Results 61 to 70 of about 50,815 (199)
BMC Genetics, 2006 Background A genetic model about quantitative trait loci (QTL) provides a basis to interpret the genetic basis of quantitative traits in a study population, such as additive, dominance and epistatic effects of QTL and the partition of genetic variance ...
Wang Tao, Zeng Zhao-Bang
doaj +1 more source
Effects of Epistasis and Pleiotropy on Fitness Landscapes
, 2013 The factors that influence genetic architecture shape the structure of the fitness landscape, and therefore play a large role in the evolutionary dynamics. Here the NK model is used to investigate how epistasis and pleiotropy -- key components of genetic
A Dawid +15 more
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Additive and Partially Dominant Effects from Genomic Variation Contribute to Rice Heterosis
Advanced Science, EarlyView.Additive and partially dominant effects, namely at mid‐parent levels or values between mid‐parent and parental levels, respectively, are the predominant inheritance patterns of heterosis‐associated molecules. These two genetic effects contribute to heterosis of agronomic traits in both rice and maize, as well as biomass heterosis in Arabidopsis ...
Zhiwu Dan +8 more
wiley +1 more source
Lower-order effects adjustment in quantitative traits model-based multifactor dimensionality reduction. [PDF]
PLoS ONE, 2012 Identifying gene-gene interactions or gene-environment interactions in studies of human complex diseases remains a big challenge in genetic epidemiology.
Jestinah M Mahachie John +4 more
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The power of many: when genetics met yeasts and high‐throughput
Biological Reviews, EarlyView.ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley +1 more source
BMC Genomics, 2008 Background The difficulty in elucidating the genetic basis of complex diseases roots in the many factors that can affect the development of a disease.
Galan Jose +10 more
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Positive epistasis drives the acquisition of multidrug resistance. [PDF]
PLoS Genetics, 2009 The evolution of multiple antibiotic resistance is an increasing global problem. Resistance mutations are known to impair fitness, and the evolution of resistance to multiple drugs depends both on their costs individually and on how they interact ...
Sandra Trindade +6 more
doaj +1 more source
Properties of selected mutations and genotypic landscapes under Fisher's Geometric Model
, 2014 The fitness landscape - the mapping between genotypes and fitness - determines properties of the process of adaptation. Several small genetic fitness landscapes have recently been built by selecting a handful of beneficial mutations and measuring fitness
Achaz, Guillaume +3 more
core +1 more source
Defense heterosis as a novel plant protection strategy: From theory to breeding practice
New Plant Protection, EarlyView.Defense heterosis, the enhanced disease resistance of hybrids compared to their parents, has evolved from early observations of hybrid vigor to a novel research concept. Advances are now clarifying its diverse genetic and molecular mechanisms across various plant–pathogen interactions.
Kaiqi Xu, Xue Li, Fangfang Li
wiley +1 more source
PLANTS, PEOPLE, PLANET, EarlyView.Biodiversity is threatened by human activities, with extinction debt accumulating rapidly. Many of these activities change the connectivity of populations, fragmenting existing population systems or bringing previously isolated populations or species into contact.
Zhiqin Long +7 more
wiley +1 more source