Results 81 to 90 of about 49,240 (217)
Recent Statistical Innovations in Human Genetics
Annals of Human Genetics, EarlyView.ABSTRACT We review three areas of human genetics that have been developed in the past few decades, in which statistical innovation has made a crucial contribution with recent important advances and the potential for further rapid progress. The first topic is the development of mathematical models for the genealogy underlying samples of genome‐wide ...
David J. Balding, Doug Speed
wiley +1 more source
DCA for genome-wide epistasis analysis: the statistical genetics perspective [PDF]
Physical Biology, 2019 Direct Coupling Analysis (DCA) is a now widely used method to leverage statistical information from many similar biological systems to draw meaningful conclusions on each system separately. DCA has been applied with great success to sequences of homologous proteins, and also more recently to whole-genome population-wide sequencing data.
Fabio Cecconi +7 more
openaire +5 more sources
Whole genome sequencing reveals epistasis effects within RET for Hirschsprung disease
Scientific Reports, 2022 Common variants in RET and NRG1 have been associated with Hirschsprung disease (HSCR), a congenital disorder characterised by incomplete innervation of distal gut, in East Asian (EA) populations.
Yanbing Wang +9 more
doaj +1 more source
Journal of Animal Breeding and Genetics, EarlyView.ABSTRACT Fitness traits described as a ratio often display non‐normal distributions; consequently, transformations are frequently applied to improve normality prior to the estimation of genetic parameters. However, the impact of different transformations on genetic parameter estimates depends on the dataset at hand.
Evan Hartono +5 more
wiley +1 more source
Epistasis: Searching for Interacting Genetic Variants Using Crosses [PDF]
G3 Genes|Genomes|Genetics, 2017 Within quantitative genetics, the term “epistasis” is used to broadly describe situations in which combinations of genetic variants show nonadditive phenotypic effects ([Phillips 1998][1], [2008][2]; [Mackay 2014][3]).
openaire +6 more sources
Journal of Animal Breeding and Genetics, EarlyView.ABSTRACT Genetic progress of breeding programs is highly dependent on the size of reference populations and the relatedness between reference populations and selection candidates. Many reasons can lead a population to split into several subpopulations (sanitary, physiological, political reasons, etc.).
M. Wicki, A. Legarra, J. Raoul
wiley +1 more source
Evolving concurrent Petri net models of epistasis [PDF]
, 2010 A genetic algorithm is used to learn a non-deterministic Petri netbased model of non-linear gene interactions, or statistical epistasis. Petri nets are computational models of concurrent processes.
Beretta, Lorenzo, Mayo, Michael
core +1 more source
Documenting homoploid hybrid speciation
Molecular Ecology, EarlyView.Abstract Homoploid hybrid speciation is challenging to document because hybridization can lead to outcomes other than speciation. Thus, some authors have argued that establishment of homoploid hybrid speciation should include evidence that reproductive barriers isolating the hybrid neo‐species from its parental species were derived from hybridization ...
Zhiqin Long, Loren H. Rieseberg
wiley +1 more source
Frontiers in Plant Science, 2018 An “immortalized F2” (IF2) population and two reciprocal backcross (HSBCF1 and MARBCF1) populations were constructed to investigate the genetic bases of fiber quality traits in upland cotton across four different environments.
Cong Li +12 more
doaj +1 more source
BioData Mining, 2021 Background In genome-wide association studies the extent and impact of confounding due to population structure have been well recognized. Inadequate handling of such confounding is likely to lead to spurious associations, hampering replication, and the ...
Fentaw Abegaz +9 more
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