A biophysical model of cell adhesion mediated by immunoadhesin drugs and antibodies [PDF]
, 2010A promising direction in drug development is to exploit the ability of natural killer cells to kill antibody-labeled target cells. Monoclonal antibodies and drugs designed to elicit this effect typically bind cell-surface epitopes that are overexpressed on target cells but also present on other cells.
A Ashkenazi+45 more
arxiv +33 more sources
Mining of linear B cell epitopes of SARS-CoV-2 ORF8 protein from COVID-19 patients
Emerging Microbes and Infections, 2021Given the on-going SARS-CoV-2 pandemic, identification of immunogenic targets against the viral protein will provide crucial advances towards the development of sensitive diagnostic tools and vaccination strategies. Our previous study has found that ORF8
Xiaohui Wang+6 more
doaj +1 more source
A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition [PDF]
, 2013The membrane proximal external region (MPER) of the HIV-1 glycoprotein gp41 is targeted by the broadly neutralizing antibodies 2F5 and 4E10. To date, no immunization regimen in animals or humans has produced HIV-1 neutralizing MPER-specific antibodies ...
Aasa-Chapman, Marlén M. I.+23 more
core +12 more sources
Incorporation of T-cell epitopes from tetanus and diphtheria toxoids into in-silico-designed hypoallergenic vaccine may enhance the protective immune response against allergens [PDF]
Iranian Journal of Basic Medical Sciences, 2020Objective(s): New generation of allergy vaccines is capable of promoting the development of protective IgG and blocking the functionality of allergen-specific IgE. We incorporated universal and powerful T-cell epitopes from tetanus and diphtheria toxoids
Ali Ghasemi+5 more
doaj +1 more source
TITAN: T Cell Receptor Specificity Prediction with Bimodal Attention Networks [PDF]
Bioinformatics 37 (2021): i237-i244, 2021Motivation: The activity of the adaptive immune system is governed by T-cells and their specific T-cell receptors (TCR), which selectively recognize foreign antigens. Recent advances in experimental techniques have enabled sequencing of TCRs and their antigenic targets (epitopes), allowing to research the missing link between TCR sequence and epitope ...
arxiv +1 more source
In silico proof of principle of machine learning-based antibody design at unconstrained scale
mAbs, 2022Generative machine learning (ML) has been postulated to become a major driver in the computational design of antigen-specific monoclonal antibodies (mAb).
Rahmad Akbar+18 more
doaj +1 more source
BeeTLe: A Framework for Linear B-Cell Epitope Prediction and Classification [PDF]
, 2023The process of identifying and characterizing B-cell epitopes, which are the portions of antigens recognized by antibodies, is important for our understanding of the immune system, and for many applications including vaccine development, therapeutics, and diagnostics.
arxiv +1 more source
Computational Design of a Novel VLP-Based Vaccine for Hepatitis B Virus
Frontiers in Immunology, 2020Hepatitis B virus (HBV) is a global virus responsible for a universal disease burden for millions of people. Various vaccination strategies have been developed using viral vector, nucleic acid, protein, peptide, and virus-like particles (VLPs) to ...
Saeed Mobini+4 more
doaj +1 more source
Japanese encephalitis virus (JEV) exposure or vaccination could elicit cross-reactive CD8 T cell immunity against heterologous flaviviruses in humans.
Marion Tarbe+19 more
doaj +1 more source
Identifying New Hybrid Insulin Peptides (HIPs) in Type 1 Diabetes
Frontiers in Immunology, 2021In 2016 Delong et al. discovered a new type of neoepitope formed by the fusion of two unrelated peptide fragments. Remarkably these neoepitopes, called hybrid insulin peptides, or HIPs, are recognized by pathogenic CD4+ T cells in the NOD mouse and human
Stuart I. Mannering+5 more
doaj +1 more source