Results 31 to 40 of about 71,733 (264)

Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape

bioRxiv, 2022
Waves of SARS-CoV-2 infection have resulted from the emergence of viral variants with neutralizing antibody resistance mutations. Simultaneously, repeated antigen exposure has generated affinity matured B cells, producing broadly neutralizing receptor ...
Leander Witte, Viren A. Baharani, F. Schmidt, Zijun Wang, A. Cho, Raphael Raspe, Camila Guzmán-Cardozo, F. Muecksch, M. Canis, Debby J. Park, C. Gaebler, M. Caskey, M. Nussenzweig, T. Hatziioannou, P. Bieniasz   +14 more
semanticscholar   +1 more source

The impact of epistasis in the heterosis and combining ability analyses

Frontiers in Plant Science, 2023
The current theoretical knowledge concerning the influence of epistasis on heterosis is based on a simplified multiplicative model. The objective of this study was to assess how epistasis affects the heterosis and combining ability analyses, assuming ...
José Marcelo Soriano Viana
doaj   +1 more source

Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape

mBio, 2022
Emergence of vaccine escape variants of SARS-CoV-2 is arguably the most pressing problem during the COVID-19 pandemic as vaccines are distributed worldwide.
N. Rochman, Guilhem Faure, Y. Wolf, L. Freddolino, Feng Zhang, E. Koonin   +5 more
semanticscholar   +1 more source

Recombining your way out of trouble: the genetic architecture of hybrid fitness under environmental stress [PDF]

, 2020
Hybridization between species is a fundamental evolutionary force that can both promote and delay adaptation. There is a deficit in our understanding of the genetic basis of hybrid fitness, especially in non-domesticated organisms.
Bendixsen, D., Greig, D., Janzen, T., Nolte, A., Stelkens, R., Zhang, Z.   +5 more
core   +1 more source

The interplay of additivity, dominance, and epistasis on fitness in a diploid yeast cross

Nature Communications, 2022
In diploid species, genetic loci can show additive, dominance, and epistatic effects. To characterize the contributions of these different types of genetic effects to heritable traits, we use a double barcoding system to generate and phenotype a panel of
Takeshi Matsui, Martin N. Mullis, Kevin R. Roy, Joseph J. Hale, Rachel Schell, Sasha F. Levy, I. M. Ehrenreich   +6 more
semanticscholar   +1 more source

Multifactorial methods integrating haplotype and epistasis effects for genomic estimation and prediction of quantitative traits

Frontiers in Genetics, 2022
The rapid growth in genomic selection data provides unprecedented opportunities to discover and utilize complex genetic effects for improving phenotypes, but the methodology is lacking. Epistasis effects are interaction effects, and haplotype effects may
Yang Da, Zuoxiang Liang, Dzianis Prakapenka   +2 more
doaj   +1 more source

Widespread epistasis among beneficial genetic variants revealed by high-throughput genome editing

bioRxiv, 2022
Genetic interactions occur when a variant’s phenotypic effect is altered by variation at other genomic loci. Also known as epistasis, these interactions shape the genetic architecture of complex traits and modify phenotypes across genetic backgrounds ...
Roy Moh Lik Ang, Shi-An A. Chen, Alexander F. Kern, Yihua Xie, Hunter B. Fraser   +4 more
semanticscholar   +1 more source

Multary epistasis

Bulletin of the Belgian Mathematical Society - Simon Stevin, 2001
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Iglesias, M. T., Vidal, C., Suys, D., Verschoren, A.   +3 more
openaire   +4 more sources

Environment-dependent epistasis increases phenotypic diversity in gene regulatory networks

bioRxiv, 2022
Mutations to gene regulatory networks can be maladaptive or a source of evolutionary novelty. Epistasis confounds our understanding of how mutations impact the expression patterns of gene regulatory networks, because such nonlinearities make it difficult
F. Baier, F. Gauye, R. Pérez-Carrasco, Joshua L. Payne, Y. Schaerli   +4 more
semanticscholar   +1 more source

Idiosyncratic epistasis leads to global fitness-correlated trends

bioRxiv, 2021
Epistasis can dramatically affect evolutionary trajectories. In recent decades, protein-level fitness landscapes have revealed extensive idiosyncratic epistasis among specific mutations.
Christopher W. Bakerlee, Alex N. Nguyen Ba, Yekaterina Shulgina, Jose I. Rojas Echenique, Michael M. Desai   +4 more
semanticscholar   +1 more source