Results 81 to 90 of about 195,613 (192)

E-cadherin loss in RMG-1 cells inhibits cell migration and its regulation by Rho GTPases

Biochemistry and Biophysics Reports, 2019
E-cadherin is an adherens junction protein that forms intercellular contacts in epithelial cells. Downregulation of E-cadherin is frequently observed in epithelial tumors and it is a hallmark of epithelial–mesenchymal transition (EMT).
Misako Haraguchi, Tomoko Fukushige, Takuro Kanekura, Masayuki Ozawa   +3 more
doaj   +1 more source

Active wetting of epithelial tissues

, 2019
Development, regeneration and cancer involve drastic transitions in tissue morphology. In analogy with the behavior of inert fluids, some of these transitions have been interpreted as wetting transitions.
A Ravasio, AF Mertz, AF Mertz, AG Clark, AMJ Edwards, AR Harris, B Smeets, B Wallmeyer, C Blanch-Mercader, C Blanch-Mercader, C Cortina, Carles Blanch-Mercader, Carlos Pérez-González, D Bonn, D Gonzalez-Rodriguez, D Oriola, D Sarrió, DK Vig, DT Tambe, DT Tambe, E Bazellières, Elsa Bazellieres, F Jülicher, G Beaune, G Beaune, H Morita, I Muhamed, I Rodriguez-Hernandez, J Notbohm, J Paredes, J Prost, Jaume Casademunt, JL Ouderkirk, K Kruse, KA Paschos, L Casares, M Behrndt, M Deforet, Manuel Gómez-González, MC Marchetti, MH Köpf, O Chepizhko, P Campinho, P Friedl, P Gennes de, P Lee, P Lee, P Lu, PL Ryan, Ricard Alert, S Banerjee, S Douezan, S Douezan, S Douezan, S Garcia, S Kaliman, S Yabunaka, T Lecuit, TB Saw, Tomasz Kolodziej, TV Stirbat, US Schwarz, X Serra-Picamal, X Trepat, Xavier Trepat   +64 more
core   +3 more sources

YES‐associated protein‐regulated Smad7 worsen epithelial barrier injury of chronic sinusitis with nasal polyps

Immunity, Inflammation and Disease, 2023
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) was potentially due to the epithelial barrier injury. YES‐associated protein (YAP) is a multifunctional transcriptional factor and plays versatile roles in the regulation and maintenance of ...
Xiaocong Jiang, Longlan Shu, Yijun Liu, Yang Shen, Xia Ke, Jie Liu, Yucheng Yang   +6 more
doaj   +1 more source

Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes [PDF]

, 2016
Desmosomes are adhesion plaques that mediate cell-cell adhesion in many tissues, including the epidermis, and generate mechanical resistance to tissues. The extracellular domains of desmosomal cadherin proteins, desmogleins and desmocollins, are required
Ali, Jawahir, Banning, Antje, Eming, Rüdiger, Exner, Yvonne, Hertl, Michael, Kurrle, Nina, Tikkanen, Ritva, Völlner, Frauke   +7 more
core   +1 more source

E-cadherin regulates MAL-SRF-mediated transcription in epithelial cells [PDF]

Journal of Cell Science, 2010
Epithelial junctions are dynamically and functionally linked to the actin cytoskeleton, and their disassembly is a key event during physiological and pathological processes. We recently showed that epithelial disintegration facilitates transcriptional activation via Rac, G-actin, MAL (also known as MRTF) and serum response factor (SRF).
Busche, S., Kremmer, E., Posern, G.
openaire   +3 more sources

Calcium-sensing receptor activation increases cell-cell adhesion and ß-cell function [PDF]

, 2012
Background/Aims: The extracellular calcium-sensing receptor (CaR) is expressed in pancreatic β-cells where it is thought to facilitate cell-to-cell communication and augment insulin secretion.
Bennett, J., Hills, C. E., Liu, K.-K., Siamantouras, E., Squires, P. E., Younis, M. Y.G.   +5 more
core   +2 more sources

Expression of the FGFR2c mesenchymal splicing variant in human keratinocytes inhibits differentiation and promotes invasion [PDF]

, 2018
The altered isoform switching of the fibroblast growth factor receptor 2 (FGFR2) and aberrant expression of the mesenchymal FGFR2c isoform in epithelial cells is involved in cancer progression.
Anacker, Barbaresi, Barton, Belleudi, Boukamp, Brooks, Candi, Capone, Chaffer, Dotto, Feng, Gaggioli, Getsios, Goetz, Grose, Harmon, Haugsten, Ishiwata, Izar, Jones, Kawase, Matsuda, Oh, Oltean, Peng, Petiot, Pickard, Pickard, Purpura, Raffa, Ramsey, Ranieri, Ranieri, Shamir, Shih, Simpson, Truong, Turner, Warzecha, Warzecha, Yang, Ye, Zhang, Zhao   +43 more
core   +1 more source

Stromal upregulation of lateral epithelial adhesions: gene expression analysis of signalling pathways in prostate epithelium [PDF]

, 2011
Background: Stromal signalling increases the lateral cell adhesions of prostate epithelial cells grown in 3D culture. The aim of this study was to use microarray analysis to identify significant epithelial signalling pathways and genes in this process ...
Chambers, Karen F., Pearson, Joanna F., Pellacani, Davide, Aziz, Naveed, Gužvić, Miodrag, Klein, Christoph A., Lang, Shona H.   +6 more
core   +4 more sources

Adherens Junction and E-Cadherin complex regulation by epithelial polarity [PDF]

Cellular and Molecular Life Sciences, 2016
E-Cadherin-based Adherens Junctions (AJs) are a defining feature of all epithelial sheets. Through the homophilic association of E-Cadherin molecules expressed on neighboring cells, they ensure intercellular adhesion amongst epithelial cells, and regulate many key aspects of epithelial biology.
Peter, Coopman, Alexandre, Djiane
openaire   +2 more sources

E-cadherin expression in the tongue epithelium of streptozotocin-induced diabetic rats: an exploratory study

Acta Odontologica Scandinavica
Objective: Little was found on the association between diabetes and its effect on epithelial intercellular adhesion. However, no study reported the association between hyperglycemia and E-cadherin-mediated cell adhesion in tongue epithelium.
Hassan Hamed Kaabi, Abdullah Mohamed Alsoghier, Islam Abdulrahim Alredah, Rayan Mohammed Alqahtani, Ibrahim Suliman Alsanie, Hanan Abdulgafour Balto   +5 more
doaj   +1 more source