Results 231 to 240 of about 93,647 (322)

The dynamic epigenome [PDF]

Nature Structural & Molecular Biology, 2013
openaire   +2 more sources

5‐Hydroxymethylcytosine Dynamics Reveals Coordinated Reprogramming of Parental Genomes and X Chromosome Dosage Balance in Mouse SCNT Embryos

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Genome‐wide, high‐resolution profiling of hydroxymethylation in mouse SCNT embryos reveals a transient, allele‐symmetric 5hmC reprogramming pattern distinct from natural embryos, with X‐chromosomes and imprinting control regions resistant to proper remodeling.
Zeming Xiang, Rui Yan, Jing Guo, Mengyao Wang, Xin Cheng, Fan Zhang, Tianzi Guo, Xin Long, Fan Guo, Dan Liang   +9 more
wiley   +1 more source

Epigenetic landscape in lysosomal storage disorders: mechanisms and modulation. [PDF]

Front Genet
Leal AF, Pachajoa H, Tomatsu S.
europepmc   +1 more source

A Pan‐TE Map Reveals the Important Role of Transposable Elements in Gene Expression and Phenotypic Diversity in 2,311 Rapeseed Accessions

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study presents the first pan‐transposable element (TE) atlas in rapeseed, profiling over 8 million TEs across 2311 accessions. Integrative analyses reveal that TEs broadly shape gene expression through diverse regulatory mechanisms, with key insertions in BnaA03.FLC and BnaA09.CYP78A9 linked to flowering time and silique development.
Zhiquan Yang, Haiyan Fan, Yifan Chen, Jiawei Li, Minjian Chen, Yingying Tan, Liang Guo, Jintao Li, Kede Liu, Qing‐Yong Yang   +9 more
wiley   +1 more source

Maternal Nutrition, Toxicants, and Epigenetic Programming of Obesity Across Generations. [PDF]

Diabetes Metab Syndr Obes
Alum EU, Aloh HE, Obasi DC, Okoroh PN, Aniokete UC, Emeruwa AP.   +5 more
europepmc   +1 more source

Epigenome-wide analysis reveals novel DNA methylation signatures significantly associated with the infant pupillary light reflex, a candidate intermediate phenotype for autism

Laurel Fish, Teodora Gliga, Anna Gui, Jannath Begum Ali, Luke Mason, Mark H. Johnson, Tony Charman, Terje Falck‐Ytter, Emily J. H. Jones, Radhika Kandaswamy, Francesca Happé, Chloe C. Y. Wong   +11 more
openalex   +1 more source

Epo reprograms the epigenome of erythroid cells

, 2017
Andrea A. Perreault, Mary Lauren Benton, Mark J. Koury, Stephen J. Brandt, Bryan J. Venters   +4 more
openalex   +2 more sources

Methodologies for Sample Multiplexing and Computational Deconvolution in Single‐Cell Sequencing

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Sample multiplexing offers a critical solution for boosting throughput and minimizing batch effects in single‐cell sequencing. This review navigates the latest experimental methodologies and computational deconvolution algorithms, bridging the gap between wet‐lab design and analytical success.
Yufei Gao, Weiwei Yin, Wei Hu, Wei Chen
wiley   +1 more source

Decoding the Adipocyte Epigenome: Differentiation, Metabolic Memory, and Obesity. [PDF]

J Obes Metab Syndr
Kato S, Waki H.
europepmc   +1 more source

Differentiated T Lymphocytes and Cancer Cell Mitochondrial Metabolism to Enhance Radioimmunotherapy by a Biomimetic Nanozyme System

Advanced Science, Volume 13, Issue 3, 14 January 2026.
T cell membrane‐coated MgCO3/Fe‐CD nanozyme loaded with TEPP‐46 (TFMP) enhances breast cancer radioimmunotherapy by reprogramming mitochondrial metabolism in T cells and tumors. It targets PD‐L1, converts H2O2 into ROS, neutralizes acidity, and releases Mg2⁺/TEPP‐46 to boost T cell activation.
Hanyu Zhang, Yuhan Deng, Yantong Lu, Miao Wang, Kun Qiao, Zifan Yang, Shipeng Ning, Tong Liu   +7 more
wiley   +1 more source