Results 81 to 90 of about 7,269 (167)
The FEBS Journal, EarlyView.This review summarizes recent structures of the UBR4 complex, a giant E4 ubiquitin ligase which recognizes proteins with pre‐existing ubiquitin modifications and marks them for degradation. The UBR4 complex uses a large arena lined with substrate interaction modules to select features on ubiquitinated substrates, such as the presence of N‐degrons or ...
Daniel B. Grabarczyk, Tim Clausen
wiley +1 more source
Use of Dalfampridine in a Young Child with Episodic Ataxia Type 2. [PDF]
Child Neurol Open, 2022 Malamud E, Otallah SI.
europepmc +1 more source
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Objective To present a practical, evidence‐based framework for the management of headache disorders in pediatric patients with prior stroke or underlying cerebral vascular lesions, with particular attention to safety and efficacy of pharmacologic and non‐pharmacologic therapies.
Allison C. Hyland +7 more
wiley +1 more source
Cognitive deficits in episodic ataxia type 2 mouse models. [PDF]
Hum Mol Genet, 2021 Bohne P, Mourabit DB, Josten M, Mark MD.
europepmc +1 more source
Visual, vestibular, and ocular motor changes during nitroglycerin‐triggered vestibular migraine
Headache: The Journal of Head and Face Pain, EarlyView.Plain Language Summary Vestibular migraine (VM) is a common cause of intermittent dizziness, but there have been no studies with provoked (induced) VM used to characterize how the vestibular and ocular (vision) systems interact. We injected 20 patients with VM with nitroglycerin to provoke an attack and used a specialized camera to record their eye ...
Maria Dolores Villar‐Martinez +4 more
wiley +1 more source
[Episodic ataxia type 2: a clinical, genetic and radiological study of 10 patients]. [PDF]
Rev Neurol, 2023 Alcalá-Torres J +4 more
europepmc +1 more source
COVID‐19–Induced Narcolepsy Type I With Cataplexy: A Short Report
Journal of Sleep Research, EarlyView.ABSTRACT Narcolepsy type I is a rare neurological sleep disorder characterised by chronic excessive daytime sleepiness, cataplexy, and low orexin (hypocretin) levels. Infection with SARS‐CoV‐2 has been linked to neurological and neuropsychiatric sequelae, but cases of post‐COVID narcolepsy remain extremely uncommon.
Torsten Vinding Merinder +2 more
wiley +1 more source
Concurrent Use of Tasipimidine Oral Solution and Fluoxetine in Dogs
Journal of Veterinary Pharmacology and Therapeutics, EarlyView.ABSTRACT This exploratory randomized crossover study investigated pharmacokinetic interactions, functional alertness, and cardiovascular safety of tasipimidine oral solution administered alone and in combination with fluoxetine in healthy Beagle dogs (n = 8; 4 dogs per dose level), with a 7‐day washout between phases. Dogs received single oral doses of
Jenni Lindstedt +5 more
wiley +1 more source
Veterinary Clinical Pathology, EarlyView.ABSTRACT A 1‐year‐old female‐intact arctic fox (Vulpes lagopus) presented for diarrhea, lethargy, severe thrombocytopenia, and hyperbilirubinemia. Blood film evaluation revealed intracytoplasmic coccoid bacteria within moderate numbers of leukocytes consistent with infection by a rickettsial organism.
Jeremy P. Bessett +3 more
wiley +1 more source
Developing a pathway to clinical trials for -related epilepsies: A patient organization perspective
Therapeutic Advances in Rare DiseaseCACNA1A-related disorders are rare neurodevelopmental disorders linked to variants in the CACNA1A gene. This gene encodes the α1 subunit of the P/Q-type calcium channel Cav2.1, which is globally expressed in the brain and crucial for fast synaptic ...
Pangkong M. Fox +4 more
doaj +1 more source