Results 161 to 170 of about 64,265 (410)
An Efficient Sufficient Dimension Reduction Method for Identifying Genetic Variants of Clinical Significance [PDF]
arXiv, 2013 Fast and cheaper next generation sequencing technologies will generate unprecedentedly massive and highly-dimensional genomic and epigenomic variation data. In the near future, a routine part of medical record will include the sequenced genomes. A fundamental question is how to efficiently extract genomic and epigenomic variants of clinical utility ...
arxiv
EpiAlign: an alignment-based bioinformatic tool for comparing chromatin state sequences. [PDF]
, 2019 The availability of genome-wide epigenomic datasets enables in-depth studies of epigenetic modifications and their relationships with chromatin structures and gene expression.
Ge, Xinzhou +5 more
core +2 more sources
Environmental and Molecular Mutagenesis, EarlyView.Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk +4 more
wiley +1 more source
Epigenome-wide association study and integrative analysis with the transcriptome based on GWAS summary statistics [PDF]
arXiv, 2017 The past decade has seen a rapid growth in omics technologies. Genome-wide association studies (GWAS) have uncovered susceptibility variants for a variety of complex traits. However, the functional significance of most discovered variants are still not fully understood. On the other hand, there is increasing interest in exploring the role of epigenetic
arxiv
Mobile DNA, 2017 Background Intracisternal A particle (IAP) is one of the most transpositionally active retrotransposons in the mouse genome, but its expression varies between cell types. This variation is believed to arise from differences in the epigenetic state (e.g.,
Ken-ichi Shimosuga +3 more
doaj +1 more source
Glia, EarlyView.ABSTRACT Multiple sclerosis (MS) is the most common nonâinfectious inflammatory CNS disease, characterized by progressive neurodegeneration and focal demyelinated lesions. Traditionally considered an autoimmune disease, MS is driven by the immune system's attack on CNS myelin, resulting in cumulative disability.
Volker Siffrin
wiley +1 more source
Applications of Novel Techniques to Health Foods, Medical and Agricultural Biotechnology [PDF]
arXiv, 2004 Selected applications of novel techniques in Agricultural Biotechnology, Health Food formulations and Medical Biotechnology are being reviewed with the aim of unraveling future developments and policy changes that are likely to open new niches for Biotechnology and prevent the shrinking or closing the existing ones.
arxiv
A reversible infinite HMM using normalised random measures [PDF]
arXiv, 2014 We present a nonparametric prior over reversible Markov chains. We use completely random measures, specifically gamma processes, to construct a countably infinite graph with weighted edges. By enforcing symmetry to make the edges undirected we define a prior over random walks on graphs that results in a reversible Markov chain. The resulting prior over
arxiv
Environmental Epigenomics, Imprinting and Disease Susceptibility [PDF]
, 2006 Jerrold J. Heindel +3 more
openalex +1 more source