Results 51 to 60 of about 12,703,452 (383)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The interplay of DNA damage, epigenetics and tumour heterogeneity in driving cancer cell fitness

Nature Communications
Intra-tumor heterogeneity is a primary cause of therapeutic failure, driving tumor progression. Within tumors, diverse cell states coexist, maintained by a specific chromatin landscape that influences various cell functions, including cancer stemness ...
Celia D. Rouault, Emmanuelle Charafe-Jauffret, Christophe Ginestier   +2 more
doaj   +1 more source

Generation of stratified squamous epithelial progenitor cells from mouse induced pluripotent stem cells. [PDF]

PLoS ONE, 2011
BACKGROUND: Application of induced pluripotent stem (iPS) cells in regenerative medicine will bypass ethical issues associated with use of embryonic stem cells.
Satoru Yoshida, Miyuki Yasuda, Hideyuki Miyashita, Yoko Ogawa, Tetsu Yoshida, Yumi Matsuzaki, Kazuo Tsubota, Hideyuki Okano, Shigeto Shimmura   +8 more
doaj   +1 more source

TGF-beta 1 induces human alveolar epithelial to mesenchymal cell transition (EMT) [PDF]

, 2005
Background: Fibroblastic foci are characteristic features in lung parenchyma of patients with idiopathic pulmonary fibrosis (IPF). They comprise aggregates of mesenchymal cells which underlie sites of unresolved epithelial injury and are associated with ...
A Atfi, A Desmouliere, A Desmouliere, CM Ewing, D Upadhyay, DA Vesey, DG. Hoyt, DW Powell, DW Powell, DY Rhyu, E Healy, E Piek, EE Moussad, EP Bottinger, F Strutz, G Raghu, GR Grotendorst, HW Yao, J Fan, J Gauldie, J Nightingale, J Yang, JT Allen, JT Allen, K Vleminckx, KA Foster, LH Pan, M Kelly, M Selman, M Selman, M Whitman, N Khalil, N Khalil, N Khalil, NA Bhowmick, NA Wahab, NA Wahab, NA Wahab, P Bonniaud, P Sharmila, PJ Miettinen, PJ Sime, R Derynck, R Kalluri, S Hashimoto, T Maeyama, TE King Jr, TJ Gross, V Mermall, Y Higashimoto, Y Liu   +50 more
core   +4 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Calu-3 epithelial cells exhibit different immune and epithelial barrier responses from freshly isolated primary nasal epithelial cells in vitro

Clinical and Translational Allergy, 2018
Epithelial cell lines are often used to evaluate the effect of exogenous/endogenous stimuli on epithelial barrier function and innate immune responses in allergic airway diseases, without clear view on differences between epithelial cell lines and ...
Katleen Martens, Peter W. Hellings, Brecht Steelant   +2 more
doaj   +1 more source

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2.

Genes & Development, 2008
Cancer progression has similarities with the process of epithelial-to-mesenchymal transition (EMT) found during embryonic development, during which cells down-regulate E-cadherin and up-regulate Vimentin expression.
Sun-Mi Park, A. Gaur, E. Lengyel, M. Peter   +3 more
semanticscholar   +1 more source

Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer

Nature Genetics, 2022
The consensus molecular subtype (CMS) classification of colorectal cancer is based on bulk transcriptomics. The underlying epithelial cell diversity remains unclear.
Ignasius Joanito, P. Wirapati, Nancy Zhao, Zahid Nawaz, Grace H. T. Yeo, Fiona Lee, C. L. Eng, D. Macalinao, Merve Kahraman, Harini Srinivasan, Vairavan Lakshmanan, Sara Verbandt, Petros K Tsantoulis, N. Gunn, P. Venkatesh, Zhong Wee Poh, R. Nahar, H. J. Oh, J. Loo, Shumei Chia, L. F. Cheow, Elsie Cheruba, M. Wong, L. Kua, C. Chua, Andy Nguyen, Justin Golovan, A. Gan, W. Lim, Y. Guo, Choon-Kong Yap, Brenda Tay, Yourae Hong, D. Chong, A. Chok, W. Park, Shuting Han, Mei-huan Chang, I. Seow-En, Cherylin Fu, Ronnie Mathew, E. Toh, Lewis Z Hong, A. Skanderup, R. Dasgupta, C. Ong, K. Lim, E. Tan, S. Koo, W. Leow, S. Tejpar, Shyam Prabhakar, I. Tan   +52 more
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Bioinformatic Integration of Molecular Networks and Major Pathways Involved in Mice Cochlear and Vestibular Supporting Cells

Frontiers in Molecular Neuroscience, 2018
Background: Cochlear and vestibular epithelial non-hair cells (ENHCs) are the supporting elements of the cellular architecture in the organ of Corti and the vestibular neuroepithelium in the inner ear.
Teresa Requena, Alvaro Gallego-Martinez, Jose A. Lopez-Escamez, Jose A. Lopez-Escamez, Jose A. Lopez-Escamez   +4 more
doaj   +1 more source