Results 81 to 90 of about 71,733 (264)

On epistasis

COMPUTING AND INFORMATICS, 1995
Summary: We compare two previously introduced notions of epistasis and prove that they are essentially equivalent.
van Hove, H., Verschoren, Alain
openaire   +3 more sources

Epistasis detectably alters correlations between genomic sites in a narrow parameter window.

PLoS ONE, 2019
Different genomic sites evolve inter-dependently due to the combined action of epistasis, defined as a non-multiplicative contribution of alleles at different loci to genome fitness, and the physical linkage of different loci in genome.
Gabriele Pedruzzi, Igor M Rouzine
doaj   +1 more source

Nonparametric method for genomics-based prediction of performance of quantitative traits involving epistasis in plant breeding. [PDF]

PLoS ONE, 2012
Genomic selection (GS) procedures have proven useful in estimating breeding value and predicting phenotype with genome-wide molecular marker information.
Xiaochun Sun, Ping Ma, Rita H Mumm
doaj   +1 more source

Epistasis Detection via the Joint Cumulant [PDF]

, 2022
Randall Reese, Guifang Fu, Geran Zhao, Xiaotian Dai, Xiaotian Li, Kenneth Chiu   +5 more
openalex   +1 more source

Higher-order epistasis and phenotypic prediction

bioRxiv, 2020
Contemporary high-throughput mutagenesis experiments are providing an increasingly detailed view of the complex patterns of genetic interaction that occur between multiple mutations within a single protein or regulatory element.
Juannan Zhou, Mandy S. Wong, Wei-Chia Chen, A. Krainer, J. Kinney, David M. McCandlish   +5 more
semanticscholar   +1 more source

Quantitative analyses of empirical fitness landscapes

, 2012
The concept of a fitness landscape is a powerful metaphor that offers insight into various aspects of evolutionary processes and guidance for the study of evolution.
de Visser, J. Arjan G. M., Franke, Jasper, Krug, Joachim, Schenk, Martijn F., Szendro, Ivan G.   +4 more
core   +2 more sources

What is "epistasis"?

Bulletin of the Belgian Mathematical Society - Simon Stevin, 1998
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Van Hove, H., Verschoren, A.
openaire   +4 more sources

Complexity of evolutionary equilibria in static fitness landscapes [PDF]

, 2013
A fitness landscape is a genetic space -- with two genotypes adjacent if they differ in a single locus -- and a fitness function. Evolutionary dynamics produce a flow on this landscape from lower fitness to higher; reaching equilibrium only if a local ...
Kaznatcheev, Artem
core  

Fitness ranking of individual mutants drives patterns of epistatic interactions in HIV-1. [PDF]

PLoS ONE, 2011
Fitness interactions between mutations, referred to as epistasis, can strongly impact evolution. For RNA viruses and retroviruses with their high mutation rates, epistasis may be particularly important to overcome fitness losses due to the accumulation ...
Javier P Martínez, Gennady Bocharov, Anna Ignatovich, Jochen Reiter, Matthias T Dittmar, Simon Wain-Hobson, Andreas Meyerhans   +6 more
doaj   +1 more source

Single-cell genomics reveals the genetic and molecular bases for escape from mutational epistasis in myeloid neoplasms.

Blood, 2020
Large-scale sequencing studies of hematologic malignancies have revealed notable epistasis among high-frequency mutations. One of the most striking examples of epistasis occurs for mutations in RNA splicing factors.
Justin Taylor, Xiaoli Mi, Khrystyna North, M. Binder, A. Penson, T. Lasho, Katherine Knorr, Michael Haddadin, Bo Liu, Joseph Pangallo, Salima Benbarche, D. Wiseman, A. Tefferi, Stephanie Halene, Yang Liang, M. Patnaik, R. Bradley, O. Abdel-Wahab   +17 more
semanticscholar   +1 more source