Results 61 to 70 of about 193,396 (281)
Frontiers in GeneticsEpigenetic aging clocks estimate age from DNA methylation patterns and have become central tools in longevity research. More recently, next-generation clocks have been developed to better compensate for the known divergence between chronological age and ...
Adiv A. Johnson, David A. Sinclair
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Epigenetics, 2023 Co-occurrence of injection drug use (IDU) and hepatitis C virus infection (HCV) is common in people living with HIV (PLWH) and leads to significantly increased mortality.
Xiaoyu Liang +4 more
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Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Frontiers in Genetics, 2022 Epigenetic clocks are the models, which use CpG methylation levels for the age prediction of an organism. Although there were several epigenetic clocks developed there is a demand for development and evaluation of the relatively accurate and sensitive ...
N. Kuzub +6 more
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Building Epigenetic Clocks for Estimating Ageing in Life After Cancer
, 2022 DNA methylation has been proven to be highly correlated with age. This has enabled the development of epigenetic clocks, which predicts age based on DNA methylation pattern. The predictions computed by epigenetic clocks have been interpreted to represent
Sydhagen, Kristin Aurora
core
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Epigenetic aging and blood based neurodegeneration markers in LASI-DAD
The Journal of Prevention of Alzheimer's DiseaseDNA methylation (DNAm)-based epigenetic clocks are emerging biomarkers of biological aging and have been linked to cognitive decline and dementia, but their relationship with blood-based neurodegenerative biomarkers remains understudied in low- and ...
Jung Ki Kim +8 more
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Epigenetic clock and methylation studies in elephants
Aging Cell, 2020 ABSTRACT Age-associated DNA-methylation profiles have been used successfully to develop highly accurate biomarkers of age (“epigenetic clocks”) in humans, mice, dogs, and other species. Here we present epigenetic clocks for African and Asian elephants.
Natalia A. Prado +11 more
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Perfect timing: Epigenetic regulation of the circadian clock [PDF]
FEBS Letters, 2011 In mammals, higher order chromatin structures are critical for downsizing the genome (packaging) so that the nucleus can be small. The adjustable density of chromatin also regulates gene expression, thus this post‐genetic molecular mechanism is one of the routes by which phenotype is shaped.
Ripperger Jürgen A, Merrow Martha
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<p>First release of MammalMethylClock R package</p> <p>Epigenetic clocks are prediction methods that relate cytosine methylation levels at specific genomic sites to chronological age, in a given species or set of species.
Joseph Zoller
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