Results 91 to 100 of about 48,693 (213)
Molecular Ecology, EarlyView.ABSTRACT Predicting the long‐term impact of releases and introgression from non‐native strains into wild populations remains an important conservation issue, particularly in fishes where stocking and aquaculture escapes have led to widespread genetic admixture between wild and cultured conspecifics.
Dorte Bekkevold +4 more
wiley +1 more source
Effects of Epistasis and Pleiotropy on Fitness Landscapes
, 2013 The factors that influence genetic architecture shape the structure of the fitness landscape, and therefore play a large role in the evolutionary dynamics. Here the NK model is used to investigate how epistasis and pleiotropy -- key components of genetic
A Dawid +15 more
core +1 more source
Reconstructing a metazoan genetic pathway with transcriptome-wide epistasis measurements [PDF]
Proceedings of the National Academy of Sciences, 2017 AbstractRNA-seq is commonly used to identify genetic modules that respond to perturbations. In single cells, transcriptomes have been used as phenotypes, but this concept has not been applied to whole-organism RNA-seq. Linear models can quantify expression effects of individual mutants and identify epistatic effects in double mutants.
Barbara J. Wold +5 more
openaire +7 more sources
Clinical Implications of Digenic Inheritance and Epistasis in Primary Immunodeficiency Disorders
Frontiers in Immunology, 2018 The existence of epistasis in humans was first predicted by Bateson in 1909. Epistasis describes the non-linear, synergistic interaction of two or more genetic loci, which can substantially modify disease severity or result in entirely new phenotypes ...
Rohan Ameratunga +9 more
doaj +1 more source
Whole genome sequencing reveals epistasis effects within RET for Hirschsprung disease
Scientific Reports, 2022 Common variants in RET and NRG1 have been associated with Hirschsprung disease (HSCR), a congenital disorder characterised by incomplete innervation of distal gut, in East Asian (EA) populations.
Yanbing Wang +9 more
doaj +1 more source
JMJ720 regulates flowering time in rice via H3K9 demethylation of Hd1
Plant Biotechnology Journal, EarlyView.Summary Heading date is a crucial agronomic trait that determines the adaptability of rice to specific planting regions and seasons. Although numerous heading date genes have been well characterized in rice, epigenetic regulation of flowering time remains limited.
Xiufeng Li +11 more
wiley +1 more source
Properties of selected mutations and genotypic landscapes under Fisher's Geometric Model
, 2014 The fitness landscape - the mapping between genotypes and fitness - determines properties of the process of adaptation. Several small genetic fitness landscapes have recently been built by selecting a handful of beneficial mutations and measuring fitness
Achaz, Guillaume +3 more
core +1 more source
From Classical Genetics to Quantitative Genetics to Systems Biology: Modeling Epistasis
PLoS Genetics, 2008 Gene expression data has been used in lieu of phenotype in both classical and quantitative genetic settings. These two disciplines have separate approaches to measuring and interpreting epistasis, which is the interaction between alleles at different loci. We propose a framework for estimating and interpreting epistasis from a classical experiment that
David L. Aylor, Zhao-Bang Zeng
openaire +5 more sources
Epistasis in a model of molecular signal transduction. [PDF]
PLoS Computational Biology, 2011 Biological functions typically involve complex interacting molecular networks, with numerous feedback and regulation loops. How the properties of the system are affected when one, or several of its parts are modified is a question of fundamental interest,
Alain Pumir, Boris Shraiman
doaj +1 more source
Plant Breeding, EarlyView.ABSTRACT Cucumis melo, a sweet‐tasting fruit from the Cucurbitaceae family, is popular in global markets. While some varieties of C. melo are used for pickling or salads, melons such as cantaloupes and honeydews are consumed as a dessert. Desirable appearance, shelf life and palatability are crucial in determining a variety's success.
Cheyenne G. Cotie +3 more
wiley +1 more source