Results 51 to 60 of about 38,666 (258)
The Case | Epistasis and urolithiasis
Kidney International, 2017 A 26-year-old woman was referred for recurrent urolithiasis. The first manifestation occurred 3 years before, followed by recurrent acute episodes. She underwent one ureteral stent placement, one shock wave lithotripsy, and at last a flexible ureteroscopy that allowed to retrieve all the remaining stones.
Michel Daudon +10 more
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, 2021 AbstractWe performed a genome-wide epistasis search across 502 phenotypes in case control matched cohorts from the UK Biobank. We identified 152,519 genome wide significant interactions in 68 distinct phenotypes, and 3,398 interactions in 19 phenotypes were successfully replicated in independent cohorts from the Finngen consortium.
Deepak Rajpal +5 more
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Bulletin of the Belgian Mathematical Society - Simon Stevin, 2001 Abstract: In this note, we introduce and study the notion of normalized epistasis of a fitness function over not necessary binary alphabets, as an indicator of its CA-hardness, Fitness functions with minimal and maximal normalized epistasis are explicitly described.
Iglesias, M. T. +3 more
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Dynamic network-based epistasis analysis: Boolean examples
Frontiers in Plant Science, 2011 In this review we focus on how the hierarchical and single-path assumptions of epistasis analysis can bias the topologies of gene interactions infered. This has been acknowledged in several previous papers and reviews, but here we emphasize the critical ...
Eugenio eAzpeitia +5 more
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Idiosyncratic epistasis creates universals in mutational effects and evolutionary trajectories
Nature Ecology & Evolution, 2020 Patterns of epistasis and shapes of fitness landscapes are of wide interest because of their bearings on a number of evolutionary theories. The common phenomena of slowing fitness increases during adaptations and diminishing returns from beneficial ...
Daniel M. Lyons +3 more
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Mathematics, 2020 Epistasis, which indicates the difficulty of a problem, can be used to evaluate the basis of the space in which the problem lies. However, calculating epistasis may be challenging as it requires all solutions to be searched.
Yong-Hoon Kim +2 more
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Epistasis: obstacle or advantage for mapping complex traits? [PDF]
PLoS ONE, 2010 Identification of genetic loci in complex traits has focused largely on one-dimensional genome scans to search for associations between single markers and the phenotype.
Koen J F Verhoeven +2 more
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Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
Nature Communications, 2020 About a thousand genes in the human genome encode for membrane transporters. Among these, several solute carrier proteins (SLCs), representing the largest group of transporters, are still orphan and lack functional characterization.
E. Girardi +17 more
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Epigenetics, epistasis and epidemics [PDF]
Evolution, Medicine, and Public Health, 2013 Department of Microbiology, Ramon y Cajal University Hospital, Ramon y Cajal Institute for Health Research (IRYCIS), Madrid, Spain *Correspondence address. Department of Microbiology, Ramon y Cajal University Hospital, Carretera de Colmenar km 9,100. 28034 Madrid, Spain.
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Mechanistic causes of sign epistasis and its applications
Frontiers in GeneticsMapping genetic variations to phenotypic variations poses a significant challenge, as mutations often combine unexpectedly, diverging from assumed additive effects even in the same environment.
Jinqiu Zhang +5 more
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