Results 241 to 250 of about 55,460 (328)

Evolutionary Analysis of Transcriptional Regulation Mediated by Cdx2 in Rodents

Cell Proliferation, EarlyView.
Our study (1) represented a first systematic analysis of species‐specific adaptation in the DNA binding pattern of transcription factor; (2) represented a first study of cis‐regulation between two reproductively isolated species by using a novel allodiploid system; (3) demonstrated a higher conservation of transcriptional output than that of DNA ...
Weizheng Liang, Guipeng Li, Yukai Wang, Wencheng Wei, Rui Chen, Siyue Sun, Diwen Gan, Hongyang Yi, Bernhard Schaefke, Yuhui Hu, Qi Zhou, Wei Li, Huanhuan Cui, Wei Chen   +13 more
wiley   +1 more source

Bridging epigenomics and tumor immunometabolism: molecular mechanisms and therapeutic implications. [PDF]

Mol Cancer
Xie X, Liu W, Yuan Z, Chen H, Mao W.
europepmc   +1 more source

Sex as a modifier of genetic risk for type 1 diabetes

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Sex differences influence the pathogenesis of type 1 diabetes (T1D), yet most genetic studies have treated sex as a control covariate rather than a dynamic effect modifier. Sex influences immune cell behaviour, including CD4+ and CD8+ T cell activation, regulatory T cell stability, B cell autoantibody production, dendritic cell priming and ...
Hui‐Qi Qu, Hakon Hakonarson
wiley   +1 more source

Transcriptomics and epigenomics datasets of primary brain cancers in formalin-fixed paraffin embedded format. [PDF]

Sci Data
García-Heredia A, Guerra-Núñez L, Martín-Climent P, Rojas E, López-Domínguez R, Alcántara-Domínguez C, Alenda C, Valor LM.   +7 more
europepmc   +1 more source

Systematic classification of non-coding RNAs by epigenomic similarity [PDF]

, 2013
Mikhail G. Dozmorov, Cory B. Giles, Kristi A. Koelsch, Jonathan D. Wren   +3 more
openalex   +1 more source

Novel neuropathological observations in an adult with Dravet syndrome

Epilepsia, EarlyView.
Abstract Dravet syndrome (DS) is a developmental and epileptic encephalopathy associated with pathogenic variants in the SCN1A gene. The neuropathological features of adult DS remain poorly understood. We report the postmortem findings of a 55‐year‐old woman with DS due to a confirmed SCN1A pathogenic variant leading to Nav1.1 loss of function ...
Danielle M. Andrade, Anne S. Bassett, Quratulain ZulfiqarAli, Victor S. T. Lira, Nikolai Gil Reyes, M. Carmela Tartaglia, Alfonso Fasano, Gabor G. Kovacs   +7 more
wiley   +1 more source

Bifaceted functions of histone methyltransferases. [PDF]

Epigenomics
Akhtar J, Saloura V.
europepmc   +1 more source

Neocortical neurogenesis: a proneural gene perspective

The FEBS Journal, EarlyView.
The neocortex is a mammalian‐specific brain region responsible for higher‐order cognitive functioning that shares fundamental similarities across species, but which is larger and more complex in humans. Proneural genes, encoding basic helix–loop–helix transcription factors (TFs), are evolutionarily conserved drivers of neurogenesis from fly to human ...
Lakshmy Vasan, Alexandra Moffat, Pierre Mattar, Carol Schuurmans   +3 more
wiley   +1 more source

Three Synchronous Pituitary Neuroendocrine Tumors-Epigenomics Confirm an Exceptional Triple PitNET. [PDF]

Endocr Pathol
Rafiq T, Matschke J, Flitsch J, Dottermusch M.   +3 more
europepmc   +1 more source

The dynamic epigenome [PDF]

Nature Structural & Molecular Biology, 2013
openaire   +2 more sources