Results 41 to 50 of about 49,916 (196)

The nk model and population genetics [PDF]

, 2005
The nk model of fitness interactions is examined. This model has been used by previous authors to investigate the effects of fitness epistasis on substitution dynamics in molecular evolution, and to make broader claims about the importance of epistasis ...
Barton, Barton, Bergman, Burch, Coyne, Edmands, Elena, Elena, Felsenstein, Fisher, Fitch, Fontana, Fraser, Gavrilets, Gillespie, Gillespie, Gillespie, Gillespie, Gumbel, Hansen, Hartl, Jeong, Kauffman, Kauffman, Kauffman, Kichler Holder, Kimura, Kimura, Kondrashov, Korona, Lenski, Macken, Mani, Maynard Smith, Moore, Ohta, Ohta, Ohta, Ohta, Orr, Orr, Orr, Peck, Perelson, Phillips, Provine, Schrag, Solow, Stephan, Tachida, Tachida, Weinberger, Welch, Whitlock, Zeng   +54 more
core   +2 more sources

A strategy to apply quantitative epistasis analysis on developmental traits

BMC Genetics, 2017
Background Genetic interactions are keys to understand complex traits and evolution. Epistasis analysis is an effective method to map genetic interactions. Large-scale quantitative epistasis analysis has been well established for single cells.
Marta K. Labocha, Wang Yuan, Boanerges Aleman-Meza, Weiwei Zhong   +3 more
doaj   +1 more source

Comparison of the Accuracy of Epistasis and Haplotype Models for Genomic Prediction of Seven Human Phenotypes

Biomolecules, 2023
The accuracy of predicting seven human phenotypes of 3657–7564 individuals using global epistasis effects was evaluated and compared to the accuracy of haplotype genomic prediction using 380,705 SNPs and 10-fold cross-validation studies.
Zuoxiang Liang, Dzianis Prakapenka, Yang Da   +2 more
doaj   +1 more source

Evidence of epistasis between Interleukin-1 and Selenoprotein-S with susceptibility to rheumatoid arthritis [PDF]

, 2009
Objective: Selenoprotein-S (SELS) is involved in the stress response within the endoplasmic reticulum (ER) and inflammation. Recently, promoter variants in the SELS gene were shown to be associated with plasma levels of interleukin (IL)6, IL1β and tumour
Binks, M.H., Dickson, M.C., Marinou, L., Montgomery, D.S., Walters, K., Wilson, A.G.   +5 more
core   +2 more sources

Lettuce Genetics: Inheritance, Linkage, and Epistasis [PDF]

Journal of the American Society for Horticultural Science, 1992
Two new lettuce (Luctuca sativa L.) genes are described and named truncated leaf (tn), and sickly (si). A gene for reflexed involucre is identical to that previously described in wild lettuce (L.
openaire   +1 more source

Mechanistic causes of sign epistasis and its applications

Frontiers in Genetics
Mapping genetic variations to phenotypic variations poses a significant challenge, as mutations often combine unexpectedly, diverging from assumed additive effects even in the same environment.
Jinqiu Zhang, Feiyu Chen, Feiyu Chen, Xianghua Li, Xianghua Li, Xianghua Li   +5 more
doaj   +1 more source

Information content of colored motifs in complex networks [PDF]

, 2011
We study complex networks in which the nodes of the network are tagged with different colors depending on the functionality of the nodes (colored graphs), using information theory applied to the distribution of motifs in such networks.
Arend Hintze, Christoph Adami, Jifeng Qian, Kolmogorov A., Matthew Rupp   +4 more
core   +1 more source

Multiallelic epistatic model for an out-bred cross and mapping algorithm of interactive quantitative trait loci

BMC Plant Biology, 2011
Background Genetic mapping has proven to be powerful for studying the genetic architecture of complex traits by characterizing a network of the underlying interacting quantitative trait loci (QTLs).
Tong Chunfa, Zhang Bo, Wang Zhong, Xu Meng, Pang Xiaoming, Si Jingna, Huang Minren, Wu Rongling   +7 more
doaj   +1 more source

Accounting for genetic interactions improves modeling of individual quantitative trait phenotypes in yeast. [PDF]

, 2016
Experiments in model organisms report abundant genetic interactions underlying biologically important traits, whereas quantitative genetics theory predicts, and data support, the notion that most genetic variance in populations is additive.
Bloom, Joshua S, Carlborg, Örjan, Forsberg, Simon KG, Kruglyak, Leonid, Sadhu, Meru J   +4 more
core   +3 more sources

Concurrent outcomes from multiple approaches of epistasis analysis for human body mass index associated loci provide insights into obesity biology

Scientific Reports, 2022
Genome wide association studies (GWAS) have focused on elucidating the genetic architecture of complex traits by assessing single variant effects in additive genetic models, albeit explaining a fraction of the trait heritability.
Sheldon D’Silva, Shreya Chakraborty, Bratati Kahali   +2 more
doaj   +1 more source