Results 151 to 160 of about 307,044 (299)

Epigenetic Regulation by Z-DNA Silencer Function Controls Cancer-Associated ADAM-12 Expression in Breast Cancer: Cross-talk between MeCP2 and NF1 Transcription Factor Family [PDF]

, 2012
Bimal K. Ray, Srijita Dhar, Carolyn J. Henry, Alexander Rich, Alpana Ray   +4 more
openalex   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

Epigenetic Regulation of Chromosomal Instability by EZH2 Methyltransferase. [PDF]

Cancer Discov
Bai Y, Agustinus AS, Yomtoubian S, Meydan C, McNally DR, Yoffe L, Hubisz MJ, Tranquille M, Pramod S, Hong C, Plasilova ML, Kapoor AR, Singh A, Withers H, Dow LE, Laughney AM, Bhinder B, Elemento O, Melnick AM, Bakhoum SF, Mittal V.   +20 more
europepmc   +1 more source

Chromatin Topology Reconfiguration Orchestrates Thermotolerant Male Fertility via GhAL5 in Cotton

Advanced Science, EarlyView.
This study investigates cotton’s high‐temperature (HT) response using multi‑omics. Dynamic 3D genome changes drive expression bias affecting male fertility. The tolerant line shows controlled chromatin dynamics, while the sensitive line exhibits overactivation.
Yanlong Li, Jing Yang, Weiran Wang, Chunyang Zuo, Liuling Pei, Yizan Ma, Rui Zhang, Yaru Fan, Huanhuan Ma, Yawei Li, Ruizhen Liu, Shuangxia Jin, Longfu Zhu, Jie Kong, Xianlong Zhang, Ling Min   +15 more
wiley   +1 more source

PB2484: IMMUNE PRIVILEGES OF NESTIN-GFP+ CELLS OF THE BONE MARROW ARE PRESERVED IN IMMUNOLOGICALLY COMPLETE IMMUNIZED WITH GFP MICE IN THE MODEL OF ECTOPIC FOCI OF HEMATOPOIESIS UNDER THE RENAL CAPSULE

HemaSphere, 2023
Dmitriy Karpenko, Nikolay Kapranov, Aleksei Bogdanov, Alexander Lazutkin, Aleksei Bigildeev   +4 more
doaj   +1 more source

Different Mechanisms of Epigenetic Regulation of Gene Expression [PDF]

, 2015
Elena Shestakova
openalex   +1 more source

Ribosome Homeostasis Regulated by SETD2 Preserves Intestinal Epithelial Barrier

Advanced Science, EarlyView.
SETD2 ablation causes dysregulation and recruitment defects of ribosome biogenesis factors, resulting in translational disorders of barrier maintenance genes, thereby compromising the intestinal barrier. These findings unveil a previously unappreciated role of ribosome biogenesis and translational regulation in preserving the intestinal epithelial ...
Hanyu Rao, Aiting Wang, Yue Xu, Wenxin Feng, Chunxiao Ma, Ziyi Wang, Wei Zhang, Wenqiong Su, Xiuying Xiao, Wei‐Qiang Gao, Xianting Ding, Li Li   +11 more
wiley   +1 more source

Epigenetic Regulation of Floral Transition. [PDF]

Plants (Basel)
Li Y, Zhang D, Wang J, Yang M, Yin Z, Zhu K, Liang Y, Tan X.   +7 more
europepmc   +1 more source

Comparative genome-wide methylation analysis reveals epigenetic regulation of muscle development in grass carp (Ctenopharyngodon idellus) fed with whole faba bean

, 2022
Yichao Li, Bing Fu, Junming Zhang, Guangjun Wang, Jingjing Tian, Hongyan Li, Yun Xia, Jun Xie, Ermeng Yu   +8 more
openalex   +1 more source