Results 41 to 50 of about 2,663,291 (229)
Epistasis: obstacle or advantage for mapping complex traits? [PDF]
PLoS ONE, 2010 Identification of genetic loci in complex traits has focused largely on one-dimensional genome scans to search for associations between single markers and the phenotype.
Koen J F Verhoeven +2 more
doaj +1 more source
Competition between recombination and epistasis can cause a transition from allele to genotype selection [PDF]
, 2009 Biochemical and regulatory interactions central to biological networks are expected to cause extensive genetic interactions or epistasis affecting the heritability of complex traits and the distribution of genotypes in populations. However, the inference
Neher, Richard A., Shraiman, Boris I.
core +3 more sources
Maternal-Zygotic Epistasis and the Evolution of Genetic Diseases [PDF]
Journal of Biomedicine and Biotechnology, 2010 Many birth defects and genetic diseases are expressed in individuals that do not carry the disease causing alleles. Genetic diseases observed in offspring can be caused by gene expression in mothers and by interactions between gene expression in mothers and offspring.
Nicholas K. Priest, Michael J. Wade
openaire +2 more sources
Idiosyncratic and dose-dependent epistasis drives variation in tomato fruit size
Science, 2023 Epistasis between genes is traditionally studied with mutations that eliminate protein activity, but most natural genetic variation is in cis-regulatory DNA and influences gene expression and function quantitatively.
Lyndsey Aguirre +4 more
semanticscholar +1 more source
Genetic epistasis in female suicide attempters
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2012 Complex behaviors such as suicidal behavior likely exhibit gene-gene interactions. The main aim of this study is to explore potential single nucleotide polymorphisms combinations with epistatic effect in suicidal behavior using a data mining tool (Multifactor Dimensionality Reduction).Genomic DNA from peripheral blood samples was analyzed using SNPlex ...
José Fernández-Piqueras +10 more
openaire +3 more sources
Genetic Dissection of Cytonuclear Epistasis in Line Crosses [PDF]
Genetics, 2007 Abstract Dissection of cytonuclear interactions is fundamentally important for understanding the genetic architecture of complex traits. Here we propose a mating design based on reciprocal crosses and extend the existing QTL mapping method to evaluate the contribution of cytoplasm and QTL × cytoplasm interactions to the phenotypic ...
Zefeng Yang +4 more
openaire +3 more sources
Stability-mediated epistasis constrains the evolution of an influenza protein. [PDF]
, 2013 John Maynard Smith compared protein evolution to the game where one word is converted into another a single letter at a time, with the constraint that all intermediates are words: WORD→WORE→GORE→GONE→GENE. In this analogy, epistasis constrains evolution,
Bloom, Jesse D +2 more
core +1 more source
Evolutionary accessibility of mutational pathways [PDF]
, 2011 Functional effects of different mutations are known to combine to the total effect in highly nontrivial ways. For the trait under evolutionary selection (`fitness'), measured values over all possible combinations of a set of mutations yield a fitness ...
de Visser, J. Arjan G. M. +3 more
core +8 more sources
Functional Regression Models for Epistasis Analysis of Multiple Quantitative Traits.
PLoS Genetics, 2016 To date, most genetic analyses of phenotypes have focused on analyzing single traits or analyzing each phenotype independently. However, joint epistasis analysis of multiple complementary traits will increase statistical power and improve our ...
Futao Zhang +4 more
doaj +1 more source
Influence of epistasis on response to genomic selection using complete sequence data
Genetics Selection Evolution, 2017 Background The effect of epistasis on response to selection is a highly debated topic. Here, we investigated the impact of epistasis on response to sequence-based selection via genomic best linear prediction (GBLUP) in a regime of strong non-symmetrical ...
Natalia S. Forneris +3 more
doaj +1 more source