Results 1 to 10 of about 58,973 (229)

Intramolecular epistasis correlates with divergence of specificity in promiscuous and bifunctional NSAR/OSBS enzymes. [PDF]

Protein Sci
Abstract Understanding the functions and evolution of specificity‐determining residues is essential for improving strategies to predict and design enzyme functions. Whether the function of an amino acid residue is retained during evolution depends on intramolecular epistasis, which occurs when the same residue contributes to different phenotypes in ...
Truong DP, Dharmatti R, Suriadinata D, Huddleston J, Skouby R, Owusu Addo G, Zhu M, Acharige AD, Sankari Bayana R, Davila C, Fults SC, Raushel FM, Hull KG, Romo D, Glasner ME.   +14 more
europepmc   +2 more sources

Distinct network patterns emerge from Cartesian and XOR epistasis models: a comparative network science analysis [PDF]

BioData Mining
Background Epistasis, the phenomenon where the effect of one gene (or variant) is masked or modified by one or more other genes, significantly contributes to the phenotypic variance of complex traits.
Zhendong Sha, Philip J. Freda, Priyanka Bhandary, Attri Ghosh, Nicholas Matsumoto, Jason H. Moore, Ting Hu   +6 more
doaj   +2 more sources

Considerations in the search for epistasis [PDF]

Genome Biology
Epistasis refers to changes in the effect on phenotype of a unit of genetic information, such as a single nucleotide polymorphism or a gene, dependent on the context of other genetic units.
Marleen Balvert, Johnathan Cooper-Knock, Julian Stamp, Ross P. Byrne, Soufiane Mourragui, Juami van Gils, Stefania Benonisdottir, Johannes Schlüter, Kevin Kenna, Sanne Abeln, Alfredo Iacoangeli, Joséphine T. Daub, Brian L. Browning, Gizem Taş, Jiajing Hu, Yan Wang, Elham Alhathli, Calum Harvey, Luna Pianesi, Sara C. Schulte, Jorge González-Domínguez, Erik Garrisson, Lorentz workshop on epistasis, Michael P. Snyder, Alexander Schönhuth, Letitia M. F. Sng, Natalie A. Twine   +26 more
doaj   +2 more sources

Multifactorial methods integrating haplotype and epistasis effects for genomic estimation and prediction of quantitative traits

Frontiers in Genetics, 2022
The rapid growth in genomic selection data provides unprecedented opportunities to discover and utilize complex genetic effects for improving phenotypes, but the methodology is lacking. Epistasis effects are interaction effects, and haplotype effects may
Yang Da, Zuoxiang Liang, Dzianis Prakapenka   +2 more
doaj   +1 more source

Global epistasis emerges from a generic model of a complex trait

eLife, 2021
Epistasis between mutations can make adaptation contingent on evolutionary history. Yet despite widespread ‘microscopic’ epistasis between the mutations involved, microbial evolution experiments show consistent patterns of fitness increase between ...
Gautam Reddy, Michael M Desai
doaj   +1 more source

Emergence and propagation of epistasis in metabolic networks

eLife, 2021
Epistasis is often used to probe functional relationships between genes, and it plays an important role in evolution. However, we lack theory to understand how functional relationships at the molecular level translate into epistasis at the level of whole-
Sergey Kryazhimskiy
doaj   +1 more source

CAPE: an R package for combined analysis of pleiotropy and epistasis. [PDF]

PLoS Computational Biology, 2013
Contemporary genetic studies are revealing the genetic complexity of many traits in humans and model organisms. Two hallmarks of this complexity are epistasis, meaning gene-gene interaction, and pleiotropy, in which one gene affects multiple phenotypes ...
Anna L Tyler, Wei Lu, Justin J Hendrick, Vivek M Philip, Gregory W Carter   +4 more
doaj   +1 more source

A general model for multilocus epistatic interactions in case-control studies. [PDF]

PLoS ONE, 2010
BACKGROUND: Epistasis, i.e., the interaction of alleles at different loci, is thought to play a central role in the formation and progression of complex diseases.
Zhong Wang, Tian Liu, Zhenwu Lin, John Hegarty, Walter A Koltun, Rongling Wu   +5 more
doaj   +1 more source

Epistasis for head morphology in Drosophila melanogaster

G3: Genes, Genomes, Genetics, 2021
Epistasis—gene–gene interaction—is common for mutations with large phenotypic effects in humans and model organisms. Epistasis impacts quantitative genetic models of speciation, response to natural and artificial selection, genetic mapping, and ...
Ergi D Özsoy, Murat Yılmaz, Bahar Patlar, Güzin Emecen, Esra Durmaz, Michael M Magwire, Shanshan Zhou, Wen Huang, Robert R H Anholt, Trudy F C Mackay   +9 more
doaj   +1 more source

A network model for the correlation between epistasis and genomic complexity. [PDF]

PLoS ONE, 2008
The study of genetic interactions (epistasis) is central to the understanding of genome organization and evolution. A general correlation between epistasis and genomic complexity has been recently shown, such that in simpler genomes epistasis is ...
Rafael Sanjuán, Miguel R Nebot
doaj   +1 more source