Results 1 to 10 of about 454,400 (350)
Impact of HLA Epitope Matching on Outcomes After Unrelated Bone Marrow Transplantation
Frontiers in Immunology, 2022 The significance of antibody-identified epitopes stimulating humoral alloimmunity is not well understood in the identification of non-permissive human leukocyte antigen (HLA) mismatching patterns in hematopoietic stem cell transplantation (HSCT).
Makoto Iwasaki +19 more
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Frontiers in Immunology, 2022 The development of an effective multivalent vaccine against SARS-CoV-2 variants is an important means to improve the global public health situation caused by COVID-19. In this study, we identified the antigen epitopes of the main global epidemic SARS-CoV-
Mingkai Yu +12 more
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Frontiers in Immunology, 2022 Histocompatibility in solid-organ transplantation has a strong impact on long-term graft survival. Although recent advances in matching of both B-cell epitopes and T-cell epitopes have improved understanding of allorecognition, the immunogenic ...
Matthias Niemann +3 more
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Frontiers in Pediatrics, 2022 Kidney transplant is the optimal treatment for end-stage kidney disease as it offers significant survival and quality of life advantages over dialysis.
Olga Charnaya +4 more
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Prediction and validation of murine MHC class I epitopes of the recombinant virus VSV-GP
Frontiers in Immunology, 2023 Oncolytic viruses are currently tested as a novel platform for cancer therapy. These viruses preferentially replicate in and kill malignant cells. Due to their microbial origin, treatment with oncolytic viruses naturally results in anti-viral responses ...
Saskia V. Vijver +11 more
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Frontiers in Immunology, 2021 The adaptive immune system in vertebrates has evolved to recognize non-self antigens, such as proteins expressed by infectious agents and mutated cancer cells.
William D. Chronister +15 more
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Incorporation of T-cell epitopes from tetanus and diphtheria toxoids into in-silico-designed hypoallergenic vaccine may enhance the protective immune response against allergens [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): New generation of allergy vaccines is capable of promoting the development of protective IgG and blocking the functionality of allergen-specific IgE. We incorporated universal and powerful T-cell epitopes from tetanus and diphtheria toxoids
Ali Ghasemi +5 more
doaj +1 more source
TITAN: T Cell Receptor Specificity Prediction with Bimodal Attention Networks [PDF]
Bioinformatics 37 (2021): i237-i244, 2021 Motivation: The activity of the adaptive immune system is governed by T-cells and their specific T-cell receptors (TCR), which selectively recognize foreign antigens. Recent advances in experimental techniques have enabled sequencing of TCRs and their antigenic targets (epitopes), allowing to research the missing link between TCR sequence and epitope ...
arxiv +1 more source
BeeTLe: A Framework for Linear B-Cell Epitope Prediction and Classification [PDF]
, 2023 The process of identifying and characterizing B-cell epitopes, which are the portions of antigens recognized by antibodies, is important for our understanding of the immune system, and for many applications including vaccine development, therapeutics, and diagnostics.
arxiv +1 more source
In silico proof of principle of machine learning-based antibody design at unconstrained scale
mAbs, 2022 Generative machine learning (ML) has been postulated to become a major driver in the computational design of antigen-specific monoclonal antibodies (mAb).
Rahmad Akbar +18 more
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