Results 11 to 20 of about 50,815 (199)
Recombining your way out of trouble: the genetic architecture of hybrid fitness under environmental stress [PDF]
, 2020 Hybridization between species is a fundamental evolutionary force that can both promote and delay adaptation. There is a deficit in our understanding of the genetic basis of hybrid fitness, especially in non-domesticated organisms.
Bendixsen, D. +5 more
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Widespread genetic epistasis among cancer genes [PDF]
Nature Communications, 2014 Quantitative genetic epistasis has been hypothesized to be an important factor in the development and progression of complex diseases. Cancers in particular are driven by the accumulation of mutations that may act epistatically during the course of the disease.
Xiaoyue, Wang +3 more
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Inferring Epistasis from Genetic Time-series Data
Molecular Biology and Evolution, 2022 AbstractEpistasis refers to fitness or functional effects of mutations that depend on the sequence background in which these mutations arise. Epistasis is prevalent in nature, including populations of viruses, bacteria, and cancers, and can contribute to the evolution of drug resistance and immune escape.
Sohail, Muhammad Saqib +4 more
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Epistasis regulates genetic control of cardiac hypertrophy
Nature Cardiovascular Research, 2023 Abstract The combinatorial effect of genetic variants is often assumed to be additive. Although genetic variation can clearly interact non-additively, methods to uncover epistatic relationships remain in their infancy. We develop low-signal signed iterative random forests to elucidate the complex genetic architecture of cardiac hypertrophy.
Qianru Wang +23 more
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Replication and explorations of high-order epistasis using a large advanced intercross line pedigree. [PDF]
PLoS Genetics, 2011 Dissection of the genetic architecture of complex traits persists as a major challenge in biology; despite considerable efforts, much remains unclear including the role and importance of genetic interactions.
Mats Pettersson +3 more
doaj +1 more source
Epistasis and Its Implications for Personal Genetics [PDF]
The American Journal of Human Genetics, 2009 The widespread availability of high-throughput genotyping technology has opened the door to the era of personal genetics, which brings to consumers the promise of using genetic variations to predict individual susceptibility to common diseases. Despite easy access to commercial personal genetics services, our knowledge of the genetic architecture of ...
Moore, Jason H., Williams, Scott M.
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A network model for the correlation between epistasis and genomic complexity. [PDF]
PLoS ONE, 2008 The study of genetic interactions (epistasis) is central to the understanding of genome organization and evolution. A general correlation between epistasis and genomic complexity has been recently shown, such that in simpler genomes epistasis is ...
Rafael Sanjuán, Miguel R Nebot
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Genetic epistasis in female suicide attempters
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2012 Complex behaviors such as suicidal behavior likely exhibit gene-gene interactions. The main aim of this study is to explore potential single nucleotide polymorphisms combinations with epistatic effect in suicidal behavior using a data mining tool (Multifactor Dimensionality Reduction).Genomic DNA from peripheral blood samples was analyzed using SNPlex ...
Pablo, Fernández-Navarro +10 more
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The causes of epistasis in genetic networks. [PDF]
Evolution; international journal of organic evolution, 2012 We thank J. Carrera, J. A. G. M. de Visser, M. A. Fares, and S. Valverde for discussions and two anonymous reviewers for insightful suggestions. This work was supported by the Spanish Ministry of Science and Innovation grant BFU2009-06993 (SFE), the Generalitat Valenciana grant PROMETEO2010/019 (SFE), the Human Frontiers Science Program grant RGP12 ...
Macía, Javier +2 more
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PERSPECTIVE: SIGN EPISTASIS AND GENETIC COSTRAINT ON EVOLUTIONARY TRAJECTORIES [PDF]
Evolution, 2005 Epistasis for fitness means that the selective effect of a mutation is conditional on the genetic background in which it appears. Although epistasis is widely observed in nature, our understanding of its consequences for evolution by natural selection remains incomplete.
Weinreich, Daniel M. +2 more
openaire +4 more sources