Results 61 to 70 of about 58,973 (229)
Dynamic epistasis for different alleles of the same gene [PDF]
, 2014 Epistasis refers to the phenomenon in which phenotypic consequences caused by mutation of one gene depend on one or more mutations at another gene. Epistasis is critical for understanding many genetic and evolutionary processes, including pathway organization, evolution of sexual reproduction, mutational load, ploidy, genomic complexity, speciation ...
arxiv +1 more source
Scientific Reports, 2022 Genome wide association studies (GWAS) have focused on elucidating the genetic architecture of complex traits by assessing single variant effects in additive genetic models, albeit explaining a fraction of the trait heritability.
Sheldon D’Silva +2 more
doaj +1 more source
wtest: an integrated R package for genetic epistasis testing [PDF]
BMC Medical Genomics, 2019 AbstractBackgroundWith the increasing amount of high-throughput genomic sequencing data, there is a growing demand for a robust and flexible tool to perform interaction analysis. The identification of SNP-SNP, SNP-CpG, and higher order interactions helps explain the genetic etiology of human diseases, yet genome-wide analysis for interactions has been ...
William K.K. Wu +5 more
openaire +4 more sources
Inferring Epistasis from Genetic Time-series Data
Molecular Biology and Evolution, 2022 AbstractEpistasis refers to fitness or functional effects of mutations that depend on the sequence background in which these mutations arise. Epistasis is prevalent in nature, including populations of viruses, bacteria, and cancers, and can contribute to the evolution of drug resistance and immune escape.
Sohail, Muhammad Saqib +4 more
openaire +3 more sources
eQTL epistasis – challenges and computational approaches
Frontiers in Genetics, 2013 The determination of eQTL epistasis - a form of functional interaction between genetic loci that affect gene expression - is an important step towards the thorough understanding of gene regulation.
Yang eHuang +2 more
doaj +1 more source
Association mapping for epistasis and environmental interaction of yield traits in 323 cotton cultivars under 9 different environments. [PDF]
PLoS ONE, 2014 Improving yield is a major objective for cotton breeding schemes, and lint yield and its three component traits (boll number, boll weight and lint percentage) are complex traits controlled by multiple genes and various environments.
Yinhua Jia +14 more
doaj +1 more source
Journal of Animal Breeding and Genetics, EarlyView.ABSTRACT Fitness traits described as a ratio often display non‐normal distributions; consequently, transformations are frequently applied to improve normality prior to the estimation of genetic parameters. However, the impact of different transformations on genetic parameter estimates depends on the dataset at hand.
Evan Hartono +5 more
wiley +1 more source
Dominance, epistasis, heritabilities and expected genetic gains [PDF]
Genetics and Molecular Biology, 2005 Although epistasis is common in gene systems that determine quantitative traits, it is usually not possible to estimate the epistatic components of genotypic variance because experiments in breeding programs include only one type of progeny. As the study of this phenomenon is complex, there is a lack of theoretical knowledge on the contribution of the ...
openaire +5 more sources
Contribution of genetic effects to genetic variance components with epistasis and linkage disequilibrium [PDF]
BMC Genetics, 2009 Cockerham genetic models are commonly used in quantitative trait loci (QTL) analysis with a special feature of partitioning genotypic variances into various genetic variance components, while the F(infinity) genetic models are widely used in genetic association studies. Over years, there have been some confusion about the relationship between these two
Zhao-Bang Zeng, Tao Wang
openaire +4 more sources
Revista Facultad Nacional de Agronomía Medellín, 2019 Genetic parameters such as leaf relative water content, leaf chlorophyll content, plant height, above-ground biomass, harvest index, grain yield, and grain yield components of Bousselam/Mrb5 durum wheat (Triticum durum Desf.) cross were estimated based ...
Manel Salmi +6 more
doaj +1 more source