Results 41 to 50 of about 49,240 (217)
Stability-mediated epistasis constrains the evolution of an influenza protein. [PDF]
, 2013 John Maynard Smith compared protein evolution to the game where one word is converted into another a single letter at a time, with the constraint that all intermediates are words: WORD→WORE→GORE→GONE→GENE. In this analogy, epistasis constrains evolution,
Bloom, Jesse D +2 more
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Evolutionary footprint of epistasis. [PDF]
PLoS Computational Biology, 2018 Variation of an inherited trait across a population cannot be explained by additive contributions of relevant genes, due to epigenetic effects and biochemical interactions (epistasis).
Gabriele Pedruzzi +2 more
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Epistasis regulates genetic control of cardiac hypertrophy
, 2023 Abstract The combinatorial effect of genetic variants is often assumed to be additive. Although genetic variation can clearly interact non-additively, methods to uncover epistatic relationships remain in their infancy. We develop low-signal signed iterative random forests to elucidate the complex genetic architecture of cardiac hypertrophy.
Qianru Wang +23 more
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Epistasis and its contribution to genetic variance components. [PDF]
Genetics, 1995 Abstract We present a new parameterization of physiological epistasis that allows the measurement of epistasis separate from its effects on the interaction (epistatic) genetic variance component. Epistasis is the deviation of two-locus genotypic values from the sum of the contributing single-locus genotypic values.
Eric J. Routman, James M. Cheverud
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, 2016 Epistatic interactions between residues determine a protein's adaptability and shape its evolutionary trajectory. When a protein experiences a changed environment, it is under strong selection to find a peak in the new fitness landscape.
Adami, Christoph, Gupta, Aditi
core +7 more sources
A strategy to apply quantitative epistasis analysis on developmental traits
BMC Genetics, 2017 Background Genetic interactions are keys to understand complex traits and evolution. Epistasis analysis is an effective method to map genetic interactions. Large-scale quantitative epistasis analysis has been well established for single cells.
Marta K. Labocha +3 more
doaj +1 more source
Biomolecules, 2023 The accuracy of predicting seven human phenotypes of 3657–7564 individuals using global epistasis effects was evaluated and compared to the accuracy of haplotype genomic prediction using 380,705 SNPs and 10-fold cross-validation studies.
Zuoxiang Liang +2 more
doaj +1 more source
The effect of host heterogeneity and parasite intragenomic interactions on parasite population structure [PDF]
, 2005 Understanding the processes that shape the genetic structure of parasite populations and the functional consequences of different parasite genotypes is critical for our ability to predict how an infection can spread through a host population and for the ...
Agrawal A +4 more
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Speciation Genetics: Epistasis, Conflict and the Origin of Species [PDF]
Current Biology, 2007 Evolutionary biologists have long recognized that the sterility and inviability of species hybrids must involve incompatible epistatic interactions between two (or more) genes. The first pair of such hybrid incompatibility genes has now been identified.
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Widespread genetic epistasis among cancer genes [PDF]
Nature Communications, 2014 Quantitative genetic epistasis has been hypothesized to be an important factor in the development and progression of complex diseases. Cancers in particular are driven by the accumulation of mutations that may act epistatically during the course of the disease.
Kevin P. White +3 more
openaire +3 more sources