Results 1 to 10 of about 599,854 (345)
BepiPred-2.0: improving sequence-based B-cell epitope prediction using conformational epitopes
Nucleic Acids Research, 2017 Antibodies have become an indispensable tool for many biotechnological and clinical applications. They bind their molecular target (antigen) by recognizing a portion of its structure (epitope) in a highly specific manner.
Martin Closter Jespersen +2 more
exaly +2 more sources
Nature Biotechnology, 2019 Prediction of HLA epitopes is important for the development of cancer immunotherapies and vaccines. However, current prediction algorithms have limited predictive power, in part because they were not trained on high-quality epitope datasets covering a ...
Susan Klaeger +2 more
exaly +2 more sources
Designing a multi-epitope based vaccine to combat Kaposi Sarcoma utilizing immunoinformatics approach [PDF]
Scientific Reports, 2019 Kaposi’s sarcoma-associated herpesvirus (KSHV) responsible for causing Kaposi sarcoma (KS), an opportunistic angioproliferative neoplasm is emerging rapidly. Despite this there is no permanent cure for this disease.
Varun Chauhan +3 more
openalex +2 more sources
Proof of principle for epitope-focused vaccine design
Nature, 2014 Vaccines prevent infectious disease largely by inducing protective neutralizing antibodies against vulnerable epitopes. Several major pathogens have resisted traditional vaccine development, although vulnerable epitopes targeted by neutralizing ...
Bruno Correia +2 more
exaly +2 more sources
A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition [PDF]
, 2013 The membrane proximal external region (MPER) of the HIV-1 glycoprotein gp41 is targeted by the broadly neutralizing antibodies 2F5 and 4E10. To date, no immunization regimen in animals or humans has produced HIV-1 neutralizing MPER-specific antibodies ...
Aasa-Chapman, Marlén M. I. +23 more
core +22 more sources
A novel HLA-B18 restricted CD8+ T cell epitope is efficiently cross-presented by dendritic cells from soluble tumor antigen [PDF]
, 2012 NY-ESO-1 has been a major target of many immunotherapy trials because it is expressed by various cancers and is highly immunogenic. In this study, we have identified a novel HLA-B*1801-restricted CD8<sup>+</sup>T cell epitope, NY-ESO-1<sub&
Ashley J. Knights +18 more
core +20 more sources
bioRxiv, 2023 T cells have the ability to eliminate infected and cancer cells and play an essential role in cancer immunotherapy. T-cell activation is elicited by the binding of the T-cell receptor (TCR) to epitopes displayed on MHC molecules, and the TCR specificity ...
Giancarlo Croce +6 more
semanticscholar +1 more source
BepiPred‐3.0: Improved B‐cell epitope prediction using protein language models
bioRxiv, 2022 B-cell epitope prediction tools are of great medical and commercial interest due to their practical applications in vaccine development. The introduction of protein language models (LM) trained on unprecedented large datasets of protein sequences and ...
Joakim Clifford +5 more
semanticscholar +1 more source
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV
Science, 2020 Targeting the SARS-CoV-2 spike The surface of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) is decorated with trimeric spikes that bind to host cell receptors.
M. Yuan +7 more
semanticscholar +1 more source
Antibody Recognition of a Highly Conserved Influenza Virus Epitope
Science, 2009 Damian C Ekiert +2 more
exaly +2 more sources