Results 91 to 100 of about 58,973 (229)

Non‐Additive Gene Expression in Carbon and Nitrogen Metabolism Drives Growth Heterosis in Populus deltoides

Plant, Cell &Environment, Volume 48, Issue 5, Page 3529-3543, May 2025.
ABSTRACT Growth heterosis is crucial for Populus deltoides breeding, a key industrial‐timber and ecological‐construction tree species in temperate regions. However, the molecular mechanisms underlying carbon (C)–nitrogen (N) metabolism coordination in regulating growth heterosis remain unclear. Herein high‐hybrids of P.
Jing Zhang, Weixi Zhang, Changjun Ding, Jun Zhao, Xuehui Su, Zhengsai Yuan, Yanguang Chu, Qinjun Huang, Xiaohua Su   +8 more
wiley   +1 more source

DCA for genome-wide epistasis analysis: the statistical genetics perspective [PDF]

Physical Biology, 2019
Direct Coupling Analysis (DCA) is a now widely used method to leverage statistical information from many similar biological systems to draw meaningful conclusions on each system separately. DCA has been applied with great success to sequences of homologous proteins, and also more recently to whole-genome population-wide sequencing data.
Fabio Cecconi, Angelo Vulpiani, Angelo Vulpiani, Erik Aurell, Erik Aurell, Erik Aurell, Hai-Jun Zhou, Chen-Yi Gao   +7 more
openaire   +5 more sources

Performance of model-based multifactor dimensionality reduction methods for epistasis detection by controlling population structure

BioData Mining, 2021
Background In genome-wide association studies the extent and impact of confounding due to population structure have been well recognized. Inadequate handling of such confounding is likely to lead to spurious associations, hampering replication, and the ...
Fentaw Abegaz, François Van Lishout, Jestinah M. Mahachie John, Kridsadakorn Chiachoompu, Archana Bhardwaj, Diane Duroux, Elena S. Gusareva, Zhi Wei, Hakon Hakonarson, Kristel Van Steen   +9 more
doaj   +1 more source

Multi‐drug resistance and compensatory mutations in Mycobacterium tuberculosis in Vietnam

Tropical Medicine &International Health, Volume 30, Issue 5, Page 426-436, May 2025.
Abstract Background Vietnam is a hotspot for the emergence and spread of multidrug‐resistant Mycobacterium tuberculosis. This study aimed to perform a retrospective study on the compensatory evolution in multidrug‐resistant M. tuberculosis strains and the association with drug‐resistant mutations and M. tuberculosis genotypes.
Quang Huy Nguyen, Thi Van Anh Nguyen, Anne‐Laure Bañuls   +2 more
wiley   +1 more source

Fiuncho: a program for any-order epistasis detection in CPU clusters [PDF]

arXiv, 2022
Epistasis can be defined as the statistical interaction of genes during the expression of a phenotype. It is believed that it plays a fundamental role in gene expression, as individual genetic variants have reported a very small increase in disease risk in previous Genome-Wide Association Studies.
arxiv  

Multiple transitions to high l‐DOPA 4,5‐dioxygenase activity reveal molecular pathways to convergent betalain pigmentation in Caryophyllales

New Phytologist, Volume 247, Issue 1, Page 341-357, July 2025.
Summary Many specialized metabolic pathways have evolved convergently in plants, but distinguishing multiple origins from alternative evolutionary scenarios can be difficult. Here, we explore the evolution of l‐3,4‐dihydroxyphenylalanine (l‐DOPA) 4,5‐dioxygenase (DODA) enzymes to better resolve the convergent evolution of the betalain biosynthetic ...
Nathanael Walker‐Hale, M. Alejandra Guerrero‐Rubio, Samuel F. Brockington   +2 more
wiley   +1 more source

Epistasis: Searching for Interacting Genetic Variants Using Crosses [PDF]

G3 Genes|Genomes|Genetics, 2017
Within quantitative genetics, the term “epistasis” is used to broadly describe situations in which combinations of genetic variants show nonadditive phenotypic effects ([Phillips 1998][1], [2008][2]; [Mackay 2014][3]).
openaire   +6 more sources

QTL Mapping and Heterosis Analysis for Fiber Quality Traits Across Multiple Genetic Populations and Environments in Upland Cotton

Frontiers in Plant Science, 2018
An “immortalized F2” (IF2) population and two reciprocal backcross (HSBCF1 and MARBCF1) populations were constructed to investigate the genetic bases of fiber quality traits in upland cotton across four different environments.
Cong Li, Hurong Yu, Cheng Li, Tianlun Zhao, Yating Dong, Xiaolei Deng, Jiahui Hu, Yi Zhang, Fan Zhang, M. K. Daud, M. K. Daud, Jinhong Chen, Shuijin Zhu   +12 more
doaj   +1 more source

Quantitative genetic analysis reveals potential to genetically improve fruit yield through selection in Solanum lycopersicum × Solanum pimpinellifolium crosses under humid condition

Agrosystems, Geosciences &Environment, Volume 8, Issue 2, June 2025.
Abstract Despite the enormous achievements recorded in tomato (Solanum lycopersicum L.) breeding using traditional and molecular approaches, most cultivars find humid environments highly unfavorable. As a result, fruit production cannot meet the rapidly increasing global demand.
Chikezie Onuora Ene, Wosene Gebreselassie Abtew, Happiness Ogba Oselebe, Temesgen Matiwos Menamo, Friday Ugadu Ozi, Chibueze Kelechi Ene, Nnamdi Ogwo   +6 more
wiley   +1 more source

A quantitative comparison of the deleteriousness of missense and nonsense mutations using the structurally resolved human protein interactome

Protein Science, Volume 34, Issue 6, June 2025.
Abstract The complex genotype‐to‐phenotype relationships in Mendelian diseases can be elucidated by mutation‐induced disturbances to the networks of molecular interactions (interactomes) in human cells. Missense and nonsense mutations cause distinct perturbations within the human protein interactome, leading to functional and phenotypic effects with ...
Ting‐Yi Su, Yu Xia
wiley   +1 more source