Results 61 to 70 of about 71,733 (264)
Mathematics, 2020 Epistasis, which indicates the difficulty of a problem, can be used to evaluate the basis of the space in which the problem lies. However, calculating epistasis may be challenging as it requires all solutions to be searched.
Yong-Hoon Kim +2 more
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A general model for multilocus epistatic interactions in case-control studies. [PDF]
PLoS ONE, 2010 BACKGROUND: Epistasis, i.e., the interaction of alleles at different loci, is thought to play a central role in the formation and progression of complex diseases.
Zhong Wang +5 more
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Idiosyncratic epistasis creates universals in mutational effects and evolutionary trajectories
Nature Ecology & Evolution, 2020 Patterns of epistasis and shapes of fitness landscapes are of wide interest because of their bearings on a number of evolutionary theories. The common phenomena of slowing fitness increases during adaptations and diminishing returns from beneficial ...
Daniel M. Lyons +3 more
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Information content of colored motifs in complex networks [PDF]
, 2011 We study complex networks in which the nodes of the network are tagged with different colors depending on the functionality of the nodes (colored graphs), using information theory applied to the distribution of motifs in such networks.
Arend Hintze +4 more
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The American Biology Teacher, 2022 Through the artistic planning tool known to comic book artists and animators as storyboarding, students will embark on comic bookâstyle adventures to plan, describe, and visualize the complex life of genes through the non-Mendelian concept of epistasis.
Caryn Babaian, Sudhir Kumar
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Mechanistic causes of sign epistasis and its applications
Frontiers in GeneticsMapping genetic variations to phenotypic variations poses a significant challenge, as mutations often combine unexpectedly, diverging from assumed additive effects even in the same environment.
Jinqiu Zhang +5 more
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Epistasis: obstacle or advantage for mapping complex traits? [PDF]
PLoS ONE, 2010 Identification of genetic loci in complex traits has focused largely on one-dimensional genome scans to search for associations between single markers and the phenotype.
Koen J F Verhoeven +2 more
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Epistasis between antibiotic tolerance, persistence, and resistance mutations
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance The failure of antibiotic treatment is a major concern worldwide. Resistance is a main determinant in the survival of bacteria under antibiotics.
Irit Levin-Reisman +3 more
semanticscholar +1 more source
Genes, 2021 Epistasis is widely considered important, but epistasis studies lag those of SNP effects. Genome-wide association study (GWAS) using 76,109 SNPs and 294,079 first-lactation Holstein cows was conducted for testing pairwise epistasis effects of five ...
Dzianis Prakapenka +4 more
semanticscholar +1 more source
The consistency of beneficial fitness effects of mutations across diverse genetic backgrounds. [PDF]
PLoS ONE, 2012 Parallel and convergent evolution have been remarkably common observations in molecular adaptation but primarily in the context of the same genotype adapting to the same conditions.
Victoria M Pearson +2 more
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