Results 61 to 70 of about 59,992 (241)
Epistatic interactions alter dynamics of multilocus gene-for-gene coevolution. [PDF]
PLoS ONE, 2007 Fitness costs associated with resistance or virulence genes are thought to play a key role in determining the dynamics of gene-for-gene (GFG) host-parasite coevolution. However, the nature of interactions between fitness effects of multiple resistance or
Andy Fenton, Michael A Brockhurst
doaj +1 more source
A Nuclear Hormone Receptor nhr‐76 Induces Age‐Dependent Chemotaxis Decline in C. elegans
Aging Cell, EarlyView.A forward genetic screen in C. elegans identified a nuclear hormone receptor, nhr‐76, as a gene that programs age‐dependent behavioral decline. In post‐reproductive adults, NHR‐76 downregulates odr‐10 that encodes an odorant receptor, leading to impaired chemotaxis.
Rikuou Yokosawa, Kentaro Noma
wiley +1 more source
Sign epistasis caused by hierarchy within signalling cascades
Nature Communications, 2018 Sign epistasis clearly constrains evolution, but its causes are difficult to decipher. Here, the authors study epistasis in a signalling cascade, and arrive at a general criterion and understanding of sign epistasis as arising from the inherent hierarchy
Philippe Nghe +2 more
doaj +1 more source
PLoS ONE, 2011 Genome-wide association (GWA) studies have identified a number of loci underlying variation in human serum uric acid (SUA) levels with the SLC2A9 gene having the largest effect identified so far.
Wenhua Wei +17 more
doaj +1 more source
ERAP1 Allotypes 2 and 10 Differentially Regulate the Immunopeptidome of Melanocytes
Immunology, EarlyView.ERAP1 is an intracellular aminopeptidase that edits antigenic peptides to be presented by MHC class I molecules and is found in distinct functional allotypes in individuals. To investigate how different disease‐associated ERAP1 allotypes affect the cellular immunopeptidome, we generated A375 melanoma cell clones carrying either allotype 2 or allotype ...
Martha Nikopaschou +6 more
wiley +1 more source
Evidence of epistasis between Interleukin-1 and Selenoprotein-S with susceptibility to rheumatoid arthritis [PDF]
, 2009 Objective: Selenoprotein-S (SELS) is involved in the stress response within the endoplasmic reticulum (ER) and inflammation. Recently, promoter variants in the SELS gene were shown to be associated with plasma levels of interleukin (IL)6, IL1β and tumour
Binks, M.H. +5 more
core +2 more sources
Journal of Animal Breeding and Genetics, EarlyView.ABSTRACT Genetic progress of breeding programs is highly dependent on the size of reference populations and the relatedness between reference populations and selection candidates. Many reasons can lead a population to split into several subpopulations (sanitary, physiological, political reasons, etc.).
M. Wicki, A. Legarra, J. Raoul
wiley +1 more source
Generation mean analysis of the key earliness related traits in cowpea (Vigna unguiculata (L.) Walp)
Scientific African, 2022 The nature of gene action controlling agronomic traits enables plant breeders to execute a successful crop improvement programme. To elucidate the type of gene action governing the key earliness related traits in cowpea, seven populations of the six ...
Emmanuel Yaw Owusu +6 more
doaj +1 more source
COMPUTING AND INFORMATICS, 1995 Summary: We compare two previously introduced notions of epistasis and prove that they are essentially equivalent.
van Hove, H., Verschoren, Alain
openaire +3 more sources
Quantitative analyses of empirical fitness landscapes
, 2012 The concept of a fitness landscape is a powerful metaphor that offers insight into various aspects of evolutionary processes and guidance for the study of evolution.
de Visser, J. Arjan G. M. +4 more
core +2 more sources