Results 51 to 60 of about 49,240 (217)

Epi-GTBN: an approach of epistasis mining based on genetic Tabu algorithm and Bayesian network

BMC Bioinformatics, 2019
Background Mining epistatic loci which affects specific phenotypic traits is an important research issue in the field of biology. Bayesian network (BN) is a graphical model which can express the relationship between genetic loci and phenotype. Until now,
Yang Guo, Zhiman Zhong, Chen Yang, Jiangfeng Hu, Yaling Jiang, Zizhen Liang, Hui Gao, Jianxiao Liu   +7 more
doaj   +1 more source

Mechanistic causes of sign epistasis and its applications

Frontiers in Genetics
Mapping genetic variations to phenotypic variations poses a significant challenge, as mutations often combine unexpectedly, diverging from assumed additive effects even in the same environment.
Jinqiu Zhang, Feiyu Chen, Feiyu Chen, Xianghua Li, Xianghua Li, Xianghua Li   +5 more
doaj   +1 more source

Multiallelic epistatic model for an out-bred cross and mapping algorithm of interactive quantitative trait loci

BMC Plant Biology, 2011
Background Genetic mapping has proven to be powerful for studying the genetic architecture of complex traits by characterizing a network of the underlying interacting quantitative trait loci (QTLs).
Tong Chunfa, Zhang Bo, Wang Zhong, Xu Meng, Pang Xiaoming, Si Jingna, Huang Minren, Wu Rongling   +7 more
doaj   +1 more source

Epistasis and the genetics of human diseases

Comptes Rendus. Biologies, 2005
Epistasis or modifier genes, that is, gene-gene interactions of non-allelic partners, play a major role in susceptibility to common human diseases. This old genetic concept has experienced a major renaissance recently. Interestingly, epistatic genes can make the disease less severe, or make it more severe.
openaire   +3 more sources

Contribution of genetic effects to genetic variance components with epistasis and linkage disequilibrium [PDF]

BMC Genetics, 2009
Cockerham genetic models are commonly used in quantitative trait loci (QTL) analysis with a special feature of partitioning genotypic variances into various genetic variance components, while the F(infinity) genetic models are widely used in genetic association studies. Over years, there have been some confusion about the relationship between these two
Zhao-Bang Zeng, Tao Wang
openaire   +4 more sources

Inferring Epistasis from Genetic Time-series Data

Molecular Biology and Evolution, 2022
AbstractEpistasis refers to fitness or functional effects of mutations that depend on the sequence background in which these mutations arise. Epistasis is prevalent in nature, including populations of viruses, bacteria, and cancers, and can contribute to the evolution of drug resistance and immune escape.
Sohail, Muhammad Saqib, Louie, Raymond H. Y., Hong, Zhenchen, Barton, John P., Mckay, Matthew Robert   +4 more
openaire   +3 more sources

Concurrent outcomes from multiple approaches of epistasis analysis for human body mass index associated loci provide insights into obesity biology

Scientific Reports, 2022
Genome wide association studies (GWAS) have focused on elucidating the genetic architecture of complex traits by assessing single variant effects in additive genetic models, albeit explaining a fraction of the trait heritability.
Sheldon D’Silva, Shreya Chakraborty, Bratati Kahali   +2 more
doaj   +1 more source

wtest: an integrated R package for genetic epistasis testing [PDF]

BMC Medical Genomics, 2019
AbstractBackgroundWith the increasing amount of high-throughput genomic sequencing data, there is a growing demand for a robust and flexible tool to perform interaction analysis. The identification of SNP-SNP, SNP-CpG, and higher order interactions helps explain the genetic etiology of human diseases, yet genome-wide analysis for interactions has been ...
William K.K. Wu, Xiaoxuan Xia, Rui Sun, Ka Chun Chong, Benny Zee, Maggie Haitian Wang   +5 more
openaire   +4 more sources

eQTL epistasis – challenges and computational approaches

Frontiers in Genetics, 2013
The determination of eQTL epistasis - a form of functional interaction between genetic loci that affect gene expression - is an important step towards the thorough understanding of gene regulation.
Yang eHuang, Stefan eWuchty, Teresa M Przytycka   +2 more
doaj   +1 more source

Floral scent of artificial hybrids between two Schiedea species that share a moth pollinator

American Journal of Botany, EarlyView.
Abstract Premise In flowering plants, pollinators' ability to recognize chemical displays of hybrids may erode reproductive barriers. Hybrids may produce novel or altered floral scent blends that are unattractive, or scents similar to either parent that remain attractive and promote backcrossing.
John M. Powers, Stephen G. Weller, Ann K. Sakai, Diane R. Campbell   +3 more
wiley   +1 more source