Results 61 to 70 of about 49,240 (217)

Genetic epistasis regulates amyloid deposition in resilient aging [PDF]

Alzheimer's & Dementia, 2017
AbstractIntroductionThe brain‐derived neurotrophic factor (BDNF) interacts with important genetic Alzheimer's disease (AD) risk factors. Specifically, variants within the SORL1 gene determine BDNF's ability to reduce amyloid β (Aβ) in vitro. We sought to test whether functional BDNF variation interacts with SORL1 genotypes to influence expression and ...
Lori B. Chibnik, Lori B. Chibnik, Daniel Felsky, Philip L. De Jager, Philip L. De Jager, Jo Knight, Jo Knight, Jo Knight, David A. Bennett, Aristotle N. Voineskos, Aristotle N. Voineskos, Julie A. Schneider, James L. Kennedy, James L. Kennedy, Jishu Xu, Jishu Xu   +15 more
openaire   +4 more sources

Generation means analysis of physiological and agronomical targeted traits in durum wheat (Triticum durum Desf.) cross

Revista Facultad Nacional de Agronomía Medellín, 2019
Genetic parameters such as leaf relative water content, leaf chlorophyll content, plant height, above-ground biomass, harvest index, grain yield, and grain yield components of Bousselam/Mrb5 durum wheat (Triticum durum Desf.) cross were estimated based ...
Manel Salmi, Amar Benmahammed, Laid Benderradji, Zine El Abidine Fellahi, Hamenna Bouzerzour, Abdelmalek Oulmi, Abdelkader Benbelkacem   +6 more
doaj   +1 more source

Rheumatoid arthritis identification using epistasis analysis through computational models

Biomedical and Biotechnology Research Journal, 2020
Rheumatoid arthritis (RA) is an autoimmune disorder that damages joints irreversibly. Many RA illnesses were also related to complex genetic characteristics and genetic interactions as well.
R Manavalan, S Priya
doaj   +1 more source

Association mapping for epistasis and environmental interaction of yield traits in 323 cotton cultivars under 9 different environments. [PDF]

PLoS ONE, 2014
Improving yield is a major objective for cotton breeding schemes, and lint yield and its three component traits (boll number, boll weight and lint percentage) are complex traits controlled by multiple genes and various environments.
Yinhua Jia, Xiwei Sun, Junling Sun, Zhaoe Pan, Xiwen Wang, Shoupu He, Songhua Xiao, Weijun Shi, Zhongli Zhou, Baoyin Pang, Liru Wang, Jianguang Liu, Jun Ma, Xiongming Du, Jun Zhu   +14 more
doaj   +1 more source

Searching for interacting QTL in related populations of an outbreeding species [PDF]

, 2009
Many important crop species are outbreeding. In outbreeding species the search for genes affecting traits is complicated by the fact that in a single cross up to four alleles may be present at each locus.
Bink, M.C.A.M., Boer, M.P., Jansen, J., Weg, W.E., van de   +3 more
core   +2 more sources

KnowVolution of an Efficient Polyamidase through Molecular Dynamics Simulations of Incrementally Docked Oligomeric Substrates

ChemSusChem, EarlyView.
Managing synthetic polymer waste is a major challenge. While enzymatic polyamide (PA) hydrolysis holds great recycling potential, it is limited by ineffective polyamidases. The polyamidase NylCp2‐TS is evolved through random mutagenesis and incremental docking, yielding NylC‐HP with enhanced activity and stability.
Hendrik Puetz, Alexander‐Maurice Illig, Mariia Vorobii, Christoph Janknecht, Francisca Contreras, Fabian Flemig, Ulrich Schwaneberg   +6 more
wiley   +1 more source

Lettuce Genetics: Inheritance, Linkage, and Epistasis [PDF]

Journal of the American Society for Horticultural Science, 1992
Two new lettuce (Luctuca sativa L.) genes are described and named truncated leaf (tn), and sickly (si). A gene for reflexed involucre is identical to that previously described in wild lettuce (L. serriola L.). Mosaic reaction (me) and light green (lg) are linked, with P = 0.448. Six gene pairs tested for linkage are independently inherited.
openaire   +1 more source

EPISTASIS BETWEEN NEW MUTATIONS AND GENETIC BACKGROUND AND A TEST OF GENETIC CANALIZATION [PDF]

Evolution, 2001
The importance for fitness of epistatic interactions among mutations is poorly known, yet epistasis can exert important effects on the dynamics of evolving populations. We showed previously that epistatic interactions are common between pairs of random insertion mutations in the bacterium Escherichia coli. In this paper, we examine interactions between
Richard E. Lenski, Santiago F. Elena
openaire   +3 more sources

Models and partition of variance for quantitative trait loci with epistasis and linkage disequilibrium

BMC Genetics, 2006
Background A genetic model about quantitative trait loci (QTL) provides a basis to interpret the genetic basis of quantitative traits in a study population, such as additive, dominance and epistatic effects of QTL and the partition of genetic variance ...
Wang Tao, Zeng Zhao-Bang
doaj   +1 more source

Microfluidic‐Assisted Evolution of a Robust NAD+‐Dependent Enzyme with Improved Isobutanol Tolerance at Elevated Temperatures

ChemSusChem, EarlyView.
Utilizing the power of the absorbance‐activated droplet sorter, a key enzyme for a cell‐free multienzymatic cascade for sustainable isobutanol biosynthesis is optimized for improved thermostability and isobutanol tolerance required for efficient cascade performance.
Mariko Teshima, Robert Genth, Tenuun Bayaraa, Manuel Döring, Barbara Beer, Gerhard Schenk, Volker Sieber   +6 more
wiley   +1 more source