Results 41 to 50 of about 38,666 (258)
Hidden epistastic interactions can favour the evolution of sex and recombination. [PDF]
PLoS ONE, 2012 Deleterious mutations can have a strong influence on the outcome of evolution. The nature of this influence depends on how mutations combine together to affect fitness.
Joel R Peck, David Waxman, John J Welch
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THE CAUSES OF EPISTASIS IN GENETIC NETWORKS [PDF]
Evolution, 2011 Epistasis refers to the nonadditive interactions between genes in determining phenotypes. Considerable efforts have shown that, even for a given organism, epistasis may vary both in intensity and sign. Recent comparative studies supported that the overall sign of epistasis switches from positive to negative as the complexity of an organism increases ...
Javier Macía +6 more
openaire +4 more sources
Genes, 2021 Epistasis is widely considered important, but epistasis studies lag those of SNP effects. Genome-wide association study (GWAS) using 76,109 SNPs and 294,079 first-lactation Holstein cows was conducted for testing pairwise epistasis effects of five ...
Dzianis Prakapenka +4 more
semanticscholar +1 more source
Whole genome sequencing reveals epistasis effects within RET for Hirschsprung disease
Scientific Reports, 2022 Common variants in RET and NRG1 have been associated with Hirschsprung disease (HSCR), a congenital disorder characterised by incomplete innervation of distal gut, in East Asian (EA) populations.
Yanbing Wang +9 more
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EpiMOGA: An Epistasis Detection Method Based on a Multi-Objective Genetic Algorithm
Genes, 2021 In genome-wide association studies, detecting high-order epistasis is important for analyzing the occurrence of complex human diseases and explaining missing heritability. However, there are various challenges in the actual high-order epistasis detection
Yuan-yuan Chen +7 more
semanticscholar +1 more source
Two-stage genome-wide search for epistasis with implementation to Recombinant Inbred Lines (RIL) populations. [PDF]
PLoS ONE, 2014 OBJECTIVE AND METHODS:This paper proposes an inegrative two-stage genome-wide search for pairwise epistasis on expression quantitative trait loci (eQTL).
Pavel Goldstein +2 more
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BMC Bioinformatics, 2008 Background Genome-wide association studies (GWAS) using single nucleotide polymorphism (SNP) markers provide opportunities to detect epistatic SNPs associated with quantitative traits and to detect the exact mode of an epistasis effect.
Garbe John R +4 more
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Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
Nature Communications, 2020 Genetic perturbations that affect bacterial resistance to antibiotics have been characterized genome-wide, but how do such perturbations interact with subsequent evolutionary adaptation to the drug?
Marta Lukačišinová +2 more
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Clinical Implications of Digenic Inheritance and Epistasis in Primary Immunodeficiency Disorders
Frontiers in Immunology, 2018 The existence of epistasis in humans was first predicted by Bateson in 1909. Epistasis describes the non-linear, synergistic interaction of two or more genetic loci, which can substantially modify disease severity or result in entirely new phenotypes ...
Rohan Ameratunga +9 more
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Epistasis between antibiotic tolerance, persistence, and resistance mutations
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance The failure of antibiotic treatment is a major concern worldwide. Resistance is a main determinant in the survival of bacteria under antibiotics.
Irit Levin-Reisman +3 more
semanticscholar +1 more source