Results 101 to 110 of about 49,916 (196)

Rate of adaptation in sexuals and asexuals: A solvable model of the Fisher-Muller effect

, 2013
The adaptation of large asexual populations is hampered by the competition between independently arising beneficial mutations in different individuals, which is known as clonal interference.
Bürger, Felsenstein, Franke, Gillespie, Joachim Krug, Kimura, Kondrashov, Kondrashov, Su-Chan Park, Turner, Wright   +10 more
core   +1 more source

WISH-R– a fast and efficient tool for construction of epistatic networks for complex traits and diseases

BMC Bioinformatics, 2018
Background Genetic epistasis is an often-overlooked area in the study of the genomics of complex traits. Genome-wide association studies are a useful tool for revealing potential causal genetic variants, but in this context, epistasis is generally ...
Victor A. O. Carmelo, Lisette J. A. Kogelman, Majbritt Busk Madsen, Haja N. Kadarmideen   +3 more
doaj   +1 more source

3D protein structure from genetic epistasis experiments

, 2018
SummaryHigh-throughput experimental techniques have made possible the systematic sampling of the single mutation landscape for many proteins, defined as the change in protein fitness as the result of point mutation sequence changes. In a more limited number of cases, and for small proteins only, we also have nearly full coverage of all possible double ...
Rollins, Nathan J., Brock, Kelly P., Poelwijk, Frank J., Stiffler, Michael A., Gauthier, Nicholas P., Sander, Chris, Marks, Debora S.   +6 more
openaire   +1 more source

Partnering Strategies for Fitness Evaluation in a Pyramidal Evolutionary Algorithm

, 2008
This paper combines the idea of a hierarchical distributed genetic algorithm with different inter-agent partnering strategies. Cascading clusters of sub-populations are built from bottom up, with higher-level sub-populations optimising larger parts of ...
Aickelin, Uwe, Bull, Larry
core  

Reducing Epistasis and Pleiotropy Can Avoid the Survival of the Flattest Tragedy

Biology
This study investigates whether reducing epistasis and pleiotropy enhances mutational robustness in evolutionary adaptation, utilizing an indirect encoded model within the “survival of the flattest” (SoF) fitness landscape.
Priyanka Mehra, Arend Hintze
doaj   +1 more source

Distributed transformer for high order epistasis detection in large-scale datasets

Scientific Reports
Understanding the genetic basis of complex diseases is one of the most important challenges in current precision medicine. To this end, Genome-Wide Association Studies aim to correlate Single Nucleotide Polymorphisms (SNPs) to the presence or absence of ...
Miguel Graça, Ricardo Nobre, Leonel Sousa, Aleksandar Ilic   +3 more
doaj   +1 more source

Considerations in the search for epistasis

Genome Biology
Epistasis refers to changes in the effect on phenotype of a unit of genetic information, such as a single nucleotide polymorphism or a gene, dependent on the context of other genetic units.
Marleen Balvert, Johnathan Cooper-Knock, Julian Stamp, Ross P. Byrne, Soufiane Mourragui, Juami van Gils, Stefania Benonisdottir, Johannes Schlüter, Kevin Kenna, Sanne Abeln, Alfredo Iacoangeli, Joséphine T. Daub, Brian L. Browning, Gizem Taş, Jiajing Hu, Yan Wang, Elham Alhathli, Calum Harvey, Luna Pianesi, Sara C. Schulte, Jorge González-Domínguez, Erik Garrisson, Lorentz workshop on epistasis, Michael P. Snyder, Alexander Schönhuth, Letitia M. F. Sng, Natalie A. Twine   +26 more
doaj   +1 more source

Optimizing progeny size and number of crosses under genomic selection: insights into additive and epistatic contributions to long-term genetic gain. [PDF]

Theor Appl Genet
da Silva Viana J, DoVale JC, Fritsche-Neto R.   +2 more
europepmc   +1 more source

Epistasis mediates the role of negative frequency-dependent selection in bacterial strain structure. [PDF]

PLoS Comput Biol
Guillemet M, Lehtinen S.
europepmc   +1 more source

Interchromosomal linkage disequilibrium analysis reveals strong indications of sign epistasis in wheat breeding families. [PDF]

G3 (Bethesda)
Tessele A, Morris G, Akhunov E, Johnson B, Clinesmith M, Hope AC, Fritz A.   +6 more
europepmc   +1 more source