Results 21 to 30 of about 2,663,291 (229)

Emergence and propagation of epistasis in metabolic networks

eLife, 2021
Epistasis is often used to probe functional relationships between genes, and it plays an important role in evolution. However, we lack theory to understand how functional relationships at the molecular level translate into epistasis at the level of whole-
Sergey Kryazhimskiy
doaj   +1 more source

EpiMOGA: An Epistasis Detection Method Based on a Multi-Objective Genetic Algorithm

Genes, 2021
In genome-wide association studies, detecting high-order epistasis is important for analyzing the occurrence of complex human diseases and explaining missing heritability. However, there are various challenges in the actual high-order epistasis detection
Yuan-yuan Chen, Fengjiao Xu, Cong Pian, Mingmin Xu, Lingpeng Kong, Jingya Fang, Zutan Li, Liangyun Zhang   +7 more
semanticscholar   +1 more source

HIGHER EPISTASIS IN GENETIC ALGORITHMS [PDF]

Bulletin of the Australian Mathematical Society, 2008
AbstractWe study thek-epistasis of a fitness function over a search space. This concept is a natural generalization of that of epistasis, previously considered by Davidor, Suys and Verschoren and Van Hove and Verschoren [Y. Davidor, in:Foundations of genetic algorithms, Vol. 1, (1991), pp. 23–25; D. Suys and A. Verschoren, ‘Proc Int. Conf.
Iglesias, M.T., Penaranda, V.S., Vidal, C., Verschoren, Alain   +3 more
openaire   +2 more sources

Epistasis regulates genetic control of cardiac hypertrophy. [PDF]

Nat Cardiovasc Res, 2023
Abstract The combinatorial effect of genetic variants is often assumed to be additive. Although genetic variation can clearly interact non-additively, methods to uncover epistatic relationships remain in their infancy. We develop low-signal signed iterative random forests to elucidate the complex genetic architecture of cardiac hypertrophy.
Wang Q, Tang TM, Youlton M, Weldy CS, Kenney AM, Ronen O, Hughes JW, Chin ET, Sutton SC, Agarwal A, Li X, Behr M, Kumbier K, Moravec CS, Tang WHW, Margulies KB, Cappola TP, Butte AJ, Arnaout R, Brown JB, Priest JR, Parikh VN, Yu B, Ashley EA.   +23 more
europepmc   +4 more sources

CAPE: an R package for combined analysis of pleiotropy and epistasis. [PDF]

PLoS Computational Biology, 2013
Contemporary genetic studies are revealing the genetic complexity of many traits in humans and model organisms. Two hallmarks of this complexity are epistasis, meaning gene-gene interaction, and pleiotropy, in which one gene affects multiple phenotypes ...
Anna L Tyler, Wei Lu, Justin J Hendrick, Vivek M Philip, Gregory W Carter   +4 more
doaj   +1 more source

Widespread genetic epistasis among cancer genes [PDF]

Nature Communications, 2014
Quantitative genetic epistasis has been hypothesized to be an important factor in the development and progression of complex diseases. Cancers in particular are driven by the accumulation of mutations that may act epistatically during the course of the disease.
Xiaoyue Wang, A. Fu, Megan E. McNerney, K. White   +3 more
semanticscholar   +4 more sources

Epistasis and Its Implications for Personal Genetics [PDF]

The American Journal of Human Genetics, 2009
The widespread availability of high-throughput genotyping technology has opened the door to the era of personal genetics, which brings to consumers the promise of using genetic variations to predict individual susceptibility to common diseases. Despite easy access to commercial personal genetics services, our knowledge of the genetic architecture of ...
Jason H. Moore, Scott M. Williams
openaire   +3 more sources

A general model for multilocus epistatic interactions in case-control studies. [PDF]

PLoS ONE, 2010
BACKGROUND: Epistasis, i.e., the interaction of alleles at different loci, is thought to play a central role in the formation and progression of complex diseases.
Zhong Wang, Tian Liu, Zhenwu Lin, John Hegarty, Walter A Koltun, Rongling Wu   +5 more
doaj   +1 more source

Epistasis for head morphology in Drosophila melanogaster

G3: Genes, Genomes, Genetics, 2021
Epistasis—gene–gene interaction—is common for mutations with large phenotypic effects in humans and model organisms. Epistasis impacts quantitative genetic models of speciation, response to natural and artificial selection, genetic mapping, and ...
Ergi D Özsoy, Murat Yılmaz, Bahar Patlar, Güzin Emecen, Esra Durmaz, Michael M Magwire, Shanshan Zhou, Wen Huang, Robert R H Anholt, Trudy F C Mackay   +9 more
doaj   +1 more source

Epistasis and Adaptation on Fitness Landscapes [PDF]

Annual Review of Ecology, Evolution and Systematics, 2022
Epistasis occurs when the effect of a mutation depends on its carrier's genetic background. Despite increasing evidence that epistasis for fitness is common, its role during evolution is contentious.
Claudia Bank
semanticscholar   +1 more source