Results 51 to 60 of about 50,815 (199)

Evolving concurrent Petri net models of epistasis [PDF]

, 2010
A genetic algorithm is used to learn a non-deterministic Petri netbased model of non-linear gene interactions, or statistical epistasis. Petri nets are computational models of concurrent processes.
Beretta, Lorenzo, Mayo, Michael
core   +1 more source

Maternal-Zygotic Epistasis and the Evolution of Genetic Diseases [PDF]

Journal of Biomedicine and Biotechnology, 2010
Many birth defects and genetic diseases are expressed in individuals that do not carry the disease causing alleles. Genetic diseases observed in offspring can be caused by gene expression in mothers and by interactions between gene expression in mothers and offspring.
Priest, Nicholas K., Wade, Michael J.
openaire   +2 more sources

eQTL epistasis – challenges and computational approaches

Frontiers in Genetics, 2013
The determination of eQTL epistasis - a form of functional interaction between genetic loci that affect gene expression - is an important step towards the thorough understanding of gene regulation.
Yang eHuang, Stefan eWuchty, Teresa M Przytycka   +2 more
doaj   +1 more source

The nk model and population genetics [PDF]

, 2005
The nk model of fitness interactions is examined. This model has been used by previous authors to investigate the effects of fitness epistasis on substitution dynamics in molecular evolution, and to make broader claims about the importance of epistasis ...
Barton, Barton, Bergman, Burch, Coyne, Edmands, Elena, Elena, Felsenstein, Fisher, Fitch, Fontana, Fraser, Gavrilets, Gillespie, Gillespie, Gillespie, Gillespie, Gumbel, Hansen, Hartl, Jeong, Kauffman, Kauffman, Kauffman, Kichler Holder, Kimura, Kimura, Kondrashov, Korona, Lenski, Macken, Mani, Maynard Smith, Moore, Ohta, Ohta, Ohta, Ohta, Orr, Orr, Orr, Peck, Perelson, Phillips, Provine, Schrag, Solow, Stephan, Tachida, Tachida, Weinberger, Welch, Whitlock, Zeng   +54 more
core   +2 more sources

p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

Advanced Science, EarlyView.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa, Teh‐Wei Wang, Satoshi Kawakami, Shota Tanimoto, Kiyoshi Yamaguchi, Taketomo Kido, Masamichi Kimura, Tsunekazu Hishima, Yuki T. Okamura, Satotaka Omori, Takumi Iritani, Toshikaze Chiba, Takehiro Jimbo, Michio Katano, Kansuporn Kamataki, Ryoichi Yokoyama, Eigo Shimizu, Kiminori Kimura, Satoshi Yamzaki, Seiya Imoto, Yoichi Furukawa, Atsushi Miyajima, Yoshikazu Johmura, Makoto Nakanishi   +23 more
wiley   +1 more source

Generation means analysis of physiological and agronomical targeted traits in durum wheat (Triticum durum Desf.) cross

Revista Facultad Nacional de Agronomía Medellín, 2019
Genetic parameters such as leaf relative water content, leaf chlorophyll content, plant height, above-ground biomass, harvest index, grain yield, and grain yield components of Bousselam/Mrb5 durum wheat (Triticum durum Desf.) cross were estimated based ...
Manel Salmi, Amar Benmahammed, Laid Benderradji, Zine El Abidine Fellahi, Hamenna Bouzerzour, Abdelmalek Oulmi, Abdelkader Benbelkacem   +6 more
doaj   +1 more source

Rheumatoid arthritis identification using epistasis analysis through computational models

Biomedical and Biotechnology Research Journal, 2020
Rheumatoid arthritis (RA) is an autoimmune disorder that damages joints irreversibly. Many RA illnesses were also related to complex genetic characteristics and genetic interactions as well.
R Manavalan, S Priya
doaj   +1 more source

Association mapping for epistasis and environmental interaction of yield traits in 323 cotton cultivars under 9 different environments. [PDF]

PLoS ONE, 2014
Improving yield is a major objective for cotton breeding schemes, and lint yield and its three component traits (boll number, boll weight and lint percentage) are complex traits controlled by multiple genes and various environments.
Yinhua Jia, Xiwei Sun, Junling Sun, Zhaoe Pan, Xiwen Wang, Shoupu He, Songhua Xiao, Weijun Shi, Zhongli Zhou, Baoyin Pang, Liru Wang, Jianguang Liu, Jun Ma, Xiongming Du, Jun Zhu   +14 more
doaj   +1 more source

Natural Negative Feedback Loops Confer Indica‐Japonica Differentiation for Grain Size Homeostasis in Rice

Advanced Science, EarlyView.
This study reveals the genetic and molecular mechanisms controlling grain size homeostasis through fine‐tuning OsGRX8 self‐expression by two natural negative feedback loops functioning in redox‐dependent or ‐independent manners and identifies two self‐regulatory haplotypes (SRHs) for the subspecies differentiation in rice.
Xingxing Li, Meng‐en Wu, Ziqi Qiao, Junkui Huang, Juncheng Zhang, Yang Ding, Junqing Zhu, Jingyue Xu, Yuxin Huang, Wei Li, Xiaomin Su, Yue Ding, Jianwei Zhang, Yibo Li   +13 more
wiley   +1 more source

Epistasis: Searching for Interacting Genetic Variants Using Crosses [PDF]

G3 Genes|Genomes|Genetics, 2017
Within quantitative genetics, the term “epistasis” is used to broadly describe situations in which combinations of genetic variants show nonadditive phenotypic effects ([Phillips 1998][1], [2008][2]; [Mackay 2014][3]).
openaire   +4 more sources