Results 41 to 50 of about 58,973 (229)
The Indian Journal of Agricultural Sciences, 2021 To estimate epistasis and components of genetic variance a study was carried out during 2016 and 2017 at Experimental Research Farm of Department of Vegetable Science, Dr YSP UH & F Nauni, Solan, (HP) and data were recorded for different qualitative and
REENA KUMARI, RAMESH KUMAR, MEENU GUPTA
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Stability-mediated epistasis constrains the evolution of an influenza protein. [PDF]
, 2013 John Maynard Smith compared protein evolution to the game where one word is converted into another a single letter at a time, with the constraint that all intermediates are words: WORD→WORE→GORE→GONE→GENE. In this analogy, epistasis constrains evolution,
Bloom, Jesse D +2 more
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The effect of host heterogeneity and parasite intragenomic interactions on parasite population structure [PDF]
, 2005 Understanding the processes that shape the genetic structure of parasite populations and the functional consequences of different parasite genotypes is critical for our ability to predict how an infection can spread through a host population and for the ...
Agrawal A +4 more
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BMC Genomics, 2022 Background The influence of linkage disequilibrium (LD), epistasis, and inbreeding on genotypic variance continues to be an important area of investigation in genetics and evolution.
José Marcelo Soriano Viana +1 more
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Enhancer-Gene Interaction Analyses Identified the Epidermal Growth Factor Receptor as a Susceptibility Gene for Type 2 Diabetes Mellitus [PDF]
Diabetes & Metabolism Journal, 2021 Background Genetic interactions are known to play an important role in the missing heritability problem for type 2 diabetes mellitus (T2DM). Interactions between enhancers and their target genes play important roles in gene regulation and disease ...
Yang Yang +4 more
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Epistasis and Adaptation on Fitness Landscapes [PDF]
arXiv, 2022 Epistasis occurs when the effect of a mutation depends on its carrier's genetic background. Despite increasing evidence that epistasis for fitness is common, its role during evolution is contentious. Fitness landscapes, mappings of genotype or phenotype to fitness, capture the full extent and complexity of epistasis.
arxiv
Evolutionary footprint of epistasis. [PDF]
PLoS Computational Biology, 2018 Variation of an inherited trait across a population cannot be explained by additive contributions of relevant genes, due to epigenetic effects and biochemical interactions (epistasis).
Gabriele Pedruzzi +2 more
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Epistasis regulates genetic control of cardiac hypertrophy
, 2023 AbstractThe combinatorial effect of genetic variants is often assumed to be additive. Although genetic variation can clearly interact non-additively, methods to uncover epistatic relationships remain in their infancy. We develop low-signal signed iterative random forests to elucidate the complex genetic architecture of cardiac hypertrophy.
Qianru Wang +23 more
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Widespread genetic epistasis among cancer genes [PDF]
Nature Communications, 2014 Quantitative genetic epistasis has been hypothesized to be an important factor in the development and progression of complex diseases. Cancers in particular are driven by the accumulation of mutations that may act epistatically during the course of the disease.
Kevin P. White +3 more
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Epi-GTBN: an approach of epistasis mining based on genetic Tabu algorithm and Bayesian network
BMC Bioinformatics, 2019 Background Mining epistatic loci which affects specific phenotypic traits is an important research issue in the field of biology. Bayesian network (BN) is a graphical model which can express the relationship between genetic loci and phenotype. Until now,
Yang Guo +7 more
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