Xiaojiao Du, Xiaodong Qian, Tingbo Jiang, Weixiang Chen   +7 more
doaj   +1 more source

Genetic association of the gut microbiota with epigenetic clocks mediated by inflammatory cytokines: a Mendelian randomization analysis

Frontiers in Immunology
BackgroundA new aging biomarker epigenetic clock has been developed. There exists a close link between aging and gut microbiota, which may be mediated by inflammatory cytokines.
Siyu Tian, Xingyu Liao, Siqi Chen, Yu Wu, Min Chen   +4 more
doaj   +1 more source

Epigenetic aging biomarkers and occupational exposure to benzene, trichloroethylene and formaldehyde

Environment International, 2022
Epigenetic aging biomarkers are associated with increased morbidity and mortality. We evaluated if occupational exposure to three established chemical carcinogens is associated with acceleration of epigenetic aging.
Lars van der Laan, Andres Cardenas, Roel Vermeulen, Raj P. Fadadu, Alan E. Hubbard, Rachael V. Phillips, Luoping Zhang, Charles Breeze, Wei Hu, Cuiju Wen, Yongshun Huang, Xiaojiang Tang, Martyn T. Smith, Nathaniel Rothman, Qing Lan   +14 more
doaj