Results 101 to 110 of about 2,663,291 (229)

Positive epistasis drives the acquisition of multidrug resistance. [PDF]

PLoS Genetics, 2009
The evolution of multiple antibiotic resistance is an increasing global problem. Resistance mutations are known to impair fitness, and the evolution of resistance to multiple drugs depends both on their costs individually and on how they interact ...
Sandra Trindade, Ana Sousa, Ana Sousa, Karina Bivar Xavier, Francisco Dionisio, Miguel Godinho Ferreira, Isabel Gordo   +6 more
doaj   +1 more source

Supervised Learning of Protein Melting Temperature: Cross‐Species vs. Species‐Specific Prediction

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Protein melting temperatures are important proxies for stability, and frequently probed in protein engineering campaigns, for instance for enzyme discovery and protein optimization. With the emergence of large datasets of melting temperatures for diverse natural proteins, it has become possible to train models to predict this quantity, and the
Sebastián García López, Jesper Salomon, Wouter Boomsma   +2 more
wiley   +1 more source

Study of Genetic Progress in the Context of Disconnection Between Two Originally Connected Populations

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Genetic progress of breeding programs is highly dependent on the size of reference populations and the relatedness between reference populations and selection candidates. Many reasons can lead a population to split into several subpopulations (sanitary, physiological, political reasons, etc.).
M. Wicki, A. Legarra, J. Raoul
wiley   +1 more source

A model and test for coordinated polygenic epistasis in complex traits

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Systems-level interactions across physiological pathways, cell types, and tissues are core biological elements widely studied across diverse fields including evolution, systems biology, and model-organism genetics.
B. Sheppard, Nadav Rappoport, Po-Ru Loh, Stephan J Sanders, N. Zaitlen, Andy Dahl   +5 more
semanticscholar   +1 more source

DCA for genome-wide epistasis analysis: the statistical genetics perspective [PDF]

Physical Biology, 2019
Direct Coupling Analysis (DCA) is a now widely used method to leverage statistical information from many similar biological systems to draw meaningful conclusions on each system separately. DCA has been applied with great success to sequences of homologous proteins, and also more recently to whole-genome population-wide sequencing data.
Fabio Cecconi, Angelo Vulpiani, Angelo Vulpiani, Erik Aurell, Erik Aurell, Erik Aurell, Hai-Jun Zhou, Chen-Yi Gao   +7 more
openaire   +5 more sources

Performance of model-based multifactor dimensionality reduction methods for epistasis detection by controlling population structure

BioData Mining, 2021
Background In genome-wide association studies the extent and impact of confounding due to population structure have been well recognized. Inadequate handling of such confounding is likely to lead to spurious associations, hampering replication, and the ...
Fentaw Abegaz, François Van Lishout, Jestinah M. Mahachie John, Kridsadakorn Chiachoompu, Archana Bhardwaj, Diane Duroux, Elena S. Gusareva, Zhi Wei, Hakon Hakonarson, Kristel Van Steen   +9 more
doaj   +1 more source

Natural variations in MdBPM2/MdRGLG3‐MdNAC83 network controlling the quantitative segregation of apple fruit storability

Journal of Integrative Plant Biology, EarlyView.
During postharvest cold storage of apples, the NAC transcription factor MdNAC83 binds to the promoters and activates the expression of downstream genes and is regulated by E3 ligases, which promote its ubiquitination and degradation. Genetic variants in MdNAC83 and its downstream genes form a network to regulate apple fruit storability.
Bei Wu, Fei Shen, Ziying Zhou, Wenhui Ren, Yi Wang, Ting Wu, Zhenhai Han, Xinzhong Zhang   +7 more
wiley   +1 more source

Global epistasis emerges from a generic model of a complex trait

bioRxiv, 2020
Epistasis between mutations can make adaptation contingent on evolutionary history. Yet despite widespread “microscopic” epistasis between the mutations involved, microbial evolution experiments show consistent patterns of fitness increase between ...
Gautam Reddy, Michael M. Desai
semanticscholar   +1 more source

Whole genome sequencing reveals epistasis effects within RET for Hirschsprung disease

Scientific Reports, 2022
Common variants in RET and NRG1 have been associated with Hirschsprung disease (HSCR), a congenital disorder characterised by incomplete innervation of distal gut, in East Asian (EA) populations.
Yanbing Wang, Timothy Shin Heng Mak, Saloni Dattani, Maria-Merce Garcia-Barcelo, Alexander Xi Fu, Kevin Y. Yip, Elly Sau-Wai Ngan, Paul Kwang-Hang Tam, Clara Sze-Man Tang, Pak Chung Sham   +9 more
doaj   +1 more source

Documenting homoploid hybrid speciation

Molecular Ecology, EarlyView.
Abstract Homoploid hybrid speciation is challenging to document because hybridization can lead to outcomes other than speciation. Thus, some authors have argued that establishment of homoploid hybrid speciation should include evidence that reproductive barriers isolating the hybrid neo‐species from its parental species were derived from hybridization ...
Zhiqin Long, Loren H. Rieseberg
wiley   +1 more source