Results 81 to 90 of about 64,265 (410)

Epigenomics of Hypertension [PDF]

Seminars in Nephrology, 2013
Multiple genes and pathways are involved in the pathogenesis of hypertension. Epigenomic studies of hypertension are beginning to emerge and hold great promise of providing novel insights into the mechanisms underlying hypertension. Epigenetic marks or mediators including DNA methylation, histone modifications, and noncoding RNA can be studied at a ...
Theodore A. Kotchen, David L. Mattson, Allen W. Cowley, Yong Liu, Mingyu Liang   +4 more
openaire   +3 more sources

Leveraging Genomics, Transcriptomics, and Epigenomics to Understand the Biology and Chemoresistance of Ovarian Cancer

Cancers, 2021
Simple Summary Ovarian cancer is the leading cause of death by a gynecological tumor, mainly due to its common detection in advanced stages and to its high resistance to conventional chemotherapy.
S. Muñoz-Galván, A. Carnero
semanticscholar   +1 more source

Essential role of long non-coding RNAs in de novo chromatin modifications: The genomic address code hypothesis [PDF]

Biophysical Reviews Vol. 9, pp. 73-77 (2017), 2017
The epigenome, i.e. the whole of chromatin modifications, is transferred from mother to daughter cells during cell differentiation. When de novo chromatin modifications (establishment or erasure of, respectively, new or pre-existing DNA methylations and/or histone modifications) are made in a daughter cell, however, it has a different epigenome than ...
arxiv   +1 more source

Multi-omics analysis based on integrated genomics, epigenomics and transcriptomics in pancreatic cancer.

Epigenomics, 2020
Aim: Integrated analysis of genomics, epigenomics, transcriptomics and clinical information contributes to identify specific molecular subgroups and find novel biomarkers for pancreatic cancer.
Lingming Kong, P. Liu, Ming-jun Zheng, Busheng Xue, Keke Liang, X. Tan   +5 more
semanticscholar   +1 more source

IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation

Nature Communications, 2018
Th17 cells are a common pathogenic effector cell in autoimmune inflammatory diseases. Here the authors show that the transcription factor RFX1 limits Th17 differentiation and is protective against the pathogenesis of Th17-driven autoimmune diseases.
Ming Zhao, Yixin Tan, Qiao Peng, Cancan Huang, Yu Guo, Gongping Liang, Bochen Zhu, Yi Huang, Aiyun Liu, Zijun Wang, Mengying Li, Xiaofei Gao, Ruifang Wu, Haijing Wu, Hai Long, Qianjin Lu   +15 more
doaj   +1 more source

Folate regulates RNA m5C modification and translation in neural stem cells

BMC Biology, 2022
Background Folate is an essential B-group vitamin and a key methyl donor with important biological functions including DNA methylation regulation. Normal neurodevelopment and physiology are sensitive to the cellular folate levels.
Xiguang Xu, Zachary Johnson, Amanda Wang, Rachel L. Padget, James W. Smyth, Hehuang Xie   +5 more
doaj   +1 more source

Acetylation and Phosphorylation in the Regulation of Hypoxia-Inducible Factor Activities: Additional Options to Modulate Adaptations to Changes in Oxygen Levels

Life, 2023
O2 is essential for the life of eukaryotic cells. The ability to sense oxygen availability and initiate a response to adapt the cell to changes in O2 levels is a fundamental achievement of evolution.
Martina Minisini, Emanuele Cricchi, Claudio Brancolini   +2 more
doaj   +1 more source

Exercise epigenetics and the foetal origins of disease [PDF]

, 2014
Exercise epigenetics is a nascent area of research with vast health implications (e.g., from the treatment of obesity-related diseases to beneficially decoupling epigenetic and chronological age).
Dale E, Thomas EW Chalk, William M Brown
core   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Nonequilibrium Theory of Epigenomic Microphase Separation in the Cell Nucleus [PDF]

, 2019
Understanding the spatial organisation of the genome in the cell nucleus is one of the current grand challenges in biophysics. Certain biochemical -- or epigenetic -- marks that are deposited along the genome are thought to play an important, yet poorly understood, role in determining genome organisation and cell identity.
arxiv   +1 more source