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Epistasis and Entropy. [PDF]

PLoS Genetics, 2016
Epistasis is a key concept in the theory of adaptation. Indicators of epistasis are of interest for large systems where systematic fitness measurements may not be possible. Some recent approaches depend on information theory.
Kristina Crona
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Evolutionary footprint of epistasis. [PDF]

PLoS Computational Biology, 2018
Variation of an inherited trait across a population cannot be explained by additive contributions of relevant genes, due to epigenetic effects and biochemical interactions (epistasis).
Gabriele Pedruzzi, Ayuna Barlukova, Igor M Rouzine   +2 more
doaj   +5 more sources

Estimating directional epistasis [PDF]

Frontiers in Genetics, 2014
Epistasis, i.e. the fact that gene effects depend on the genetic background, is a direct consequence of the complexity of genetic architectures. Despite this, most of the models used in evolutionary and quantitative genetics pay scant attention to ...
Arnaud eLE ROUZIC
doaj   +4 more sources

Epistasis in Monkeyflowers [PDF]

Genetics, 2005
AbstractEpistasis contributes significantly to intrapopulation variation in floral morphology, development time, and male fitness components of Mimulus guttatus. This is demonstrated with a replicated line-cross experiment involving slightly over 7000 plants. The line-cross methodology is based on estimates for means. It thus has greater power than the
John K. Kelly
openalex   +4 more sources

Considerations in the search for epistasis. [PDF]

Genome Biol
Abstract Epistasis refers to changes in the effect on phenotype of a unit of genetic information, such as a single nucleotide polymorphism or a gene, dependent on the context of other genetic units. Such interactions are both biologically plausible and good candidates to explain observations which are not fully explained by an additive ...
Balvert M, Cooper-Knock J, Stamp J, Byrne RP, Mourragui S, van Gils J, Benonisdottir S, Schlüter J, Kenna K, Abeln S, Iacoangeli A, Daub JT, Browning BL, Taş G, Hu J, Wang Y, Alhathli E, Harvey C, Pianesi L, Schulte SC, González-Domínguez J, Garrisson E, Lorentz workshop on epistasis, Snyder MP, Schönhuth A, Sng LMF, Twine NA.   +26 more
europepmc   +6 more sources

Resolving discrepancies between chimeric and multiplicative measures of higher-order epistasis [PDF]

Nature Communications
Epistasis - the interaction between alleles at different genetic loci - plays a fundamental role in biology. However, several recent approaches quantify epistasis using a chimeric formula that measures deviations from a multiplicative fitness model on an
Uthsav Chitra, Brian Arnold, Benjamin J. Raphael   +2 more
doaj   +2 more sources

Dominance and Epistasis [PDF]

Poultry Science, 1958
Elliot Kimball
openalex   +2 more sources

Dominance, codominance and epistasis

Brazilian Journal of Genetics, 1997
W.J. Miller
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Global epistasis emerges from a generic model of a complex trait

eLife, 2021
Epistasis between mutations can make adaptation contingent on evolutionary history. Yet despite widespread ‘microscopic’ epistasis between the mutations involved, microbial evolution experiments show consistent patterns of fitness increase between ...
Gautam Reddy, Michael M Desai
doaj   +1 more source

Emergence and propagation of epistasis in metabolic networks

eLife, 2021
Epistasis is often used to probe functional relationships between genes, and it plays an important role in evolution. However, we lack theory to understand how functional relationships at the molecular level translate into epistasis at the level of whole-
Sergey Kryazhimskiy
doaj   +1 more source