Results 1 to 10 of about 472,049 (341)

A novel HLA-B18 restricted CD8+ T cell epitope is efficiently cross-presented by dendritic cells from soluble tumor antigen [PDF]

, 2012
NY-ESO-1 has been a major target of many immunotherapy trials because it is expressed by various cancers and is highly immunogenic. In this study, we have identified a novel HLA-B*1801-restricted CD8⁺T cell epitope, NY-ESO-1<sub&
Ashley J. Knights, Emmanuel Scotet, Eugene Maraskovsky, Heather M. Jackson, Ian D. Davis, Immanuel F. Luescher, Jonathan Cebon, Kok-Fei Chan, Kun Xiao, Neil C. Robson, Nektaria Dimopoulos, Nicole A. Mifsud, Philippe Guillaume, Rona Y. Zhao, Sara Oveissi, Sarah E. Russell, Sylvie Le Gall, Tamara Lowen, Weisan Chen   +18 more
core   +19 more sources

Mining of linear B cell epitopes of SARS-CoV-2 ORF8 protein from COVID-19 patients

Emerging Microbes and Infections, 2021
Given the on-going SARS-CoV-2 pandemic, identification of immunogenic targets against the viral protein will provide crucial advances towards the development of sensitive diagnostic tools and vaccination strategies. Our previous study has found that ORF8
Xiaohui Wang, Joy-Yan Lam, Linlei Chen, Shannon Wing-Ngor Au, Kelvin K. W. To, Kwok-Yung Yuen, Kin-Hang Kok   +6 more
doaj   +1 more source

A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition [PDF]

, 2013
The membrane proximal external region (MPER) of the HIV-1 glycoprotein gp41 is targeted by the broadly neutralizing antibodies 2F5 and 4E10. To date, no immunization regimen in animals or humans has produced HIV-1 neutralizing MPER-specific antibodies ...
Aasa-Chapman, Marlén M. I., Battella, Simone, Bonvin, Alexandre M. J. J., Davis, David, El Khattabi, Mohamed, Favier, Adrien, Forsman Quigley, Anna, Hinz, Andreas, Hock, Miriam, Hulsik, David Lutje, Langedijk, Johannes P. M., Liu, Ying-ying, Macheboeuf, Pauline, McCoy, Laura E., Poignard, Pascal, Ramos, Alejandra, Rutten, Lucy, Sabin, Charles, Seaman, Michael S., Simorre, Jean-Pierre, Strokappe, Nika M., Verrips, C. Theo, Weiss, Robin A., Weissenhorn, Winfried   +23 more
core   +15 more sources

Antibodies validated for routinely processed tissues stain frozen sections unpredictably

BioTechniques, 2021
Background: Antibody validation for tissue staining is required for reproducibility; criteria to ensure validity have been published recently. The majority of these recommendations imply the use of routinely processed (formalin-fixed, paraffin-embedded ...
Maddalena M Bolognesi, Francesco Mascadri, Laura Furia, Mario Faretta, Francesca M Bosisio, Giorgio Cattoretti   +5 more
doaj   +1 more source

Development of a Universal Epitope-Based Influenza Vaccine and Evaluation of Its Effectiveness in Mice

Vaccines, 2022
Vaccination is an effective and economically viable means of protection against the influenza virus, but due to rapid viral evolution, modern seasonal vaccines are not effective enough.
Ramil R. Mintaev, Dina V. Glazkova, Olga V. Orlova, Elena V. Bogoslovskaya, German A. Shipulin   +4 more
doaj   +1 more source

Revealing Novel-Strain-Specific and Shared Epitopes of Infectious Bronchitis Virus Spike Glycoprotein Using Chemical Linkage of Peptides onto Scaffolds Precision Epitope Mapping

Viruses, 2023
The avian coronavirus, infectious bronchitis virus (IBV), is an economically important infectious disease affecting chickens, with a diverse range of serotypes found globally.
Samantha Sives, Sarah Keep, Erica Bickerton, Lonneke Vervelde   +3 more
doaj   +1 more source

Pediatric Kidney Transplantation—Can We Do Better? The Promise and Limitations of Epitope/Eplet Matching

Frontiers in Pediatrics, 2022
Kidney transplant is the optimal treatment for end-stage kidney disease as it offers significant survival and quality of life advantages over dialysis.
Olga Charnaya, Daniella Levy Erez, Daniella Levy Erez, Sandra Amaral, Dimitrios S. Monos   +4 more
doaj   +1 more source

Combining different bacteria in vaccine formulations enhances the chance for antiviral cross-reactive immunity: a detailed in silico analysis for influenza A virus

Frontiers in Immunology, 2023
Bacteria are well known to provide heterologous immunity against viral infections through various mechanisms including the induction of innate trained immunity and adaptive cross-reactive immunity.
Andrés Bodas-Pinedo, Esther M. Lafuente, Hector F. Pelaez-Prestel, Alvaro Ras-Carmona, Jose L. Subiza, Pedro A. Reche   +5 more
doaj   +1 more source

Epitope mapping of ORF3a Protein SARS-CoV-2 in Indonesia through computational study

Journal of Tropical Life Science, 2022
In Indonesia, the vaccine for SARS-CoV-2 is still being developed. ORF3a protein of SARS-CoV-2 could be a potential peptide to be used in the vaccine, therapeutic antibodies, and diagnostic kit development. We used the computational approach in designing
Hartiyowidi Yuliawuri, Jeanne Elvia Christian   +1 more
doaj   +1 more source

Potent neutralizing monoclonal antibodies against Ebola virus isolated from vaccinated donors

mAbs, 2020
Ebola virus (EBOV) can cause severe hemorrhagic fever in humans, and no approved treatment is currently available. Although several antibodies have achieved good protection in animal models, the potential emerging isolates of ebolavirus and the unknown ...
Pengfei Fan, Xiangyang Chi, Guodong Liu, Guanying Zhang, Zhengshan Chen, Yujiao Liu, Ting Fang, Jianmin Li, Logan Banadyga, Shihua He, Changming Yu, Xiangguo Qiu, Wei Chen   +12 more
doaj   +1 more source