Results 1 to 10 of about 412,636 (314)
BepiPred-2.0: improving sequence-based B-cell epitope prediction using conformational epitopes
Nucleic Acids Research, 2017 Antibodies have become an indispensable tool for many biotechnological and clinical applications. They bind their molecular target (antigen) by recognizing a portion of its structure (epitope) in a highly specific manner.
Martin Closter Jespersen +2 more
exaly +2 more sources
Nature Biotechnology, 2019 Prediction of HLA epitopes is important for the development of cancer immunotherapies and vaccines. However, current prediction algorithms have limited predictive power, in part because they were not trained on high-quality epitope datasets covering a ...
Susan Klaeger +2 more
exaly +2 more sources
Proof of principle for epitope-focused vaccine design
Nature, 2014 Vaccines prevent infectious disease largely by inducing protective neutralizing antibodies against vulnerable epitopes. Several major pathogens have resisted traditional vaccine development, although vulnerable epitopes targeted by neutralizing ...
Bruno Correia +2 more
exaly +2 more sources
bioRxiv, 2023 T cells have the ability to eliminate infected and cancer cells and play an essential role in cancer immunotherapy. T-cell activation is elicited by the binding of the T-cell receptor (TCR) to epitopes displayed on MHC molecules, and the TCR specificity ...
Giancarlo Croce +6 more
semanticscholar +1 more source
BepiPred‐3.0: Improved B‐cell epitope prediction using protein language models
bioRxiv, 2022 B-cell epitope prediction tools are of great medical and commercial interest due to their practical applications in vaccine development. The introduction of protein language models (LM) trained on unprecedented large datasets of protein sequences and ...
Joakim Clifford +5 more
semanticscholar +1 more source
Antibody Recognition of a Highly Conserved Influenza Virus Epitope
Science, 2009 Damian C Ekiert +2 more
exaly +2 more sources
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV
Science, 2020 Targeting the SARS-CoV-2 spike The surface of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) is decorated with trimeric spikes that bind to host cell receptors.
M. Yuan +7 more
semanticscholar +1 more source
Recent Progress Towards a Gonococcal Vaccine
Frontiers in Cellular and Infection Microbiology, 2022 Gonorrhea is a global health concern. Its etiological agent, Neisseria gonorrhoeae, rapidly acquires antimicrobial resistance and does not confer protective immunity as a consequence of infection.
Stavros A. Maurakis +1 more
doaj +1 more source
Computational Design of a Novel VLP-Based Vaccine for Hepatitis B Virus
Frontiers in Immunology, 2020 Hepatitis B virus (HBV) is a global virus responsible for a universal disease burden for millions of people. Various vaccination strategies have been developed using viral vector, nucleic acid, protein, peptide, and virus-like particles (VLPs) to ...
Saeed Mobini +4 more
doaj +1 more source
Identifying New Hybrid Insulin Peptides (HIPs) in Type 1 Diabetes
Frontiers in Immunology, 2021 In 2016 Delong et al. discovered a new type of neoepitope formed by the fusion of two unrelated peptide fragments. Remarkably these neoepitopes, called hybrid insulin peptides, or HIPs, are recognized by pathogenic CD4+ T cells in the NOD mouse and human
Stuart I. Mannering +5 more
doaj +1 more source