Results 1 to 10 of about 428,284 (191)

Mining of linear B cell epitopes of SARS-CoV-2 ORF8 protein from COVID-19 patients

Emerging Microbes and Infections, 2021
Given the on-going SARS-CoV-2 pandemic, identification of immunogenic targets against the viral protein will provide crucial advances towards the development of sensitive diagnostic tools and vaccination strategies. Our previous study has found that ORF8
Xiaohui Wang, Joy-Yan Lam, Linlei Chen, Shannon Wing-Ngor Au, Kelvin K. W. To, Kwok-Yung Yuen, Kin-Hang Kok   +6 more
doaj   +1 more source

Antibodies validated for routinely processed tissues stain frozen sections unpredictably

BioTechniques, 2021
Background: Antibody validation for tissue staining is required for reproducibility; criteria to ensure validity have been published recently. The majority of these recommendations imply the use of routinely processed (formalin-fixed, paraffin-embedded ...
Maddalena M Bolognesi, Francesco Mascadri, Laura Furia, Mario Faretta, Francesca M Bosisio, Giorgio Cattoretti   +5 more
doaj   +1 more source

Development of a Universal Epitope-Based Influenza Vaccine and Evaluation of Its Effectiveness in Mice

Vaccines, 2022
Vaccination is an effective and economically viable means of protection against the influenza virus, but due to rapid viral evolution, modern seasonal vaccines are not effective enough.
Ramil R. Mintaev, Dina V. Glazkova, Olga V. Orlova, Elena V. Bogoslovskaya, German A. Shipulin   +4 more
doaj   +1 more source

HLA Class-II Associated HIV Polymorphisms Predict Escape from CD4+ T Cell Responses. [PDF]

, 2015
Antiretroviral therapy, antibody and CD8+ T cell-mediated responses targeting human immunodeficiency virus-1 (HIV-1) exert selection pressure on the virus necessitating escape; however, the ability of CD4+ T cells to exert selective pressure remains ...
Allen, S, Bansal, A, Carlson, J, Dilernia, D, Du, VY, Erdmann, N, Gilmour, J, Goepfert, PA, Heath, S, Hunter, E, Jureka, A, Lakhi, S, Schaefer, M, Sidney, J, Sterrett, S, Tang, J, Yue, L   +16 more
core   +12 more sources

Revealing Novel-Strain-Specific and Shared Epitopes of Infectious Bronchitis Virus Spike Glycoprotein Using Chemical Linkage of Peptides onto Scaffolds Precision Epitope Mapping

Viruses, 2023
The avian coronavirus, infectious bronchitis virus (IBV), is an economically important infectious disease affecting chickens, with a diverse range of serotypes found globally.
Samantha Sives, Sarah Keep, Erica Bickerton, Lonneke Vervelde   +3 more
doaj   +1 more source

Pediatric Kidney Transplantation—Can We Do Better? The Promise and Limitations of Epitope/Eplet Matching

Frontiers in Pediatrics, 2022
Kidney transplant is the optimal treatment for end-stage kidney disease as it offers significant survival and quality of life advantages over dialysis.
Olga Charnaya, Daniella Levy Erez, Daniella Levy Erez, Sandra Amaral, Dimitrios S. Monos   +4 more
doaj   +1 more source

Combining different bacteria in vaccine formulations enhances the chance for antiviral cross-reactive immunity: a detailed in silico analysis for influenza A virus

Frontiers in Immunology, 2023
Bacteria are well known to provide heterologous immunity against viral infections through various mechanisms including the induction of innate trained immunity and adaptive cross-reactive immunity.
Andrés Bodas-Pinedo, Esther M. Lafuente, Hector F. Pelaez-Prestel, Alvaro Ras-Carmona, Jose L. Subiza, Pedro A. Reche   +5 more
doaj   +1 more source

Epitope mapping of ORF3a Protein SARS-CoV-2 in Indonesia through computational study

Journal of Tropical Life Science, 2022
In Indonesia, the vaccine for SARS-CoV-2 is still being developed. ORF3a protein of SARS-CoV-2 could be a potential peptide to be used in the vaccine, therapeutic antibodies, and diagnostic kit development. We used the computational approach in designing
Hartiyowidi Yuliawuri, Jeanne Elvia Christian   +1 more
doaj   +1 more source

A Linear Epitope in the N-Terminal Domain of CCR5 and Its Interaction with Antibody. [PDF]

, 2015
The CCR5 receptor plays a role in several key physiological and pathological processes and is an important therapeutic target. Inhibition of the CCR5 axis by passive or active immunisation offers one very selective strategy for intervention.
Akthar, S, Arnold, J, Brandt, M, Chain, B, Chayen, NE, Davis, D, Govada, L, Ji, C, Lapp, T, Noursadeghi, M, Sankuratri, S, Saridakis, E, Zhang, Y   +12 more
core   +8 more sources

Epitope Tagging [PDF]

BioTechniques, 2008
Epitope tagging is widely used in the characterization of newly discovered proteins. This review presents an overview of how the technique evolved and how it is being used today, with a focus on its use in the study of protein-protein interactions. In addition, the evolution of the technique for proteomic analyses is described.
openaire   +3 more sources