Results 31 to 40 of about 58,973 (229)
Maternal-Zygotic Epistasis and the Evolution of Genetic Diseases [PDF]
Journal of Biomedicine and Biotechnology, 2010 Many birth defects and genetic diseases are expressed in individuals that do not carry the disease causing alleles. Genetic diseases observed in offspring can be caused by gene expression in mothers and by interactions between gene expression in mothers and offspring.
Nicholas K. Priest, Michael J. Wade
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Epistasis: obstacle or advantage for mapping complex traits? [PDF]
PLoS ONE, 2010 Identification of genetic loci in complex traits has focused largely on one-dimensional genome scans to search for associations between single markers and the phenotype.
Koen J F Verhoeven +2 more
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Pervasive epistasis exposes intramolecular networks in adaptive enzyme evolution
Nature Communications, 2023 Enzyme evolution is characterized by constant alterations of the intramolecular residue networks supporting their functions. The rewiring of these network interactions can give rise to epistasis.
Karol Buda +2 more
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Statistical Modeling of Epistasis and Linkage Decay using Logic Regression [PDF]
, 2008 Logic regression has been recognized as a tool that can identify and model non-additive genetic interactions using Boolean logic groups. Logic regression, TASSEL-GLM and SAS-GLM were compared for analytical precision using a previously characterized ...
Jean-Luc Jannink +4 more
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Genetic epistasis in female suicide attempters
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2012 Complex behaviors such as suicidal behavior likely exhibit gene-gene interactions. The main aim of this study is to explore potential single nucleotide polymorphisms combinations with epistatic effect in suicidal behavior using a data mining tool (Multifactor Dimensionality Reduction).Genomic DNA from peripheral blood samples was analyzed using SNPlex ...
José Fernández-Piqueras +10 more
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The effect of epistasis on sexually antagonistic genetic variation [PDF]
Proceedings of the Royal Society B: Biological Sciences, 2014 There is increasing evidence of segregating sexually antagonistic (SA) genetic variation for fitness in laboratory and wild populations, yet the conditions for the maintenance of such variation can be restrictive. Epistatic interactions between genes can contribute to the maintenance of genetic variance in fitness and we suggest that epistasis between ...
G. Arnqvist, N. Vellnow, L. Rowe
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Exploring the effect of sex on empirical fitness landscapes [PDF]
, 2009 The nature of epistasis has important consequences for the evolutionary significance of sex and recombination. Recent efforts to find negative epistasis as a source of negative linkage disequilibrium and associated long-term advantage to sex have yielded
Krug, J. +2 more
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Genetic Dissection of Cytonuclear Epistasis in Line Crosses [PDF]
Genetics, 2007 Abstract Dissection of cytonuclear interactions is fundamentally important for understanding the genetic architecture of complex traits. Here we propose a mating design based on reciprocal crosses and extend the existing QTL mapping method to evaluate the contribution of cytoplasm and QTL × cytoplasm interactions to the phenotypic ...
Zefeng Yang +4 more
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Functional Regression Models for Epistasis Analysis of Multiple Quantitative Traits.
PLoS Genetics, 2016 To date, most genetic analyses of phenotypes have focused on analyzing single traits or analyzing each phenotype independently. However, joint epistasis analysis of multiple complementary traits will increase statistical power and improve our ...
Futao Zhang +4 more
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Influence of epistasis on response to genomic selection using complete sequence data
Genetics Selection Evolution, 2017 Background The effect of epistasis on response to selection is a highly debated topic. Here, we investigated the impact of epistasis on response to sequence-based selection via genomic best linear prediction (GBLUP) in a regime of strong non-symmetrical ...
Natalia S. Forneris +3 more
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