Results 11 to 20 of about 2,663,291 (229)
GenEpi: gene-based epistasis discovery using machine learning [PDF]
BMC Bioinformatics, 2020 Background Genome-wide association studies (GWAS) provide a powerful means to identify associations between genetic variants and phenotypes. However, GWAS techniques for detecting epistasis, the interactions between genetic variants associated with ...
Yu-Chuan Chang +9 more
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Epistasis: Searching for Interacting Genetic Variants Using Crosses [PDF]
G3 Genes|Genomes|Genetics, 2017 Within quantitative genetics, the term “epistasis” is used to broadly describe situations in which combinations of genetic variants show nonadditive phenotypic effects ([Phillips 1998][1], [2008][2]; [Mackay 2014][3]). Although most work on epistasis has
I. M. Ehrenreich
semanticscholar +7 more sources
PLoS Genetics, 2017 Epistasis, commonly defined as the interaction between multiple genes, is an important genetic component underlying phenotypic variation. Many statistical methods have been developed to model and identify epistatic interactions between genetic variants ...
Lorin Crawford +3 more
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Dynamic Epistasis under Varying Environmental Perturbations [PDF]
, 2014 Epistasis describes the phenomenon that mutations at different loci do not have independent effects with regard to certain phenotypes. Understanding the global epistatic landscape is vital for many genetic and evolutionary theories. Current knowledge for
Barker, Brandon, Gu, Zhenglong, Xu, Lin
core +29 more sources
Epistasis interaction of QTL effects as a genetic parameter influencing estimation of the genetic additive effect [PDF]
Genetics and Molecular Biology, 2013 Epistasis, an additive-by-additive interaction between quantitative trait loci, has been defined as a deviation from the sum of independent effects of individual genes.
J. Bocianowski
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On the relationship between epistasis and genetic variance-heterogeneity [PDF]
Journal of Experimental Botany, 2017 AbstractEpistasis and genetic variance heterogeneity are two non-additive genetic inheritance patterns that are often, but not always, related. Here we use theoretical examples and empirical results from analyses of experimental data to illustrate the connection between the two.
Simon K. G. Forsberg, Ö. Carlborg
semanticscholar +4 more sources
Global epistasis emerges from a generic model of a complex trait
eLife, 2021 Epistasis between mutations can make adaptation contingent on evolutionary history. Yet despite widespread ‘microscopic’ epistasis between the mutations involved, microbial evolution experiments show consistent patterns of fitness increase between ...
Gautam Reddy, Michael M Desai
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Widespread epistasis among beneficial genetic variants revealed by high-throughput genome editing
bioRxiv, 2022 Genetic interactions occur when a variant’s phenotypic effect is altered by variation at other genomic loci. Also known as epistasis, these interactions shape the genetic architecture of complex traits and modify phenotypes across genetic backgrounds ...
Roy Moh Lik Ang +4 more
semanticscholar +1 more source
The effect of epistasis on sexually antagonistic genetic variation [PDF]
Proceedings of the Royal Society B: Biological Sciences, 2014 There is increasing evidence of segregating sexually antagonistic (SA) genetic variation for fitness in laboratory and wild populations, yet the conditions for the maintenance of such variation can be restrictive. Epistatic interactions between genes can contribute to the maintenance of genetic variance in fitness and we suggest that epistasis between ...
G. Arnqvist, Nikolas Vellnow, L. Rowe
semanticscholar +4 more sources
THE CAUSES OF EPISTASIS IN GENETIC NETWORKS [PDF]
Evolution, 2011 Epistasis refers to the nonadditive interactions between genes in determining phenotypes. Considerable efforts have shown that, even for a given organism, epistasis may vary both in intensity and sign. Recent comparative studies supported that the overall sign of epistasis switches from positive to negative as the complexity of an organism increases ...
Javier Macía +6 more
openaire +4 more sources