Results 71 to 80 of about 55,446 (204)
Evidence of epistasis between Interleukin-1 and Selenoprotein-S with susceptibility to rheumatoid arthritis [PDF]
, 2009 Objective: Selenoprotein-S (SELS) is involved in the stress response within the endoplasmic reticulum (ER) and inflammation. Recently, promoter variants in the SELS gene were shown to be associated with plasma levels of interleukin (IL)6, IL1β and tumour
Binks, M.H. +5 more
core +2 more sources
Plant, Cell &Environment, Volume 48, Issue 5, Page 3529-3543, May 2025.ABSTRACT Growth heterosis is crucial for Populus deltoides breeding, a key industrial‐timber and ecological‐construction tree species in temperate regions. However, the molecular mechanisms underlying carbon (C)–nitrogen (N) metabolism coordination in regulating growth heterosis remain unclear. Herein high‐hybrids of P.
Jing Zhang +8 more
wiley +1 more source
Sign epistasis caused by hierarchy within signalling cascades
Nature Communications, 2018 Sign epistasis clearly constrains evolution, but its causes are difficult to decipher. Here, the authors study epistasis in a signalling cascade, and arrive at a general criterion and understanding of sign epistasis as arising from the inherent hierarchy
Philippe Nghe +2 more
doaj +1 more source
Detecting epistasis via Markov bases [PDF]
, 2010 Rapid research progress in genotyping techniques have allowed large genome-wide association studies. Existing methods often focus on determining associations between single loci and a specific phenotype.
Malaspinas, Anna-Sapfo, Uhler, Caroline
core +1 more source
Multi‐drug resistance and compensatory mutations in Mycobacterium tuberculosis in Vietnam
Tropical Medicine &International Health, Volume 30, Issue 5, Page 426-436, May 2025.Abstract Background Vietnam is a hotspot for the emergence and spread of multidrug‐resistant Mycobacterium tuberculosis. This study aimed to perform a retrospective study on the compensatory evolution in multidrug‐resistant M. tuberculosis strains and the association with drug‐resistant mutations and M. tuberculosis genotypes.
Quang Huy Nguyen +2 more
wiley +1 more source
HAMILTONIAN MODEL FOR MULTIDIMENSIONAL EPISTASIS [PDF]
International Journal of Modern Physics C, 2003 We propose and solve a Hamiltonian model for multidimensional epistatic interactions between beneficial mutations. The model gives rise to either a phase transition between two equilibrium states, without any coexistence, or exhibits a state where hybrid species coexist, with gradual passage from one wild type to another. The transition takes place as
Ayşe Erzan, Ayşe Erzan, Seher Ozcelik
openaire +4 more sources
Evolution of robustness in digital organisms [PDF]
, 2004 We study the evolution of robustness in digital organisms adapting to a high mutation rate. As genomes adjust to the harsh mutational environment, the mean effect of single Imitations decreases, up until the point where a sizable fraction (up to 30% in ...
Adami, Christoph, Edlund, Jeffrey A.
core +1 more source
New Phytologist, Volume 247, Issue 1, Page 341-357, July 2025.Summary Many specialized metabolic pathways have evolved convergently in plants, but distinguishing multiple origins from alternative evolutionary scenarios can be difficult. Here, we explore the evolution of l‐3,4‐dihydroxyphenylalanine (l‐DOPA) 4,5‐dioxygenase (DODA) enzymes to better resolve the convergent evolution of the betalain biosynthetic ...
Nathanael Walker‐Hale +2 more
wiley +1 more source
Inferring the shape of global epistasis [PDF]
Proceedings of the National Academy of Sciences, 2018 AbstractGenotype-phenotype relationships are notoriously complicated. Idiosyncratic interactions between specific combinations of mutations occur, and are difficult to predict. Yet it is increasingly clear that many interactions can be understood in terms ofglobal epistasis.
Jakub Otwinowski +2 more
openaire +4 more sources
G3: Genes, Genomes, Genetics, 2019 Epistasis is an important contributor to genetic variance. In inbred populations, pairwise epistasis is present as additive by additive interactions.
Nicholas Santantonio +2 more
doaj +1 more source