Results 21 to 30 of about 58,973 (229)
Epistasis and Its Implications for Personal Genetics [PDF]
The American Journal of Human Genetics, 2009 The widespread availability of high-throughput genotyping technology has opened the door to the era of personal genetics, which brings to consumers the promise of using genetic variations to predict individual susceptibility to common diseases. Despite easy access to commercial personal genetics services, our knowledge of the genetic architecture of ...
Jason H. Moore, Scott M. Williams
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Recombining your way out of trouble: the genetic architecture of hybrid fitness under environmental stress [PDF]
, 2020 Hybridization between species is a fundamental evolutionary force that can both promote and delay adaptation. There is a deficit in our understanding of the genetic basis of hybrid fitness, especially in non-domesticated organisms.
Bendixsen, D. +5 more
core +1 more source
The context-dependence of mutations: a linkage of formalisms [PDF]
, 2015 Defining the extent of epistasis - the non-independence of the effects of mutations - is essential for understanding the relationship of genotype, phenotype, and fitness in biological systems.
Krishna, Vinod +2 more
core +10 more sources
Dominance, Epistasis and the Genetics of Postzygotic Isolation [PDF]
Genetics, 2000 AbstractThe sterility and inviability of species hybrids can be explained by between-locus “Dobzhansky-Muller” incompatibilities: alleles that are fit on their “normal” genetic backgrounds sometimes lower fitness when brought together in hybrids.
Michael Turelli, H A Orr
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Replication and explorations of high-order epistasis using a large advanced intercross line pedigree. [PDF]
PLoS Genetics, 2011 Dissection of the genetic architecture of complex traits persists as a major challenge in biology; despite considerable efforts, much remains unclear including the role and importance of genetic interactions.
Mats Pettersson +3 more
doaj +1 more source
On the relationship between epistasis and genetic variance heterogeneity [PDF]
Journal of Experimental Botany, 2017 AbstractEpistasis and genetic variance heterogeneity are two non-additive genetic inheritance patterns that are often, but not always, related. Here we use theoretical examples and empirical results from analyses of experimental data to illustrate the connection between the two.
Forsberg, Simon, Carlborg, Örjan
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Genome-wide epistasis analysis for Alzheimer’s disease and implications for genetic risk prediction
Alzheimer’s Research & Therapy, 2021 Background Single-nucleotide polymorphisms (SNPs) identified by genome-wide association studies only explain part of the heritability of Alzheimer’s disease (AD).
Hui Wang +4 more
doaj +1 more source
PERSPECTIVE: SIGN EPISTASIS AND GENETIC COSTRAINT ON EVOLUTIONARY TRAJECTORIES [PDF]
Evolution, 2005 Epistasis for fitness means that the selective effect of a mutation is conditional on the genetic background in which it appears. Although epistasis is widely observed in nature, our understanding of its consequences for evolution by natural selection remains incomplete.
Weinreich, Daniel M. +2 more
openaire +5 more sources
Weak Epistasis Generally Stabilizes Phenotypes in a Mouse Intercross. [PDF]
PLoS Genetics, 2016 The extent and strength of epistasis is commonly unresolved in genetic studies, and observed epistasis is often difficult to interpret in terms of biological consequences or overall genetic architecture. We investigated the prevalence and consequences of
Anna L Tyler +3 more
doaj +1 more source
Estimating directional epistasis
Frontiers in Genetics, 2014 Epistasis, i.e. the fact that gene effects depend on the genetic background, is a direct consequence of the complexity of genetic architectures. Despite this, most of the models used in evolutionary and quantitative genetics pay scant attention to ...
Arnaud eLE ROUZIC
doaj +1 more source