Results 51 to 60 of about 29,904 (215)
Fitness ranking of individual mutants drives patterns of epistatic interactions in HIV-1. [PDF]
PLoS ONE, 2011 Fitness interactions between mutations, referred to as epistasis, can strongly impact evolution. For RNA viruses and retroviruses with their high mutation rates, epistasis may be particularly important to overcome fitness losses due to the accumulation ...
Javier P Martínez +6 more
doaj +1 more source
Epistasis Detection via the Joint Cumulant [PDF]
, 2022 Randall Reese +5 more
openalex +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Plant‐derived secondary metabolites act as regulators of in planta defence. Plant phenylpropanoid metabolic compounds, including final metabolites such as lignin and flavonoids, and a few intermediate metabolites play critical roles in defence.
Dan Chen +9 more
wiley +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Genomic selection (GS) is critical for accelerating genetic gain in modern plant breeding. Deep learning approaches offer powerful non‐linear representation capabilities for modelling non‐additive effects. However, their application in GS remains restricted, as high‐dimensional, low‐sample and noisy data hinder the identification of ...
Yuexin Ma +7 more
wiley +1 more source
PLoS Computational BiologyEpistasis among driver mutations is pervasive and explains relevant features of cancer, such as differential therapy response and convergence towards well-characterized molecular subtypes.
Carla Alejandre +2 more
doaj +1 more source
G3: Genes, Genomes, Genetics, 2019 Epistasis is an important contributor to genetic variance. In inbred populations, pairwise epistasis is present as additive by additive interactions.
Nicholas Santantonio +2 more
doaj +1 more source
Long-Range Epistasis Mediated by Structural Change in a Model of Ligand Binding Proteins. [PDF]
PLoS ONE, 2016 Recent analyses of amino acid mutations in proteins reveal that mutations at many pairs of sites are epistatic-i.e., their effects on fitness are non-additive-the combined effect of two mutations being significantly larger or smaller than the sum of ...
Erik D Nelson, Nick V Grishin
doaj +1 more source
Artificial intelligence‐powered plant phenomics: Progress, challenges, and opportunities
The Plant Phenome Journal, Volume 9, Issue 1, December 2026.Abstract Artificial intelligence (AI), a key driver of the Fourth Industrial Revolution, is being rapidly integrated into plant phenomics to automate sensing, accelerate data analysis, and support decision‐making in phenomic prediction and genomic selection.
Xu Wang +12 more
wiley +1 more source
Influence of epistasis on response to genomic selection using complete sequence data
Genetics Selection Evolution, 2017 Background The effect of epistasis on response to selection is a highly debated topic. Here, we investigated the impact of epistasis on response to sequence-based selection via genomic best linear prediction (GBLUP) in a regime of strong non-symmetrical ...
Natalia S. Forneris +3 more
doaj +1 more source
A century of theories of balancing selection
Biological Reviews, Volume 101, Issue 2, Page 804-825, April 2026.ABSTRACT Traits that affect organismal fitness are often highly genetically variable. This genetic variation is vital for populations to adapt to their environments, but it is also surprising given that nature – after all – ‘selects’ the best genotypes at the expense of those that fall short.
Filip Ruzicka +10 more
wiley +1 more source