Results 1 to 10 of about 554,474 (398)
Universal characterization of epitope immunodominance from a multi-scale model of clonal competition in germinal centers [PDF]
arXiv, 2023 We introduce a novel, multi-scale model for affinity maturation, which aims to capture the intra-clonal, inter-clonal and epitope-specific organization of the B cell population in a germinal center. We describe the evolution of the B cell population via a quasispecies dynamics, with species corresponding to unique B cell receptors (BCRs), where the ...
arxiv
Detection of Enriched T Cell Epitope Specificity in Full T Cell Receptor Sequence Repertoires
bioRxiv, 2018 High-throughput T cell receptor (TCR) sequencing allows the characterization of an individual’s TCR repertoire and directly query their immune state. However, it remains a non-trivial task to couple these sequenced TCRs to their antigenic targets.
Sofie Gielis +6 more
semanticscholar +1 more source
Molecules, 2022 Tropomyosin in shellfish is considered a major cross-reactive allergen in house dust mites and cockroaches; however, the specific epitopes have not been elucidated. Therefore, this study aimed to identify the consensus antigenic determinant among shrimp,
Jirakrit Saetang +2 more
doaj +1 more source
Dynamics of Virus and Immune Response in Multi-Epitope Network [PDF]
, 2017 The host immune response can often efficiently suppress a virus infection, which may lead to selection for immune-resistant viral variants within the host. For example, during HIV infection, an array of CTL immune response populations recognize specific epitopes (viral proteins) presented on the surface of infected cells to effectively mediate their ...
arxiv +1 more source
The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor. [PDF]
, 1995 Although inhibition of natural killer (NK) cell-mediated lysis by the class I HLA molecules of target cells is an established phenomenon, knowledge of the features of class I molecules which induce this effect remains rudimentary.
Gumperz, JE +4 more
core
Journal of Translational Medicine, 2019 Middle East Respiratory Syndrome Coronavirus (MERS-COV) is the main cause of lung and kidney infections in developing countries such as Saudi Arabia and South Korea. This infectious single-stranded, positive (+) sense RNA virus enters the host by binding
Muhammad Tahir ul Qamar +5 more
semanticscholar +1 more source
Neutralizing Antibody Response to Hepatitis C Virus
Viruses, 2011 A critical first step in a “rational vaccine design” approach for hepatitis C virus (HCV) is to identify the most relevant mechanisms of immune protection. Emerging evidence provides support for a protective role of virus neutralizing antibodies, and the
Zhen-Yong Keck +2 more
doaj +1 more source
Potent neutralizing monoclonal antibodies against Ebola virus isolated from vaccinated donors
mAbs, 2020 Ebola virus (EBOV) can cause severe hemorrhagic fever in humans, and no approved treatment is currently available. Although several antibodies have achieved good protection in animal models, the potential emerging isolates of ebolavirus and the unknown ...
Pengfei Fan +12 more
doaj +1 more source
Recent Progress in Antibody Epitope Prediction
Antibodies, 2023 Recent progress in epitope prediction has shown promising results in the development of vaccines and therapeutics against various diseases. However, the overall accuracy and success rate need to be improved greatly to gain practical application ...
Xincheng Zeng +3 more
doaj +1 more source
Autoantibody recognition mechanisms of MUC1 [PDF]
, 2016 The most cost-effective blood-based, noninvasive molecular cancer biomarkers are based on p53 epitopes and MUC1 tandem repeats. Here we use dimensionally compressed bioinformatic fractal scaling analysis to compare the two distinct and comparable probes, which examine different sections of the autoantibody population, achieving combined sensitivities ...
arxiv +1 more source