Results 61 to 70 of about 29,904 (215)

Privacy-preserving decision tree for epistasis detection

Cybersecurity, 2019
The interaction between gene loci, namely epistasis, is a widespread biological genetic phenomenon. In genome-wide association studies(GWAS), epistasis detection of complex diseases is a major challenge. Although many approaches using statistics, machine
Qingfeng Chen, Xu Zhang, Ruchang Zhang
doaj   +1 more source

Phenotype Prediction Under Epistasis

, 2021
Reliable methods of phenotype prediction from genomic data play an increasingly important role in many areas of plant and animal breeding. Thus, developing methods that enhance prediction accuracy is of major interest. Here, we provide three methods for this purpose: (1) Genomic Best Linear Unbiased Prediction (GBLUP) as a model just accounting for ...
Vojgani, Elaheh, Pook, Torsten, Simianer, Henner, Wong, Ka-Chun   +3 more
openaire   +3 more sources

Small RNAs regulation and genomic harmony: insights into allopolyploid evolution in marsh orchids (Dactylorhiza)

New Phytologist, Volume 250, Issue 1, Page 648-660, April 2026.
Summary Hybridization and polyploidy are major drivers of plant diversification, often accompanied by shifts in gene expression and genome composition. Small RNAs (smRNAs) are thought to influence such genomic changes, particularly through their interactions with transposable elements (TEs).
Mimmi C. Eriksson, Matthew Thornton, Emiliano Trucchi, Thomas M. Wolfe, Francisco Balao, Mikael Hedrén, Ovidiu Paun   +6 more
wiley   +1 more source

Evaluating Methods for Modeling Epistasis Networks with Application to Head and Neck Cancer

Cancer Informatics, 2015
Epistasis helps to explain how multiple single-nucleotide polymorphisms (SNPs) interact to cause disease. A variety of tools have been developed to detect epistasis.
Rajesh Talluri, Sanjay Shete
doaj   +1 more source

Strong Selection Significantly Increases Epistatic Interactions in the Long-Term Evolution of a Protein. [PDF]

PLoS Genetics, 2016
Epistatic interactions between residues determine a protein's adaptability and shape its evolutionary trajectory. When a protein experiences a changed environment, it is under strong selection to find a peak in the new fitness landscape.
Aditi Gupta, Christoph Adami
doaj   +1 more source

UGA4 and YBR062C Regulate Oxidative Stress Tolerance Under Heavy Metal Toxicity

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Under heavy metal stress, global cap‐dependent translation is compromised. However, expression of URE2, a key gene involved in cellular tolerance to heavy metal toxicity, is maintained through an internal ribosome entry site (IRES)–mediated mode of translation.
Mustafa Al‐gafari, Houman Moteshareie, Thomas D. D. Kazmirchuk, Jiashu Wang, Sarah Takallou, Parvin Khosravifar, Mohsen Hooshyar, Bahram Samanfar, Ashkan Golshani   +8 more
wiley   +1 more source

Evolution of Senescence by Damage Accumulation That Accelerates With Age Throughout an Organism's Lifespan

Ecology and Evolution, Volume 16, Issue 3, March 2026.
Senescence evolution is usually explained by reduced selection on late acting genes. Here we develop a new model for senescence evolution that complements the classic theory by focusing on genes that affect mortality throughout lifespan. Our work sheds light on the dynamics of senescence evolution and helps to reconcile phenomena that presented ...
Darar Bega, Lilach Hadany
wiley   +1 more source

CRISPR‐induced knockouts reveal a dual role for the soybean NFR5α gene in symbiotic nitrogen fixation and root hair development

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Nitrogen fixation in soybeans, facilitated by symbiotic interactions with rhizobia, is a cornerstone of sustainable agriculture, reducing reliance on synthetic fertilizers. However, the efficiency of symbiotic nitrogen fixation (SNF) varies due to natural genetic variation in SNF‐related genes.
Mohsen Niazian, Maxime de Ronne, Chantal J. Beauchamp, François Belzile, Davoud Torkamaneh   +4 more
wiley   +1 more source

Interaction models matter: an efficient, flexible computational framework for model-specific investigation of epistasis

BioData Mining
Purpose Epistasis, the interaction between two or more genes, is integral to the study of genetics and is present throughout nature. Yet, it is seldom fully explored as most approaches primarily focus on single-locus effects, partly because analyzing all
Sandra Batista, Vered Senderovich Madar, Philip J. Freda, Priyanka Bhandary, Attri Ghosh, Nicholas Matsumoto, Apurva S. Chitre, Abraham A. Palmer, Jason H. Moore   +8 more
doaj   +1 more source

Hybrid kernels integrating genomic and multispectral data improve wheat genomic prediction accuracy

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Genomic selection (GS) is transforming plant breeding by enabling more accurate and efficient identification of superior genotypes. However, its practical implementation remains challenging, as achieving high prediction accuracy is critical for its success. Several factors—including sample size, the degree of relatedness among individuals, and
Osval A. Montesinos‐López, Joel A. Martínez‐Regalado, Cintia Leonora Murillo‐Avalos, Andrew W. Herr, Abelardo Montesinos‐López, Iván Delgado‐Enciso, Jaime Cuevas, José Crossa, Arron H. Carter   +8 more
wiley   +1 more source