Results 231 to 240 of about 2,264,000 (323)

Gut–Metabolome–Proteome Interactions in Age‐Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi‐Omics Analyses

Advanced Science, EarlyView.
Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang, Ziwen Gao, Hui Huang, Chanyuan Zhang, Yiquan Tang, Qianhui Qu, Huabin Li, Jing Ke, Zhiji Chen, Menglong Feng, Hu Zhou, Yilai Shu, Wei Yuan   +12 more
wiley   +1 more source

Paternal DEHP Exposure Triggers Reproductive Toxicity in Offspring via Epigenetic Modification of H3K27me3. [PDF]

Toxics
Zhang L, Yang R, Xu G, Wang L, Chen W, Tan Y, Zhang G, Liu W, Zhang G, Li J, Zhou Z.   +10 more
europepmc   +1 more source

KDM4A Erases the H3R17me2a Mark, Facilitating Chromosome Condensation

Advanced Science, EarlyView.
This study reveals a reversible histone modification switch governing chromosome condensation during mitosis. PKCα‐activated KDM4A removes H3R17me2a, permitting Suv39h1‐driven H3K9me3 deposition. This epigenetic transition recruits the chromosomal passenger complex and triggers Aurora B‐dependent H3S10 phosphorylation, coordinating chromatin remodeling
Yena Cho, Jee Won Hwang, Gyu Hwan Hyun, Sangkyu Lee, Dae‐Geun Song, Su‐Nam Kim, Yong Kee Kim   +6 more
wiley   +1 more source

Epigenetic modification of hepatitis B virus infection and related hepatocellular carcinoma. [PDF]

Virulence
Zhang Y, Cao W, Wang S, Zhang L, Li X, Zhang Z, Xie Y, Li M.   +7 more
europepmc   +1 more source

Epigenetic modification and antibody-dependent expansion of memory-like NK cells in human cytomegalovirus-infected individuals.

Immunity, 2015
Jaewon Lee, Tianxiang Zhang, Ilwoong Hwang, Ahrom Kim, Larissa Nitschke, Minju Kim, Jeannine M Scott, Yosuke Kamimura, L. Lanier, Sungjin Kim   +9 more
semanticscholar   +1 more source

Material‐Induced Nuclear Deformation Controls Chromatin Architecture in Adipose Stem Cells

Advanced Science, EarlyView.
Tuning cell and cytoskeleton mechanics modulated nuclear shape and heterochromatin organization in ASCs. Distinct cytoskeletal architectures induced nuclear morphologies from oblate to prolate ellipsoids. Large elongated cells with a structured actin cap exhibited high nuclear strain, driving nuclear envelope deformation and heterochromatin ...
Carlo F. Natale, Luca Messina, Valeria Panzetta, Stefania Saporito, Costantino Menna, Maurizio Ventre, Paolo A. Netti   +6 more
wiley   +1 more source

PlantEMS: A comprehensive database of epigenetic modification sites across multiple plant species. [PDF]

Plant Commun
Dao F, Xie X, Zhang H, Guan Z, Wu C, Su W, Wei Y, Hong F, Luo X, Xie S, Lai H, Gao D, Yang Y, Zhang Y, Ning L, Li S, Hao Y, Lebeau B, Ling CCY, Huang J, Fullwood MJ, Lin H, Lv H.   +22 more
europepmc   +1 more source

Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging.

Cell, 2018
Peggie Cheung, Francesco Vallania, H. Warsinske, Michele Donato, S. Schaffert, S. Chang, Mai Dvorak, C. Dekker, Mark M. Davis, P. Utz, P. Khatri, A. Kuo   +11 more
semanticscholar   +1 more source

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

Distinct role of perlecan in mesenchymal tissue regeneration via genetic and epigenetic modification. [PDF]

Chem Eng J
Wang B, Lu Z, Gao G, Mikaeiliagah E, Wang L, Yu Q, Wang Z, Hu G, Chen S, Zhang X, Pei M.   +10 more
europepmc   +1 more source