Results 81 to 90 of about 58,973 (229)
Genetic mapping of sterile genes with epistasis in backcross designs [PDF]
Heredity, 2013 The mapping of sterile genes is an essential issue, which should be solved for the investigation of sterility mechanism in wide hybridization of plants. However, the methods formerly developed cannot address the problem of mapping sterile loci with epistasis.
Shang-Qian Xie, Bruce Walsh, J Chen
openaire +3 more sources
BMC Genomics, 2008 Background The difficulty in elucidating the genetic basis of complex diseases roots in the many factors that can affect the development of a disease.
Galan Jose +10 more
doaj +1 more source
Positive epistasis drives the acquisition of multidrug resistance. [PDF]
PLoS Genetics, 2009 The evolution of multiple antibiotic resistance is an increasing global problem. Resistance mutations are known to impair fitness, and the evolution of resistance to multiple drugs depends both on their costs individually and on how they interact ...
Sandra Trindade +6 more
doaj +1 more source
Causes and Consequences of genetic background effects illuminated by integrative genomic analysis [PDF]
Genetics 2014 196(4):1321-1336, 2013 The phenotypic consequences of individual mutations are modulated by the wild type genetic background in which they occur.Although such background dependence is widely observed, we do not know whether general patterns across species and traits exist, nor about the mechanisms underlying it.
arxiv +1 more source
Mixed Outcomes in Recombination Rates After Domestication: Revisiting Theory and Data
Molecular Ecology, EarlyView.ABSTRACT The process of domestication has altered many phenotypes. Selection on these phenotypes has long been hypothesised to indirectly select for increases in the genome‐wide recombination rate. This hypothesis is potentially consistent with theory on the evolution of the recombination rate, but empirical support has been unclear. We review relevant
Madeline Bursell +6 more
wiley +1 more source
Quantitative analyses of empirical fitness landscapes
, 2012 The concept of a fitness landscape is a powerful metaphor that offers insight into various aspects of evolutionary processes and guidance for the study of evolution.
de Visser, J. Arjan G. M. +4 more
core +2 more sources
The strength of genetic interactions scales weakly with the mutational effects [PDF]
Genome Biology 2013, 14:R76, 2013 Genetic interactions pervade every aspect of biology, from evolutionary theory where they determine the accessibility of evolutionary paths, to medicine where they contribute to complex genetic diseases. Until very recently, studies on epistatic interactions have been based on a handful of mutations, providing at best anecdotal evidence about the ...
arxiv +1 more source
Using Fitness Surfaces to Better Link Conservation Breeding Programmes With Wild Population Recovery
Molecular Ecology, EarlyView.ABSTRACT Fitness surfaces offer a valuable tool for bridging the gap between captive breeding programmes and wild populations. By quantifying the relationship between phenotypes and reproductive success in captive and wild settings, fitness surfaces can help identify the fitness consequences of phenotypic change in either environment. Measuring fitness
Drew Sauve +3 more
wiley +1 more source
Evolving concurrent Petri net models of epistasis [PDF]
, 2010 A genetic algorithm is used to learn a non-deterministic Petri netbased model of non-linear gene interactions, or statistical epistasis. Petri nets are computational models of concurrent processes.
Beretta, Lorenzo, Mayo, Michael
core +1 more source
Whole genome sequencing reveals epistasis effects within RET for Hirschsprung disease
Scientific Reports, 2022 Common variants in RET and NRG1 have been associated with Hirschsprung disease (HSCR), a congenital disorder characterised by incomplete innervation of distal gut, in East Asian (EA) populations.
Yanbing Wang +9 more
doaj +1 more source