Results 31 to 40 of about 59,992 (241)
Bulletin of the Belgian Mathematical Society - Simon Stevin, 1999 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Naudts, B., Verschoren, A.
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Epistasis shapes the fitness landscape of an allosteric specificity switch
Nature Communications, 2021 Epistasis plays an important role in the evolution of novel protein functions because it determines the mutational path a protein takes. Here, the authors combine functional, structural and biophysical analyses to characterize epistasis in a ...
Kyle K. Nishikawa +4 more
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Global epistasis on fitness landscapes
Philosophical Transactions of the Royal Society B: Biological Sciences, 2023 Epistatic interactions between mutations add substantial complexity to adaptive landscapes and are often thought of as detrimental to our ability to predict evolution. Yet, patterns of global epistasis, in which the fitness effect of a mutation is well-predicted by the fitness of its genetic background, may actually be of help in our efforts to ...
Juan Diaz-Colunga +6 more
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Hidden epistastic interactions can favour the evolution of sex and recombination. [PDF]
PLoS ONE, 2012 Deleterious mutations can have a strong influence on the outcome of evolution. The nature of this influence depends on how mutations combine together to affect fitness.
Joel R Peck, David Waxman, John J Welch
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Bulletin of the Belgian Mathematical Society - Simon Stevin, 1998 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Van Hove, H., Verschoren, A.
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Stability-mediated epistasis constrains the evolution of an influenza protein. [PDF]
, 2013 John Maynard Smith compared protein evolution to the game where one word is converted into another a single letter at a time, with the constraint that all intermediates are words: WORD→WORE→GORE→GONE→GENE. In this analogy, epistasis constrains evolution,
Bloom, Jesse D +2 more
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Whole genome sequencing reveals epistasis effects within RET for Hirschsprung disease
Scientific Reports, 2022 Common variants in RET and NRG1 have been associated with Hirschsprung disease (HSCR), a congenital disorder characterised by incomplete innervation of distal gut, in East Asian (EA) populations.
Yanbing Wang +9 more
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THE CAUSES OF EPISTASIS IN GENETIC NETWORKS [PDF]
Evolution, 2011 Epistasis refers to the nonadditive interactions between genes in determining phenotypes. Considerable efforts have shown that, even for a given organism, epistasis may vary both in intensity and sign. Recent comparative studies supported that the overall sign of epistasis switches from positive to negative as the complexity of an organism increases ...
Javier Macía +6 more
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Bulletin of the Belgian Mathematical Society - Simon Stevin, 2001 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Iglesias, M. T. +3 more
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BMC Bioinformatics, 2008 Background Genome-wide association studies (GWAS) using single nucleotide polymorphism (SNP) markers provide opportunities to detect epistatic SNPs associated with quantitative traits and to detect the exact mode of an epistasis effect.
Garbe John R +4 more
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