Results 91 to 100 of about 193,396 (281)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Development of an epigenetic clock resistant to changes in immune cell composition

Communications Biology
Epigenetic clocks are age predictors that use machine-learning models trained on DNA CpG methylation values to predict chronological or biological age. Increases in predicted epigenetic age relative to chronological age (epigenetic age acceleration) are ...
Alan Tomusiak, Ariel Floro, Ritesh Tiwari, Rebeccah Riley, Hiroyuki Matsui, Nicolas Andrews, Herbert G. Kasler, Eric Verdin   +7 more
doaj   +1 more source

The Link Between Epigenetic Clocks for Aging and Senescence [PDF]

, 2019
Replicative senescence of cells in vitro is often considered as counterpart for aging of the organism in vivo. In fact, both processes are associated with functional decay and similar molecular modifications.
Wolfgang Wagner
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Critical review of aging clocks and factors that may influence the pace of aging

Frontiers in Aging
Background and objectivesAging clocks are computational models designed to measure biological age and aging rate based on age-related markers including epigenetic, proteomic, and immunomic changes, gut and skin microbiota, among others. In this narrative
Mildred Min, Mildred Min, Mildred Min, Caitlin Egli, Caitlin Egli, Caitlin Egli, Ajay S. Dulai, Ajay S. Dulai, Raja K. Sivamani, Raja K. Sivamani, Raja K. Sivamani, Raja K. Sivamani, Raja K. Sivamani   +12 more
doaj   +1 more source

Epigenetic regulation of adaptive responses of forest tree species to the environment [PDF]

, 2013
Epigenetic variation is likely to contribute to the phenotypic plasticity and adaptative capacity of plant species, and may be especially important for long-lived organisms with complex life cycles, including forest trees.
Maury, Stéphane, Bräutigam, Katharina, Antje Rohde, M. Ángeles Guevara, Dolores Abarca, Rohde, Antje, Fluch, S., Fluch, Silvia, Fraga, Mario F., Clément Lafon‐Placette, Johnsen, Oystein, Lafon-Placette, Clément, Jose, Gutiérrez-Marcos, Angeles Guevara, M., Campbell, Malcolm M., Fossdal, Carl G., Steven H. Strauss, Bräutigam, K., Fossdal, C. G., Abarca, Dolores, Mirouze, M., Katharina Bräutigam, Malcolm M. Campbell, Lafon-Placette, C., Vining, Kelly J., Gutierrez Marcos, Jose, Campbell, M. M., Rohde, A., Fernandez Fraga, Mario, José Gutiérrez Marcos, Marcos, J. G., Marie Mirouze, Silvia Fluch, Fraga, Mario Fernández, Cervera, María-Teresa, Díaz-Sala, Carmen, María‐Teresa Cervera, Guevara, M. Ángeles, Cervera, María Teresa, Johnsen, Øystein, Strauss, Steven H., Mario Fernández Fraga, Braeutigam, Katharina, Guevara, M Ángeles, Øystein Johnsen, Stéphane Maury, Mirouze, Marie, Kelly J. Vining, Johnsen, O., Vining, K. J., Carl G. Fossdal, Carmen Díaz‐Sala   +51 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Abnormal epigenetic aging of epigenetic outliers in normal colon mucosa from colorectal cancer patients

Scientific Reports
A subset of colorectal cancer (CRC) patients displays abnormal DNA methylation patterns (“Outlier Methylation Phenotype” (OMP)) in normal adjacent tissue (NAT).
Bryant M. Schultz, Olorunfemi Ayeotan, Juie N. Rana, Samuel Litwin, Stanley Basickes, Carmen Sapienza, Jayashri Ghosh   +6 more
doaj   +1 more source