Results 11 to 20 of about 18,265 (273)

Caylobolide B: Structure Revision, Total Synthesis, Biological Characterization, and Discovery of New Analogues. [PDF]

Angew Chem Int Ed Engl
Marine polyhydroxylated macrolides’ drug discovery potential is limited by structural complexity and scarce material supply, hindering structure assignment, synthesis, and biological studies. Here, we present an integrated workflow that combines chemogenomic profiling, ultra‐high‐resolution NMR‐guided structural revision and stereochemical assignment ...
George MRP, Elsadek LA, Deering M, de Almeida LC, Tyler JL, Noble A, Paul VJ, Luesch H, Butts CP, Aggarwal VK.   +9 more
europepmc   +3 more sources

Stereoselective Total Synthesis of (+)-Giganin and Its C10 Epimer by Using Late-Stage LithiationBorylation Methodology [PDF]

, 2013
Alali, Bandur, Beckmann, Besong, Blakemore, Crimmins, Curran, Davoli, De Luca, Dearden, Debré, Dixon, Donohoe, Donohoe, Duret, Duval, Elford, Esposti, Fang, Furuhata, Gao, Gralla, Griggs, Hattori, Hiscox, Hoppe, Hu, Hu, Huh, Kolb, Larouche-Gauthier, Liu, Marshall, Matteson, Matteson, Matteson, Matteson, Matteson, McLaughlin, Miyoshi, Oasa, Oberlies, Okun, Persich, Sohn, Strand, Strand, Strand, Stymiest, Takahashi, Takahashi, Takahashi, White, Yamamoto, Ye, Yu   +55 more
core   +4 more sources

The Effect of Vitamin D Supplementation with or without Calcium on Vitamin D Epimer and Metabolites. [PDF]

Metabolites
Gariballa S, Al-Bluwi GSM, Yasin J.
europepmc   +3 more sources

Distinguishing Epimers Through Raman Optical Activity [PDF]

The Journal of Physical Chemistry A, 2016
The Raman optical activity spectra of the epimers β-D-glucose and β-D-galactose, two monosaccharides of biological importance, have been calculated using molecular dynamics combined with a quantum mechanics/molecular mechanics approach. Good agreement between theoretical and experimental spectra is observed for both monosaccharides.
Mutter, Shaun, Zielinski, Francois, Johannessen, Christian, Popelier, Paul, Blanch, Ewan W.   +4 more
openaire   +5 more sources

Anti-Angiogenic Properties of Ginsenoside Rg3

Molecules, 2020
Ginsenoside Rg3 (Rg3) is a member of the ginsenoside family of chemicals extracted from Panax ginseng. Like other ginsenosides, Rg3 has two epimers: 20(S)-ginsenoside Rg3 (SRg3) and 20(R)-ginsenoside Rg3 (RRg3).
Maryam Nakhjavani, Eric Smith, Amanda R. Townsend, Timothy J. Price, Jennifer E. Hardingham   +4 more
doaj   +1 more source

Chiral Separation, Configuration Confirmation and Bioactivity Determination of the Stereoisomers of Hesperidin and Narirutin in Citrus reticulata Blanco

Molecules, 2023
Hesperidin and narirutin are a class of flavanone glycosides, which are the main active constituents in Citrus reticulata Blanco. In the present study, a chiral HPLC-UV method with amylose tris(3,5-dimethylphenylcarbamate) as a stationary phase under a ...
Bingtong Jiang, Sirong Cao, Jiayu Zhang, Zhaokun Wang   +3 more
doaj   +1 more source

Epimerisation in Peptide Synthesis

Molecules, 2023
Epimerisation is basically a chemical conversion that includes the transformation of an epimer into another epimer or its chiral partner. Epimerisation of amino acid is a side reaction that sometimes happens during peptide synthesis.
Suleman Duengo, Muhamad Imam Muhajir, Ace Tatang Hidayat, Weny J. A. Musa, Rani Maharani   +4 more
doaj   +1 more source

Total Synthesis of 6-Deoxydihydrokalafungin, a Key Biosynthetic Precursor of Actinorhodin, and Its Epimer

Molecules, 2021
In this article, we report the total synthesis of 6-deoxydihydrokalafungin (DDHK), a key biosynthetic intermediate of a dimeric benzoisochromanequinone antibiotic, actinorhodin (ACT), and its epimer, epi-DDHK.
Takuya Kumamoto, Mika Kainuma, Azusa Takahashi, Yoshika Matsuo, Kazuaki Katakawa, Takaaki Taguchi, Koji Ichinose   +6 more
doaj   +1 more source

Epimers with distinct mechanical behaviours

CrystEngComm, 2021
Two epimeric series of esters exhibit distinct mechanical behaviour: brittle crystals for one series and ductile crystals for the other series.
Udaya B. Rao Khandavilli, Aoife M. Buckley, Anita R. Maguire, Mangalampalli S. R. N. Kiran, Upadrasta Ramamurty, Simon E. Lawrence   +5 more
openaire   +2 more sources

Bioinspired Synthesis of Twin abeo-Steroids Bufogargarizins A and B via a Divergent Intramolecular Aldol Addition Reaction. [PDF]

Angew Chem Int Ed Engl
Twin natural products. This manuscript describes a concise biomimetic synthesis of twin abeo‐steroids bufogargarizins A and B with an unusual [7.5.6.5] and [5.7.6.5] skeletons in 19 steps (LLS). The described synthetic approach features the application of a bioinspired regiodivergent intramolecular aldol addition reaction and a selective singlet oxygen‐
Surma ZJ, Hiiuk V, Zviagin E, Ouyang Y, Chacko A, Qu F, Zimmerman PM, Nagorny P.   +7 more
europepmc   +3 more sources