Results 1 to 10 of about 18,265 (273)
Epimers of Vitamin D: A Review [PDF]
International Journal of Molecular Sciences, 2020 In this review, we discuss the sources, formation, metabolism, function, biological activity, and potency of C3-epimers (epimers of vitamin D). We also determine the role of epimerase in vitamin D-binding protein (DBP) and vitamin D receptors (VDR) according to different subcellular localizations.
Bashar Al-Zohily +4 more
+7 more sources
Two new xanthone epimers from the processed gamboge
Natural Product Research, 2016 Two new xanthones, gambogollic acid (1), epigambogollic acid (2), together with three rare compounds, gambogellic acid (3), epigambogellic acid (4) and gambogic acid (5), were isolated from the processed gamboge. The new structures were determined by 1D and 2D NMR spectroscopic analysis.
Bang, Dong +6 more
openaire +4 more sources
The genetic determinants of circulating C3-epimers of 25-hydroxyvitamin D
Journal of Clinical & Translational Endocrinology, 2018 Background: The complexity of vitamin D metabolites especially the contribution of C3-epimers of 25-hydroxyvitamin D (C3-epimers) in human sera remains unclear.
Sirikunya Torugsa +6 more
doaj +2 more sources
An epimer of threose nucleic acid enhances oligonucleotide exonuclease resistance through end capping [PDF]
Communications ChemistryEnd capping of oligonucleotides by modified nucleotides is essential for boosting resistance to 3’ exonuclease degradation, thereby enhancing their stability and therapeutic efficacy in vivo.
Junlin Wen +9 more
doaj +2 more sources
Marine Drugs, 2023 The fungal genus Meira was first reported in 2003 and has mostly been found on land. This is the first report of second metabolites from the marine-derived yeast-like fungus Meira sp.
Hee Jae Shin +3 more
doaj +1 more source
Investigation of the relationship between ergocristinine and vascular receptors
Toxicology Reports, 2023 Ergot alkaloids are secondary metabolites that exist in two configurations, the C-8-R-isomer (R-epimer), and the C-8-S-isomer (S-epimer). Toxic effects of ergot, such as vasoconstriction, have been primarily attributed to the R-epimer bioactivity, as ...
Jensen E. Cherewyk +2 more
doaj +1 more source
Stereoselective property of 20(S)-protopanaxadiol ocotillol type epimers affects its absorption and also the inhibition of P-glycoprotein. [PDF]
PLoS ONE, 2014 Stereoselectivity has been proved to be tightly related to drug action including pharmacodynamics and pharmacokinetics. (20S,24R)-epoxy-dammarane-3,12,25-triol (24R-epimer) and (20S,24S)-epoxy-dammarane-3,12,25-triol (24S-epimer), a pair of 20(S ...
Wenyan Wang +4 more
doaj +1 more source
The Impact of Storage Temperature and Time on Ergot Alkaloid Concentrations
Toxins, 2023 Ergot sclerotia produce toxic secondary metabolites, ergot alkaloids, that infect cereal crops and grasses. Ergot alkaloids have two isomeric configurations: the C-8-R-isomer (R-epimer), and the C-8-S-isomer (S-epimer).
Jensen E. Cherewyk +4 more
doaj +1 more source
Population Pharmacokinetics and Dosing Regimen Optimization of Latamoxef in Chinese Children
Pharmaceutics, 2022 The present study aimed to establish population pharmacokinetic models of latamoxef, as well as its R- and S-epimers, and generate findings to guide the individualized administration of latamoxef in pediatric patients. A total of 145 in-hospital children
Yang Wang +9 more
doaj +1 more source