Results 41 to 50 of about 59,992 (241)
Two-stage genome-wide search for epistasis with implementation to Recombinant Inbred Lines (RIL) populations. [PDF]
PLoS ONE, 2014 OBJECTIVE AND METHODS:This paper proposes an inegrative two-stage genome-wide search for pairwise epistasis on expression quantitative trait loci (eQTL).
Pavel Goldstein +2 more
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Dynamic network-based epistasis analysis: Boolean examples
Frontiers in Plant Science, 2011 In this review we focus on how the hierarchical and single-path assumptions of epistasis analysis can bias the topologies of gene interactions infered. This has been acknowledged in several previous papers and reviews, but here we emphasize the critical ...
Eugenio eAzpeitia +5 more
doaj +1 more source
, 2021 AbstractWe performed a genome-wide epistasis search across 502 phenotypes in case control matched cohorts from the UK Biobank. We identified 152,519 genome wide significant interactions in 68 distinct phenotypes, and 3,398 interactions in 19 phenotypes were successfully replicated in independent cohorts from the Finngen consortium.
Deepak Rajpal +5 more
openaire +1 more source
Competition between recombination and epistasis can cause a transition from allele to genotype selection [PDF]
, 2009 Biochemical and regulatory interactions central to biological networks are expected to cause extensive genetic interactions or epistasis affecting the heritability of complex traits and the distribution of genotypes in populations. However, the inference
Neher, Richard A., Shraiman, Boris I.
core +3 more sources
Clinical Implications of Digenic Inheritance and Epistasis in Primary Immunodeficiency Disorders
Frontiers in Immunology, 2018 The existence of epistasis in humans was first predicted by Bateson in 1909. Epistasis describes the non-linear, synergistic interaction of two or more genetic loci, which can substantially modify disease severity or result in entirely new phenotypes ...
Rohan Ameratunga +9 more
doaj +1 more source
The Case | Epistasis and urolithiasis
Kidney International, 2017 A 26-year-old woman was referred for recurrent urolithiasis. The first manifestation occurred 3 years before, followed by recurrent acute episodes. She underwent one ureteral stent placement, one shock wave lithotripsy, and at last a flexible ureteroscopy that allowed to retrieve all the remaining stones.
Michel Daudon +10 more
openaire +4 more sources
Epistasis not needed to explain low dN/dS
, 2012 An important question in molecular evolution is whether an amino acid that occurs at a given position makes an independent contribution to fitness, or whether its effect depends on the state of other loci in the organism's genome, a phenomenon known as ...
AL Halpern +19 more
core +1 more source
Statistical Modeling of Epistasis and Linkage Decay using Logic Regression [PDF]
, 2008 Logic regression has been recognized as a tool that can identify and model non-additive genetic interactions using Boolean logic groups. Logic regression, TASSEL-GLM and SAS-GLM were compared for analytical precision using a previously characterized ...
Jean-Luc Jannink +4 more
core +2 more sources
Mathematics, 2020 Epistasis, which indicates the difficulty of a problem, can be used to evaluate the basis of the space in which the problem lies. However, calculating epistasis may be challenging as it requires all solutions to be searched.
Yong-Hoon Kim +2 more
doaj +1 more source
Epistasis: obstacle or advantage for mapping complex traits? [PDF]
PLoS ONE, 2010 Identification of genetic loci in complex traits has focused largely on one-dimensional genome scans to search for associations between single markers and the phenotype.
Koen J F Verhoeven +2 more
doaj +1 more source