Results 71 to 80 of about 38,666 (258)
ChemSusChem, EarlyView.Utilizing the power of the absorbance‐activated droplet sorter, a key enzyme for a cell‐free multienzymatic cascade for sustainable isobutanol biosynthesis is optimized for improved thermostability and isobutanol tolerance required for efficient cascade performance.
Mariko Teshima +6 more
wiley +1 more source
Epistasis detectably alters correlations between genomic sites in a narrow parameter window.
PLoS ONE, 2019 Different genomic sites evolve inter-dependently due to the combined action of epistasis, defined as a non-multiplicative contribution of alleles at different loci to genome fitness, and the physical linkage of different loci in genome.
Gabriele Pedruzzi, Igor M Rouzine
doaj +1 more source
PLANTS, PEOPLE, PLANET, EarlyView.Plant breeding is a critical tool for increasing the productivity, climate resilience, and sustainability of agriculture, but current phenotyping methods are a bottleneck due to the amount of human labor involved. Here, we demonstrate high‐throughput phenotyping with an unmanned aerial vehicle (UAV) to analyze the season‐long flowering pattern in ...
Jeevan Adhikari +5 more
wiley +1 more source
Long-Range Epistasis Mediated by Structural Change in a Model of Ligand Binding Proteins. [PDF]
PLoS ONE, 2016 Recent analyses of amino acid mutations in proteins reveal that mutations at many pairs of sites are epistatic-i.e., their effects on fitness are non-additive-the combined effect of two mutations being significantly larger or smaller than the sum of ...
Erik D Nelson, Nick V Grishin
doaj +1 more source
Higher-order epistasis and phenotypic prediction
bioRxiv, 2020 Contemporary high-throughput mutagenesis experiments are providing an increasingly detailed view of the complex patterns of genetic interaction that occur between multiple mutations within a single protein or regulatory element.
Juannan Zhou +5 more
semanticscholar +1 more source
Supervised Learning of Protein Melting Temperature: Cross‐Species vs. Species‐Specific Prediction
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Protein melting temperatures are important proxies for stability, and frequently probed in protein engineering campaigns, for instance for enzyme discovery and protein optimization. With the emergence of large datasets of melting temperatures for diverse natural proteins, it has become possible to train models to predict this quantity, and the
Sebastián García López +2 more
wiley +1 more source
COMPUTING AND INFORMATICS, 1995 In this note, we compare two previously introduced notions of epistasis and prove that they are essentially equivalent.
van Hove, H., Verschoren, Alain
openaire +2 more sources
HAMILTONIAN MODEL FOR MULTIDIMENSIONAL EPISTASIS [PDF]
International Journal of Modern Physics C, 2003 We propose and solve a Hamiltonian model for multidimensional epistatic interactions between beneficial mutations. The model gives rise to either a phase transition between two equilibrium states, without any coexistence, or exhibits a state where hybrid species coexist, with gradual passage from one wild type to another. The transition takes place as
Ayşe Erzan, Ayşe Erzan, Seher Ozcelik
openaire +4 more sources
Recent Statistical Innovations in Human Genetics
Annals of Human Genetics, EarlyView.ABSTRACT We review three areas of human genetics that have been developed in the past few decades, in which statistical innovation has made a crucial contribution with recent important advances and the potential for further rapid progress. The first topic is the development of mathematical models for the genealogy underlying samples of genome‐wide ...
David J. Balding, Doug Speed
wiley +1 more source
Strong Selection Significantly Increases Epistatic Interactions in the Long-Term Evolution of a Protein. [PDF]
PLoS Genetics, 2016 Epistatic interactions between residues determine a protein's adaptability and shape its evolutionary trajectory. When a protein experiences a changed environment, it is under strong selection to find a peak in the new fitness landscape.
Aditi Gupta, Christoph Adami
doaj +1 more source