Results 11 to 20 of about 49,916 (196)
GenEpi: gene-based epistasis discovery using machine learning [PDF]
BMC Bioinformatics, 2020 Background Genome-wide association studies (GWAS) provide a powerful means to identify associations between genetic variants and phenotypes. However, GWAS techniques for detecting epistasis, the interactions between genetic variants associated with ...
Yu-Chuan Chang +9 more
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Functional bottlenecks can emerge from non-epistatic underlying traits. [PDF]
PLoS Computational BiologyProtein fitness landscapes frequently exhibit epistasis, where the effect of a mutation depends on the genetic context in which it occurs, i.e., the rest of the protein sequence.
Anna Ottavia Schulte +3 more
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PLoS Genetics, 2017 Epistasis, commonly defined as the interaction between multiple genes, is an important genetic component underlying phenotypic variation. Many statistical methods have been developed to model and identify epistatic interactions between genetic variants ...
Lorin Crawford +3 more
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Dynamic Epistasis under Varying Environmental Perturbations [PDF]
, 2014 Epistasis describes the phenomenon that mutations at different loci do not have independent effects with regard to certain phenotypes. Understanding the global epistatic landscape is vital for many genetic and evolutionary theories. Current knowledge for
Barker, Brandon, Gu, Zhenglong, Xu, Lin
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Frontiers in Genetics, 2022 The rapid growth in genomic selection data provides unprecedented opportunities to discover and utilize complex genetic effects for improving phenotypes, but the methodology is lacking. Epistasis effects are interaction effects, and haplotype effects may
Yang Da +2 more
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Global epistasis emerges from a generic model of a complex trait
eLife, 2021 Epistasis between mutations can make adaptation contingent on evolutionary history. Yet despite widespread ‘microscopic’ epistasis between the mutations involved, microbial evolution experiments show consistent patterns of fitness increase between ...
Gautam Reddy, Michael M Desai
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HIGHER EPISTASIS IN GENETIC ALGORITHMS [PDF]
Bulletin of the Australian Mathematical Society, 2008 AbstractWe study thek-epistasis of a fitness function over a search space. This concept is a natural generalization of that of epistasis, previously considered by Davidor, Suys and Verschoren and Van Hove and Verschoren [Y. Davidor, in:Foundations of genetic algorithms, Vol. 1, (1991), pp. 23–25; D. Suys and A. Verschoren, ‘Proc Int. Conf.
Iglesias, M.T. +3 more
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CAPE: an R package for combined analysis of pleiotropy and epistasis. [PDF]
PLoS Computational Biology, 2013 Contemporary genetic studies are revealing the genetic complexity of many traits in humans and model organisms. Two hallmarks of this complexity are epistasis, meaning gene-gene interaction, and pleiotropy, in which one gene affects multiple phenotypes ...
Anna L Tyler +4 more
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Emergence and propagation of epistasis in metabolic networks
eLife, 2021 Epistasis is often used to probe functional relationships between genes, and it plays an important role in evolution. However, we lack theory to understand how functional relationships at the molecular level translate into epistasis at the level of whole-
Sergey Kryazhimskiy
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A general model for multilocus epistatic interactions in case-control studies. [PDF]
PLoS ONE, 2010 BACKGROUND: Epistasis, i.e., the interaction of alleles at different loci, is thought to play a central role in the formation and progression of complex diseases.
Zhong Wang +5 more
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