Results 61 to 70 of about 475,691 (380)

Serum microRNA array analysis identifies miR-140-3p, miR-33b-3p and miR-671-3p as potential osteoarthritis biomarkers involved in metabolic processes. [PDF]

, 2017
Background: MicroRNAs (miRNAs) in circulation have emerged as promising biomarkers. In this study, we aimed to identify a circulating miRNA signature for osteoarthritis (OA) patients and in combination with bioinformatics analysis to evaluate the utility
A Brazma, A Nan, A Okuhara, A Turchinovich, B Aryal, B Mayr, B Sharif, B Zhang, BM Bolstad, BM Kuhn, BM Mayr, C Beyer, C Chen, C Guay, C Taurino, CL Andersen, D Dlouha, D Iliopoulos, D Zhang, DT Felson, F Kostopoulou, FE Nicolas, G Dennis Jr, G Li, G Tardif, GD Miles, GR Sondag, GS Lien, H Causton, JB van Meurs, JD Storey, JD Storey, KC Vickers, L Qi, M Cross, M Parrizas, MB Goldring, MC Hochberg, MD Paraskevopoulou, MP Gantier, OF Laterza, Q Zhuo, R Gernapudi, RF Loeser, RI Gregory, S Kluzek, S Kumar, S Miyaki, T Thomou, TA Karlsen, VM Borgonio Cuadra, W Cleveland, WM Reichmann, X Chen, X Chen, X Tan, X Wang, Y Klipper-Aurbach, Y Zhang, YH Li   +59 more
core   +2 more sources

Cancer epigenetics: from laboratory studies and clinical trials to precision medicine

Cell Death Discovery
Epigenetic dysregulation is a common feature of a myriad of human diseases, particularly cancer. Defining the epigenetic defects associated with malignant tumors has become a focus of cancer research resulting in the gradual elucidation of cancer cell ...
Xinyang Yu, Hao Zhao, Ruiqi Wang, Yingyin Chen, Xumei Ouyang, Wenting Li, Yihao Sun, Anghui Peng   +7 more
semanticscholar   +1 more source

Machine learning and clinical epigenetics: a review of challenges for diagnosis and classification

Clinical Epigenetics, 2020
Machine learning is a sub-field of artificial intelligence, which utilises large data sets to make predictions for future events. Although most algorithms used in machine learning were developed as far back as the 1950s, the advent of big data in ...
S. Rauschert, K. Raubenheimer, P. Melton, P. Melton, P. Melton, Rae-Chi Huang   +5 more
semanticscholar   +1 more source

Epigenetics and immunometabolism in diabetes and aging [PDF]

, 2018
Significance: A strong relationship between hyperglycemia, impaired insulin pathway and cardiovascular disease in type 2 diabetes (T2D) is linked to oxidative stress and inflammation.
Cosentino, Francesco, Guzik, Tomasz J.
core   +2 more sources

Replication timing and epigenome remodelling are associated with the nature of chromosomal rearrangements in cancer

Nature Communications, 2019
The connection between DNA replication timing and changes that occur to the epigenome in cancer are still poorly understood. Here, the authors perform Repli-Seq and integrated epigenome analyses and find that genomic regions that undergo long-range ...
Qian Du, Saul A. Bert, Nicola J. Armstrong, C. Elizabeth Caldon, Jenny Z. Song, Shalima S. Nair, Cathryn M. Gould, Phuc-Loi Luu, Timothy Peters, Amanda Khoury, Wenjia Qu, Elena Zotenko, Clare Stirzaker, Susan J. Clark   +13 more
doaj   +1 more source

The social construction of the social epigenome and the larger biological context

Epigenetics & Chromatin, 2020
Epigenetics researchers in developmental, cell, and molecular biology greatly diverge in their understanding and definitions of epigenetics. In contrast, social epigeneticists, e.g., sociologists, scholars of STS, and behavioural scientists, share a ...
Ute Deichmann
doaj   +1 more source

Epigenetics of Sepsis

Critical Care Medicine, 2020
Objectives: Recent evidence from the fields of microbiology and immunology, as well as a small number of human sepsis studies, suggest that epigenetic regulation may play a central role in the pathogenesis of sepsis. The term “epigenetics” refers to regulatory mechanisms that control gene expression but are not related to ...
Pedro Castelo-Branco, Alexandra Binnie, Claudia C. dos Santos, Claudia C. dos Santos, Pingzhao Hu, Gabriela Carrasqueiro, Jennifer L Y Tsang   +6 more
openaire   +4 more sources

What is a Gene? A Two Sided View [PDF]

, 2017
The need to account for all currently available experimental observations concerning the gene nature, has reshaped the concept of gene turning it from the essentially mechanistic unit, predominant during the '70s, into a quite abstract open ...
Bolondi, A., Caldarelli, F., Camilloni, Giorgio, DI FELICE, Francesca, Durano, Diletta, Germani, G., Micheli, G., Michetti, L., Tramutolo, A.   +8 more
core   +1 more source

Epigenetic Regulation and Measurement of Epigenetic Changes [PDF]

Biological Research For Nursing, 2012
Epigenetic mechanisms provide an adaptive layer of control in the regulation of gene expression that enables an organism to adjust to a changing environment. Epigenetic regulation increases the functional complexity of deoxyribonucleic acid (DNA) by altering chromatin structure, nuclear organization, and transcript stability.
Stephens, Kimberly E, Miaskowski, Christine A, Levine, Jon D, Pullinger, Clive R, Aouizerat, Bradley E   +4 more
openaire   +5 more sources

The Many Faces of EpigeneticsOxford, December 2017

Epigenetics, 2019
The conference ‘The Many Faces of Epigenetics: Multidisciplinary Perspectives “over” Genetics’ was held in Oxford (6–8 December 2017) and offered a valuable window into the domain of Epigenetics and its promises.
Paola B. Arimondo, Anouk Barberousse, Gaëlle Pontarotti   +2 more
doaj   +1 more source