Results 81 to 90 of about 49,916 (196)
EPISTASIS BETWEEN NEW MUTATIONS AND GENETIC BACKGROUND AND A TEST OF GENETIC CANALIZATION [PDF]
Evolution, 2001 The importance for fitness of epistatic interactions among mutations is poorly known, yet epistasis can exert important effects on the dynamics of evolving populations. We showed previously that epistatic interactions are common between pairs of random insertion mutations in the bacterium Escherichia coli. In this paper, we examine interactions between
S F, Elena, R E, Lenski
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PLoS Biology, 2017 Independently evolving populations may adapt to similar selection pressures via different genetic changes. The interactions between such changes, such as in a hybrid individual, can inform us about what course adaptation may follow and allow us to ...
Jasmine Ono +2 more
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Speciation Genetics: Epistasis, Conflict and the Origin of Species [PDF]
Current Biology, 2007 Evolutionary biologists have long recognized that the sterility and inviability of species hybrids must involve incompatible epistatic interactions between two (or more) genes. The first pair of such hybrid incompatibility genes has now been identified.
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Multidimensional epistasis and the transitory advantage of sex
, 2014 Identifying and quantifying the benefits of sex and recombination is a long standing problem in evolutionary theory. In particular, contradictory claims have been made about the existence of a benefit of recombination on high dimensional fitness ...
Krug, Joachim +3 more
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The Self-Organization of Interaction Networks for Nature-Inspired Optimization
, 2009 Over the last decade, significant progress has been made in understanding complex biological systems, however there have been few attempts at incorporating this knowledge into nature inspired optimization algorithms.
Pham, Q. Tuan +2 more
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Detection and Mapping of Quantitative Trait Loci that Determine Responsiveness [PDF]
, 2004 Exposure to 70% N2O evokes a robust antinociceptive effect in C57BL/6 (B6) but not in DBA/2 (D2) inbred mice. This study was conducted to identify quantitative trait loci (QTL) in the mouse genome that might determine responsiveness to N2O.
Belknap, John K. +4 more
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Determination of Nonlinear Genetic Architecture using Compressed Sensing
, 2015 We introduce a statistical method that can reconstruct nonlinear genetic models (i.e., including epistasis, or gene-gene interactions) from phenotype-genotype (GWAS) data.
Ho, Chiu Man, Hsu, Stephen D. H.
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Does replication groups scoring reduce false positive rate in SNP interaction discovery? [PDF]
, 2010 BACKGROUNG. Computational methods that infer single nucleotide polymorphism (SNP) interactions from phenotype data may uncover new biological mechanisms in non-Mendelian diseases. However, practical aspects of such analysis face many problems.
Curk, Tomaz +3 more
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Mutation supply and the repeatability of selection for antibiotic resistance
, 2017 Whether evolution can be predicted is a key question in evolutionary biology. Here we set out to better understand the repeatability of evolution. We explored experimentally the effect of mutation supply and the strength of selective pressure on the ...
de Visser, J. Arjan G. M. +4 more
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Dominance, epistasis, heritabilities and expected genetic gains [PDF]
Genetics and Molecular Biology, 2005 Although epistasis is common in gene systems that determine quantitative traits, it is usually not possible to estimate the epistatic components of genotypic variance because experiments in breeding programs include only one type of progeny. As the study of this phenomenon is complex, there is a lack of theoretical knowledge on the contribution of the ...
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