Results 111 to 120 of about 193,396 (281)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Framework for Age Estimation Using Epigenetic Clocks Library

Ovaj rad bavi se razvojem i primjenom radnog okvira epygenetics za razvoj i laku integraciju epigenetičkih satova. U kratkom pregledu povijesnog razvoja epigenetičkih satova detaljno su opisane neki od postojećih epigenetičkih satova.
Brečić, Luka
core   +2 more sources

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Aging, exceptional longevity and comparisons of the Hannum and Horvath epigenetic clocks

, 2017
To examine the relationships between two epigenetic clocks, aging and exceptional longevity.Participants were from three adult cohorts with blood DNA methylation data (Illumina 450 K, n = 275, 34-103 years).
Schofield, P.R., Armstrong, Nicola J., Kwok, J.B., Thalamuthu, Anbupalam, Brodaty, H ; https://orcid.org/, Thalamuthu, A ; https://orcid.org/, Trollor, JN ; https://orcid.org/, Armstrong, NJ, Sachdev, Perminder S., Brodaty, Henry, Wright, M.J., Mather, K.A., Brodaty, H., Thalamuthu, A., Mather, Karen A., Mather, KA ; https://orcid.org/, Trollor, J.N., Wright, MJ, Ames, D., Sachdev, P.S., Ames, D, Ames, David, Sachdev, PS ; https://orcid.org/, Wright, Margaret J., Trollor, Julian N., Kwok, JB ; https://orcid.org/, Schofield, Peter R., Armstrong, N.J., Schofield, PR ; https://orcid.org/, Kwok, John B.   +29 more
core   +2 more sources

A SuperLearner-based pipeline for the development of DNA methylation-derived predictors of phenotypic traits.

PLoS Computational Biology
BackgroundDNA methylation (DNAm) provides a window to characterize the impacts of environmental exposures and the biological aging process. Epigenetic clocks are often trained on DNAm using penalized regression of CpG sites, but recent evidence suggests ...
Dennis Khodasevich, Nina Holland, Lars van der Laan, Andres Cardenas   +3 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Mendelian randomization implicates causal association between epigenetic age acceleration and age-related eye diseases or glaucoma endophenotypes

Clinical Epigenetics
Background Age-related eye diseases (AREDs) have become increasingly prevalent with the aging population, serving as the leading causes of visual impairment worldwide.
Jiawei Chen, Xiang-Ling Yuan, Xiaoyu Zhou, Jiahao Xu, Xinyue Zhang, Xuanchu Duan   +5 more
doaj   +1 more source

A Systematic Review of Phenotypic and Epigenetic Clocks Used for Aging and Mortality Quantification in Humans [PDF]

Aging is the leading driver of disease in humans and has profound impacts on mortality. Biological clocks are used to measure the aging process in the hopes of identifying possible interventions.
Warner, Brandon, Datta, Anirban, Lendasse, Amaury, Ratner, Edward   +3 more
core   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source