Results 41 to 50 of about 71,733 (264)
Physical Constraints on Epistasis [PDF]
Molecular Biology and Evolution, 2020 Abstract Living systems evolve one mutation at a time, but a single mutation can alter the effect of subsequent mutations. The underlying mechanistic determinants of such epistasis are unclear. Here, we demonstrate that the physical dynamics of a biological system can generically constrain epistasis.
Husain, Kabir, Murugan, Arvind
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Genome-wide epistasis analysis for Alzheimer’s disease and implications for genetic risk prediction
Alzheimer's Research & Therapy, 2021 Background Single-nucleotide polymorphisms (SNPs) identified by genome-wide association studies only explain part of the heritability of Alzheimer’s disease (AD).
Hui Wang +4 more
semanticscholar +1 more source
Hidden epistastic interactions can favour the evolution of sex and recombination. [PDF]
PLoS ONE, 2012 Deleterious mutations can have a strong influence on the outcome of evolution. The nature of this influence depends on how mutations combine together to affect fitness.
Joel R Peck, David Waxman, John J Welch
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Stability-mediated epistasis constrains the evolution of an influenza protein. [PDF]
, 2013 John Maynard Smith compared protein evolution to the game where one word is converted into another a single letter at a time, with the constraint that all intermediates are words: WORD→WORE→GORE→GONE→GENE. In this analogy, epistasis constrains evolution,
Bloom, Jesse D +2 more
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Whole genome sequencing reveals epistasis effects within RET for Hirschsprung disease
Scientific Reports, 2022 Common variants in RET and NRG1 have been associated with Hirschsprung disease (HSCR), a congenital disorder characterised by incomplete innervation of distal gut, in East Asian (EA) populations.
Yanbing Wang +9 more
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Global epistasis emerges from a generic model of a complex trait
bioRxiv, 2020 Epistasis between mutations can make adaptation contingent on evolutionary history. Yet despite widespread “microscopic” epistasis between the mutations involved, microbial evolution experiments show consistent patterns of fitness increase between ...
Gautam Reddy, Michael M. Desai
semanticscholar +1 more source
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2021 Key message Including additive and additive-by-additive epistasis in a NOIA parametrization did not yield orthogonal partitioning of genetic variances, nevertheless, it improved predictive ability in a leave-one-out cross-validation for wheat grain yield.
M. Raffo +7 more
semanticscholar +1 more source
Dynamic network-based epistasis analysis: Boolean examples
Frontiers in Plant Science, 2011 In this review we focus on how the hierarchical and single-path assumptions of epistasis analysis can bias the topologies of gene interactions infered. This has been acknowledged in several previous papers and reviews, but here we emphasize the critical ...
Eugenio eAzpeitia +5 more
doaj +1 more source
Two-stage genome-wide search for epistasis with implementation to Recombinant Inbred Lines (RIL) populations. [PDF]
PLoS ONE, 2014 OBJECTIVE AND METHODS:This paper proposes an inegrative two-stage genome-wide search for pairwise epistasis on expression quantitative trait loci (eQTL).
Pavel Goldstein +2 more
doaj +1 more source
BMC Bioinformatics, 2008 Background Genome-wide association studies (GWAS) using single nucleotide polymorphism (SNP) markers provide opportunities to detect epistatic SNPs associated with quantitative traits and to detect the exact mode of an epistasis effect.
Garbe John R +4 more
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