Results 41 to 50 of about 324,947 (241)

Expression of the FGFR2c mesenchymal splicing variant in human keratinocytes inhibits differentiation and promotes invasion [PDF]

, 2018
The altered isoform switching of the fibroblast growth factor receptor 2 (FGFR2) and aberrant expression of the mesenchymal FGFR2c isoform in epithelial cells is involved in cancer progression.
Anacker, Barbaresi, Barton, Belleudi, Boukamp, Brooks, Candi, Capone, Chaffer, Dotto, Feng, Gaggioli, Getsios, Goetz, Grose, Harmon, Haugsten, Ishiwata, Izar, Jones, Kawase, Matsuda, Oh, Oltean, Peng, Petiot, Pickard, Pickard, Purpura, Raffa, Ramsey, Ranieri, Ranieri, Shamir, Shih, Simpson, Truong, Turner, Warzecha, Warzecha, Yang, Ye, Zhang, Zhao   +43 more
core   +1 more source

Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability [PDF]

, 2018
The epithelial-to-mesenchymal transition enables carcinoma cells to acquire malignancy-associated traits and the properties of tumor-initiating cells (TICs).
Bierie, B., Kober, K. I., Krall, J. A., Pattabiraman, D. R., Reinhardt, F., Tam, W. L., Thiru, P., Zill, C.   +7 more
core   +1 more source

Targeting epithelial–mesenchymal transition [PDF]

Journal of Molecular Medicine, 2015
The epithelial–mesenchymal transition (EMT) is a process in which epithelial cells dedifferentiate to become mesenchymal cells [1–3]. The process requires them to lose their cell polarity, to relinquish their cell–cell adhesion, and to gain migratory and invasive properties.
openaire   +3 more sources

Epithelial-mesenchymal transition in keloid tissue [PDF]

Archives of Plastic Surgery, 2018
open
Ju Hee Lee, Chae-Ok Yun, Chae Eun Yang, Won Jai Lee, Dae Hyun Lew, Soo Jung Kim, Seung Jin Moon   +6 more
openaire   +4 more sources

[Role of epithelial-mesenchymal transition in the pathogenesis of dermal wound healing] [PDF]

Морфологія, 2015
Background. Investigation of mechanisms of wound healing remains relevant. It remains unknown the role of epithelial to mesenchymal transition in the regeneration. Epithelial to mesenchymal transition is a fundamental process, that leads epithelial cells
Volkov K.S., Kramar S.B.
doaj  

Lipoxin A4 ameliorates lipopolysaccharide-induced lung injury through stimulating epithelial proliferation, reducing epithelial cell apoptosis and inhibits epithelial–mesenchymal transition

Respiratory Research, 2019
Background Acute respiratory distress syndrome (ARDS) is characterized by alveolar epithelial disruption. Lipoxins (LXs), as so-called “braking signals” of inflammation, are the first mediators identified to have dual anti-inflammatory and inflammatory ...
Jing-xiang Yang, Ming Li, Xin-ou Chen, Qing-quan Lian, Qian Wang, Fang Gao, Sheng-wei Jin, Sheng-xing Zheng   +7 more
doaj   +1 more source

p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. [PDF]

PLoS ONE, 2013
The transcription factor p63 is central for epithelial homeostasis and development. In our model of epithelial to mesenchymal transition (EMT) in human prostate cells, p63 was one of the most down-regulated transcription factors during EMT.
Jan Roger Olsen, Anne Margrete Oyan, Kari Rostad, Margrete R Hellem, Jie Liu, Lisha Li, David R Micklem, Hallvard Haugen, James B Lorens, Varda Rotter, Xi-Song Ke, Biaoyang Lin, Karl-Henning Kalland   +12 more
doaj   +1 more source

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities [PDF]

, 2018
The cell-biological program termed the epithelial-to-mesenchymal transition (EMT) plays an important role in both development and cancer progression. Depending on the contextual signals and intracellular gene circuits of a particular cell, this program ...
Weinberg, Robert A., Zhang, Yun
core   +1 more source

MicroRNAs regulate the epithelial–mesenchymal transition and influence breast cancer invasion and metastasis

Tumor Biology, 2017
MicroRNAs are small RNA molecules that play a major role in the post-transcriptional regulation of genes and influence the development, differentiation, proliferation, and apoptosis of cells and the development and progression of tumors.
Min Zhao, Lin Ang, Jin Huang, Jin Wang
doaj   +1 more source

Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells [PDF]

, 2013
During embryonic development, many cells are born far from their final destination and must travel long distances. To become motile and invasive, embryonic epithelial cells undergo a process of mesenchymal conversion known as epithelial-to-mesenchymal ...
Nieto, M. Ángela
core   +1 more source