Results 51 to 60 of about 55,446 (204)
The consistency of beneficial fitness effects of mutations across diverse genetic backgrounds. [PDF]
PLoS ONE, 2012 Parallel and convergent evolution have been remarkably common observations in molecular adaptation but primarily in the context of the same genotype adapting to the same conditions.
Victoria M Pearson +2 more
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Epigenetics, epistasis and epidemics [PDF]
Evolution, Medicine, and Public Health, 2013 Department of Microbiology, Ramon y Cajal University Hospital, Ramon y Cajal Institute for Health Research (IRYCIS), Madrid, Spain *Correspondence address. Department of Microbiology, Ramon y Cajal University Hospital, Carretera de Colmenar km 9,100. 28034 Madrid, Spain.
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Mechanistic causes of sign epistasis and its applications
Frontiers in GeneticsMapping genetic variations to phenotypic variations poses a significant challenge, as mutations often combine unexpectedly, diverging from assumed additive effects even in the same environment.
Jinqiu Zhang +5 more
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Competition between recombination and epistasis can cause a transition from allele to genotype selection [PDF]
, 2009 Biochemical and regulatory interactions central to biological networks are expected to cause extensive genetic interactions or epistasis affecting the heritability of complex traits and the distribution of genotypes in populations. However, the inference
Neher, Richard A., Shraiman, Boris I.
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Journal of Animal Breeding and Genetics, EarlyView.ABSTRACT Fitness traits described as a ratio often display non‐normal distributions; consequently, transformations are frequently applied to improve normality prior to the estimation of genetic parameters. However, the impact of different transformations on genetic parameter estimates depends on the dataset at hand.
Evan Hartono +5 more
wiley +1 more source
A general model for multilocus epistatic interactions in case-control studies. [PDF]
PLoS ONE, 2010 BACKGROUND: Epistasis, i.e., the interaction of alleles at different loci, is thought to play a central role in the formation and progression of complex diseases.
Zhong Wang +5 more
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Documenting homoploid hybrid speciation
Molecular Ecology, EarlyView.Abstract Homoploid hybrid speciation is challenging to document because hybridization can lead to outcomes other than speciation. Thus, some authors have argued that establishment of homoploid hybrid speciation should include evidence that reproductive barriers isolating the hybrid neo‐species from its parental species were derived from hybridization ...
Zhiqin Long, Loren H. Rieseberg
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Epistasis in protein evolution [PDF]
Protein Science, 2016 AbstractThe structure, function, and evolution of proteins depend on physical and genetic interactions among amino acids. Recent studies have used new strategies to explore the prevalence, biochemical mechanisms, and evolutionary implications of these interactions—called epistasis—within proteins.
Tyler N. Starr, Joseph W. Thornton
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Selection on genome‐wide gene expression plasticity of rice in wet and dry field environments
Molecular Ecology, EarlyView.Abstract Gene expression can be highly plastic in response to environmental variation. However, we know little about how expression plasticity is shaped by natural selection and evolves in wild and domesticated species. We used genotypic selection analysis to characterize selection on drought‐induced plasticity of over 7,500 leaf transcripts of 118 ...
Elena Hamann +7 more
wiley +1 more source
Epistatic interactions alter dynamics of multilocus gene-for-gene coevolution. [PDF]
PLoS ONE, 2007 Fitness costs associated with resistance or virulence genes are thought to play a key role in determining the dynamics of gene-for-gene (GFG) host-parasite coevolution. However, the nature of interactions between fitness effects of multiple resistance or
Andy Fenton, Michael A Brockhurst
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