Results 91 to 100 of about 49,916 (196)

Correction: From Classical Genetics to Quantitative Genetics to Systems Biology: Modeling Epistasis

PLoS Genetics, 2008
Table 1b is not displayed correctly in the published article. Please see the correct Table 1 here:
David L. Aylor, Zhao-Bang Zeng
openaire   +3 more sources

Robustness and epistasis in mutation-selection models

, 2009
We investigate the fitness advantage associated with the robustness of a phenotype against deleterious mutations using deterministic mutation-selection models of quasispecies type equipped with a mesa shaped fitness landscape.
Andrea Wolff, Crow J F, Garske T, Hofbauer J, Joachim Krug, Peliti L, Phillips P C, Rollnik H, Schuster P, Sornette D, Weinreich D M, Wilke C   +11 more
core   +2 more sources

Poor statistical power in population-based association study of gene interaction

BMC Medical Genomics
Background Statistical epistasis, or “gene–gene interaction” in genetic association studies, means the nonadditive effects between the polymorphic sites on two different genes affecting the same phenotype.
Jiarui Ma, Jian Li, Yuqi Chen, Zhen Yang, Yungang He   +4 more
doaj   +1 more source

Confounding of linkage disequilibrium patterns in large scale DNA based gene-gene interaction studies

BioData Mining, 2019
Background In Genome-Wide Association Studies (GWAS), the concept of linkage disequilibrium is important as it allows identifying genetic markers that tag the actual causal variants.
Marc Joiret, Jestinah M. Mahachie John, Elena S. Gusareva, Kristel Van Steen   +3 more
doaj   +1 more source

Universality classes of interaction structures for NK fitness landscapes

, 2018
Kauffman's NK-model is a paradigmatic example of a class of stochastic models of genotypic fitness landscapes that aim to capture generic features of epistatic interactions in multilocus systems. Genotypes are represented as sequences of $L$ binary loci.
Ferretti, Luca, Hwang, Sungmin, Krug, Joachim, Schmiegelt, Benjamin   +3 more
core   +2 more sources

DCA for genome-wide epistasis analysis: the statistical genetics perspective

Physical Biology, 2019
Direct Coupling Analysis (DCA) is a now widely used method to leverage statistical information from many similar biological systems to draw meaningful conclusions on each system separately. DCA has been applied with great success to sequences of homologous proteins, and also more recently to whole-genome population-wide sequencing data.
Gao, Chen-Yi, Cecconi, Fabio, Vulpiani, Angelo, Zhou, Hai-Jun, Aurell, Erik   +4 more
openaire   +5 more sources

Distinct network patterns emerge from Cartesian and XOR epistasis models: a comparative network science analysis

BioData Mining
Background Epistasis, the phenomenon where the effect of one gene (or variant) is masked or modified by one or more other genes, significantly contributes to the phenotypic variance of complex traits.
Zhendong Sha, Philip J. Freda, Priyanka Bhandary, Attri Ghosh, Nicholas Matsumoto, Jason H. Moore, Ting Hu   +6 more
doaj   +1 more source

Privacy-preserving decision tree for epistasis detection

Cybersecurity, 2019
The interaction between gene loci, namely epistasis, is a widespread biological genetic phenomenon. In genome-wide association studies(GWAS), epistasis detection of complex diseases is a major challenge. Although many approaches using statistics, machine
Qingfeng Chen, Xu Zhang, Ruchang Zhang
doaj   +1 more source

'On the Application of Hierarchical Coevolutionary Genetic Algorithms: Recombination and Evaluation Partners' [PDF]

, 2003
This paper examines the use of a hierarchical coevolutionary genetic algorithm under different partnering strategies. Cascading clusters of sub-populations are built from the bottom up, with higher-level sub-populations optimising larger parts of the ...
Aickelin, Uwe, Bull, Larry
core   +5 more sources

Orthogonal Decomposition of the Genetic Variance for Epistatic Traits Under Linkage Disequilibrium—Applications to the Analysis of Bateson-Dobzhansky-Müller Incompatibilities and Sign Epistasis

Frontiers in Genetics, 2019
The one-century-old theory of orthogonal genetic variance decomposition originated the field of quantitative genetics and has kept on being improved ever since.
José M. Álvarez-Castro, Rosa M. Crujeiras   +1 more
doaj   +1 more source