Results 71 to 80 of about 324,947 (241)

miR-375 mediated acquired chemo-resistance in cervical cancer by facilitating EMT.

PLoS ONE, 2014
Acquired chemo-resistance is one of the key causal factors in cancer death. Emerging evidences suggest that miRNA and epithelial-mesenchymal transition play critical roles in the chemo-resistance in cancers.
Yuanming Shen, Jiansong Zhou, Yang Li, Feng Ye, Xiaoyun Wan, Weiguo Lu, Xing Xie, Xiaodong Cheng   +7 more
doaj   +1 more source

STAT3 and epithelial–mesenchymal transitions in carcinomas [PDF]

JAK-STAT, 2014
Cellular programs coupled to cycles of epithelial-mesenchymal transitions (EMTs) play critical roles during embryogenesis, as well as during tissue development, remodeling, and repair. Research over the last decade has established the importance of an ever-expanding list of master EMT transcription factors, whose activity is regulated by STAT3 and ...
William P. Schiemann, Cathleen R. Carlin, Michael K. Wendt, Nikolas G. Balanis   +3 more
openaire   +3 more sources

Evidence for mesenchymal-epithelial transition associated with mouse hepatic stem cell differentiation.

PLoS ONE, 2011
UnlabelledMesenchymal-epithelial transition events are related to embryonic development, tissue construction, and wound healing. Stem cells are involved in all of these processes, at least in part.
Bin Li, Yun-Wen Zheng, Yuuki Sano, Hideki Taniguchi   +3 more
doaj   +1 more source

Epithelial-Mesenchymal Transition in Colorectal Carcinoma: Comparison Between Primary Tumor, Lymph Node and Liver Metastases

Frontiers in Oncology, 2021
There is emerging evidence suggesting that epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) play an important role in colorectal carcinoma (CRC), but their exact role remains controversial.
Ana Pavlič, Kristian Urh, Katarina Štajer, Emanuela Boštjančič, Nina Zidar   +4 more
doaj   +1 more source

Epigenetic control of EMT/MET dynamics: HNF4α impacts DNMT3s through miRs-29 [PDF]

, 2015
Background and aims: Epithelial-to-mesenchymal transition (EMT) and the reverse mesenchymal-to-epithelial transition (MET) are manifestations of cellular plasticity that imply a dynamic and profound gene expression reprogramming.
Amicone, Laura, Battistelli, Cecilia, Brocker, Chad, Ciafrè, Silvia Anna, Cicchini, Carla, Cozzolino, ANGELA MARIA, DE NONNO, Valeria, DE SANTIS PUZZONIA, Marco, Gonzalez, Frank J., Tripodi, Marco   +9 more
core   +1 more source

Epithelial-Mesenchymal Transition in Pancreatic Carcinoma [PDF]

Cancers, 2010
Pancreatic carcinoma is the fourth-leading cause of cancer death and is characterized by early invasion and metastasis. The developmental program of epithelial-mesenchymal transition (EMT) is of potential importance for this rapid tumor progression. During EMT, tumor cells lose their epithelial characteristics and gain properties of mesenchymal cells ...
Thomas Wirth, Harald J. Maier, Hartmut Beug   +2 more
openaire   +2 more sources

The mechanisms of colorectal cancer cell mesenchymal–epithelial transition induced by hepatocyte exosome-derived miR-203a-3p

Journal of Bio-X Research, 2018
. Phosphatase of regenerating liver 3 (PRL3) promotes colorectal cancer (CRC) metastasis by inducing epithelial-to-mesenchymal transition. Mesenchymal-to-epithelial transition (MET), the opposite of epithelial-to-mesenchymal transition, has been proposed
Heyang Xu, MD, Yongliang Huang, MD, Qiusheng Lan, MD, Yang Zhang, MD, Yujie Zeng, PhD, Tao Zhang, BA, Chisheng Chen, MD, Pengwei Su, BA, Ziqiang Chu, BA, Wei Lai, MD, Zhonghua Chu, MD   +10 more
doaj   +1 more source

Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis. [PDF]

, 2016
Cytochrome P450 (CYP) monooxygenases epoxidize the omega-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid into novel epoxydocosapentaenoic acids (EDPs) that have multiple biological actions.
Hammock, Bruce D, Hye Khan, Md Abdul, Imig, John D, Lee, Kin Sing Stephen, Levick, Scott P, Sharma, Amit   +5 more
core   +3 more sources

Molecular mechanisms of epithelial–mesenchymal transition [PDF]

Nature Reviews Molecular Cell Biology, 2014
The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as epithelial-mesenchymal transition (EMT), is integral in development, wound healing and stem cell behaviour, and contributes pathologically to fibrosis and cancer progression.
Lamouille, Samy, Xu, Jian, Derynck, Rik
openaire   +5 more sources

Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts

Stem Cell Reports, 2014
Previous studies have suggested that breast cancer stem cells (BCSCs) mediate metastasis, are resistant to radiation and chemotherapy, and contribute to relapse.
Suling Liu, Yang Cong, Dong Wang, Yu Sun, Lu Deng, Yajing Liu, Rachel Martin-Trevino, Li Shang, Sean P. McDermott, Melissa D. Landis, Suhyung Hong, April Adams, Rosemarie D’Angelo, Christophe Ginestier, Emmanuelle Charafe-Jauffret, Shawn G. Clouthier, Daniel Birnbaum, Stephen T. Wong, Ming Zhan, Jenny C. Chang, Max S. Wicha   +20 more
doaj   +1 more source