Results 81 to 90 of about 193,396 (281)

The Cutting Edge of Epigenetic Clocks: In Search of Mechanisms Linking Aging and Mental Health

, 2023
Individuals with psychiatric disorders are at increased risk of age-related diseases and early mortality. Recent studies demonstrate that this link between mental health and aging is reflected in epigenetic clocks, aging biomarkers based on DNA ...
Boks, Marco P., Higgins-Chen, Albert T., Vinkers, Christiaan H., Harvanek, Zachary M.   +3 more
core   +2 more sources

Mammalian circadian clock and metabolism – the epigenetic link [PDF]

Journal of Cell Science, 2010
Circadian rhythms regulate a wide variety of physiological and metabolic processes. The clock machinery comprises complex transcriptional–translational feedback loops that, through the action of specific transcription factors, modulate the expression of as many as 10% of cellular transcripts. This marked change in gene expression necessarily implicates
Bellet M. M., Sassone-Corsi P.
openaire   +3 more sources

Hippocampal and cortical tissue-specific epigenetic clocks indicate an increased epigenetic age in a mouse model for Alzheimer's disease

, 2020
Epigenetic clocks are based on age-associated changes in DNA methylation of CpG-sites, which can accurately measure chronological age in different species.
Chew, Yap Ching, Quintens, Roel, Coolkens, Amelie, Wei, Guo, Baatout, Sarah, Moons, Lieve, Verslegers, Mieke, Coninx, Emma, Xiaojing, Yang   +8 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Examining epigenetic aging in the post-mortem brain in attention deficit hyperactivity disorder

Frontiers in Genetics
Mathematical algorithms known as “epigenetic clocks” use methylation values at a set of CpG sites to estimate the biological age of an individual in a tissue-specific manner. These clocks have demonstrated both acceleration and delays in epigenetic aging
Gauri G. Shastri, Gauri G. Shastri, Gustavo Sudre, Kwangmi Ahn, Benjamin Jung, Bhaskar Kolachana, Pavan K. Auluck, Laura Elnitski, Philip Shaw, Philip Shaw   +9 more
doaj   +1 more source

A new timepiece: an epigenetic mitotic clock

Genome Biology, 2016
A new mitotic clock and mathematical approach that incorporates DNA methylation biology common among human cell types provides a new tool for cancer epigenetics research.
Christensen, Brock C., Kelsey, Karl T.
openaire   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

How old are you really? Epigenetic clocks – A narrative review

Journal of Integrative Medicine and Research
The epigenetic clock, defined by DNA methylation patterns at specific CpG sites, represents one of the most precise molecular biomarkers of biological aging, differentiating it from chronological age by capturing cumulative, systemic epigenetic ...
Amrita Satapathy, Rajlaxmi Sarangi, Subhashree Nath   +2 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Applicability of epigenetic age models to next-generation methylation arrays

Genome Medicine
Background Epigenetic clocks are mathematical models used to estimate epigenetic age based on DNA methylation at specific CpG sites. As new methylation microarrays are developed and older models discontinued, existing epigenetic clocks might become ...
Leonardo D. Garma, Miguel Quintela-Fandino   +1 more
doaj   +1 more source