Results 291 to 300 of about 2,264,000 (323)

Multiple functions of p27 in cell cycle, apoptosis, epigenetic modification and transcriptional regulation for the control of cell growth: A double-edged sword protein.

DNA Repair, 2018
The cell cycle is controlled by precise mechanisms to prevent malignancies such as cancer, and the cell needs these tight and advanced controls. Cyclin dependent kinase inhibitor p27 (also known as KIP1) is a factor that inhibits the progression of the ...
Maryam Abbastabar, Maryam Kheyrollah, K. Azizian, Nazanin Bagherlou, S. Tehrani, M. Maniati, Ansar Karimian   +6 more
semanticscholar   +1 more source

Epigenetic Modification in Neuropathic Pain

Current Pharmaceutical Design, 2014
Neuropathic pain is characterized by complicated combination of positive (e.g., hyperalgesia and allodynia) and negative (e.g., hypoesthesia and hypoalgesia) symptoms, and is often refractory to conventional pharmacological agents, including morphine.
Hiroshi, Ueda, Hitoshi, Uchida
openaire   +2 more sources

Epigenetic Modification in Macrophages: A Promising Target for Tumor and Inflammation-associated Disease Therapy.

Current Topics in Medicinal Chemistry, 2019
Macrophages are essential for supporting tissue homeostasis, regulating immune response, and promoting tumor progression. Due to its heterogeneity, macrophages have different phenotypes and functions in various tissues and diseases.
P. Sun, Shujing Zhang, S. Maksim, Yongfang Yao, Hong-min Liu, Juan Du   +5 more
semanticscholar   +1 more source

Epigenetic Modifications in Vitiligo

Clinical Reviews in Allergy & Immunology
Vitiligo is an autoimmune depigmenting skin disorder and can affect the mental health of the patients. Current research suggests that the development of vitiligo involves a combination of genetic susceptibility, immune imbalance, and oxidative stress. However, its pathogenesis has not been fully elucidated. Epigenetic modification has gained increasing
Xin, Huang, Jing, Zhu, Tianqi, Wei, Lingling, Luo, Chengrang, Li, Ming, Zhao   +5 more
openaire   +2 more sources

Epigenetic modifications of the neuroproteome

PROTEOMICS, 2012
In the central nervous system, epigenetic processes are involved in a multitude of brain functions ranging from the development and differentiation of the nervous system through to higher‐order cognitive processes such as learning and memory. This review summarises the current state of the art for the proteomic analysis of the epigenetic regulation of ...
Brunner Andrea M, Tweedie-Cullen Ry Y, Mansuy Isabelle M   +2 more
openaire   +2 more sources

Epigenetic modifications and human disease

Nature Biotechnology, 2010
Epigenetics is one of the most rapidly expanding fields in biology. The recent characterization of a human DNA methylome at single nucleotide resolution, the discovery of the CpG island shores, the finding of new histone variants and modifications, and the unveiling of genome-wide nucleosome positioning maps highlight the accelerating speed of ...
Anna, Portela, Manel, Esteller
openaire   +2 more sources

Effects of obesity and diabetes on the epigenetic modification of mammalian gametes

Journal of Cellular Physiology, 2018
Obesity and diabetes are closely associated with numerous reproductive disorders, including termination of ovulation, irregular menstruation, low fertility, abortion, and risky pregnancy, which are now regarded as global health problems.
Xiang-Hong Ou, Chengcheng Zhu, Shao‐Chen Sun   +2 more
semanticscholar   +1 more source

Transcriptomic analysis of epigenetic modification genes in the termite Reticulitermes speratus

Insect Science, 2018
Eusocial insects display a caste system in which different castes are morphologically and physiologically specialized for different tasks. Recent studies have revealed that epigenetic modifications, including DNA methylation and histone modification ...
Y. Mitaka, E. Tasaki, T. Nozaki, Taro Fuchikawa, K. Kobayashi, K. Matsuura   +5 more
semanticscholar   +1 more source

Assessment of DNA Epigenetic Modifications

Chemical Research in Toxicology, 2019
DNA molecules utilize adenine, thymine, cytosine, and guanine for coding genetic information. In addition to these four canonical nucleobases, DNA molecules also contain a variety of modified nucleobases that can control and regulate gene expression and chromosome structure.
openaire   +2 more sources

Epigenetic Modifications of the FMR1 Gene

2013
The fragile X syndrome (FXS), the most common cause of heritable intellectual disability, is caused by expansion of a CGG repeat located at the 5' UTR of the FMR1 gene and subsequent epigenetic modifications of its promoter. Epigenetic modifications include both methylation of the cytosines of the CpG island in the promoter region and of the expanded ...
Tabolacci, Elisabetta, Neri, Giovanni
openaire   +2 more sources