Results 61 to 70 of about 49,916 (196)

Genetic draft, selective interference, and population genetics of rapid adaptation [PDF]

, 2013
To learn about the past from a sample of genomic sequences, one needs to understand how evolutionary processes shape genetic diversity. Most population genetic inference is based on frameworks assuming adaptive evolution is rare.
Neher, Richard A.
core   +1 more source

A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis

BMC Genomics, 2008
Background The difficulty in elucidating the genetic basis of complex diseases roots in the many factors that can affect the development of a disease.
Galan Jose, Quintas Antonio, Royo Jose, Sáez María, Bermudo Fernando, González-Pérez Antonio, Gayán Javier, Morón Francisco, Ramirez-Lorca Reposo, Real Luis, Ruiz Agustín   +10 more
doaj   +1 more source

Positive epistasis drives the acquisition of multidrug resistance. [PDF]

PLoS Genetics, 2009
The evolution of multiple antibiotic resistance is an increasing global problem. Resistance mutations are known to impair fitness, and the evolution of resistance to multiple drugs depends both on their costs individually and on how they interact ...
Sandra Trindade, Ana Sousa, Ana Sousa, Karina Bivar Xavier, Francisco Dionisio, Miguel Godinho Ferreira, Isabel Gordo   +6 more
doaj   +1 more source

Epistasis not needed to explain low dN/dS

, 2012
An important question in molecular evolution is whether an amino acid that occurs at a given position makes an independent contribution to fitness, or whether its effect depends on the state of other loci in the organism's genome, a phenomenon known as ...
AL Halpern, AS Kondrashov, AU Tamuri, David M. McCandlish, DM Fowler, Etienne Rajon, J da Silva, Joshua B. Plotkin, MA DePristo, MLM Salverda, MS Breen, N Rodrigue, Premal Shah, S Kryazhimskiy, SC Choi, TF Hansen, WH Li, Yang Ding, Z Yang, Z Yang   +19 more
core   +3 more sources

Properties of selected mutations and genotypic landscapes under Fisher's Geometric Model

, 2014
The fitness landscape - the mapping between genotypes and fitness - determines properties of the process of adaptation. Several small genetic fitness landscapes have recently been built by selecting a handful of beneficial mutations and measuring fitness
Achaz, Guillaume, Bataillon, Thomas, Blanquart, François, Tenaillon, Olivier   +3 more
core   +1 more source

Epistasis and the genetics of human diseases

Comptes Rendus. Biologies, 2005
Epistasis or modifier genes, that is, gene-gene interactions of non-allelic partners, play a major role in susceptibility to common human diseases. This old genetic concept has experienced a major renaissance recently. Interestingly, epistatic genes can make the disease less severe, or make it more severe.
openaire   +2 more sources

Whole genome sequencing reveals epistasis effects within RET for Hirschsprung disease

Scientific Reports, 2022
Common variants in RET and NRG1 have been associated with Hirschsprung disease (HSCR), a congenital disorder characterised by incomplete innervation of distal gut, in East Asian (EA) populations.
Yanbing Wang, Timothy Shin Heng Mak, Saloni Dattani, Maria-Merce Garcia-Barcelo, Alexander Xi Fu, Kevin Y. Yip, Elly Sau-Wai Ngan, Paul Kwang-Hang Tam, Clara Sze-Man Tang, Pak Chung Sham   +9 more
doaj   +1 more source

Performance of model-based multifactor dimensionality reduction methods for epistasis detection by controlling population structure

BioData Mining, 2021
Background In genome-wide association studies the extent and impact of confounding due to population structure have been well recognized. Inadequate handling of such confounding is likely to lead to spurious associations, hampering replication, and the ...
Fentaw Abegaz, François Van Lishout, Jestinah M. Mahachie John, Kridsadakorn Chiachoompu, Archana Bhardwaj, Diane Duroux, Elena S. Gusareva, Zhi Wei, Hakon Hakonarson, Kristel Van Steen   +9 more
doaj   +1 more source

Quantitative analyses of empirical fitness landscapes

, 2012
The concept of a fitness landscape is a powerful metaphor that offers insight into various aspects of evolutionary processes and guidance for the study of evolution.
de Visser, J. Arjan G. M., Franke, Jasper, Krug, Joachim, Schenk, Martijn F., Szendro, Ivan G.   +4 more
core   +2 more sources

From Classical Genetics to Quantitative Genetics to Systems Biology: Modeling Epistasis

PLoS Genetics, 2008
Gene expression data has been used in lieu of phenotype in both classical and quantitative genetic settings. These two disciplines have separate approaches to measuring and interpreting epistasis, which is the interaction between alleles at different loci. We propose a framework for estimating and interpreting epistasis from a classical experiment that
David L Aylor, Zhao-Bang Zeng
openaire   +4 more sources