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Effects of Epistasis and Pleiotropy on Fitness Landscapes
, 2013 The factors that influence genetic architecture shape the structure of the fitness landscape, and therefore play a large role in the evolutionary dynamics. Here the NK model is used to investigate how epistasis and pleiotropy -- key components of genetic
A Dawid +15 more
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Evolving concurrent Petri net models of epistasis [PDF]
, 2010 A genetic algorithm is used to learn a non-deterministic Petri netbased model of non-linear gene interactions, or statistical epistasis. Petri nets are computational models of concurrent processes.
Beretta, Lorenzo, Mayo, Michael
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Maternal-Zygotic Epistasis and the Evolution of Genetic Diseases [PDF]
Journal of Biomedicine and Biotechnology, 2010 Many birth defects and genetic diseases are expressed in individuals that do not carry the disease causing alleles. Genetic diseases observed in offspring can be caused by gene expression in mothers and by interactions between gene expression in mothers and offspring.
Priest, Nicholas K., Wade, Michael J.
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eQTL epistasis – challenges and computational approaches
Frontiers in Genetics, 2013 The determination of eQTL epistasis - a form of functional interaction between genetic loci that affect gene expression - is an important step towards the thorough understanding of gene regulation.
Yang eHuang +2 more
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Association mapping for epistasis and environmental interaction of yield traits in 323 cotton cultivars under 9 different environments. [PDF]
PLoS ONE, 2014 Improving yield is a major objective for cotton breeding schemes, and lint yield and its three component traits (boll number, boll weight and lint percentage) are complex traits controlled by multiple genes and various environments.
Yinhua Jia +14 more
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Revista Facultad Nacional de Agronomía Medellín, 2019 Genetic parameters such as leaf relative water content, leaf chlorophyll content, plant height, above-ground biomass, harvest index, grain yield, and grain yield components of Bousselam/Mrb5 durum wheat (Triticum durum Desf.) cross were estimated based ...
Manel Salmi +6 more
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Rheumatoid arthritis identification using epistasis analysis through computational models
Biomedical and Biotechnology Research Journal, 2020 Rheumatoid arthritis (RA) is an autoimmune disorder that damages joints irreversibly. Many RA illnesses were also related to complex genetic characteristics and genetic interactions as well.
R Manavalan, S Priya
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Epistasis: Searching for Interacting Genetic Variants Using Crosses [PDF]
G3 Genes|Genomes|Genetics, 2017 Within quantitative genetics, the term “epistasis” is used to broadly describe situations in which combinations of genetic variants show nonadditive phenotypic effects ([Phillips 1998][1], [2008][2]; [Mackay 2014][3]).
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BMC Genetics, 2006 Background A genetic model about quantitative trait loci (QTL) provides a basis to interpret the genetic basis of quantitative traits in a study population, such as additive, dominance and epistatic effects of QTL and the partition of genetic variance ...
Wang Tao, Zeng Zhao-Bang
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Lower-order effects adjustment in quantitative traits model-based multifactor dimensionality reduction. [PDF]
PLoS ONE, 2012 Identifying gene-gene interactions or gene-environment interactions in studies of human complex diseases remains a big challenge in genetic epidemiology.
Jestinah M Mahachie John +4 more
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