Results 21 to 30 of about 12,703,452 (383)
The landscape of somatic mutation in normal colorectal epithelial cells
Nature, 2018 The colorectal adenoma–carcinoma sequence has provided a paradigmatic framework for understanding the successive somatic genetic changes and consequent clonal expansions that lead to cancer1.
H. Lee-Six +21 more
semanticscholar +1 more source
A genome‐wide RNAi screen reveals essential therapeutic targets of breast cancer stem cells
EMBO Molecular Medicine, 2019 Therapeutic resistance is a major clinical challenge in oncology. Evidence identifies cancer stem cells (CSCs) as a driver of tumor evolution. Accordingly, the key stemness property unique to CSCs may represent a reservoir of therapeutic target to ...
Abir Arfaoui +20 more
doaj +1 more source
Roles of intestinal epithelial cells in the maintenance of gut homeostasis
Experimental &Molecular Medicine, 2017 The intestine is a unique organ inhabited by a tremendous number of microorganisms. Intestinal epithelial cells greatly contribute to the maintenance of the symbiotic relationship between gut microbiota and the host by constructing mucosal barriers ...
Ryu Okumura, K. Takeda
semanticscholar +1 more source
Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte [PDF]
, 2014 The complex spatial and paracrine relationships between the various liver histotypes are essential for proper functioning of the hepatic parenchymal cells.
Fausto N +6 more
core +3 more sources
Frontiers in Cell and Developmental Biology, 2022 The transparent ocular lens in the anterior chamber of the eye is responsible for fine focusing of light onto the retina. The lens is entirely cellular with bulk of the tissue composed of fiber cells, and the anterior hemisphere of the lens is covered by
Justin Parreno +8 more
doaj +1 more source
Gonococcal invasion into epithelial cells depends on both cell polarity and ezrin.
PLoS Pathogens, 2021 Neisseria gonorrhoeae (GC) establishes infection in women from the cervix, lined with heterogeneous epithelial cells from non-polarized stratified at the ectocervix to polarized columnar at the endocervix.
Qian Yu +4 more
doaj +1 more source
Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity
Nature Communications, 2018 Breast cancer arises from breast epithelial cells that acquire genetic alterations leading to subsequent loss of tissue homeostasis. Several distinct epithelial subpopulations have been proposed, but complete understanding of the spectrum of ...
Q. Nguyen +16 more
semanticscholar +1 more source
Optimisation of growth conditions for ovine airway epithelial cell differentiation at an air-liquid interface [PDF]
, 2018 Respiratory tract infections are of significant concern in the agriculture industry. There is a requirement for the development of well-characterised in vitro epithelial cell culture models in order to dissect the diverse molecular interactions occurring
Berry, Catherine C. +3 more
core +2 more sources
iScience, 2022 Summary: The Mammary gland undergoes complicated epithelial remodeling to form lobuloalveoli during pregnancy, in which basal epithelial cells remarkably increase to form a basket-like architecture. However, it remains largely unknown how dormant mammary
Ruiqi Liu +11 more
doaj +1 more source
Epithelial organization and cyst lumen expansion require efficient Sec13-Sec31-driven secretion [PDF]
, 2012 Epithelial morphogenesis is directed by interactions with the underlying extracellular matrix. Secretion of collagen and other matrix components requires efficient coat complex II (COPII) vesicle formation at the endoplasmic reticulum. Here, we show that
Hodgson, Lorna +3 more
core +2 more sources