Results 81 to 90 of about 59,992 (241)
Effects of Epistasis and Pleiotropy on Fitness Landscapes
, 2013 The factors that influence genetic architecture shape the structure of the fitness landscape, and therefore play a large role in the evolutionary dynamics. Here the NK model is used to investigate how epistasis and pleiotropy -- key components of genetic
A Dawid +15 more
core +1 more source
Evolving concurrent Petri net models of epistasis [PDF]
, 2010 A genetic algorithm is used to learn a non-deterministic Petri netbased model of non-linear gene interactions, or statistical epistasis. Petri nets are computational models of concurrent processes.
Beretta, Lorenzo, Mayo, Michael
core +1 more source
G3: Genes, Genomes, Genetics, 2019 Epistasis is an important contributor to genetic variance. In inbred populations, pairwise epistasis is present as additive by additive interactions.
Nicholas Santantonio +2 more
doaj +1 more source
Coexistence in Sympatry With Gene Flow Before Speciation Has Completed
Molecular Ecology, EarlyView.ABSTRACT Incipient species often coexist in sympatry before complete reproductive isolation has evolved between them. How do they persist in the face of hybridization and gene flow? The challenge is more acute than ordinary ecological coexistence not only because gene flow erodes and recombines genetic differences, but also because selection against ...
Dolph Schluter +4 more
wiley +1 more source
Accounting for genetic interactions improves modeling of individual quantitative trait phenotypes in yeast. [PDF]
, 2016 Experiments in model organisms report abundant genetic interactions underlying biologically important traits, whereas quantitative genetics theory predicts, and data support, the notion that most genetic variance in populations is additive.
Bloom, Joshua S +4 more
core +3 more sources
PLoS Computational BiologyEpistasis among driver mutations is pervasive and explains relevant features of cancer, such as differential therapy response and convergence towards well-characterized molecular subtypes.
Carla Alejandre +2 more
doaj +1 more source
Inferring the shape of global epistasis [PDF]
Proceedings of the National Academy of Sciences, 2018 AbstractGenotype-phenotype relationships are notoriously complicated. Idiosyncratic interactions between specific combinations of mutations occur, and are difficult to predict. Yet it is increasingly clear that many interactions can be understood in terms ofglobal epistasis.
Jakub Otwinowski +2 more
openaire +4 more sources
The Shapes of Clines and Wavefronts
Molecular Ecology, EarlyView.ABSTRACT Cline theory has a central place in speciation studies. Cline locations delimit taxon boundaries, cline widths scale with barrier strength, and the shapes of clines (smooth or stepped) suggest whether species barriers are mono‐ or polygenic. How cline shapes vary along chromosomes therefore forms part of the genome's species barrier landscape.
Stuart J. E. Baird, Nina Daley
wiley +1 more source
Influence of epistasis on response to genomic selection using complete sequence data
Genetics Selection Evolution, 2017 Background The effect of epistasis on response to selection is a highly debated topic. Here, we investigated the impact of epistasis on response to sequence-based selection via genomic best linear prediction (GBLUP) in a regime of strong non-symmetrical ...
Natalia S. Forneris +3 more
doaj +1 more source
Epistasis correlates to genomic complexity [PDF]
Proceedings of the National Academy of Sciences, 2006 Whether systematic genetic interactions (epistasis) occur at the genomic scale remains a challenging topic in evolutionary biology. Epistasis should make a significant contribution to variation in complex traits and influence the evolution of genetic systems as sex, diploidy, dominance, or the contamination of genomes with deleterious mutations.
Sanjuán, Rafael, Elena, Santiago F.
openaire +4 more sources