Results 1 to 10 of about 474,243 (340)

A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition [PDF]

, 2013
The membrane proximal external region (MPER) of the HIV-1 glycoprotein gp41 is targeted by the broadly neutralizing antibodies 2F5 and 4E10. To date, no immunization regimen in animals or humans has produced HIV-1 neutralizing MPER-specific antibodies ...
Aasa-Chapman, Marlén M. I., Battella, Simone, Bonvin, Alexandre M. J. J., Davis, David, El Khattabi, Mohamed, Favier, Adrien, Forsman Quigley, Anna, Hinz, Andreas, Hock, Miriam, Hulsik, David Lutje, Langedijk, Johannes P. M., Liu, Ying-ying, Macheboeuf, Pauline, McCoy, Laura E., Poignard, Pascal, Ramos, Alejandra, Rutten, Lucy, Sabin, Charles, Seaman, Michael S., Simorre, Jean-Pierre, Strokappe, Nika M., Verrips, C. Theo, Weiss, Robin A., Weissenhorn, Winfried   +23 more
core   +15 more sources

Recent Progress in Antibody Epitope Prediction

Antibodies, 2023
Recent progress in epitope prediction has shown promising results in the development of vaccines and therapeutics against various diseases. However, the overall accuracy and success rate need to be improved greatly to gain practical application ...
Xincheng Zeng, Ganggang Bai, Chuance Sun, Buyong Ma   +3 more
doaj   +1 more source

Combining different bacteria in vaccine formulations enhances the chance for antiviral cross-reactive immunity: a detailed in silico analysis for influenza A virus

Frontiers in Immunology, 2023
Bacteria are well known to provide heterologous immunity against viral infections through various mechanisms including the induction of innate trained immunity and adaptive cross-reactive immunity.
Andrés Bodas-Pinedo, Esther M. Lafuente, Hector F. Pelaez-Prestel, Alvaro Ras-Carmona, Jose L. Subiza, Pedro A. Reche   +5 more
doaj   +1 more source

Epitope mapping of ORF3a Protein SARS-CoV-2 in Indonesia through computational study

Journal of Tropical Life Science, 2022
In Indonesia, the vaccine for SARS-CoV-2 is still being developed. ORF3a protein of SARS-CoV-2 could be a potential peptide to be used in the vaccine, therapeutic antibodies, and diagnostic kit development. We used the computational approach in designing
Hartiyowidi Yuliawuri, Jeanne Elvia Christian   +1 more
doaj   +1 more source

Immunoinformatics-Based Identification of B and T Cell Epitopes in RNA-Dependent RNA Polymerase of SARS-CoV-2

Vaccines, 2022
Introduction: The ongoing coronavirus disease 2019 (COVID-19), which emerged in December 2019, is a serious health concern throughout the world. Despite massive COVID-19 vaccination on a global scale, there is a rising need to develop more effective ...
Shabir Ahmad Mir, Mohammed Alaidarous, Bader Alshehri, Abdul Aziz Bin Dukhyil, Saeed Banawas, Yahya Madkhali, Suliman A. Alsagaby, Ayoub Al Othaim   +7 more
doaj   +1 more source

Non-Toxin-Based Clostridioides difficile Vaccination Approaches

Pathogens, 2023
Clostridioides difficile (CD) is a Gram-positive, anaerobic bacterium that infects mainly hospitalized and elderly people who have been treated with long-term antibiotic therapy leading to dysbiosis.
Agnieszka Razim, Sabina Górska, Andrzej Gamian   +2 more
doaj   +1 more source

Identification of the Binding Epitope of an Anti-Mouse CCR6 Monoclonal Antibody (C₆Mab-13) Using 1× Alanine Scanning

Antibodies, 2023
CC chemokine receptor 6 (CCR6) is one of the members of the G-protein-coupled receptor (GPCR) family that is upregulated in many immune-related cells, such as B lymphocytes, effector and memory T cells, regulatory T cells, and immature dendritic cells ...
Tomohiro Tanaka, Mayuki Tawara, Hiroyuki Suzuki, Mika K. Kaneko, Yukinari Kato   +4 more
doaj   +1 more source

Functional epitopes and neutralizing antibodies of vaccinia virus

Frontiers in Microbiology, 2023
Smallpox is an infectious disease caused by the variola virus, and it has a high mortality rate. Historically it has broken out in many countries and it was a great threat to human health.
Fenghao Peng, Naijing Hu, Yingjun Liu, Cong Xing, Longlong Luo, Xinying Li, Jing Wang, Guojiang Chen, He Xiao, Chenghua Liu, Beifen Shen, Jiannan Feng, Chunxia Qiao   +12 more
doaj   +1 more source

Features of the Human Antibody Response against the Respiratory Syncytial Virus Surface Glycoprotein G

Vaccines, 2020
Respiratory syncytial virus (RSV) infections are a major cause of serious respiratory disease in infants. RSV occurs as two major subgroups A and B, which mainly differ regarding the surface glycoprotein G. The G protein is important for virus attachment
Kristina Borochova, Katarzyna Niespodziana, Katarina Stenberg Hammar, Marianne van Hage, Gunilla Hedlin, Cilla Söderhäll, Margarete Focke-Tejkl, Rudolf Valenta   +7 more
doaj   +1 more source

The Impact of Mutations on the Pathogenic and Antigenic Activity of SARS-CoV-2 during the First Wave of the COVID-19 Pandemic: A Comprehensive Immunoinformatics Analysis

Vaccines, 2021
An in-depth analysis of first-wave SARS-CoV-2 genome is required to identify various mutations that significantly affect viral fitness. In the present study, we performed a comprehensive in silico mutational analysis of 3C-like protease (3CLpro), RNA ...
Zulqarnain Baloch, Aqsa Ikram, Mohamad S. Hakim, Faryal Mehwish Awan   +3 more
doaj   +1 more source