Results 1 to 10 of about 55,446 (204)
PLOS Genetics, 2015 ABSTRACTEpistasis is a key concept in the theory of adaptation. Indicators of epistasis are of interest for large system where systematic fitness measurements may not be possible. Some recent approaches depend on information theory. We show that considering shared entropy for pairs of loci can be misleading.
Kristina Crona
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Intramolecular epistasis correlates with divergence of specificity in promiscuous and bifunctional NSAR/OSBS enzymes. [PDF]
Protein SciAbstract Understanding the functions and evolution of specificity‐determining residues is essential for improving strategies to predict and design enzyme functions. Whether the function of an amino acid residue is retained during evolution depends on intramolecular epistasis, which occurs when the same residue contributes to different phenotypes in ...
Truong DP +14 more
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Considerations in the search for epistasis. [PDF]
Genome BiolAbstract Epistasis refers to changes in the effect on phenotype of a unit of genetic information, such as a single nucleotide polymorphism or a gene, dependent on the context of other genetic units. Such interactions are both biologically plausible and good candidates to explain observations which are not fully explained by an additive ...
Balvert M +26 more
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Proceedings of the Royal Society B: Biological Sciences, 2011 Since Bateson's discovery that genes can suppress the phenotypic effects of other genes, gene interactions—called epistasis—have been the topic of a vast research effort. Systems and developmental biologists study epistasis to understand the genotype–phenotype map, whereas evolutionary biologists recognize the fundamental importance of epistasis for ...
De Visser, J. +3 more
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Journal of Biology, 2009 Epistasis under the classical definition describes only interactions in which one mutant phenotype is masked or suppressed in the presence of the other mutation. The population geneticist's definition includes classical epistasis, but also encompasses 'aggravating' or 'synthetic' interactions – where two mutations together yield a surprisingly ...
Roth, Fritz +2 more
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Physical Constraints on Epistasis [PDF]
Molecular Biology and Evolution, 2020 Abstract Living systems evolve one mutation at a time, but a single mutation can alter the effect of subsequent mutations. The underlying mechanistic determinants of such epistasis are unclear. Here, we demonstrate that the physical dynamics of a biological system can generically constrain epistasis.
Arvind Murugan, Kabir Husain
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Global epistasis on fitness landscapes
Philosophical Transactions of the Royal Society B: Biological Sciences, 2023 Epistatic interactions between mutations add substantial complexity to adaptive landscapes and are often thought of as detrimental to our ability to predict evolution. Yet, patterns of global epistasis, in which the fitness effect of a mutation is well-predicted by the fitness of its genetic background, may actually be of help in our efforts to ...
Juan Diaz-Colunga +6 more
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Epistasis in Monkeyflowers [PDF]
Genetics, 2005 AbstractEpistasis contributes significantly to intrapopulation variation in floral morphology, development time, and male fitness components of Mimulus guttatus. This is demonstrated with a replicated line-cross experiment involving slightly over 7000 plants. The line-cross methodology is based on estimates for means. It thus has greater power than the
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THE CAUSES OF EPISTASIS IN GENETIC NETWORKS [PDF]
Evolution, 2011 Epistasis refers to the nonadditive interactions between genes in determining phenotypes. Considerable efforts have shown that, even for a given organism, epistasis may vary both in intensity and sign. Recent comparative studies supported that the overall sign of epistasis switches from positive to negative as the complexity of an organism increases ...
Javier Macía +6 more
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Bulletin of the Belgian Mathematical Society - Simon Stevin, 1999 Deceptivity and epistasis both contribute to make tness functions hard to optimize for a genetic algorithm. In this note we examine the relation between these concepts, with particular emphasis on their mutual reinforcement.
Naudts, B., Verschoren, A.
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