Results 61 to 70 of about 2,663,291 (229)

Epistasis and its contribution to genetic variance components. [PDF]

Genetics, 1995
Abstract We present a new parameterization of physiological epistasis that allows the measurement of epistasis separate from its effects on the interaction (epistatic) genetic variance component. Epistasis is the deviation of two-locus genotypic values from the sum of the contributing single-locus genotypic values.
Eric J. Routman, James M. Cheverud
openaire   +3 more sources

Epistasis between antibiotic resistance mutations and genetic background shape the fitness effect of resistance across species of Pseudomonas

Proceedings of the Royal Society B: Biological Sciences, 2016
Antibiotic resistance often evolves by mutations at conserved sites in essential genes, resulting in parallel molecular evolution between divergent bacterial strains and species.
T. Vogwill, Mila Kojadinovic, Mila Kojadinovic, R. MacLean   +3 more
semanticscholar   +1 more source

Comparison of the Accuracy of Epistasis and Haplotype Models for Genomic Prediction of Seven Human Phenotypes

Biomolecules, 2023
The accuracy of predicting seven human phenotypes of 3657–7564 individuals using global epistasis effects was evaluated and compared to the accuracy of haplotype genomic prediction using 380,705 SNPs and 10-fold cross-validation studies.
Zuoxiang Liang, Dzianis Prakapenka, Yang Da   +2 more
doaj   +1 more source

Reverse Pathway Genetic Approach Identifies Epistasis in Autism Spectrum Disorders

PLoS Genetics, 2017
Although gene-gene interaction, or epistasis, plays a large role in complex traits in model organisms, genome-wide by genome-wide searches for two-way interaction have limited power in human studies.
Ileena Mitra, A. Lavillaureix, E. Yeh, M. Traglia, Kathryn M. Tsang, C. Bearden, K. Rauen, L. Weiss   +7 more
semanticscholar   +1 more source

Speciation Genetics: Epistasis, Conflict and the Origin of Species [PDF]

Current Biology, 2007
Evolutionary biologists have long recognized that the sterility and inviability of species hybrids must involve incompatible epistatic interactions between two (or more) genes. The first pair of such hybrid incompatibility genes has now been identified.
openaire   +3 more sources

Mechanistic causes of sign epistasis and its applications

Frontiers in Genetics
Mapping genetic variations to phenotypic variations poses a significant challenge, as mutations often combine unexpectedly, diverging from assumed additive effects even in the same environment.
Jinqiu Zhang, Feiyu Chen, Feiyu Chen, Xianghua Li, Xianghua Li, Xianghua Li   +5 more
doaj   +1 more source

The nk model and population genetics [PDF]

, 2005
The nk model of fitness interactions is examined. This model has been used by previous authors to investigate the effects of fitness epistasis on substitution dynamics in molecular evolution, and to make broader claims about the importance of epistasis ...
Barton, Barton, Bergman, Burch, Coyne, Edmands, Elena, Elena, Felsenstein, Fisher, Fitch, Fontana, Fraser, Gavrilets, Gillespie, Gillespie, Gillespie, Gillespie, Gumbel, Hansen, Hartl, Jeong, Kauffman, Kauffman, Kauffman, Kichler Holder, Kimura, Kimura, Kondrashov, Korona, Lenski, Macken, Mani, Maynard Smith, Moore, Ohta, Ohta, Ohta, Ohta, Orr, Orr, Orr, Peck, Perelson, Phillips, Provine, Schrag, Solow, Stephan, Tachida, Tachida, Weinberger, Welch, Whitlock, Zeng   +54 more
core   +2 more sources

Multiallelic epistatic model for an out-bred cross and mapping algorithm of interactive quantitative trait loci

BMC Plant Biology, 2011
Background Genetic mapping has proven to be powerful for studying the genetic architecture of complex traits by characterizing a network of the underlying interacting quantitative trait loci (QTLs).
Tong Chunfa, Zhang Bo, Wang Zhong, Xu Meng, Pang Xiaoming, Si Jingna, Huang Minren, Wu Rongling   +7 more
doaj   +1 more source

Direct and indirect genetic effects of sex-specific mitonuclear epistasis on reproductive ageing

Heredity, 2016
Mitochondria are involved in ageing and their function requires coordinated action of both mitochondrial and nuclear genes. Epistasis between the two genomes can influence lifespan but whether this also holds for reproductive senescence is unclear ...
Elina Immonen, M. Collet, J. Goenaga, G. Arnqvist   +3 more
semanticscholar   +1 more source

Idiosyncratic epistasis leads to global fitness-correlated trends

bioRxiv, 2021
Epistasis can dramatically affect evolutionary trajectories. In recent decades, protein-level fitness landscapes have revealed extensive idiosyncratic epistasis among specific mutations.
Christopher W. Bakerlee, Alex N. Nguyen Ba, Yekaterina Shulgina, Jose I. Rojas Echenique, Michael M. Desai   +4 more
semanticscholar   +1 more source