Results 201 to 210 of about 86,342 (328)

Management of T‐cell malignancies: Bench‐to‐bedside targeting of epigenetic biology

CA: A Cancer Journal for Clinicians, EarlyView.
Abstract The peripheral T‐cell lymphomas (PTCL) are the only disease for which four histone deacetylase (HDAC) inhibitors have been approved globally as single agents. Although it is not clear why the PTCL exhibit such a vulnerability to these drugs, understanding the biological basis for this activity is essential.
Ariana Sabzevari, Johnson Ung, Jeffrey W. Craig, Kallesh D. Jayappa, Ipsita Pal, David J. Feith, Thomas P. Loughran Jr, Owen A. O’Connor   +7 more
wiley   +1 more source

Epigenetic reprogramming in the germline: towards the ground state of the epigenome [PDF]

, 2011
Petra Hájková
openalex   +1 more source

DinoSource: A comprehensive database of dinoflagellate genomic resources

Plant Biotechnology Journal, EarlyView.
Fuming Lai, Chongping Li, Yidong Zhang, Ying Li, Yuci Wang, Qiangwei Zhou, Yaping Fang, Hao Chen, Guoliang Li   +8 more
wiley   +1 more source

Perspectives on integrating artificial intelligence and single‐cell omics for cellular plasticity research

Quantitative Biology, Volume 13, Issue 4, December 2025.
Abstract Cellular plasticity enables cells to dynamically adapt to environmental changes by altering their phenotype. This plasticity plays a crucial role in tissue repair and regeneration and contributes to pathological processes such as cancer metastasis.
Ahmed Ghobashi, Qin Ma
wiley   +1 more source

Hypermethylation of serotonin transporter gene in bipolar disorder detected by epigenome analysis of discordant monozygotic twins [PDF]

, 2011
Hiroko Sugawara, Kazuya Iwamoto, Miki Bundo, Junko Ueda, T. Miyauchi, Atsuko Komori, An‐a Kazuno, Naoki Adati, Ichiro Kusumi, Yozo Okazaki, Jun Ishigooka, Takashi Kojima, Tadafumi Kato   +12 more
openalex   +1 more source

Computational systems biology approaches to cellular aging—Integrating network maps and dynamical models

Quantitative Biology, Volume 13, Issue 4, December 2025.
Abstract Cellular aging is a multifaceted complex process. Many genes and factors have been identified that regulate cellular aging. However, how these genes and factors interact with one another and how these interactions drive the aging processes in single cells remain largely unclear.
Hetian Su, Nan Hao
wiley   +1 more source

Frontiers in Toxicogenomics – The Grand Challenge: To Understand How the Genome and Epigenome Interact with the Toxic Environment [PDF]

, 2011
Douglas M. Ruden
openalex   +1 more source

Antitumor efficacy of intermittent low‐dose erlotinib plus sulindac via MHC upregulation and remodeling of the immune cell niche

International Journal of Cancer, Volume 157, Issue 2, Page 355-370, 15 July 2025.
What's new? Novel immunomodulatory insights derived from experimental models and clinical samples reveal the cancer‐preventive potential of intermittent low‐dose erlotinib plus sulindac (ERL + SUL). This study shows that ERL + SUL treatment upregulates MHC class I and II expression and remodels the immune cell niche, with significant tumor suppression ...
Chakrapani Tripathi, Jorge E. Tovar Perez, Sabeeta Kapoor, Ahmed Muhsin, Wan Mohaiza Dashwood, Yunus Demirhan, Melek Demirhan, Alessandro Shapiro, Altaf Mohammed, Shizuko Sei, Jacklyn Thompson, Mahira Zaheer, Krishna M. Sinha, Powel H. Brown, Michelle I. Savage, Eduardo Vilar, Praveen Rajendran, Roderick H. Dashwood   +17 more
wiley   +1 more source

Genomic Investigation of Dedifferentiated Liposarcoma Suggests a Role for Therapeutic Targeting of the Tumor Epigenome [PDF]

, 2011
Paul S. Meltzer, Lee J. Helman
openalex   +1 more source

Captive rearing effects on the methylome of Atlantic salmon after oceanic migration: Sex‐specificity and intergenerational stability

Molecular Ecology Resources, Volume 25, Issue 5, July 2025.
Abstract Captive rearing in salmon hatcheries can have considerable impacts on both fish phenotype and fitness within a single generation, even in the absence of genetic change. Evidence for hatchery‐induced changes in DNA methylation is becoming abundant, though questions remain on the sex‐specificity of these effects, their persistence until spawning
Clare J. Venney, Raphaël Bouchard, Julien April, Eric Normandeau, Laurie Lecomte, Guillaume Côté, Louis Bernatchez   +6 more
wiley   +1 more source