Results 31 to 40 of about 38,666 (258)

The interplay of additivity, dominance, and epistasis on fitness in a diploid yeast cross

Nature Communications, 2022
In diploid species, genetic loci can show additive, dominance, and epistatic effects. To characterize the contributions of these different types of genetic effects to heritable traits, we use a double barcoding system to generate and phenotype a panel of
Takeshi Matsui, Martin N. Mullis, Kevin R. Roy, Joseph J. Hale, Rachel Schell, Sasha F. Levy, I. M. Ehrenreich   +6 more
semanticscholar   +1 more source

Widespread epistasis among beneficial genetic variants revealed by high-throughput genome editing

bioRxiv, 2022
Genetic interactions occur when a variant’s phenotypic effect is altered by variation at other genomic loci. Also known as epistasis, these interactions shape the genetic architecture of complex traits and modify phenotypes across genetic backgrounds ...
Roy Moh Lik Ang, Shi-An A. Chen, Alexander F. Kern, Yihua Xie, Hunter B. Fraser   +4 more
semanticscholar   +1 more source

Genome-wide epistasis analysis for Alzheimer’s disease and implications for genetic risk prediction

Alzheimer's Research & Therapy, 2021
Background Single-nucleotide polymorphisms (SNPs) identified by genome-wide association studies only explain part of the heritability of Alzheimer’s disease (AD).
Hui Wang, D. Bennett, P. D. De Jager, Qing-Ye Zhang, Hong-yu Zhang   +4 more
semanticscholar   +1 more source

Multifactorial methods integrating haplotype and epistasis effects for genomic estimation and prediction of quantitative traits

Frontiers in Genetics, 2022
The rapid growth in genomic selection data provides unprecedented opportunities to discover and utilize complex genetic effects for improving phenotypes, but the methodology is lacking. Epistasis effects are interaction effects, and haplotype effects may
Yang Da, Zuoxiang Liang, Dzianis Prakapenka   +2 more
doaj   +1 more source

Idiosyncratic epistasis leads to global fitness-correlated trends

bioRxiv, 2021
Epistasis can dramatically affect evolutionary trajectories. In recent decades, protein-level fitness landscapes have revealed extensive idiosyncratic epistasis among specific mutations.
Christopher W. Bakerlee, Alex N. Nguyen Ba, Yekaterina Shulgina, Jose I. Rojas Echenique, Michael M. Desai   +4 more
semanticscholar   +1 more source

Improvement of genomic prediction in advanced wheat breeding lines by including additive-by-additive epistasis

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2021
Key message Including additive and additive-by-additive epistasis in a NOIA parametrization did not yield orthogonal partitioning of genetic variances, nevertheless, it improved predictive ability in a leave-one-out cross-validation for wheat grain yield.
M. Raffo, P. Sarup, Xiangyu Guo, Huiming Liu, J. R. Andersen, J. Orabi, A. Jahoor, J. Jensen   +7 more
semanticscholar   +1 more source

Positive epistasis between disease-causing missense mutations and silent polymorphism with effect on mRNA translation velocity

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance The same mutation can have different effects among individuals, and one reason for this is the presence of additional mutations, a relationship known as epistasis. Epistatic effects are difficult to predict.
Robert Rauscher, G. Bampi, M. Guevara-Ferrer, Leonardo A. Santos, D. Joshi, David Mark, L. Strug, J. Rommens, M. Ballmann, E. Sorscher, Kathryn E. Oliver, Z. Ignatova   +11 more
semanticscholar   +1 more source

A model and test for coordinated polygenic epistasis in complex traits

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Systems-level interactions across physiological pathways, cell types, and tissues are core biological elements widely studied across diverse fields including evolution, systems biology, and model-organism genetics.
B. Sheppard, Nadav Rappoport, Po-Ru Loh, Stephan J Sanders, N. Zaitlen, Andy Dahl   +5 more
semanticscholar   +1 more source

Global epistasis emerges from a generic model of a complex trait

bioRxiv, 2020
Epistasis between mutations can make adaptation contingent on evolutionary history. Yet despite widespread “microscopic” epistasis between the mutations involved, microbial evolution experiments show consistent patterns of fitness increase between ...
Gautam Reddy, Michael M. Desai
semanticscholar   +1 more source

Epistasis and deceptivity

Bulletin of the Belgian Mathematical Society - Simon Stevin, 1999
Deceptivity and epistasis both contribute to make tness functions hard to optimize for a genetic algorithm. In this note we examine the relation between these concepts, with particular emphasis on their mutual reinforcement.
Naudts, B., Verschoren, A.
openaire   +3 more sources