Immunohistochemistry guided segmentation of benign epithelial cells, in situ lesions, and invasive epithelial cells in breast cancer slides [PDF]
arXiv, 2023 Digital pathology enables automatic analysis of histopathological sections using artificial intelligence (AI). Automatic evaluation could improve diagnostic efficiency and help find associations between morphological features and clinical outcome. For development of such prediction models, identifying invasive epithelial cells, and separating these ...
arxiv
High efficiency transfection of thymic epithelial cell lines and primary thymic epithelial cells by Nucleofection [PDF]
, 2011 Thymic epithelial cells (TECs) are required for the development and differentiation of T cells and are sufficient for the positive and negative selection of developing T cells.
Brian G. Condie +2 more
core +2 more sources
Nature CommunicationsThe targeting of cancer stem cells (CSCs) has proven to be an effective approach for limiting tumor progression, thus necessitating the identification of new drugs with anti-CSC activity.
Celia D. Rouault +23 more
doaj +1 more source
TGF-beta 1 induces human alveolar epithelial to mesenchymal cell transition (EMT) [PDF]
, 2005 Background: Fibroblastic foci are characteristic features in lung parenchyma of patients with idiopathic pulmonary fibrosis (IPF). They comprise aggregates of mesenchymal cells which underlie sites of unresolved epithelial injury and are associated with ...
A Atfi +50 more
core +4 more sources
Epithelial-substrate coupling strength regulates the landscape of the traction in cohesive monolayers: a parametric study and a revisit to "size effect" [PDF]
arXiv, 2023 Epithelial cells can assemble into cohesive colonies and collectively interact with substrates by generating extracellular forces through focal adhesions. Recently, a molecularly based thermodynamic model, which integrates both the monolayer elasticity and force-mediated focal adhesion formation, has been developed to elucidate the regulation of the ...
arxiv
Th2 Responses Elicited by Nasal Epithelial Cells Exposed to House Dust Mite Extract [PDF]
Clinical and Experimental Otorhinolaryngology, 2009 ObjectivesRespiratory epithelial cells are the first site of interaction of allergens with the immune system. The aim of this study was to examine the effect of epithelial cells, which were stimulated with house dust mite (HDM) extracts, on the immune ...
Seung-Heon Shin, Mi-Kyung Ye
doaj +1 more source
CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells
iScience, 2021 Summary: The apoptosis inducing receptor CD95/Fas has multiple tumorigenic activities. In different genetically engineered mouse models tumor-expressed CD95 was shown to be critical for cell growth.
Abdul S. Qadir +18 more
doaj
Efficient immortalization of primary nasopharyngeal epithelial cells for EBV infection study. [PDF]
PLoS ONE, 2013 Nasopharyngeal carcinoma (NPC) is common among southern Chinese including the ethnic Cantonese population living in Hong Kong. Epstein-Barr virus (EBV) infection is detected in all undifferentiated type of NPC in this endemic region.
Yim Ling Yip +9 more
doaj +1 more source
Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity. [PDF]
, 2018 Breast cancer arises from breast epithelial cells that acquire genetic alterations leading to subsequent loss of tissue homeostasis. Several distinct epithelial subpopulations have been proposed, but complete understanding of the spectrum of ...
Blake, Kerrigan +16 more
core +1 more source
Active wetting of epithelial tissues: modeling considerations [PDF]
arXiv, 2022 Morphogenesis, tissue regeneration and cancer invasion involve transitions in tissue morphology. These transitions, caused by collective cell migration (CCM), have been interpreted as active wetting/de-wetting transitions. This phenomenon is considered on model system such as wetting of cell aggregate on rigid substrate which includes cell aggregate ...
arxiv