Results 1 to 10 of about 2,663,291 (229)

Genome-wide epistasis analysis for Alzheimer’s disease and implications for genetic risk prediction

Alzheimer’s Research & Therapy, 2021
Background Single-nucleotide polymorphisms (SNPs) identified by genome-wide association studies only explain part of the heritability of Alzheimer’s disease (AD).
Hui Wang, David A. Bennett, Philip L. De Jager, Qing-Ye Zhang, Hong-Yu Zhang   +4 more
doaj   +2 more sources

Epi-GTBN: an approach of epistasis mining based on genetic Tabu algorithm and Bayesian network

BMC Bioinformatics, 2019
Background Mining epistatic loci which affects specific phenotypic traits is an important research issue in the field of biology. Bayesian network (BN) is a graphical model which can express the relationship between genetic loci and phenotype. Until now,
Yang Guo, Zhiman Zhong, Chen Yang, Jiangfeng Hu, Yaling Jiang, Zizhen Liang, Hui Gao, Jianxiao Liu   +7 more
doaj   +2 more sources

Pervasive epistasis exposes intramolecular networks in adaptive enzyme evolution

Nature Communications, 2023
Enzyme evolution is characterized by constant alterations of the intramolecular residue networks supporting their functions. The rewiring of these network interactions can give rise to epistasis.
Karol Buda, Charlotte M. Miton, Nobuhiko Tokuriki   +2 more
doaj   +2 more sources

Inferring Epistasis from Genetic Time-series Data

Molecular Biology and Evolution, 2022
Epistasis refers to fitness or functional effects of mutations that depend on the sequence background in which these mutations arise. Epistasis is prevalent in nature, including populations of viruses, bacteria, and cancers, and can contribute to the ...
M. S. Sohail, Raymond H. Y. Louie, Zhenchen Hong, J. Barton, Matthew Mckay   +4 more
semanticscholar   +4 more sources

Phosphate ions modulate enzyme activity and epistatic effects in two clavulanic acid-resistant β-lactamase mutants. [PDF]

Protein Sci
Abstract Epistasis, the non‐additive effect of mutations, substantially undermines our ability to predict the evolutionary trajectories of enzymes. Epistatic effects are evident in the evolution of serine β‐lactamases, where synergistic mutations can enhance antimicrobial resistance.
Radojković M, Koene SF, Chikunova A, Florea BI, Natarajan SV, Boyle AL, Ubbink M.   +6 more
europepmc   +2 more sources

Mean and variance heterogeneity loci impact kernel compositional traits in maize. [PDF]

Plant Genome
Abstract Maize (Zea mays) kernel composition is critical for food, feed, and industrial applications. Improving traits such as starch, protein, oil, fiber, and ash requires understanding their genetic basis. We conducted genome‐wide association studies (GWAS) and variance genome‐wide association studies (vGWAS) analyses using 954 inbred lines from the ...
Ismail YMA, Mujjabi C, Olatoye MO, Gray S, Lipka AE, Bohn MO.   +5 more
europepmc   +2 more sources

Considerations in the search for epistasis [PDF]

Genome Biology
Epistasis refers to changes in the effect on phenotype of a unit of genetic information, such as a single nucleotide polymorphism or a gene, dependent on the context of other genetic units.
Marleen Balvert, Johnathan Cooper-Knock, Julian Stamp, Ross P. Byrne, Soufiane Mourragui, Juami van Gils, Stefania Benonisdottir, Johannes Schlüter, Kevin Kenna, Sanne Abeln, Alfredo Iacoangeli, Joséphine T. Daub, Brian L. Browning, Gizem Taş, Jiajing Hu, Yan Wang, Elham Alhathli, Calum Harvey, Luna Pianesi, Sara C. Schulte, Jorge González-Domínguez, Erik Garrisson, Lorentz workshop on epistasis, Michael P. Snyder, Alexander Schönhuth, Letitia M. F. Sng, Natalie A. Twine   +26 more
doaj   +2 more sources

Multifactorial methods integrating haplotype and epistasis effects for genomic estimation and prediction of quantitative traits

Frontiers in Genetics, 2022
The rapid growth in genomic selection data provides unprecedented opportunities to discover and utilize complex genetic effects for improving phenotypes, but the methodology is lacking. Epistasis effects are interaction effects, and haplotype effects may
Yang Da, Zuoxiang Liang, Dzianis Prakapenka   +2 more
doaj   +1 more source

An extension of the Walsh-Hadamard transform to calculate and model epistasis in genetic landscapes of arbitrary shape and complexity

bioRxiv, 2023
Accurate models describing the relationship between genotype and phenotype are necessary in order to understand and predict how mutations to biological sequences affect the fitness and evolution of living organisms.
André J. Faure, Ben Lehner, V. Miró Pina, Claudia Serrano Colomé, Donate Weghorn   +4 more
semanticscholar   +1 more source

Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape

bioRxiv, 2022
Waves of SARS-CoV-2 infection have resulted from the emergence of viral variants with neutralizing antibody resistance mutations. Simultaneously, repeated antigen exposure has generated affinity matured B cells, producing broadly neutralizing receptor ...
Leander Witte, Viren A. Baharani, F. Schmidt, Zijun Wang, A. Cho, Raphael Raspe, Camila Guzmán-Cardozo, F. Muecksch, Marie Canis, Debby J. Park, C. Gaebler, M. Caskey, M. Nussenzweig, T. Hatziioannou, P. Bieniasz   +14 more
semanticscholar   +1 more source