Results 31 to 40 of about 2,663,291 (229)
Recombining your way out of trouble: the genetic architecture of hybrid fitness under environmental stress [PDF]
, 2020 Hybridization between species is a fundamental evolutionary force that can both promote and delay adaptation. There is a deficit in our understanding of the genetic basis of hybrid fitness, especially in non-domesticated organisms.
Bendixsen, D. +5 more
core +1 more source
A network model for the correlation between epistasis and genomic complexity. [PDF]
PLoS ONE, 2008 The study of genetic interactions (epistasis) is central to the understanding of genome organization and evolution. A general correlation between epistasis and genomic complexity has been recently shown, such that in simpler genomes epistasis is ...
Rafael Sanjuán, Miguel R Nebot
doaj +1 more source
Dominance, Epistasis and the Genetics of Postzygotic Isolation [PDF]
Genetics, 2000 AbstractThe sterility and inviability of species hybrids can be explained by between-locus “Dobzhansky-Muller” incompatibilities: alleles that are fit on their “normal” genetic backgrounds sometimes lower fitness when brought together in hybrids.
Michael Turelli, H A Orr
openaire +3 more sources
Replication and explorations of high-order epistasis using a large advanced intercross line pedigree. [PDF]
PLoS Genetics, 2011 Dissection of the genetic architecture of complex traits persists as a major challenge in biology; despite considerable efforts, much remains unclear including the role and importance of genetic interactions.
Mats Pettersson +3 more
doaj +1 more source
Reconstructing a metazoan genetic pathway with transcriptome-wide epistasis measurements [PDF]
Proceedings of the National Academy of Sciences, 2017 AbstractRNA-seq is commonly used to identify genetic modules that respond to perturbations. In single cells, transcriptomes have been used as phenotypes, but this concept has not been applied to whole-organism RNA-seq. Linear models can quantify expression effects of individual mutants and identify epistatic effects in double mutants.
David Angeles-Albores +4 more
semanticscholar +8 more sources
Global epistasis on fitness landscapes [PDF]
Philosophical Transactions of the Royal Society of London. Biological Sciences, 2022 Epistatic interactions between mutations add substantial complexity to adaptive landscapes and are often thought of as detrimental to our ability to predict evolution.
Juan Díaz-Colunga +6 more
semanticscholar +1 more source
Blood, 2020 Large-scale sequencing studies of hematologic malignancies have revealed notable epistasis among high-frequency mutations. One of the most striking examples of epistasis occurs for mutations in RNA splicing factors.
Justin Taylor +17 more
semanticscholar +1 more source
Weak Epistasis Generally Stabilizes Phenotypes in a Mouse Intercross. [PDF]
PLoS Genetics, 2016 The extent and strength of epistasis is commonly unresolved in genetic studies, and observed epistasis is often difficult to interpret in terms of biological consequences or overall genetic architecture. We investigated the prevalence and consequences of
Anna L Tyler +3 more
doaj +1 more source
PERSPECTIVE: SIGN EPISTASIS AND GENETIC COSTRAINT ON EVOLUTIONARY TRAJECTORIES [PDF]
Evolution, 2005 Epistasis for fitness means that the selective effect of a mutation is conditional on the genetic background in which it appears. Although epistasis is widely observed in nature, our understanding of its consequences for evolution by natural selection remains incomplete.
Weinreich, Daniel M. +2 more
openaire +5 more sources
Estimating directional epistasis
Frontiers in Genetics, 2014 Epistasis, i.e. the fact that gene effects depend on the genetic background, is a direct consequence of the complexity of genetic architectures. Despite this, most of the models used in evolutionary and quantitative genetics pay scant attention to ...
Arnaud eLE ROUZIC
doaj +1 more source