Results 71 to 80 of about 71,733 (264)
EpiMOGA: An Epistasis Detection Method Based on a Multi-Objective Genetic Algorithm
Genes, 2021 In genome-wide association studies, detecting high-order epistasis is important for analyzing the occurrence of complex human diseases and explaining missing heritability. However, there are various challenges in the actual high-order epistasis detection
Yuan-yuan Chen +7 more
semanticscholar +1 more source
Hamiltonian model for multidimensional epistasis [PDF]
, 2002 We propose and solve a Hamiltonian model for multidimensional epistastatic interactions between beneficial mutations. The model is able to give rise either to a phase transition between two equilibrium states, without any coexistence, or exhibits a state
AYŞE ERZAN +3 more
core +2 more sources
Proceedings of the Royal Society B: Biological Sciences, 2011 Since Bateson's discovery that genes can suppress the phenotypic effects of other genes, gene interactions—called epistasis—have been the topic of a vast research effort. Systems and developmental biologists study epistasis to understand the genotype–phenotype map, whereas evolutionary biologists recognize the fundamental importance of epistasis for ...
de Visser, J.A.G.M. +2 more
openaire +4 more sources
Sign epistasis caused by hierarchy within signalling cascades
Nature Communications, 2018 Sign epistasis clearly constrains evolution, but its causes are difficult to decipher. Here, the authors study epistasis in a signalling cascade, and arrive at a general criterion and understanding of sign epistasis as arising from the inherent hierarchy
Philippe Nghe +2 more
doaj +1 more source
Epistatic interactions alter dynamics of multilocus gene-for-gene coevolution. [PDF]
PLoS ONE, 2007 Fitness costs associated with resistance or virulence genes are thought to play a key role in determining the dynamics of gene-for-gene (GFG) host-parasite coevolution. However, the nature of interactions between fitness effects of multiple resistance or
Andy Fenton, Michael A Brockhurst
doaj +1 more source
Generation mean analysis of the key earliness related traits in cowpea (Vigna unguiculata (L.) Walp)
Scientific African, 2022 The nature of gene action controlling agronomic traits enables plant breeders to execute a successful crop improvement programme. To elucidate the type of gene action governing the key earliness related traits in cowpea, seven populations of the six ...
Emmanuel Yaw Owusu +6 more
doaj +1 more source
Effects of Epistasis and Pleiotropy on Fitness Landscapes
, 2013 The factors that influence genetic architecture shape the structure of the fitness landscape, and therefore play a large role in the evolutionary dynamics. Here the NK model is used to investigate how epistasis and pleiotropy -- key components of genetic
A Dawid +15 more
core +1 more source
Evidence of epistasis between Interleukin-1 and Selenoprotein-S with susceptibility to rheumatoid arthritis [PDF]
, 2009 Objective: Selenoprotein-S (SELS) is involved in the stress response within the endoplasmic reticulum (ER) and inflammation. Recently, promoter variants in the SELS gene were shown to be associated with plasma levels of interleukin (IL)6, IL1β and tumour
Binks, M.H. +5 more
core +2 more sources
PLoS ONE, 2011 Genome-wide association (GWA) studies have identified a number of loci underlying variation in human serum uric acid (SUA) levels with the SLC2A9 gene having the largest effect identified so far.
Wenhua Wei +17 more
doaj +1 more source
Robustness and epistasis in mutation-selection models
, 2009 We investigate the fitness advantage associated with the robustness of a phenotype against deleterious mutations using deterministic mutation-selection models of quasispecies type equipped with a mesa shaped fitness landscape.
Andrea Wolff +11 more
core +2 more sources