Results 101 to 110 of about 307,044 (299)

Supplementary Table S7 from Targeting p300/CBP Attenuates Hepatocellular Carcinoma Progression through Epigenetic Regulation of Metabolism

, 2023
Ling-Yan Cai, Shi‐Jie Chen, Sen-Hao Xiao, Qin-Juan Sun, Chen‐Hong Ding, Bai-Nan Zheng, Xinyan Zhu, Shuqing Liu, Feng Yang, Yaxi Yang, Bing Zhou, Cheng Luo, Xin Zhang, Wei‐Fen Xie   +13 more
openalex   +1 more source

[Retracted] Histone Deacetylase9 Represents the Epigenetic Promotion of M1 Macrophage Polarization and Inflammatory Response via TLR4 Regulation [PDF]

, 2022
Xi Cao, Man Zhang, Hui Li, Kaiming Chen, Yong Wang, Jia Yang   +5 more
openalex   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Postnatal epigenetic regulation of intestinal stem cells requires DNA methylation and is guided by the microbiome [PDF]

, 2015
Dahai Yu, Manasi Gadkari, Quan Zhou, Shiyan Yu, Nan Gao, Yongtao Guan, Deborah Schady, Tony Roshan, Miao-Hsueh Chen, Eleonora Laritsky, Zhongqi Ge, Hui Wang, Rui Chen, Caroline Westwater, Lynn Bry, Robert A. Waterland, Chelsea Moriarty, Cindy S. Hwang, Alton G. Swennes, Sean R. Moore, Lanlan Shen   +20 more
openalex   +1 more source

Supplementary Data from Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer

, 2023
Ellen Langille, Khalid N. Al‐Zahrani, Zhibo Ma, Minggao Liang, Liis Uusküla-Reimand, Roderic Espín, Katie Teng, Ahmad Malik, Helga Bergholtz, Samah El Ghamrasni, Somaieh Afiuni‐Zadeh, Ricky Tsai, Sana Alvi, Andrew Elia, YiQing Lü, Robin H. Oh, Katelyn J. Kozma, Daniel Trcka, Masahiro Narimatsu, Jeff C. Liu, Thomas Nguyen, Seda Barutcu, Sampath K. Loganathan, Rod Bremner, Gary D. Bader, Sean E. Egan, David W. Cescon, Thérese Sørlie, Jeffrey L. Wrana, Hartland W. Jackson, Michael D. Wilson, Agnieszka K. Witkiewicz, Erik S. Knudsen, Miguel Ángel Pujana, Geoffrey M. Wahl, Daniel Schramek   +35 more
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Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Extensive folding variability between homologous chromosomes in mammalian cells

Molecular Systems Biology
Genetic variation and 3D chromatin structure have major roles in gene regulation. Due to challenges in mapping chromatin conformation with haplotype-specific resolution, the effects of genetic sequence variation on 3D genome structure and gene expression
Ibai Irastorza-Azcarate, Alexander Kukalev, Rieke Kempfer, Christoph J Thieme, Guido Mastrobuoni, Julia Markowski, Gesa Loof, Thomas M Sparks, Emily Brookes, Kedar Nath Natarajan, Stephan Sauer, Amanda G Fisher, Mario Nicodemi, Bing Ren, Roland F Schwarz, Stefan Kempa, Ana Pombo   +16 more
doaj   +1 more source

Supplementary material from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation

, 2023
Wenchu Lin, Hideo Watanabe, Shouyong Peng, Joshua M. Francis, Nathan O. Kaplan, Chandra Sekhar Pedamallu, Aruna Ramachandran, Agoston Agoston, Adam J. Bass, Matthew Meyerson   +9 more
openalex   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Prenatal exposure to environmental air pollution and psychosocial stress jointly contribute to the epigenetic regulation of the serotonin transporter gene in newborns

, 2023
Sarah Nazzari, Lucia Cagliero, Serena Grumi, Enrico Pisoni, Giulia Mallucci, Roberto Bergamaschi, M. Julià, Roberto Giorda, Livio Provenzi   +8 more
openalex   +1 more source