Results 41 to 50 of about 60,491 (200)

A Forward Genetics Strategy for High‐Throughput Gene Identification via Precise Image‐Based Phenotyping of an Indexed EMS Mutant Library

Advanced Science, EarlyView.
The GeneHunter‐Gene‐Level Association (GH‐GLA) pipeline enables high‐throughput gene identification in an indexed EMS population of wheat cultivar KN9204. It identifies 5905 trait‐associated wheat genes and validates key regulators of kernel weight and spikelet architecture via gene editing and haplotype analysis.
Haojie Wang, Fujun Sun, Zeyu Shi, Yufeng Yang, Yi Ding, Tengteng Zhang, Caihong Zhao, Jingzhong Xie, Yaqian Zhang, Caihua Li, Wenqiang Tang, Junming Li, Xigang Liu, Shusong Zheng, Ni Jiang, Fei He, Shuzhi Zheng   +16 more
wiley   +1 more source

Whole-genome sequencing bulked segregant analysis uncovered FW7, a Fusarium wilt resistance gene masked by epistasis in octoploid strawberry. [PDF]

Plant Genome
Abstract Fusarium wilt, a vascular disease of strawberry (Fragaria ×$\times$ ananassa) caused by the soilborne fungal pathogen Fusarium oxysporum f. sp. fragariae, has emerged over the past 20 years as a leading cause of severe plant wilt and death in California and many other parts of the world. We previously described several sources of resistance to
Vachev MV, Bjornson M, Pincot DDA, Famula RA, Lovell JT, Harder AM, Handley LH, Grimwood J, Brukental H, Lòpez CM, Cole GS, Feldmann MJ, Knapp SJ.   +12 more
europepmc   +2 more sources

Evolving concurrent Petri net models of epistasis [PDF]

, 2010
A genetic algorithm is used to learn a non-deterministic Petri netbased model of non-linear gene interactions, or statistical epistasis. Petri nets are computational models of concurrent processes.
Beretta, Lorenzo, Mayo, Michael
core   +1 more source

Engineered Leaf‐Branch Compost Cutinase with Enhanced PET Degradation Across a Broad Temperature Range

ChemSusChem, EarlyView.
This study aimed to identify poly(ethylene terephthalate) (PET)‐degrading enzymes effective under industrially relevant conditions. An engineered leaf and branch compost cutinase variant showed enhanced PET hydrolysis across multiple temperatures, outperforming existing enzymes.
Kavita G. Ramnath, Colin T. Pierce, Guillem Casadevall, Silvia Osuna, Jadyn Ide‐Pech, Bryan Zeng, Vishnu Iyer, Romas J. Kazlauskas, Richard A. Gross   +8 more
wiley   +1 more source

Epistatic interactions alter dynamics of multilocus gene-for-gene coevolution. [PDF]

PLoS ONE, 2007
Fitness costs associated with resistance or virulence genes are thought to play a key role in determining the dynamics of gene-for-gene (GFG) host-parasite coevolution. However, the nature of interactions between fitness effects of multiple resistance or
Andy Fenton, Michael A Brockhurst
doaj   +1 more source

Accelerating Enzyme Engineering With Artificial Intelligence in Biocatalysis: Challenges and Opportunities

Food Bioengineering, EarlyView.
ABSTRACT Artificial intelligence (AI) has emerged as a paradigm‐shifting force in enzyme engineering, enabling data‐driven prediction of catalytic activity, stability, and substrate specificity. By integrating large‐scale datasets from structured databases (e.g., PDB, BRENDA) and high‐throughput experimentation (e.g., deep mutational scanning ...
Xiafeng Lu, Min Cao, Muqing Ma, Yan Wu, Maohua Qu, Feng Du, Rongtao Ji, Mimi Duan, Leichi Dong, Kai Liu, Xueqi Zhang, Zhibo Luo   +11 more
wiley   +1 more source

Sign epistasis caused by hierarchy within signalling cascades

Nature Communications, 2018
Sign epistasis clearly constrains evolution, but its causes are difficult to decipher. Here, the authors study epistasis in a signalling cascade, and arrive at a general criterion and understanding of sign epistasis as arising from the inherent hierarchy
Philippe Nghe, Manjunatha Kogenaru, Sander J. Tans   +2 more
doaj   +1 more source

Characterisation of genome-wide association epistasis signals for serum uric acid in human population isolates.

PLoS ONE, 2011
Genome-wide association (GWA) studies have identified a number of loci underlying variation in human serum uric acid (SUA) levels with the SLC2A9 gene having the largest effect identified so far.
Wenhua Wei, Gibran Hemani, Andrew A Hicks, Veronique Vitart, Claudia Cabrera-Cardenas, Pau Navarro, Jennifer Huffman, Caroline Hayward, Sara A Knott, Igor Rudan, Peter P Pramstaller, Sarah H Wild, James F Wilson, Harry Campbell, Malcolm G Dunlop, Nicholas Hastie, Alan F Wright, Chris S Haley   +17 more
doaj   +1 more source

Quantitative Insights into the Genetic Mechanisms of Crop Heterosis

Advanced Genetics, EarlyView.
Inheritance patterns of genomics‐downstream molecules, including transcripts, proteins, and metabolites, are analyzed in hybrid crops. The additive effect, which describes mid‐parent level, is a predominant inheritance pattern in crop heterosis and can be used to improve breeding efficiency of high‐yield hybrid varieties.
Zhiwu Dan, Yunping Chen, Wenchao Huang
wiley   +1 more source

Estimating directional epistasis

Frontiers in Genetics, 2014
Epistasis, i.e. the fact that gene effects depend on the genetic background, is a direct consequence of the complexity of genetic architectures. Despite this, most of the models used in evolutionary and quantitative genetics pay scant attention to ...
Arnaud eLE ROUZIC
doaj   +1 more source