Results 161 to 170 of about 43,487 (351)
Pash 3.0: A versatile software package for read mapping and integrative analysis of genomic and epigenomic variation using massively parallel DNA sequencing [PDF]
, 2010 Cristian Coarfa +5 more
openalex +1 more source
Epigenetic reprogramming in multiple myeloma—Challenges and opportunities
International Journal of Cancer, EarlyView.Abstract In cancer, mutational processes act in concert with epigenetic reprogramming to endow malignant cells with hallmark properties that underpin tumorigenesis. Compared with the relatively rigid and slow processes of genetic evolution, the plastic nature of chromatin enables cells to adapt to a changing environment more rapidly.
Subhasree Kumar +2 more
wiley +1 more source
PB1808: EPIGENETIC INHIBITOR SCREEN TO IDENTIFY THERAPEUTIC CANDIDATES FOR MNX1-OVEREXPRESSING AML
HemaSphere, 2023 Simge Kelekci +13 more
doaj +1 more source
Genome3D: A viewer-model framework for integrating and visualizing multi-scale epigenomic information within a three-dimensional genome [PDF]
, 2010 Thomas M. Asbury +3 more
openalex +1 more source
Epigenetics and epigenomics in diabetic kidney disease and metabolic memory
Nature Reviews Nephrology, 2019 Mitsuo Kato, R. Natarajan
semanticscholar +1 more source
International Journal of Cancer, EarlyView.What's New? The rarity of acute lymphoblastic leukaemia and lack of available environmental data have made the role of environmental factors in genetic subtypes challenging to investigate. Here, the authors performed a CpG‐level analysis to investigate DNA methylation as an intermediate mechanism between environmental risk exposures and acute ...
Jessica R. Saville +5 more
wiley +1 more source
Experimental approaches to the study of epigenomic dysregulation in ageing [PDF]
, 2010 Reid F. Thompson +2 more
openalex +1 more source
iLABMED, EarlyView.Circulating tumor cell (CTC) analysis has become a powerful tool for the early diagnosis of cancer, monitoring disease progression, and evaluating treatment efficacy. This article reviews the latest progress in CTC detection, capture, and release methods based on DNA materials and provides insights into current development trends and future research ...
Lin Zhou, Yongchang Yang, Jie Liu
wiley +1 more source
TBCancer: A database for exploring characteristics and functions of tissue‐biased genes in cancer
iMetaOmics, EarlyView.This study defined 10,921 tissue‐biased genes across 54 normal tissues and 41 cancer types. Tumor‐associated tissue‐biased genes exhibit downregulation, mutations, and epigenetic modifications, correlating with poor clinical outcomes. Their inactivation promotes tumorigenesis by enhancing stemness and immune evasion, highlighting their value as ...
Zhuobin Lin +7 more
wiley +1 more source
iMeta, EarlyView.RepliChrom is an interpretable machine learning model that predicts enhancer‐promoter interactions using DNA replication timing across multiple cell types. By integrating replication timing with chromatin interaction data from multiple experimental platforms, it accurately distinguishes true interactions and reveals promoter‐region signals as key ...
Fuying Dao +7 more
wiley +1 more source