Results 61 to 70 of about 38,666 (258)
The consistency of beneficial fitness effects of mutations across diverse genetic backgrounds. [PDF]
PLoS ONE, 2012 Parallel and convergent evolution have been remarkably common observations in molecular adaptation but primarily in the context of the same genotype adapting to the same conditions.
Victoria M Pearson +2 more
doaj +1 more source
GenEpi: gene-based epistasis discovery using machine learning
BMC Bioinformatics, 2020 Background Genome-wide association studies (GWAS) provide a powerful means to identify associations between genetic variants and phenotypes. However, GWAS techniques for detecting epistasis, the interactions between genetic variants associated with ...
Yu-Chuan Chang +9 more
doaj +1 more source
A general model for multilocus epistatic interactions in case-control studies. [PDF]
PLoS ONE, 2010 BACKGROUND: Epistasis, i.e., the interaction of alleles at different loci, is thought to play a central role in the formation and progression of complex diseases.
Zhong Wang +5 more
doaj +1 more source
Blood, 2020 Large-scale sequencing studies of hematologic malignancies have revealed notable epistasis among high-frequency mutations. One of the most striking examples of epistasis occurs for mutations in RNA splicing factors.
Justin Taylor +17 more
semanticscholar +1 more source
Drug Resistance Predictions Based on a Directed Flag Transformer
Advanced Science, EarlyView.CAPTURE, a deep learning framework combining structural and sequence data to predict drug‐resistant Mpro mutations, revealing that PAXLOVID use may be accelerating resistance—supporting real‐time viral surveillance and therapeutic design. Abstract The evolving SARS‐CoV‐2 virus threatens global public health, particularly with potential resistance to ...
Dong Chen +8 more
wiley +1 more source
Floral scent of artificial hybrids between two Schiedea species that share a moth pollinator
American Journal of Botany, Volume 112, Issue 7, July 2025.Abstract Premise In flowering plants, pollinators' ability to recognize chemical displays of hybrids may erode reproductive barriers. Hybrids may produce novel or altered floral scent blends that are unattractive, or scents similar to either parent that remain attractive and promote backcrossing.
John M. Powers +3 more
wiley +1 more source
ChemSusChem, EarlyView.Managing synthetic polymer waste is a major challenge. While enzymatic polyamide (PA) hydrolysis holds great recycling potential, it is limited by ineffective polyamidases. The polyamidase NylCp2‐TS is evolved through random mutagenesis and incremental docking, yielding NylC‐HP with enhanced activity and stability.
Hendrik Puetz +6 more
wiley +1 more source
Epistatic interactions alter dynamics of multilocus gene-for-gene coevolution. [PDF]
PLoS ONE, 2007 Fitness costs associated with resistance or virulence genes are thought to play a key role in determining the dynamics of gene-for-gene (GFG) host-parasite coevolution. However, the nature of interactions between fitness effects of multiple resistance or
Andy Fenton, Michael A Brockhurst
doaj +1 more source
Sign epistasis caused by hierarchy within signalling cascades
Nature Communications, 2018 Sign epistasis clearly constrains evolution, but its causes are difficult to decipher. Here, the authors study epistasis in a signalling cascade, and arrive at a general criterion and understanding of sign epistasis as arising from the inherent hierarchy
Philippe Nghe +2 more
doaj +1 more source
PLoS ONE, 2011 Genome-wide association (GWA) studies have identified a number of loci underlying variation in human serum uric acid (SUA) levels with the SLC2A9 gene having the largest effect identified so far.
Wenhua Wei +17 more
doaj +1 more source