Results 1 to 10 of about 552,242 (397)

A biophysical model of cell adhesion mediated by immunoadhesin drugs and antibodies [PDF]

, 2010
A promising direction in drug development is to exploit the ability of natural killer cells to kill antibody-labeled target cells. Monoclonal antibodies and drugs designed to elicit this effect typically bind cell-surface epitopes that are overexpressed on target cells but also present on other cells.
A Ashkenazi, A Iannello, AF Wells, AJ da Silva, BJ Scallon, Byron Goldstein, C Anderson, C Fewtrell, C Wofsy, CN Ellis, DA Hammer, Daniel Coombs, DM Zhu, DM Zhu, E Jones, F Chamian, G Bell, G Majeau, GI Bell, H Koon, J Cooper, J Galon, JA Trapani, JY Shao, K Maenaka, L Arnould, LJ Harris, LM Friedman, Lucienne Chatenoud, M Dustin, MA Ghetie, Michael L. Dustin, MJ Rosenbluth, ML Dustin, ML Dustin, ML Dustin, RA Byrn, RA Clynes, Ryan N. Gutenkunst, S Chandrasekhar, S Preithner, SE Chesla, TA Waldmann, Toby Starr, Y Kaizuka, YT Bryceson   +45 more
arxiv   +34 more sources

T Cell Epitope Predictions.

Annual Review of Immunology, 2020
Throughout the body, T cells monitor MHC-bound ligands expressed on the surface of essentially all cell types. MHC ligands that trigger a T cell immune response are referred to as T cell epitopes.
Bjoern Peters, M. Nielsen, A. Sette
semanticscholar   +5 more sources

An Introduction to B-Cell Epitope Mapping and In Silico Epitope Prediction [PDF]

Journal of Immunology Research, 2016
Identification of B-cell epitopes is a fundamental step for development of epitope-based vaccines, therapeutic antibodies, and diagnostic tools. Epitope-based antibodies are currently the most promising class of biopharmaceuticals. In the last decade, in-
L. Potocnakova, M. Bhide, L. Pulzova
semanticscholar   +4 more sources

Impact of HLA Epitope Matching on Outcomes After Unrelated Bone Marrow Transplantation

Frontiers in Immunology, 2022
The significance of antibody-identified epitopes stimulating humoral alloimmunity is not well understood in the identification of non-permissive human leukocyte antigen (HLA) mismatching patterns in hematopoietic stem cell transplantation (HSCT).
Makoto Iwasaki, Junya Kanda, Hidenori Tanaka, Takero Shindo, Takahiko Sato, Noriko Doki, Takahiro Fukuda, Yukiyasu Ozawa, Tetsuya Eto, Naoyuki Uchida, Yuta Katayama, Keisuke Kataoka, Takahide Ara, Shuichi Ota, Makoto Onizuka, Yoshinobu Kanda, Tatsuo Ichinohe, Yoshiko Atsuta, Yoshiko Atsuta, Satoko Morishima   +19 more
doaj   +1 more source

Mining of linear B cell epitopes of SARS-CoV-2 ORF8 protein from COVID-19 patients

Emerging Microbes and Infections, 2021
Given the on-going SARS-CoV-2 pandemic, identification of immunogenic targets against the viral protein will provide crucial advances towards the development of sensitive diagnostic tools and vaccination strategies. Our previous study has found that ORF8
Xiaohui Wang, Joy-Yan Lam, Linlei Chen, Shannon Wing-Ngor Au, Kelvin K. W. To, Kwok-Yung Yuen, Kin-Hang Kok   +6 more
doaj   +1 more source

BepiPred‐3.0: Improved B‐cell epitope prediction using protein language models

bioRxiv, 2022
B-cell epitope prediction tools are of great medical and commercial interest due to their practical applications in vaccine development. The introduction of protein language models (LM) trained on unprecedented large datasets of protein sequences and ...
J. Clifford, M. H. Høie, Morten Nielsen, Sebastian Deleuran, B. Peters, P. Marcatili   +5 more
semanticscholar   +1 more source

Design of a Recombinant Multivalent Epitope Vaccine Based on SARS-CoV-2 and Its Variants in Immunoinformatics Approaches

Frontiers in Immunology, 2022
The development of an effective multivalent vaccine against SARS-CoV-2 variants is an important means to improve the global public health situation caused by COVID-19. In this study, we identified the antigen epitopes of the main global epidemic SARS-CoV-
Mingkai Yu, Mingkai Yu, Yuejie Zhu, Yujiao Li, Zhiqiang Chen, Zhiqiang Chen, Zhiwei Li, Jing Wang, Zheng Li, Fengbo Zhang, Fengbo Zhang, Jianbing Ding, Jianbing Ding   +12 more
doaj   +1 more source

A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition [PDF]

, 2013
The membrane proximal external region (MPER) of the HIV-1 glycoprotein gp41 is targeted by the broadly neutralizing antibodies 2F5 and 4E10. To date, no immunization regimen in animals or humans has produced HIV-1 neutralizing MPER-specific antibodies ...
Aasa-Chapman, Marlén M. I., Battella, Simone, Bonvin, Alexandre M. J. J., Davis, David, El Khattabi, Mohamed, Favier, Adrien, Forsman Quigley, Anna, Hinz, Andreas, Hock, Miriam, Hulsik, David Lutje, Langedijk, Johannes P. M., Liu, Ying-ying, Macheboeuf, Pauline, McCoy, Laura E., Poignard, Pascal, Ramos, Alejandra, Rutten, Lucy, Sabin, Charles, Seaman, Michael S., Simorre, Jean-Pierre, Strokappe, Nika M., Verrips, C. Theo, Weiss, Robin A., Weissenhorn, Winfried   +23 more
core   +13 more sources

Snowflake: A deep learning-based human leukocyte antigen matching algorithm considering allele-specific surface accessibility

Frontiers in Immunology, 2022
Histocompatibility in solid-organ transplantation has a strong impact on long-term graft survival. Although recent advances in matching of both B-cell epitopes and T-cell epitopes have improved understanding of allorecognition, the immunogenic ...
Matthias Niemann, Benedict M. Matern, Eric Spierings, Eric Spierings   +3 more
doaj   +1 more source

Pediatric Kidney Transplantation—Can We Do Better? The Promise and Limitations of Epitope/Eplet Matching

Frontiers in Pediatrics, 2022
Kidney transplant is the optimal treatment for end-stage kidney disease as it offers significant survival and quality of life advantages over dialysis.
Olga Charnaya, Daniella Levy Erez, Daniella Levy Erez, Sandra Amaral, Dimitrios S. Monos   +4 more
doaj   +1 more source