Results 121 to 130 of about 921,216 (339)

Pomegranate extract inhibits EMT in clear cell renal cell carcinoma in a NF-κB and JNK dependent manner. [PDF]

, 2015
Objective:Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC) and is characterized by biallelic inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene.
Afaq, Ahmed, An, An, An, An, An, Baba, Bosniak, DeSantis, Figlin, Hollingsworth, Koyama, Lamb, Mori, Oya, Oya, Rasheed, Rendon, Rettig, Schubert, Seeram, Semenza, Siegel, Smith, Thomas, Volpe, Wehle, Yang   +28 more
core   +2 more sources

High‐Throughput Generation of Tumor Spheroids via Droplet Microfluidics for siRNA‐Loaded Nanomedicine Assessment

Advanced Healthcare Materials, EarlyView.
A droplet microfluidic platform is employed to enable high‐throughput, uniform tumor spheroid generation for evaluating siRNA‐loaded nanomedicines at the protein level. As a proof of concept, breast (MCF‐7) and brain (U87 MG) cancer cell lines are investigated using this platform, revealing penetration profiles and therapeutic responses between the two
Ling Liu, Guoying Wang, Yang Zhang, Bingyang Shi, Ming Li   +4 more
wiley   +1 more source

Form follows function: Morphological and immunohistological insights into epithelial–mesenchymal transition characteristics of tumor buds

Tumor Biology, 2017
In cancer biology, the architectural concept “form follows function” is reflected by cell morphology, migration, and epithelial–mesenchymal transition protein pattern. In vivo, features of epithelial–mesenchymal transition have been associated with tumor
Kathrin Enderle-Ammour, Moritz Bader, Theresa Dorothee Ahrens, Kai Franke, Sylvia Timme, Agnes Csanadi, Jens Hoeppner, Birte Kulemann, Jochen Maurer, Philip Reiss, Oliver Schilling, Tobias Keck, Thomas Brabletz, Elmar Stickeler, Martin Werner, Ulrich Friedrich Wellner, Peter Bronsert   +16 more
doaj   +1 more source

E-cadherin involvement in human lens epithelial cell transdifferentiation may be associated with N-cadherin

Molecular Medicine Reports, 2017
E-cadherin, β-catenin and N‑cadherin serve key roles in the epithelial‑to‑mesenchymal transition (EMT) that leads to human lens epithelial cell (LEC) transdifferentiation and subsequent cataract formation. The present study aimed to investigate the role of E‑cadherin in LEC transdifferentiation.
Lei, Huang, Jie, Jiang, Qiang, Guo, Hongbin, Yang   +3 more
openaire   +3 more sources

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

Advanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

E-Cadherin is a diagnostic biomarker in the progression of oral epithelial dysplasia to squamous cell carcinoma

Journal of Oral Biology and Craniofacial Research
Background: Oral squamous cell carcinoma is a common cancer of head and neck region with poor prognosis and may sometimes show a premalignant stage. Cell-cell adhesion molecules play an important role in the process of malignant transformation.
Dhanusree Kani, Vindhya Savithri, Rakesh Suresh, Ramanarayanan Venkitachalam, Mahija Janardhanan, Thara Aravind   +5 more
doaj   +1 more source

Cigarette and IL-17A synergistically induce bronchial epithelial-mesenchymal transition via activating IL-17R/NF-κB signaling

BMC Pulmonary Medicine, 2020
Background IL-17A directly induces epithelial-mesenchymal transition (EMT) in alveolar epithelial cells. It could coordinate with cigarette smoke extract (CSE) to promote proliferation of bronchial epithelial cells.
Libing Ma, Ming Jiang, Xiaoli Zhao, Jingyi Sun, Qilu Pan, Shuyuan Chu   +5 more
doaj   +1 more source

Overexpression of SPARC obliterates the in vivo tumorigenicity of human hepatocellular carcinoma cells [PDF]

, 2010
Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third leading cause of cancer-related death worldwide. Current treatments are extremely disappointing.
Alaniz, Laura Daniela, Aquino, Jorge Benjamin, Atorrasagasti, María Catalina, Bolontrade, Marcela Fabiana, García, Mariana Gabriela, Malvicini, Mariana, Mazzolini Rizzo, Guillermo Daniel, Podhajcer, Osvaldo Luis, Rizzo, Manglio Miguel   +8 more
core   +1 more source

Copper–Collagen Interactions Regulate the Mechanical and Invasive Properties of Tumor Spheroids

Advanced Healthcare Materials, EarlyView.
Ionic copper is investigated as a modulator of tumor spheroid growth and invasiveness in a 3D microfluidic glioblastoma model. Copper exposure alters metabolic activity, cytoskeletal organization, protrusion dynamics, and EMT‐related phenotypes in a dose‐ and timing‐dependent manner, revealing how copper bioavailability shapes tumor aggressiveness ...
Paula Guerrero‐López, Jose I. Garcia‐Peiro, Felipe Hornos, Jose L. Hueso, Jesus Santamaria, J. Manuel Garcia‐Aznar   +5 more
wiley   +1 more source

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source