Results 51 to 60 of about 71,733 (264)
A model and test for coordinated polygenic epistasis in complex traits
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Systems-level interactions across physiological pathways, cell types, and tissues are core biological elements widely studied across diverse fields including evolution, systems biology, and model-organism genetics.
B. Sheppard +5 more
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Detecting epistasis via Markov bases [PDF]
, 2010 Rapid research progress in genotyping techniques have allowed large genome-wide association studies. Existing methods often focus on determining associations between single loci and a specific phenotype.
Malaspinas, Anna-Sapfo, Uhler, Caroline
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Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance The same mutation can have different effects among individuals, and one reason for this is the presence of additional mutations, a relationship known as epistasis. Epistatic effects are difficult to predict.
Robert Rauscher +11 more
semanticscholar +1 more source
Epistasis in Monkeyflowers [PDF]
Genetics, 2005 AbstractEpistasis contributes significantly to intrapopulation variation in floral morphology, development time, and male fitness components of Mimulus guttatus. This is demonstrated with a replicated line-cross experiment involving slightly over 7000 plants. The line-cross methodology is based on estimates for means. It thus has greater power than the
openaire +2 more sources
Clinical Implications of Digenic Inheritance and Epistasis in Primary Immunodeficiency Disorders
Frontiers in Immunology, 2018 The existence of epistasis in humans was first predicted by Bateson in 1909. Epistasis describes the non-linear, synergistic interaction of two or more genetic loci, which can substantially modify disease severity or result in entirely new phenotypes ...
Rohan Ameratunga +9 more
doaj +1 more source
Epistasis not needed to explain low dN/dS
, 2012 An important question in molecular evolution is whether an amino acid that occurs at a given position makes an independent contribution to fitness, or whether its effect depends on the state of other loci in the organism's genome, a phenomenon known as ...
AL Halpern +19 more
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Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
Nature Communications, 2020 Genetic perturbations that affect bacterial resistance to antibiotics have been characterized genome-wide, but how do such perturbations interact with subsequent evolutionary adaptation to the drug?
Marta Lukačišinová +2 more
semanticscholar +1 more source
Addressing epistasis in the design of protein function
Proceedings of the National Academy of Sciences of the United States of AmericaMutations in protein active sites can dramatically improve function. The active site, however, is densely packed and extremely sensitive to mutations.
Rosalie Lipsh-Sokolik, S. Fleishman
semanticscholar +1 more source
Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
Nature Communications, 2020 About a thousand genes in the human genome encode for membrane transporters. Among these, several solute carrier proteins (SLCs), representing the largest group of transporters, are still orphan and lack functional characterization.
E. Girardi +17 more
semanticscholar +1 more source
Competition between recombination and epistasis can cause a transition from allele to genotype selection [PDF]
, 2009 Biochemical and regulatory interactions central to biological networks are expected to cause extensive genetic interactions or epistasis affecting the heritability of complex traits and the distribution of genotypes in populations. However, the inference
Neher, Richard A., Shraiman, Boris I.
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