Results 1 to 10 of about 39,859 (194)
Global epistasis on fitness landscapes [PDF]
Philosophical Transactions of the Royal Society of London. Biological Sciences, 2022 Epistatic interactions between mutations add substantial complexity to adaptive landscapes and are often thought of as detrimental to our ability to predict evolution.
Juan Díaz‐Colunga +6 more
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Pervasive epistasis exposes intramolecular networks in adaptive enzyme evolution
Nature Communications, 2023 Enzyme evolution is characterized by constant alterations of the intramolecular residue networks supporting their functions. The rewiring of these network interactions can give rise to epistasis.
Karol Buda +2 more
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Emergence and propagation of epistasis in metabolic networks
eLife, 2021 Epistasis is often used to probe functional relationships between genes, and it plays an important role in evolution. However, we lack theory to understand how functional relationships at the molecular level translate into epistasis at the level of whole-
Sergey Kryazhimskiy
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Epistasis shapes the fitness landscape of an allosteric specificity switch
Nature Communications, 2021 Epistasis plays an important role in the evolution of novel protein functions because it determines the mutational path a protein takes. Here, the authors combine functional, structural and biophysical analyses to characterize epistasis in a ...
Kyle K. Nishikawa +4 more
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Learning the pattern of epistasis linking genotype and phenotype in a protein [PDF]
Nature Communications, 2017 Understanding the pattern of epistasis—the non-independence of mutations—is critical for relating genotype and phenotype. However, the combinatorial complexity of potential epistatic interactions has severely limited the analysis of this problem.
Frank J. Poelwijk +2 more
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Epistasis and Adaptation on Fitness Landscapes [PDF]
Annual Review of Ecology, Evolution and Systematics, 2022 Epistasis occurs when the effect of a mutation depends on its carrier's genetic background. Despite increasing evidence that epistasis for fitness is common, its role during evolution is contentious.
Claudia Bank
semanticscholar +1 more source
The effect of haplotype size on genomic selection accuracy and epistasis: An empirical study in rice. [PDF]
Plant GenomeMontiel M +8 more
europepmc +3 more sources
Global epistasis emerges from a generic model of a complex trait
eLife, 2021 Epistasis between mutations can make adaptation contingent on evolutionary history. Yet despite widespread ‘microscopic’ epistasis between the mutations involved, microbial evolution experiments show consistent patterns of fitness increase between ...
Gautam Reddy, Michael M Desai
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Epistasis and evolution: recent advances and an outlook for prediction
BMC Biology, 2023 As organisms evolve, the effects of mutations change as a result of epistatic interactions with other mutations accumulated along the line of descent. This can lead to shifts in adaptability or robustness that ultimately shape subsequent evolution. Here,
Milo S. Johnson +2 more
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High-order epistasis shapes evolutionary trajectories. [PDF]
PLoS Computational Biology, 2017 High-order epistasis-where the effect of a mutation is determined by interactions with two or more other mutations-makes small, but detectable, contributions to genotype-fitness maps. While epistasis between pairs of mutations is known to be an important
Zachary R Sailer, Michael J Harms
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