Results 41 to 50 of about 2,478,278 (345)

Epithelial barriers in allergy and asthma [PDF]

Journal of Allergy and Clinical Immunology, 2020
The respiratory epithelium provides a physical, functional, and immunologic barrier to protect the host from the potential harming effects of inhaled environmental particles and to guarantee maintenance of a healthy state of the host. When compromised, activation of immune/inflammatory responses against exogenous allergens, microbial substances, and ...
Hellings, Peter W., Steelant, Brecht
openaire   +3 more sources

Porphyromonas gingivalis Infection Induces Lipopolysaccharide and Peptidoglycan Penetration Through Gingival Epithelium

Frontiers in Oral Health, 2022
Periodontal diseases initiate on epithelial surfaces of the subgingival compartment, while the gingival epithelium functions as an epithelial barrier against microbial infection and orchestrates immune responses.
Hiroki Takeuchi, Eriko Nakamura, Shunsuke Yamaga, Atsuo Amano   +3 more
doaj   +1 more source

Dysregulation of the epithelial barrier by environmental and other exogenous factors

Contact Dermatitis, 2021
The “epithelial barrier hypothesis” proposes that the exposure to various epithelial barrier–damaging agents linked to industrialization and urbanization underlies the increase in allergic diseases.
Y. Mitamura, I. Ogulur, Yagiz Pat, Arturo O. Rinaldi, O. Ardicli, Lacin Cevhertas, Charlotte Brüggen, C. Traidl‐Hoffmann, M. Akdiş, C. Akdis   +9 more
semanticscholar   +1 more source

Microbial products induce claudin-2 to compromise gut epithelial barrier function. [PDF]

PLoS ONE, 2013
The epithelial barrier dysfunction is an important pathogenic feature in a number of diseases. The underlying mechanism is to be further investigated.
Xiaoyu Liu, Gui Yang, Xiao-Rui Geng, Yanjuan Cao, Na Li, Li Ma, Si Chen, Ping-Chang Yang, Zhigang Liu   +8 more
doaj   +1 more source

Regulation of Oxygen Homeostasis at the Intestinal Epithelial Barrier Site

International Journal of Molecular Sciences, 2021
The unique biology of the intestinal epithelial barrier is linked to a low baseline oxygen pressure (pO2), characterised by a high rate of metabolites circulating through the intestinal blood and the presence of a steep oxygen gradient across the ...
Š. Konjar, Miha Pavšič, M. Veldhoen
semanticscholar   +1 more source

Butyrate and propionate restore interleukin 13‐compromised esophageal epithelial barrier function

Allergy. European Journal of Allergy and Clinical Immunology, 2021
Eosinophilic esophagitis (EoE) is a food allergen driven disease that is accompanied by interleukin (IL) 13 overexpression and esophageal barrier dysfunction allowing transepithelial food allergen permeation.
M. Kleuskens, Maria-Louise Haasnoot, Bart M Herpers, M. V. van Ampting, A. Bredenoord, J. Garssen, F. Redegeld, B. Van Esch   +7 more
semanticscholar   +1 more source

Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates airway epithelial barrier integrity

Allergology International, 2015
Background: Inhaled corticosteroids enhance airway epithelial barrier integrity. However, the mechanism by which they accomplish this is unclear. Therefore, we investigated steroid-inducible genes and signaling pathways that were involved in enhancing ...
Yoshitaka Shintani, Shuichiro Maruoka, Yasuhiro Gon, Daisuke Koyama, Akiko Yoshida, Yutaka Kozu, Kazumichi Kuroda, Ikuko Takeshita, Eriko Tsuboi, Kaori Soda, Shu Hashimoto   +10 more
doaj   +1 more source

Curcumin Mitigates Immune-Induced Epithelial Barrier Dysfunction by Campylobacter jejuni [PDF]

, 2019
Campylobacter jejuni (C. jejuni) is the most common cause of foodborne gastroenteritis worldwide. The bacteria induce diarrhea and inflammation by invading the intestinal epithelium. Curcumin is a natural polyphenol from turmeric rhizome of Curcuma longa,
Bereswill, Stefan, Butkevych, Eduard, Bücker, Roland, Fromm, Anja, Golz, Julia C., Heimesaat, Markus M., Kehrenberg, Corinna, Kittler, Sophie, Lobo de Sá, Fábia Daniela, Moos, Verena, Mousavi, Soraya, Nattramilarasu, Praveen Kumar, Schulzke, Jörg-Dieter, Seinige, Diana, Stingl, Kerstin   +14 more
core   +1 more source

Underestimated health risks: polystyrene micro- and nanoplastics jointly induce intestinal barrier dysfunction by ROS-mediated epithelial cell apoptosis

Particle and Fibre Toxicology, 2021
Background Micro- and nanoplastic pollution has become a global environmental problem. Nanoplastics in the environment are still hard to detect because of analysis technology limitations.
B. Liang, Yizhou Zhong, Yuji Huang, Xi Lin, Jun Liu, Li Lin, Manjiang Hu, Junying Jiang, Mingzhu Dai, Bo Wang, Bingli Zhang, H. Meng, J. J. J. Lelaka, Haixia Sui, Xingfen Yang, Zhenlie Huang   +15 more
semanticscholar   +1 more source

The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression [PDF]

, 2009
The gastrointestinal tract represents the first barrier against food contaminants as well as the first target for these toxicants. Deoxynivalenol (DON) is a mycotoxin that commonly contaminates cereals and causes various toxicological effects.
Bracarense, Ana-Paula, Del Rio, Juan-Carlos, Ferrier, Laurent, Kolf-Clauw, Martine, Marin, Daniela E., Moreno, Carolina, Nougayrède, Jean-Philippe, Oswald, Isabelle P, Pinton, Philippe   +8 more
core   +2 more sources