Results 61 to 70 of about 55,446 (204)
Dynamic epistasis for different alleles of the same gene [PDF]
, 2014 Epistasis refers to the phenomenon in which phenotypic consequences caused by mutation of one gene depend on one or more mutations at another gene. Epistasis is critical for understanding many genetic and evolutionary processes, including pathway organization, evolution of sexual reproduction, mutational load, ploidy, genomic complexity, speciation ...
arxiv +1 more source
Molecular Ecology, EarlyView.ABSTRACT Plants adapt to their local environment through complex interactions between genes, gene networks and hormones. Although the impact of gene expression on trait regulation and evolution has been recognised for many decades, its role in the evolution of adaptation is still a subject of intense exploration.
Zoe Broad +7 more
wiley +1 more source
PLoS ONE, 2011 Genome-wide association (GWA) studies have identified a number of loci underlying variation in human serum uric acid (SUA) levels with the SLC2A9 gene having the largest effect identified so far.
Wenhua Wei +17 more
doaj +1 more source
Global epistasis on fitness landscapes [PDF]
arXiv, 2022 Epistatic interactions between mutations add substantial complexity to adaptive landscapes, and are often thought of as detrimental to our ability to predict evolution. Yet, patterns of global epistasis, in which the fitness effect of a mutation is well-predicted by the fitness of its genetic background, may actually be of help in our efforts to ...
arxiv
The effect of host heterogeneity and parasite intragenomic interactions on parasite population structure [PDF]
, 2005 Understanding the processes that shape the genetic structure of parasite populations and the functional consequences of different parasite genotypes is critical for our ability to predict how an infection can spread through a host population and for the ...
Agrawal A +4 more
core +2 more sources
Mixed Outcomes in Recombination Rates After Domestication: Revisiting Theory and Data
Molecular Ecology, EarlyView.ABSTRACT The process of domestication has altered many phenotypes. Selection on these phenotypes has long been hypothesised to indirectly select for increases in the genome‐wide recombination rate. This hypothesis is potentially consistent with theory on the evolution of the recombination rate, but empirical support has been unclear. We review relevant
Madeline Bursell +6 more
wiley +1 more source
Using Fitness Surfaces to Better Link Conservation Breeding Programmes With Wild Population Recovery
Molecular Ecology, EarlyView.ABSTRACT Fitness surfaces offer a valuable tool for bridging the gap between captive breeding programmes and wild populations. By quantifying the relationship between phenotypes and reproductive success in captive and wild settings, fitness surfaces can help identify the fitness consequences of phenotypic change in either environment. Measuring fitness
Drew Sauve +3 more
wiley +1 more source
Epistasis detectably alters correlations between genomic sites in a narrow parameter window.
PLoS ONE, 2019 Different genomic sites evolve inter-dependently due to the combined action of epistasis, defined as a non-multiplicative contribution of alleles at different loci to genome fitness, and the physical linkage of different loci in genome.
Gabriele Pedruzzi, Igor M Rouzine
doaj +1 more source
Long-Range Epistasis Mediated by Structural Change in a Model of Ligand Binding Proteins. [PDF]
PLoS ONE, 2016 Recent analyses of amino acid mutations in proteins reveal that mutations at many pairs of sites are epistatic-i.e., their effects on fitness are non-additive-the combined effect of two mutations being significantly larger or smaller than the sum of ...
Erik D Nelson, Nick V Grishin
doaj +1 more source
Quantitative analyses of empirical fitness landscapes
, 2012 The concept of a fitness landscape is a powerful metaphor that offers insight into various aspects of evolutionary processes and guidance for the study of evolution.
de Visser, J. Arjan G. M. +4 more
core +2 more sources