A hitchhiker's guide to single‐cell epigenomics: Methods and applications for cancer research
International Journal of Cancer, EarlyView.Abstract Genetic mutations are well known to influence tumorigenesis, tumor progression, treatment response and relapse, but the role of epigenetic variation in cancer progression is still largely unexplored. The lack of epigenetic understanding in cancer evolution is in part due to the limited availability of methods to examine such a heterogeneous ...
Marta Moreno‐Gonzalez +2 more
wiley +1 more source
Integrative clustering of high-dimensional data with joint and individual clusters, with an application to the Metabric study [PDF]
arXiv, 2014 When measuring a range of different genomic, epigenomic, transcriptomic and other variables, an integrative approach to analysis can strengthen inference and give new insights. This is also the case when clustering patient samples, and several integrative cluster procedures have been proposed.
arxiv
Quantitative DNA Methylation Analysis: The Promise of High-Throughput Epigenomic Diagnostic Testing in Human Neoplastic Disease [PDF]
, 2006 William B. Coleman, Ashley G. Rivenbark
openalex +1 more source
Cell Death and DiseaseAn important epigenetic switch marks the onset and maintenance of senescence. This allows transcription of the genetic programs that arrest the cell cycle and alter the microenvironment.
Eros Di Giorgio +6 more
doaj +1 more source
RGmatch: matching genomic regions to proximal genes in omics data integration
BMC Bioinformatics, 2016 Background The integrative analysis of multiple genomics data often requires that genome coordinates-based signals have to be associated with proximal genes.
Pedro Furió-Tarí +2 more
doaj +1 more source
Novel Techniques and Their Applications to Health Foods, Agricultural and Medical Biotechnology: Functional Genomics and Basic Epigenetic Controls in Plant and Animal Cells [PDF]
, 2004 Selected applications of novel techniques for analyzing Health Food formulations, as well as for advanced investigations in Agricultural and Medical Biotechnology aimed at defining the multiple connections between functional genomics and epigenomic ...
Baianu, I.C. +3 more
core
Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution
International Journal of Cancer, EarlyView.Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano +6 more
wiley +1 more source
Spectral Learning of Large Structured HMMs for Comparative Epigenomics [PDF]
arXiv, 2015 We develop a latent variable model and an efficient spectral algorithm motivated by the recent emergence of very large data sets of chromatin marks from multiple human cell types. A natural model for chromatin data in one cell type is a Hidden Markov Model (HMM); we model the relationship between multiple cell types by connecting their hidden states by
arxiv
Genomes: Epigenomics and the Future of Genome Sciences [PDF]
, 2006 Laura A. Katz
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Frontiers in Plant Science, 2016 Common bean (Phaseolus vulgaris L.) is economically important for its high protein, fiber, and micronutrient contents, with a relatively small genome size of ~587 Mb. Common bean is genetically diverse with two major gene pools, Meso-American and Andean.
Mollee eCrampton +3 more
doaj +1 more source