Results 11 to 20 of about 49,240 (217)
PLoS Genetics, 2017 Epistasis, commonly defined as the interaction between multiple genes, is an important genetic component underlying phenotypic variation. Many statistical methods have been developed to model and identify epistatic interactions between genetic variants ...
Lorin Crawford +3 more
doaj +6 more sources
THE CAUSES OF EPISTASIS IN GENETIC NETWORKS [PDF]
Evolution, 2011 Epistasis refers to the nonadditive interactions between genes in determining phenotypes. Considerable efforts have shown that, even for a given organism, epistasis may vary both in intensity and sign. Recent comparative studies supported that the overall sign of epistasis switches from positive to negative as the complexity of an organism increases ...
Javier Macía +6 more
openaire +4 more sources
HIGHER EPISTASIS IN GENETIC ALGORITHMS [PDF]
Bulletin of the Australian Mathematical Society, 2008 AbstractWe study thek-epistasis of a fitness function over a search space. This concept is a natural generalization of that of epistasis, previously considered by Davidor, Suys and Verschoren and Van Hove and Verschoren [Y. Davidor, in:Foundations of genetic algorithms, Vol. 1, (1991), pp. 23–25; D. Suys and A. Verschoren, ‘Proc Int. Conf.
Iglesias, M.T. +3 more
openaire +2 more sources
Epistasis and Its Implications for Personal Genetics [PDF]
The American Journal of Human Genetics, 2009 The widespread availability of high-throughput genotyping technology has opened the door to the era of personal genetics, which brings to consumers the promise of using genetic variations to predict individual susceptibility to common diseases. Despite easy access to commercial personal genetics services, our knowledge of the genetic architecture of ...
Jason H. Moore, Scott M. Williams
openaire +3 more sources
Recombining your way out of trouble: the genetic architecture of hybrid fitness under environmental stress [PDF]
, 2020 Hybridization between species is a fundamental evolutionary force that can both promote and delay adaptation. There is a deficit in our understanding of the genetic basis of hybrid fitness, especially in non-domesticated organisms.
Bendixsen, D. +5 more
core +1 more source
A network model for the correlation between epistasis and genomic complexity. [PDF]
PLoS ONE, 2008 The study of genetic interactions (epistasis) is central to the understanding of genome organization and evolution. A general correlation between epistasis and genomic complexity has been recently shown, such that in simpler genomes epistasis is ...
Rafael Sanjuán, Miguel R Nebot
doaj +1 more source
Dominance, Epistasis and the Genetics of Postzygotic Isolation [PDF]
Genetics, 2000 AbstractThe sterility and inviability of species hybrids can be explained by between-locus “Dobzhansky-Muller” incompatibilities: alleles that are fit on their “normal” genetic backgrounds sometimes lower fitness when brought together in hybrids.
Michael Turelli, H A Orr
openaire +3 more sources
The context-dependence of mutations: a linkage of formalisms [PDF]
, 2015 Defining the extent of epistasis - the non-independence of the effects of mutations - is essential for understanding the relationship of genotype, phenotype, and fitness in biological systems.
Krishna, Vinod +2 more
core +10 more sources
Replication and explorations of high-order epistasis using a large advanced intercross line pedigree. [PDF]
PLoS Genetics, 2011 Dissection of the genetic architecture of complex traits persists as a major challenge in biology; despite considerable efforts, much remains unclear including the role and importance of genetic interactions.
Mats Pettersson +3 more
doaj +1 more source
Genome-wide epistasis analysis for Alzheimer’s disease and implications for genetic risk prediction
Alzheimer’s Research & Therapy, 2021 Background Single-nucleotide polymorphisms (SNPs) identified by genome-wide association studies only explain part of the heritability of Alzheimer’s disease (AD).
Hui Wang +4 more
doaj +1 more source