Results 71 to 80 of about 212,176 (344)

Specific Palmitoyltransferases Associate with and Activate the Epithelial Sodium Channel*

Journal of Biological Chemistry, 2017
The epithelial sodium channel (ENaC) has an important role in regulating extracellular fluid volume and blood pressure, as well as airway surface liquid volume and mucociliary clearance. ENaC is a trimer of three homologous subunits (α, β, and γ).
A. Mukherjee, Zhijian Wang, C. Kinlough, P. Poland, Allison L. Marciszyn, N. Montalbetti, M. Carattino, M. Butterworth, T. Kleyman, R. Hughey   +9 more
semanticscholar   +1 more source

Effects of aminoperimidine on electrolyte transport across amphibian skin [PDF]

, 1998
The effect of aminoperimidine (AP)on transepithelial Na+ transport and Cl- conductance (G(Cl)) of isolated amphibian skin (Bufo viridis and Rana esculenta) was analyzed using transepithelial and intracellular electrophysiological techniques.
Katz, U., Nagel, W., Shalitin, Y.
core   +1 more source

Intracellular Sodium Regulates Proteolytic Activation of the Epithelial Sodium Channel [PDF]

Journal of Biological Chemistry, 2008
Na(+) transport across epithelia is mediated in part by the epithelial Na(+) channel ENaC. Previous work indicates that Na(+) is an important regulator of ENaC, providing a negative feedback mechanism to maintain Na(+) homeostasis. ENaC is synthesized as an inactive precursor, which is activated by proteolytic cleavage of the extracellular domains of ...
Kristin K, Knight, Danielle M, Wentzlaff, Peter M, Snyder   +2 more
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Wuji Wan ameliorates ulcerative colitis by restoring impaired membrane transport

Frontiers in Pharmacology
IntroductionWuji Wan (WJW) is a classical Chinese formula traditionally prescribed for diarrhea/dysentery and abdominal pain. In ulcerative colitis (UC), inflammatory diarrhea reflects not only mucosal inflammation but also inflammation-linked disruption
Jianyu Zhang, Yang Zhang, Yuxuan Guo, Yi Sun, Yujie Li, Qi Li, Ying Chen, Yajie Wang, Qing Yang, Meiyu Zhang, Xiaogang Weng, Zhihao Deng   +11 more
doaj   +1 more source

Duramycin-induced calcium release in cancer cells [PDF]

, 2015
Introduction: Duramycin through binding with phosphatidylethanolamine (PE) has shown potential to be an effective anti-tumour agent. However its mode of action in relation to tumour cells is not fully understood.
Broughton, Laura J., Crow, Chris, Madden, Leigh A., Maraveyas, Anthony   +3 more
core   +1 more source

Expression cloning of the epithelial sodium channel

Kidney International, 1995
Complex organisms take sodium from the external environment to achieve and maintain extracellular volume and blood pressure. Many sodium transporter systems have evolved, and among them the epithelial sodium channel plays a fundamental role in determining the final amount of sodium reabsorbed.
Canessa, Cecilia M., Horisberger, Jean-Daniel, Schild, Laurent, Rossier, Bernard C.   +3 more
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Complex evolutionary dynamics of massively expanded chemosensory receptor families in an extreme generalist chelicerate herbivore [PDF]

, 2016
While mechanisms to detoxify plant produced, anti-herbivore compounds have been associated with plant host use by herbivores, less is known about the role of chemosensory perception in their life histories.
Bajda-Wybouw, Sabina, Cao, Thi Ngoc Phuong, Clark, Richard M, Dermauw, Wannes, Grbić, Miodrag, Greenhalgh, Robert, Rombauts, Stephane, Rouzé, Pierre, Van de Peer, Yves, Van Leeuwen, Thomas, Zhurov, Vladimir   +10 more
core   +4 more sources

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source