Results 81 to 90 of about 43,487 (351)

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Designing the Next Generation of Biomaterials through Nanoengineering

Advanced Materials, EarlyView.
Nanoengineering enables precise control over biomaterial interactions with living systems by tuning surface energy, defects, porosity, and crystallinity. This review highlights how these nanoscale design parameters drive advances in regenerative medicine, drug delivery, bioprinting, biosensing, and bioimaging, while outlining key translational ...
Ryan Davis Jr., Ishaan Duggal, Nicholas A. Peppas, Akhilesh K. Gaharwar   +3 more
wiley   +1 more source

Hypermethylation of the TPEF/HPP1 Gene in Primary, Metastatic Colorectal Cancers

Neoplasia: An International Journal for Oncology Research, 2005
The role of promoter methylation in the process of cancer cell metastasis has not yet been studied. Recently, methylation of the TPEF (transmembrane protein containing epidermal growth factor, follistatin domain) gene was reported in human colon, gastric,
Matthias P.A. Ebert, Suzanne H. Mooney, Lori Tonnes-Priddy, Joe Lograsso, Juliane Hoffmann, Jie Chent, Christoph Rocken, Hans-Ulrich Schulz, Peter Malfertheiner, Catherine Lofton-Day   +9 more
doaj   +1 more source

Recent Evidence in Epigenomics and Proteomics Biomarkers for Early and Minimally Invasive Diagnosis of Alzheimer’s and Parkinson’s Diseases

Current Neuropharmacology, 2020
Background: Alzheimer’s (AD) and Parkinson’s diseases (PD) show deposits of improperly folded modified proteins. Protein expression mechanisms are involved since the early stages.
S. Mayo, J. Benito‐León, C. Peña-Bautista, M. Baquero, C. Cháfer-Pericás   +4 more
semanticscholar   +1 more source

Thermal Annealing Enhances Piezoelectricity and Regenerative Potential of PVDF‐TrFE Nanofiber Scaffolds

Advanced Materials Technologies, EarlyView.
Thermal annealing improves the structure, stiffness, and piezoelectric properties of poly(vinylidene flouride‐trifluoroethylene) (PVDF‐TrFE) nanofiber scaffolds. These annealed scaffolds promote Schwann cell proliferation and matrix remodeling in vitro and demonstrate in vivo biocompatibility.
Maksym Krutko, Holly M. Poling, Maulee Sheth, Supasek Kongsomros, Andrew E. Bryan, Manju Sharma, Akaljot Singh, Hasan A. Reza, Kathryn A. Wikenheiser‐Brokamp, Takanori Takebe, Michael A. Helmrath, Greg M. Harris, Leyla Esfandiari   +12 more
wiley   +1 more source

Implementing Curcumin in Translational Oncology Research

Molecules, 2020
Most data published on curcumin and curcumin-based formulations are very promising. In cancer research, the majority of data has been obtained in vitro. Less frequently, researchers used experimental animals.
Koraljka Gall Trošelj, Ivana Samaržija, Marko Tomljanović, Renata Novak Kujundžić, Nikola Đaković, Anamarija Mojzeš   +5 more
doaj   +1 more source

AIM2 deficiency in B cells ameliorates systemic lupus erythematosus by regulating Blimp-1–Bcl-6 axis-mediated B-cell differentiation

Signal Transduction and Targeted Therapy, 2021
Absent in melanoma 2 (AIM2) has been reported to be a component of inflammasomes in innate immune cells. Surprisingly, AIM2 is expressed by B cells, and higher AIM2 expression is observed in the B cells from lupus patients.
Ming Yang, Di Long, Longyuan Hu, Zhidan Zhao, Qianwen Li, Yunkai Guo, Zhenghao He, Ming Zhao, Liwei Lu, Fen Li, Hai Long, Haijing Wu, Qianjin Lu   +12 more
doaj   +1 more source

The Promises and Challenges of Toxico-Epigenomics: Environmental Chemicals and Their Impacts on the Epigenome

Environmental Health Perspectives, 2020
Background: It has been estimated that a substantial portion of chronic and noncommunicable diseases can be caused or exacerbated by exposure to environmental chemicals.
F. Chung, Z. Herceg
semanticscholar   +1 more source

GDC: Integration of Multi‐Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss

Advanced Science, EarlyView.
Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng, Xuegang Wang, Mingjun Zhong, Jia Geng, Wenjian Li, Kanglu Pei, Jing Wang, Lanchen Wang, Yu Lu, Jing Cheng, Fengxiao Bu, Huijun Yuan   +11 more
wiley   +1 more source

How chronic inflammation fuels carcinogenesis as an environmental epimutagen

Discover Oncology
Chronic inflammation, induced by environmental and intrinsic factors, frequently leads to carcinogenesis. In inflammation-associated cancers, such as gastric, colon, and cervical cancers, an important role of epigenetic alterations has been implicated ...
Yu-Yu Liu, Yui Ohashi, Toshikazu Ushijima   +2 more
doaj   +1 more source