Results 61 to 70 of about 2,478,278 (345)

The epithelial barrier theory and its associated diseases

Allergy. European Journal of Allergy and Clinical Immunology
The prevalence of many chronic noncommunicable diseases has been steadily rising over the past six decades. During this time, over 350,000 new chemical substances have been introduced to the lives of humans. In recent years, the epithelial barrier theory
Na Sun, I. Ogulur, Y. Mitamura, D. Yazici, Yagiz Pat, Xiangting Bu, Manru Li, Xueyi Zhu, H. Babayev, S. Ardıçlı, O. Ardicli, Paolo D'Avino, A. Kıykım, M. Sokolowska, W. van de Veen, Lukas Weidmann, Deniz Akdis, B. Ozdemir, M. Brüggen, L. Biedermann, A. Straumann, Andrea Kreienbühl, E. Guttman‐Yassky, Alexandra F. Santos, S. D. Del Giacco, C. Traidl‐Hoffmann, D. J. Jackson, D. Wang, A. Lauerma, H. Breiteneder, Luo Zhang, L. O’Mahony, O. Pfaar, R. O’Hehir, T. Eiwegger, W. Fokkens, B. Cabanillas, C. Ozdemir, Kistler Walter, Mahmut Bayik, K. Nadeau, M. Torres, M. Akdiş, M. Jutel, I. Agache, C. Akdis   +45 more
semanticscholar   +1 more source

Recent advances in the epithelial barrier theory

International Immunology
The epithelial barrier theory links the recent rise in chronic non-communicable diseases, notably autoimmune and allergic disorders, to environmental agents disrupting the epithelial barrier.
Yagiz Pat, D. Yazici, Paolo D'Avino, Manru Li, S. Ardıçlı, O. Ardicli, Y. Mitamura, M. Akdiş, Raja Dhir, Kari C Nadeau, I. Agache, I. Ogulur, C. Akdis   +12 more
semanticscholar   +1 more source

The role and mechanisms of gingival epithelial cells in maintaining periodontal homeostasis [PDF]

口腔疾病防治
Periodontal homeostasis is regulated by the complex interplay between the gingival epithelial barrier, the extracellular matrix of soft tissues, the bone coupling system, and immune responses within the periodontal region.
WANG Xiao, WU Yajie, SU Zhifei, LI Jiyao
doaj   +1 more source

Glaesserella parasuis serotype 5 breaches the porcine respiratory epithelial barrier by inducing autophagy and blocking the cell membrane Claudin-1 replenishment.

PLoS Pathogens, 2022
Glaesserella parasuis (G. parasuis), the primary pathogen of Glässer's disease, colonizes the upper respiratory tract and can break through the epithelial barrier of the respiratory tract, leading to lung infection. However, the underlying mechanisms for
Mingxing Liu, Qing Wang, Wenda Wu, Min Chen, Pengyun Zhang, Mengru Guo, Huixing Lin, Zhe Ma, Hong Zhou, Hongjie Fan   +9 more
doaj   +1 more source

Claudins in the Renal Collecting Duct [PDF]

, 2019
The renal collecting duct fine-tunes urinary composition, and thereby, coordinates key physiological processes, such as volume/blood pressure regulation, electrolyte-free water reabsorption, and acid-base homeostasis.
Leiz, Janna, Schmitt-Ott, Kai M.
core   +1 more source

Involvement and repair of epithelial barrier dysfunction in allergic diseases

Frontiers in Immunology
The epithelial barrier serves as a critical defense mechanism separating the human body from the external environment, fulfilling both physical and immune functions.
Hui-Fei Lu, Yi-Chi Zhou, Litao Yang, Qian Zhou, Xi-Jia Wang, Shu-Qi Qiu, Bao-Hui Cheng, Xian-Hai Zeng   +7 more
semanticscholar   +1 more source

Optimisation of growth conditions for ovine airway epithelial cell differentiation at an air-liquid interface [PDF]

, 2018
Respiratory tract infections are of significant concern in the agriculture industry. There is a requirement for the development of well-characterised in vitro epithelial cell culture models in order to dissect the diverse molecular interactions occurring
Berry, Catherine C., Davies, Robert L., O'Boyle, Nicky, Sutherland, Erin   +3 more
core   +2 more sources

Mechanisms of pulmonary fibrosis and lung cancer induced by chronic PM2.5 exposure: Focus on the airway epithelial barrier and epithelial-mesenchymal transition

Ecotoxicology and Environmental Safety
This study aims to provide new insights into PM2.5-induced lung diseases through a focus on the pulmonary epithelial barrier and epithelial-mesenchymal transition (EMT).
Yuyu Shi, Qi Shao, Zilin Ren, Guojiao Shang, Jinhua Han, Jialin Cheng, Yuxiao Zheng, Fafeng Cheng, Changxiang Li, Qingguo Wang, Xueqian Wang   +10 more
doaj   +1 more source

Tilivalline- and Tilimycin-Independent Effects of Klebsiella oxytoca on Tight Junction-Mediated Intestinal Barrier Impairment [PDF]

, 2019
Klebsiella oxytoca causes antibiotic-associated hemorrhagic colitis and diarrhea. This was attributed largely to its secreted cytotoxins tilivalline and tilimycin, inductors of epithelial apoptosis.
Bücker, Roland, Fromm, Anja, Fromm, Michael, Gorkiewicz, Gregor, Hering, Nina A., Högenauer, Christoph, Schulzke, Jörg-Dieter, Troeger, Hanno, Zechner, Ellen   +8 more
core   +1 more source

Type III interferons disrupt the lung epithelial barrier upon viral recognition

Science, 2020
Interferons interfere with lung repair Interferons (IFNs) are central to antiviral immunity. Viral recognition elicits IFN production, which in turn triggers the transcription of IFN-stimulated genes (ISGs), which engage in various antiviral functions ...
A. Broggi, Sreya Ghosh, B. Sposito, R. Spreafico, F. Balzarini, Antonino Lo Cascio, Nicola Clementi, Maria De Santis, N. Mancini, F. Granucci, I. Zanoni   +10 more
semanticscholar   +1 more source